Stem Cells From Menstrual Blood May Benefit Stroke Patients

In VICTORIES & SUCCESS STORIES on April 28, 2010 at 7:11 am


Cerebral ischemia, or reduced blood flow to the brain, as occurs in stroke or trauma, is a significant clinical problem.

Menstrual Blood Cells Display Stem Cell–Like Phenotypic Markers and Exert Neuroprotection Following Transplantation in Experimental Stroke

Cesar V. Borlongan,1 Yuji Kaneko,1 Mina Maki,2 Seong-Jin Yu,1 Mohammed Ali,2 Julie G. Allickson,3 Cyndy D. Sanberg,4 Nicole Kuzmin-Nichols,4 and Paul R. Sanberg1,5

Cell therapy remains an experimental treatment for neurological disorders. A major obstacle in pursuing the clinical application of this therapy is fi nding the optimal cell type that will allow benefi t to a large patient population with minimal complications. A cell type that is a complete match of the transplant recipient appears as an optimal scenario.

Here, we report that menstrual blood may be an important source of autologous stem cells. Immunocytochemical assays of cultured menstrual blood reveal that they express embryonic-like stem cell phenotypic markers (Oct4, SSEA, Nanog), and when grown in appropriate conditioned media, express neuronal phenotypic markers (Nestin, MAP2). In order to test the therapeutic potential of these cells, we used the in vitro stroke model of oxygen glucose deprivation (OGD) and found that OGD-exposed primary rat neurons
that were co-cultured with menstrual blood-derived stem cells or exposed to the media collected from cultured menstrual blood exhibited signifi cantly reduced cell death. Trophic factors, such as VEGF, BDNF, and NT-3, were up-regulated in the media of OGD-exposed cultured menstrual blood-derived stem cells.

Transplantation of menstrual blood-derived stem cells, either intracerebrally or intravenously and without immunosuppression,
after experimentally induced ischemic stroke in adult rats also signifi cantly reduced behavioral and histological impairments compared to vehicle-infused rats. Menstrual blood-derived cells exemplify a source of “individually tailored” donor cells that completely match the transplant recipient, at least in women. The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke.

Via http://www.liebertonline.com/doi/abs/10.1089/scd.2009.0340 or scd.2009.0340 (application/pdf Object).

  1. Yes You are right.I like your writing, menstrual blood stem cells can be used for curing diseases like cancer, heart stroke, diabetes, etc.
    You can also store menstrual blood for future references.

    Thanks a lot for the nice blog, Keep blogging.

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