Jordan to host ground-breaking trial on heart patients | Ascent | AMEinfo.com

In STEM CELLS IN THE NEWS on April 7, 2010 at 10:49 pm


“As we tell you every chance we get, virtually everything you hear about stem cells in America is a lie—especially the nonsense about the science fiction known as “embryonic stem cells.”  However, those USA researchers who are using the only stem cells that work, Adult Stem Cells, also exaggerate regularly about their “new” “groundbreaking” discoveries.

Bioheart is a Florida company, one which we have long admired for its efforts to bring stem cells to the thousands of heart patients who could live longer and better lives rather than suffer with the obsolete, toxic medicines their doctors are forced to use.

Notice in this article about a new clinical trial in Jordan, how CEO Karl Groth carefully explains, without exaggeration, the potential benefits of his truly groundbreaking product.  But then read this statement from the doctor in Jordan who is running the trial.  His statement wasn’t even true five years ago!

“He said that until now heart muscle damage was considered irreversible and permanent.”

That is something we hear from USA promoters all the time. The super hype bologna is now in the middle-east!

VesCell (Thailand, Israel, Dominican Rep) has treated 500 patients, starting 1/1/05, with autologous stem cells, while the Johann Strauss Institute in Frankfurt has done about that many—all OUTSIDE clinical trials, for patients who once had no options and no hope.   90%+ of VesCell’s patients would not qualify for any trial.  Indeed, over half of them could not even qualify for a transplant!

So, Dr. Imad, we are sorry you are five years behind the times, as most Americans are.  We wish you the best in your upcoming trial.”

For the full story on available data and stem cell treatments for heart disease: https://repairstemcell.wordpress.com/heart-disease-treatment/

To find the best clinic in the world for treating Heart Disease, all you need to do is fill out this form HEART DISEASE TREATMENT – INFO REQUEST

Jordan to host ground-breaking trial on heart patients

A ground-breaking clinical trial on patients with congestive heart failure is to take place in Jordan in the capital’s Jordan Hospital, according to Dr Karl Groth, Chairman and CEO of Bioheart, Inc. Bioheart is fueled by a Middle East medical fund, the Ascent Medical Technology Fund II, LP.

The FDA-approved study, REGEN, is set to observe 15 patients with congestive heart failure treated with genetically-modified MyoCell, a process that uses the patient’s own muscle as a basis for treatment.

Groth said that MyoCell has been successfully tested in four clinical trials and advised that pre-trial research results from studies using Myocell with SDF-1, indicate significant improvement in patients with congestive heart failure (CHF).

“The results of REGEN pre-clinical studies using modified myoblasts show a marked improvement in the heart function of patients with CHF,” said Dr Groth. Groth is also President and CEO of the General Partner, and member of the Ascent Group.

He explained that modified myoblasts induce a higher release of SDF-1 protein, the catalyst that generates stem cells in the body after an injury.

“The research conducted in advance of pre-clinical trials strongly indicates that genetically modified stem cell therapy may increase the speed of repair or regeneration of heart muscles. This means that a patient can return to a normal lifestyle, faster.

We have found that SDF-1 releases additional therapeutic proteins to assist in the tissue repair process, resulting in a more expansive and quicker repair,” said Groth.

The REGEN clinical trial is the first and only FDA-approved clinical study evaluating the therapeutic benefit of combined modified gene-cell therapy for CHF.

Dr. Imad Alh addad, MD, FACC, FACP and Co-Director of the Jordan Cardiovascular Centre, is Principal Investigator, leading the Study. He said that until now heart muscle damage was considered irreversible and permanent. “As a result of the trials, we can now help regenerate and repair heart muscle using innovative techniques like stem cell therapy. The REGEN trial is the milestone study that will help us achieve these goals.”

Groth added that the REGEN trial is designed to test the safety and effectiveness of the composition of muscle stem cells that have been gene-modified to induce a greater than usual release of the SDF-1 protein.

“We fully expect that this trial will significantly enhance the clinical improvements we have already observed in our Phase II/III MyoCell study,” Groth said.

He explained that unlike other tissues, the heart muscle does not release sufficient SDF-1 to attract the number of stem cells to promote complete self-healing, often resulting in scar tissue formation and an impairment of normal heart function.

According to statistics (American Heart Association), the US spends approximately US$22.5 billion per year on the treatment of patients with heart failure.

After completing the REGEN trial, we plan to transition this second-generation product into its FDA approved Phase II/III MARVEL study.

“Bioheart plans to further study the impact of modified myoblasts by observing three groups; a set of patients who are participating in the study and observing the differences in clinical and heart function among the modified group, those who are treated with MyoCell alone, and a placebo group, concluded Groth.

via Jordan


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