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CATCH UP!! – US Cardiac Stem Cell Trial is years behind

In CATCH UP! on October 5, 2009 at 11:16 pm

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“UCSF Medical Center (has)begun enrollment for an early-stage clinical trial…(using) adult stem cell therapy for patients who have just experienced their first acute myocardial infarction, or heart attack.”

THIS IS YEARS BEHIND!! HERE’S WHY:

“First came a year or two of (repair stem cell/cardiac) animal tests, then, in Paris, 2000, doctors gave a dying 70-year-old heart patient bone marrow cells and he lived four years, at which time the doctors ‘fessed up and released his name.

In 2001, USA pioneer Warren Sherman, MD (Columbia U, Mt. Sinai NY Hosp) went to Rotterdam and became the first American to implant ASC into a human heart. However, if you can believe it, the same Sherman, calls those that have taken forward what he did eight years ago, “snake oil salesmen.”

In 2002, a very daring clinical trial led by Dr. Hans Dohmann plus six colleagues in Brazil took 21 transplant candidates and gave 14 of them bone marrow cells. The results were so spectacular that the AHA accepted the paper and it was presented in 2003. Five of the seven in the control group opted in to make a total of 19 stem cell transplants. The mortality rate for transplant candidates is about 35% per year. At that rate there would be, of those 19, only 2.2 patients still alive after five years. There were, in fact, 12 alive as of Dec. 31, 2007; more than five years down the road.

In 2003, Dr. Andreas Zeiher of the Goethe Institute in Frankfurt began much larger trials. As of 2007, he has overseen more ASC implants into hearts than anyone, both in and out of clinical trials.

In 2004, Dr. Amit Patel of Pittsburgh completed two of the most successful trials ever, especially when, in Uruguay, he proved, on a group of ischemic heart failure patients, that a bypass plus cells was infinitely better than a bypass only. That same year, TheraVitae, in Israel, developed a new, powerful blood-derived stem cell and dared to treat the sickest patients no clinical trial would consider.

Also in 2004, one of the Brazilians, Dr. Perin, came to Texas and used the Brazil results to get the first ASC heart clinical trial approved by the FDA. Over a dozen such approvals were granted in the next 12-18 months.

Meanwhile, around the world, while USA stem cell research remains mired in politics instead of science, ASC advances in virtually every sector of medicine are rocketing forward without any sign of letting up.

In 2005, Drs. Vina & Saslavsky in Argentina completed the very first successful diabetes2 stem cell clinical trial in the world: 13 out of 16 successfully cured. Spinal problems and emphysema and renal failure and cirrhosis of the liver treatments will be moving to the forefront in 2008-9. (Yes, but mostly in China and elsewhere, while Americans die with those diseases without a chance of help from their “doctors.”

AND MORE:

More info on heart disease and stem cells treatment: https://repairstemcell.wordpress.com/2009/09/24/heart-disease-asc-a-brief-history/

Patients are being treated all over the world today with years of research and clinical trials behind the procedures.

Excerpt from the original YEARS BEHIND article:

Cardiac Stem Cell Trial Seeks To Treat Some Heart Attack Patients

Monday, October 05, 2009

Researchers at UCSF Medical Center have begun enrollment for an early-stage clinical trial to evaluate the safety and efficacy of an adult stem cell therapy for patients who have just experienced their first acute myocardial infarction, or heart attack. The trial is part of a multi-center national study.

The cells used, known as mesenchymal stem cells, were obtained from the bone marrow of healthy adult donors. Depending on their location in the body, mesenchymal stem cells give rise to bone, cartilage, fat, muscle and connective tissue.

The experimental therapy is intended to combat the symptoms related to heart damage that continue to develop following a heart attack, including low pumping capacity, inflammation and increased scar tissue.

via Cardiac Stem Cell Trial Seeks To Treat Some Heart Attack Patients – The Philadelphia Bulletin.

 

STEM CELL BREAST RECONSTRUCTION

In ALL ARTICLES on October 5, 2009 at 2:02 pm

breast reconstruction

Cytori Therapeutics, Tissue Genesis, Thermogenesis, Stem Cell Therapies, Branding, And Joining Forces

Stem cell therapy is quietly entering areas where it provides improved or alternative therapeutic results. Cytori is showing continually improved study and anecdotal results in breast reconstruction with adipose stem cells, a result which implicitly includes the creation of new blood vessels. If positive results continue, breast reconstruction is going to be an excellent market for Cytori, one already generating the lion’s share of its current revenues, and one in which it is clearly establishing a leadership position.

via Stem Cell Research: Cytori Therapeutics, Tissue Genesis, Thermogenesis, Stem Cell Therapies, Branding, And Joining Forces.

RECENT REGENERATIVE MEDICINE STORIES

In ALL ARTICLES on October 5, 2009 at 1:52 pm

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Bioaesthetics and regenerative medicine

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Chris Mason et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 635-637.
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Sep 17, 2009 12:27 PM

Launching intravenous bone marrow cell trials for acute stroke

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Sean I Savitz et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 639-641.
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Sep 17, 2009 12:27 PM

News & Views in … Regenerative Medicine

Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 643-645.
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Sep 17, 2009 12:27 PM

Industry Update: Latest developments in stem cell research and regenerative medicine

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Dusko Ilic)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 647-657.
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Sep 17, 2009 12:27 PM

Interview: Discussions on the development of human embryonic stem cell-based therapies

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Jane S Lebkowski)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 659-661.
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Sep 17, 2009 12:27 PM

Research Highlights

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Mariann Gyöngyösi)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 663-666.
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Sep 17, 2009 12:27 PM

Hair follicle neogenesis induced by cultured human scalp dermal papilla cells

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Jizeng Qiao et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 667-676.
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Sep 17, 2009 12:27 PM

Conjunctival epithelial cells maintain stem cell properties after long-term culture and cryopreservation

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (S Schrader et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 677-687.
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Sep 17, 2009 12:27 PM

Ficoll-Paque™ versus Lymphoprep™: a comparative study of two density gradient media for therapeutic bone marrow mononuclear cell preparations

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Chia Yeo et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 689-696.
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Sep 17, 2009 12:27 PM

Pulp and dentin tissue engineering and regeneration: current progress

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (George TJ Huang)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 697-707.
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Sep 17, 2009 12:27 PM

Intracoronary blood- or bone marrow-derived cell transplantation in patients with ischemic heart disease

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Thorsten Reffelmann et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 709-719.
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Sep 17, 2009 12:27 PM

Engineering microenvironments for embryonic stem cell differentiation to cardiomyocytes

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Renita E Horton et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 721-732.
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Sep 17, 2009 12:27 PM

Microencapsulated stem cells for tissue repairing: implications in cell-based myocardial therapy

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Arghya Paul et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 733-745.
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Sep 17, 2009 12:27 PM

Reclaiming a natural beauty: whole-organ engineering with natural extracellular materials

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Samantha Traphagen et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 747-758.
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Sep 17, 2009 12:27 PM

Induced pluripotent stem cells in regenerative medicine: an argument for continued research on human embryonic stem cells

from Future Medicine: Regenerative Medicine: Table of Contents by info@futuremedicine.com (Han Lee et al)
Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 759-769.
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Sep 17, 2009 12:27 PM

Acknowledgements

Regenerative Medicine , September 2009, Vol. 4, No. 5, Pages 781-781.
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Johns Hopkins stem cell research site is launched

In ALL ARTICLES on October 5, 2009 at 1:51 pm

Web site on Johns Hopkins stem cell research is launched

September 28, 2009 – By Gazette Contributor

In conjunction with last week’s 2009 World Stem Cell Summit, co-hosted by Johns Hopkins and held in Baltimore, Johns Hopkins Medicine launched an interactive Web site on which its researchers and clinicians collectively describe their explorations into stem cell biology and engineering.

The multimedia production, which went live Sept. 21 at http://www.hopkinsmedicine.org/stem_cell_research, emphasizes applications of stem cell technologies in regenerative medicine and underscores the collaborative effort that is fundamental to translational research.

The site includes everything from a narrated timeline of stem cell research to a video feature of a Johns Hopkins patient, physician and bench scientist who are linked by stem cell research as it relates to Parkinson’s disease. Johns Hopkins experts also weigh in on state-of-the-art issues of ethics and safety as they apply to stem cells.

via Web site on Johns Hopkins stem cell research is launched : The Gazette.

US Medical System is Leading Cause of Death

In ALL ARTICLES on October 5, 2009 at 1:48 pm

reapers_curse_poster“…the American medical system is the leading cause of death and injury in the US.”

Death by Medicine

By Gary Null, PhD; Carolyn Dean MD, ND; Martin Feldman, MD; Debora Rasio, MD; and Dorothy Smith, PhD

…researchers meticulously reviewed the statistical evidence and their findings are absolutely shocking. These researchers have authored a paper titled “Death by Medicine” that presents compelling evidence that today’s system frequently causes more harm than good.

  • This fully referenced report shows the number of people having in-hospital, adverse reactions to prescribed drugs to be 2.2 million per year.
  • The number of unnecessary antibiotics prescribed annually for viral infections is 20 million per year.
  • The number of unnecessary medical and surgical procedures performed annually is 7.5 million per year.
  • The number of people exposed to unnecessary hospitalization annually is 8.9 million per year.
  • The most stunning statistic, however, is that the total number of deaths caused by conventional medicine is an astounding 783,936 per year.

It is now evident that the American medical system is the leading cause of death and injury in the US.

(By contrast, the number of deaths attributable to heart disease in 2001 was 699,697, while the number of deaths attributable to cancer was 553,251.5)

ALS Stem Cell Trial Gets FDA Go Ahead

In ALL ARTICLES on October 5, 2009 at 1:48 pm

ALS Stem Cell Trial Gets FDA Go Ahead The US Food and Drug Administration (FDA) said the first clinical trial to test a new stem cell treatment for the fatal neurodegenerative disease ALS (amyotrophic lateral sclerosis) this month (ALS) can go ahead.

Adult stem cells offer fracture treatment

In VICTORIES & SUCCESS STORIES on October 5, 2009 at 11:19 am

old news but more ammo for the argument that adult stem cells work, plain and simple.

Fracture

Adult stem cells offer new fracture treatment

ANI5 October 2009, 12:44pm IST

Adult stem cells can offer a new treatment for the 10 to 20 percent of fractures that fail to heal, according to a new study .

via Adult stem cells offer new fracture treatment – Health – Health & Fitness – LIFE & STYLE – The Times of India.

UCSF’s Elizabeth Blackburn wins Nobel Prize – San Francisco Business Times:

In ALL ARTICLES on October 5, 2009 at 11:17 am
Nobel Prize

Three U.S. scientists who discovered key aspects of how cells and animals age and how cancer cells become immortal today won the 2009 Nobel Prize in physiology or medicine.

Elizabeth Blackburn of UC San Francisco, Carol W. Greider of the Johns Hopkins University School of Medicine and Jack W. Szostak of Harvard Medical School share the $1.4-million award for their discovery of telomeres, small sections of DNA that protect the integrity of cellular DNA as animals and most other organisms age. They also discovered telomerase, the enzyme that manufactures telomeres and gives cancer cells their eternal life.

Blackburn, Greider
Biologists Elizabeth Blackburn, left, and Carol Greider, two of the three Nobel prize winners, are shown in March, when they won the Paul Ehrlich and Ludwig Darmstaedter Prize in Frankfurt, Germany

Elizabeth Blackburn of the University of California, San Francisco, was named the Nobel Prize winner in physiology or medicine for discovering how chromosomes are protected…

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Chromosome

The discoveries have an impact on cancer research as well as research into aging and other diseases. Blackburn and her UCSF colleagues have found, for example, that telomeres are worn down in people who are stressed for long periods of time, like a parent caring for a chronically ill child.

Blackburn is the fourth UCSF Nobel Prize winner, joining Stanley Prusiner, Harold Varmus and former chancellor J. Michael Bishop.

Blackburn, Greider and Szostak beat out other notable scientists, including Shinya Yamanaka of UCSF and the J. David Gladstone Institutes, whose work at Kyoto University in Japan produced an embryonic-like stem cell from adult stem cells.

Yamanaka last month won the Lasker Award, considered a precursor to a Nobel Prize. It is the same award that Blackburn, Greider and Szostak won in 2006.

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