DAVID GRANOVSKY

No More Chemo + Radiation For Kids Getting Stem Cells

In VICTORIES & SUCCESS STORIES on September 2, 2009 at 11:31 am

FINALLY!!

This novel approach represents a shift from the paradigm that intensive chemotherapy or radiotherapy is needed for donor stem-cell engraftment.

New Technique Reduces Toxicity Associated With Stem Cell Transplants in Children

NEW YORK — September 1, 2009 — A minimal-intensity conditioning (MIC) regimen using antibodies instead of high dose chemotherapy may reduce the short and long term toxicity associated with stem cell transplants in children, and enable successful transplantation even in the sickest children, according to a study published online first and in an upcoming edition of The Lancet…

This study analysed the results of antibody-based conditioning in 16 children with primary immunodeficiencies (PID) who were too sick to undergo a traditional stem cell transplant. The average age of these patients was 11 months and 11 of 16 had previously been ventilated on a life-support machine. The majority (11) were transplanted from unrelated donors and 5 from matched siblings.

The researchers found that antibody-based MIC was well tolerated despite the fact that most patients were extremely sick at the time of transplant, with only 2 cases of serious toxicity. The sickness and hair loss associated with high dose chemotherapy were not seen, and there was much less damage to the liver, lungs, and gut.

Patients recovered twice as quickly as those given standard treatment and the rates of graft-versus-host disease (GVHD were similar to with conventional transplant. Fifteen of the 16 patients (94%) engrafted, although in 2 cases this was not sufficient for cure.

At an average of 40 months post-transplant, 13 of 16 patients (81%) were alive and cured from their underlying disease. Almost all of these patients now have excellent quality of life and it is predicted that they will have very little in the way of late effects.

This novel approach represents a shift from the paradigm that intensive chemotherapy or radiotherapy is needed for donor stem-cell engraftment.

via News – New Technique Reduces Toxicity Associated With Stem Cell Transplants in Children.

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