DAVID GRANOVSKY

Archive for May 7th, 2009|Daily archive page

Adult VS Embryonic Stem Cell Research

In ALL ARTICLES, STEM CELLS IN THE NEWS on May 7, 2009 at 5:22 pm
ADULT STEM CELL TREATMENTS VS EMBRYONIC STEM CELL TREATMENTS

ADULT STEM CELL TREATMENTS VS EMBRYONIC STEM CELL TREATMENTS

by Dr Centeno

We’ve all heard about embryonic stem cells (ESC’s).  They have been in the news and the focus of controversy for a decade.  We’ve seen far less media coverage of  adult stem cells.  Adult stem cells (ASC’s) are found in everyone’s body and they are capable of repairing a host of tissues.  In fact, the research on adult cell lines has surpassed embryonic.

My search begins at the National Library of Medicine, looking at all embryonic stem cell published papers vs. the total on all adult stem cell lines. For every one ESC paper, there were at least two ASC papers.

asc vs esc chart

In addition, the research on ASC’s is vastly more mature, focusing on animal models of tissue healing, dosing, early human cases, medication interaction with cells, possible complications, etc…  The ESC research is more test tube and review articles on what might be possible someday.  Looking in specific categories, I found the following:

  • Cartilage Repair: 230 articles on embryonic vs. 1,113 for just one adult stem cell line (mesenchymal stem cells)
  • Myocardial Infarction:  186 for embryonic stem cells vs.  341 for adult mesenchymal stem cells, 69 for endothelial progenitor cells
  • Wound Healing: 114 for embryonic stem cells vs.  330 for adult mesenchymal stem cells, 565 for adult epithelial stem cells

For a more detailed analysis, take a look at the American Stem Cell Therapy Assocition (ASCTA) white paper on adult stem cells vs. embronic stem cell research.    Summary?  Adult stem cell research is much farther ahead.  In addition, as I have posted on before, if the cells are autologous (from the same patient), they also have a much lower risk profile.  While one day embryonic cells may rule the day, for now, adult stem cells are beating the pants off ESC’s in practical research.

To delve further, the first 20 references for myocardial infarction for adult stem cells are almost all devoted to actual animal models of treatment, advanced concepts such as dosing, etc…

Almost none of the 20 references in the same search for embryonic stem cells reveal any animal testing; the focus being review articles what about might be theoretically possible.  The conclusion, adult stem cells are much farther along in their development with regard to real world treatments.

What have these actual animal and early human models shown that adult stem cells are capable of healing?

•Orthopedic tissues such as cartilage, bone, muscle, tendon, spinal disc, and ligament[1‐25]
• Heart [26‐40]
• Pancreas (Diabetes)[41‐50]
• Wound Healing[51‐61]
• Lungs[62‐70]
• Brain (stroke, brain injury, Multiple Sclerosis, ALS)[71‐94]
• Spinal Cord (Spinal Cord Injury)[95‐99]
• Liver[100‐110]
• Kidney[111‐125]

http://www.regenexx.com/2009/05/embryonic-vs-adult-stem-cells/

“And the blind shall see” – 10 REAL STEM CELL VICTORIES!

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on May 7, 2009 at 1:39 pm
and the blind shall see

and the blind shall see

For Blind Girl, Seeing is Believing After Stem Cell Therapy

Posted 6 May, 2009 in Optic Nerve Hypoplasia | Stem Cell Research Helps Blind Girl See

Hayley Pelletier had been legally blind since birth due to her Optic Nerve Hypoplasia. However, thanks to the wonders of stem cell research using Adult Stem Cells, these days Hayley can now see and in the words of her mother “Basically, her whole quality of life was just bumped up 110 percent.”

No Medications, No Treatments, Nowhere To Go

Before the stem cell research that changed her life occurred, Hayley was learning how to read Braille and how to get around with a cane due to the Optic Nerve Hypoplasia, a leading cause of blindness in children where the optic nerve fails to develop.

Until an amazing new  stem cell treatment using cord blood stem cells, there was no drugs, no treatments that could improve Optic Nerve Hypoplasia.

Cord Blood Stem Cells- Only Treatment Available

Hayley and her mother Heather went to China for the stem cell treatment in November 2008.  And the results have been amazing.  Before, Hayley could barely only make out the difference between light and dark, but now-

  1. She can now draw pictures of people on paper
  2. She can identify colors easily
  3. She can watch television from 3 feet away.

From the stem cell article:

“It’s been incredible,” Pelletier said. “Basically, her whole quality of life was just bumped up 110 percent. She’s so much happier.”

Her self confidence has soared, too. Pelletier managed to say a few words at a Lions Club banquet, but she admits she was intimidated by the hundreds of people in the room. Hayley wasn’t.

“I brought a different child home from China. She stood on a chair and told them all about her experiences there,” said Pelletier, astonished. “Then she thanked them for honoring her with their support.”

Hayley Joins the Stem Cells for Optic Nerve Hypoplasia Club

Hayley now becomes the latest addition to our “club” of children who have been to China for stem cell therapy for their Optic Nerve Hypoplasia and the closely related Septo-Optic Dysplasia and then come back to the United States, UK and  Canada with better vision and other benefits to their development.

Before that there was Jakob Bielski from Canada

Just last week, we added Dakota Clarke , her mom said “It’s been worth every single penny to see the changes in her.”

A few weeks ago we added Macie Morse who can now see well enough to drive after her stem cell therapy.

And before that Coby Fend’s mother said ““We are talking about going back — we’d almost be crazy not to, because right now it’s the best thing going in the entire world.”

And we also had Connor CorkernHe’s doing great. He is doing wonderful. It’s like we’ve got a totally new baby, Coye Corkern said

We had Cameron Petersen – Grandma Petersen said “There was nothing for Cameron before this treatment. Now, his world is limitless.”

Lydia Black- From her father – “the treatment is already having a huge effect on her life, and he is glad that she was able to receive stem cell treatment in China.

Lydia Olmstead and Rylea Barlett – “After her second treatment, we started to notice a change,”

Savannah Watring“She said hello to herself in an elevator (after seeing her reflection). It blew everyone away. We weren’t expecting that.”

Xavier Carballo-Xavier’s ophthalmologist, Dr. Jack Guggino of Tampa, said he did a baseline exam on the boy before the trip to China and after his return. He said before the treatment Xavier could only detect hand motion at 1 to 2 feet, and after the treatment he could count fingers at 3 to 4 feet.

As far as Xavier is concerned, there has been definite and measurable improvement, neurologically and ophthalmologically,” Guggino said.

If you or someone you know has a similar condition or perhaps another disease,  please go to www.bit.ly/stemcellhelp

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