DAVID GRANOVSKY

Archive for March 1st, 2009|Daily archive page

Dolly the Sheep Shorn – Part 1 – Cloning 101

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS - 101 on March 1, 2009 at 6:41 pm

Dolly the Sheep & Clone

Dolly the Sheep & Clone

Cloning 101

Cloning is the process of creating living organisms identical to a single parent.  A clone is a group of organisms genetically identical individuals descended from the same parent (organism or cell) by some kind of asexual reproduction.  Some simple plants (such as tubers) and animals (such as sea anemones) reproduce naturally in this way, and identical twins are actually natural human clones, produced when the 2-cell-staged embryo split into two, known as embryo splitting.  Today, scientists clone by extracting the genetic material from a donor cell and putting it into an egg with its own genetic material removed.  The resulting embryo is allowed to develop, put into a surrogate mother, and come to term.  This is known as ‘nuclear transfer, the method used in creating Dolly, the sheep that made news headlines around the world and achieved a major scientific breakthrough.  What made her so special was that she was cloned from adult differentiated cells, a way that was considered impossible at that time.

The purpose of cloning research is to change living organisms so as to improve people’s lives.  Recently, developments in genetic engineering, and cloning in particular, show a promising future, but also raise frightening prospects.  Here we will further explore all these aspects and the risks and possibilities in this ‘tool for mankind’. http://library.thinkquest.org/C0122429/index1.htm

IMMACULATE CONCEPTION

In ALL ARTICLES on March 1, 2009 at 5:54 pm

https://repairstemcell.wordpress.com/2009/02/25/researchers-make-nerve-cells-from-new-stem-cells-science-reuters/

Adult Stem Cells for Shoulder Injuries

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 1, 2009 at 3:16 pm

“If a tear (in the shoulder labrum) is present, a patient’s own expanded mesenchymal stem cells (MSC)  are injected directly into the damaged areaand will differentiate into the cartilage which makes up the labrum.”

Labral Tears in the Shoulder

The labrum is a cartilaginous cup which circles the shallow shoulder socket (the glenoid) to make the socket deeper.  The labrum supports and stabilizes the shoulder joint.

Shoulder Labrum

Shoulder Labrum

Injury to the labrum typically occurs from repetitive trauma in overhead throwers, such as in baseball.  It can also occur from a traction injury to the arm, such as lifting a heavy object off the ground or getting your arm jerked.

Typical symptoms include pain in the front of the shoulder or deep inside the joint.

Treatment options initially  include physical therapy which is designed to restore range of motion and strength to the shoulder.  Often times shoulder arthroscopy is recommended where the damaged labrum is identified and then repaired using suture anchors to sew the labrum back in place.

Surgical Repair of Labrum

Surgical Repair of Labrum

At the Centeno-Schultz Clinic we have developed x-ray guided techniques to safely inject the labrum.  Once a small needle is appropriately placed, we inject a very small amount of contrast(dye) to confirm accurate placement.  The  x-ray pictures below illustrate the labrum being outlined with contrast. There are two pictures one of which is looking from the side where you can see the thin black line outlining the labrum and an oblique view in which you are looking down into the cup.

Oblique View of Labral Injection

Oblique View of Labral Injection

Lateral View of Labral Injection

Lateral View of Labral Injection

If a tear is present, a patient’s own stem cells can then be injected.  Regenexx allows a patient to have their own expanded mesenchymal stem cells (MSC)  injected directly into the damaged area.  Mesenchymal stem cells will differentiate into the cartilage which makes up the labrum.

Oral Surgeon Harvests Stem Cells For Patients – Denver News Story – KMGH Denver

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 1, 2009 at 2:56 pm

girl-smile-missing-tooeth

Oral Surgeon Harvests Stem Cells For Patients

UPDATED: 8:50 am MST March 1, 2009

STEAMBOAT SPRINGS, Colo. — Some Steamboat Springs residents are forgoing the Tooth Fairy, hoping their teeth wind up being worth much more than a quarter.

Steamboat Springs oral surgeon Dr. John Lupori offers patients the chance to store the stem cells in the teeth he extracts. Lupori partners with StemSave, a New York-based company that freezes and stores stem cells found in the pulp at the base of teeth. Science is moving fast, those involved said, and the cells might someday save the patient’s life.

stemsave

“Potentially, they’re incredibly miraculous,” said Dr. Bob Pensack, who had his daughter, Miriam, save her cells. “They’ve already been miraculous in the lab.”

Stem cells exist throughout the body and differentiate into organs and tissue. Stem cells that could be used to grow new organs, for example, are the type that haven’t differentiated. Dental stem cells fall into this category, StemSave CEO Art Greco said.

via Oral Surgeon Harvests Stem Cells For Patients – Denver News Story – KMGH Denver.

Stem Cells Derived from Menstrual Blood

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 1, 2009 at 1:52 pm

blood, bone marrow, testicles, fat, milk teeth, umbilical cord, breast milk, brain, nose and of course, menstruation.  the list goes on and on.  new discoveries and adult stem cell victories every day. -dg

isolated-menstrual-stem-cells

isolated-menstrual-stem-cells

Exclusive: Discoveries of Stem Cell Derived from Menstrual Blood Significant Step Forward to Transplantation – posted on 01/03/2009 – By Sally Robbins

A new type of stem cell derived from menstrual blood and other discoveries are providing significant steps forward in providing an ethical, easily accessible, and potentially highly useful adult stem cell for treatment of numerous degenerative conditions.

Recent scientific studies show cells taken from menstrual blood can be converted into major tissues of the body, can be cultivated in the lab and used like stem cells in repairing damaged heart tissue, and address major issues including routine and safe cell harvesting of renewable cells that maintain their differentiation capacity and can be scaled for widespread clinical use.

http://www.lifesciencesworld.com/news/view/97403

BALLS INTO BONES, BALLS INTO MUSCLES

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 1, 2009 at 12:37 pm

Is there any part of the human body that doesn’t have adult stem cells? -DG

balls

Testicle Stem Cells Become Bone, Muscle in German Experiments

Stem cells were isolated from the testicles of adult men and turned into bone, muscle, neural and other kinds of cells, German researchers said.

The advance, reported today in the journal Nature, may provide an alternative way to generate powerful stem cells that might be used to repair or replace damaged tissue in male patients with hard-to-treat diseases. Currently, scientists create stem cells by extracting them from embryos or genetically manipulating adult cells to make them pluripotent, or able to become many other cell types…

 

FAT STEM CELLS ARE GOOD FOR KIDNEY DAMAGE!

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on March 1, 2009 at 11:43 am

kidney

kidney

Adipose (FAT)-Derived (ADULT) Stem And Regenerative Cells Prevent Mortality And Reduce Kidney Damage In Preclinical Study

Article Date: 01 Mar 2009 – 1:00 PST

Cytori Therapeutics, Inc. (NASDAQ: CYTX) finds adipose tissue-derived stem and regenerative cells (ADRCs) significantly reduce mortality and improve renal function in an acute kidney injury model. The preclinical results were reported today at the 14th Annual International Conference on Continuous Renal Replacement Therapies.

http://www.medicalnewstoday.com/articles/140616.php

Will Rover outlive Grandma?

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS on March 1, 2009 at 10:58 am

What does it say about the medical establishment and government when your dog can get better health care care than you can? -DG

happy-dog

RNL Offers a Free Stem Cell Shot for Pets for New Banking Customers

As a promotional event from RNL Bio, pet owners who register RNL’s stem cell bank for animals will have unique opportunity for free stem cell therapy for their pets.

(PRWEB) March 1, 2009 — RNL Bio, a leading stem cell firm dedicated to the commercialization of adult stem cell based therapeutics, announced today that any pet owner whose dogs, cats or even horses are registered in the stem cell bank will get free one coupon for one time stem cell therapy valid through one year.

RNL has operated a stem cell bank for animals in Rockville, Maryland. The one time processing fee for stem cell banking is only $999. The stem cells will be preserved alive in liquid nitrogen tank and hold good up to 15 years. During the preservation period, customers can claim stem cells whenever their beloved pets are in need of stem cell therapy to treat various obstinate diseases, including but not limited to osteoarthritis, spinal cord injury, heart condition, aging, kidney failure and even brain damage while they are alive. The stored cells can also be used for cloning dogs after their dogs pass away.

“I am very glad to offer new banking customers free stem cell therapy for lovely pets and you will get the wonderful experience of state of the art technology,” said Jeong Chan Ra, chief executive of RNL Bio. He added, “Stem cell has lots of potential. When your dog is alive, stem cell can be used to treat your dog’s illness. The stem cell will remain alive in our stem cell bank. When your dog passes away, the banked stem cells remain still alive. You can use them to clone your dog if you want to. We recommend our pet lover to register their pets’ stem cell while they are younger and healthier. Stem cells harvested when young have more efficiency.”

http://www.prweb.com/releases/2009/03/prweb2194834.htm

STEM CELL VICTORIES – Dilated Cardio-Myopathy

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on March 1, 2009 at 10:19 am

cardiomyopathy

cardiomyopathy

Leonard Narracci – Dilated Cardio-Myopathy

My name is Leonard Narracci, and I live in Venice, Florida. Three years ago, I was diagnosed with Dilated Cardio-Myopathy. I was always tired, listless, and completely lethargic. I underwent all the traditional cardiac testing, and the bottom line was that I would be on medication, Toprol and Atacand, Ace inhibitors and Beta Blockers, to maintain the status quo, but there was little hope of improving my cardiac condition.

Discovering Dr. Zannos Grekos

After 3 years of living like this, I told my wife that I could not continue to live like this, but that I had to search for a more viable option. I began my research to find a “better way”. I found Regenocyte and Dr. Zannos Grekos, right here in my backyard in Bonita Springs, Florida. I researched his Stem Cell Therapy treatment intensely. Then, I attended a seminar of his, which confirmed the action that I had to take to repair my heart. I made an appointment with him and underwent all the necessary testing to determine if I was a viable candidate. Fortunately, I was! I expressed the desire to have the treatment, and his office set everything in motion.

Treatment Abstract

The entire Regenocyte experience was nothing short of perfection, beginning with his very capable and competent assistant, Nancy Trombino. Nancy made all the necessary arrangements and reservations and provided me with an itinerary that explicitly told me where and when I had to be all at times during the treatment. I had 8 ounces of blood drawn, and a courier was waiting to transport the blood to Miami Airport to be flown to a bio-tech lab in Israel. My stem cells were extracted, genetically engineered for heart repair, and then replicated to 143,000,000 stem cells.

Experience as a patient

On October 7, 2008, my wife, my friend, and I left Miami Airport for the Dominican Republic. As soon as we deplaned, we were met by two Regenocyte agents, who were wonderful. They transported us to the Marriott Hotel, which was charming and very comfortable. The staff there made every effort to provide us with all that we needed. The Regenocyte agents catered to our every want and need, even providing me with a cell phone. All I had to do was press a single number and I could make contact with an agent at any time of the day or night.

Treatment Procedure

On October 8th. Dr. Grekos had also flown in to the Dominican republic to perform the procedure. The agent took us to the hospital where I was prepped for the procedure and then taken to the Catheterization Lab for the procedure. The procedure takes between an hour and an hour and a half. The procedure consisted of 2 parts. In the first, my arteries in my heart were each shut off for 3 minutes, while the stem cells were infused. In the second part, the stem cells were directly injected into the diseased walls of my heart.

Treatment Experience

I felt absolutely nothing, and was totally fascinated watching the entire procedure on the monitor. During the entire treatment, Dr. Grekos would check on me, and tell me that everything was proceeding perfectly.Upon completion of the treatment, I was taken to an ICU room to be monitored overnight.

Post treatment

The next morning, October 9th., I was discharged, and the agents took me back to the hotel to relax for the rest of the day, per Dr. Grekos’ orders. The next morning, October 10th. The Regenocyte agents took us to the airport, and before we knew it, we were back in Miami, and my wife and I were on our way back home to Venice, Florida. For the next few days, I just took it easy and rested.

7 Days Later -Improvement

Exactly 7 days after the treatment I was feeling a renewed engergy and sense of well-being that I had not experienced in three years.

2 Weeks Later -Ejection Fraction up from 20 to 28

Two weeks after the treatment, I had a follow-up appointment with Dr. Grekos. He was much more than pleased with the results he found. He did an Echogram, and the results were nothing short of remarkable. After only two weeks he found that my heart apex was normal, my heart had decreased in size and my ejection fraction had risen from 20 to 28. On November 25th.

7 Weeks Later – Ejection Fraction up from 28 – 33

I went back to Doctor Grekos’ office for more testing, 7 weeks after treatment. The Echogram showed the walls of my heart thickening, indicating that the stem cells were regenerating healthy heart muscle that previously was non-functional and not contracting. It was now contracting strongly, evidenced by the fact that my ejection fraction was now up to 33. I guess these results say it all, and I am looking forward to the progression of these results over the next several months.

3 Months Later – Ejection Fraction up from 33 – 45

The middle of January, I will have more heart tests for the 3 month follow-up and then again at 6 months and at 9 months. January 23rd. I had my important 3 month follow-up appointment with Dr. Grekos. The week before, I had the testing: EKG, ICG, Nuclear Stress Test, and Muga Scan. The tests revealed that the dimensions of my enlarged heart had decreased and that my Ejection Fraction had now increased from 33 to 45. This is especially significant in light of the fact that I am only 10 points away from 55 which is a normal Ejection Fraction.

My Opinion of Dr Grekkos

Other than Dr. Grekos, there is no other invasive cardiologist in the world who has done more to advance and effectively apply the principles of Adult Stem Cell Therapy. Even the typically sceptical medical community is beginning to acknowlege the efficacy of the treatment and the expertise of Dr. Grekos. I cannot help but show my enthusiasm for a procedure and a doctor who has given back to me a quality of life that I never thought I would see again.

My hope and prayer

My hope and prayer is that the medical community and the FDA will very soon come to the realization of the significance of this treatment and provide the necessary approval, so that patients do not have to continue to go out of the country.

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