DAVID GRANOVSKY

Archive for February 12th, 2009|Daily archive page

Recent STEM CELLS & HIV News Is Encouraging

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 12, 2009 at 7:25 pm

Recent HIV News Is Encouraging—

but Also Provides Cause for Concern

February 12, 2009 05:03 PM ET | January W. Payne | Permanent Link | Print

We’ve heard the message: HIV is spreading rapidly, so the onus is on us to protect ourselves from getting infected in the first place…

Still, not all the recent HIV news has been bad. A new report from the New England Journal of Medicine describes a stem cell transplant that appears to have wiped out HIV in a 42-year-old patient. The transplant involved an HIV-positive man who had leukemia and received a transplant from a donor who possessed a gene mutation that provided a natural resistance to HIV. There is no sign of HIV in the patient’s blood since the transplant…

via Recent HIV News Is Encouraging—but Also Provides Cause for Concern – On Medicine (usnews.com).

STEM CELLS IN IRAN – 60% SUCCESS W/SPINAL CORD INJURIES

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 12, 2009 at 7:19 pm

Iran celebrates 30 years of medical success
Sun, 08 Feb 2009 18:30:50 GMT
By Patricia Khashayar, MD., Press TV, Tehran

In the three decades since the victory of the Islamic Revolution, Iranian researchers have made several crowning achievements in the field of medicine.

Iran is one of the 10 countries that produce human embryonic stem cells. The country has emerged as the leading stem cell researcher in the Middle East, due to its innovative scientific studies in this field.

Last year, Iranian researchers celebrated two thousand stem cell transplants and cell therapies performed at the BMT Research Center.

Iranian scientists have successfully identified and isolated human kidney stem cells, cultured and produced differentiated splenic and liver tissues in mice, and produced smooth muscle cells from human bone marrow-derived mesenchymal cells.

Iranian researchers have successfully used Schwann cell transplantation to repair spinal cord injuries, a procedure which is not routinely performed in countries other than Russia, China, and Germany.

The technique has so far been used to treat about 300 patients. The success rate was reported to be about 60 percent, whereas the success rate of the techniques used in other countries was no higher than 10 percent.

Following their latest achievements in the application of stem cells in treating patients with cardiac arrest, chronic lower extremities ulcers, limbal stem cell deficiency, liver cirrhosis, and vitiligo, the country’s first cellular therapy center was inaugurated in 2008 for the purpose of treating refractory diseases.

via Press TV – Iran celebrates 30 years of medical success.

STEM CELLS & PLURIPOTENCE

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS - 101, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 12, 2009 at 7:02 pm

Please be careful when reading this article.  You must understand that the stem cells being discussed here have almost nothing in common with embryonic stem cells except for their ability to become any cell in the body (pluripotent).  So these stem cells are NOT “embryonic-like” but rather adult stem cells that are modified to become pluripotent…or “induced ploripotent stem cells” (iPSC).  Not to be confused with the

Induced Pluripotent Stem Cells (iPSC) have:

  1. All of the repair benefits of adult stem cells
  2. The ability to become any cell in the human body
  3. None of the “controversy” of embryonic stem cells
  4. They do not become tumorous (leading to cancer) like ESC seem to
  5. They do not require immune suppressive drugs like ESC

I’ll say it in other words.  These are modified ADULT STEM CELLS.  They are not embryonic stem cells.  A semantic difference for sure but the simple fact is; adult stem cells have a proven history outside the US of providing significant therapeutic benefit to human patients, embryonic don’t and now it would seem, adult stem cells can do anything that embryonic stem cells can.

-DG

ipsc-neural-stem-cells

Reported February 13, 2009

New Recipe Could Lead to Stem Cell Breakthrough

(Ivanhoe Newswire)- The formula scientists concocted to make adult stem cells work like embryonic-like stem cells is now much more simple to perform.

For the first time, a new report shows how neural stem cells taken from adult mice can take on characteristics of embryonic stem cells. Researchers made this discovery by adding a single transcription factor to the mix, a gene that controls the activity of other genes.

According to Hans Scholer of the Max Planck Instute for Molecular Biomedicine in Germany, the discovery sheds light on long standing questions about what distinguishes the embryonic stem cells that can trigger egg and sperm cells to develop from other body cells. The discovery might also help figure out how reprogrammed stem cells could be used to replace cells lost to disease or injury.

SOURCE: Cell, February 2009

via Ivanhoe’s Medical Breakthroughs – New Recipe Could Lead to Stem Cell Breakthrough.

STEM CELLS & TYPE 2 DIABETES

In ALL ARTICLES, CATCH UP!, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 12, 2009 at 6:05 pm

diabetes_0

Stem Cell Research Uncovers Mechanism for Type 2 Diabetes

Published on 12 February 2009, 14:33 Last Update: 17 minute(s) ago by Insciences

Tags: Stem Cell Diabetes Medicine Progenitor cells

LA JOLLA, Calif., February 12, 2009—Taking clues from their stem cell research, investigators at the University of California San Diego (UC San Diego) and Burnham Institute for Medical Research (Burnham) have discovered that a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. Their findings, published online January 9 in Experimental Diabetes Research, could provide a potential new target for therapy.

Pamela Itkin-Ansari, Ph.D., assistant adjunct professor at the UC San Diego School of Medicine and Burnham; Fred Levine, M.D., Ph.D., professor and director of the Sanford Children’s Health Research Center at Burnham, and colleagues showed that the Wnt signaling pathway is up-regulated in insulin producing cells of pancreases from adults with type 2 diabetes…

via insciences.org – Stem Cell Research Uncovers Mechanism for Type 2 Diabetes.

STEM CELLS & CEREBRAL PALSY (CP)

In ALL ARTICLES, SCIENCE & STEM CELLS on February 12, 2009 at 4:52 pm

Through years of involvement in stem cells I have come to know some of the top stem cell scientists and doctors in the world.   Ask me any questions about treatments that you have and I will either get an answer for you or show you how to get it yourself! -dg

cerebralpalsy

Cerebral Palsy -Stem Cell Treatment Detail

Email the treatment center with details of the medical disease and diagnosis in question and ask if they can help. If there are two or three different stem cell therapy clinics, email one or all of them! No need to let us know, no need to register.

via Treatment Detail for Cerebral Palsy | Repair Stem Cell Institute™ Repair Stem Cell Institute™.

STEM CELLS & Autism Cure?

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES, VIDEOS on February 12, 2009 at 12:37 pm

Video of an autistic girl improving after receiving stem cell injections

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Treatment center uses adult stem cells to treat Autism.

Stem Cells Used In Woman’s Windpipe Transplant : NPR

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES, VIDEOS on February 12, 2009 at 12:10 pm

Stem Cells Used In Woman’s Windpipe Transplant

by Joe Neel and Joanne Silberner


Windpipe transplant patient Claudia Castillo. CREDIT: Courtesy of The Lancet

All Things Considered, November 19, 2008 · Doctors in Spain have implanted a new windpipe into a woman whose airway was badly damaged by tuberculosis.

The pioneering operation used a section of windpipe engineered in a laboratory with adult human stem cells, according to Dr. Paolo Macchiarini, of the Hospital Clinic in Barcelona, Spain.

Engineering new tissues and organs from stem cells has long been a goal of researchers, because it would help overcome a chronic shortage of donor organs.

via Stem Cells Used In Woman’s Windpipe Transplant : NPR.

SKorean Firm: Dogs Cloned Using Stem Cells

In ALL ARTICLES, STEM CELLS IN THE NEWS, VIDEOS on February 12, 2009 at 12:01 pm

REX IS BESIDES HIMSELF

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more about “SKorean Firm: Dogs Cloned Using Stem …“, posted with vodpod

STEM CELLS & MS – Multiple Sclerosis Cured by Adult Stem Cells- Video – Stem Cell Research and Stem Cell Therapy

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES, VIDEOS on February 12, 2009 at 11:40 am

Multiple Sclerosis Cured by Adult Stem Cells- Video

Today, Edwin's symptoms of MS have completely disappeared.

Written by Stemcells on Feb-11-09 2:13am

From: donmargolis.com

Posted 11 February, 2009 in Multiple Sclerosis |

In yet another triumph for Adult Stem Cell research- two weeks ago, Dr. Richard Burt came out with sensational results of his study at Northwestern University treating Multiple Sclerosis (MS) with the patient’s own Adult Stem Cells. This study showed that of the 21 patients with Multiple Sclerosis treated with their own stem cells taken from their bone marrow, 16 have had their MS “disappear” . Excellent!

Edwin McClure was one of those treated and cured of his MS by the stem cell treatment . He is interviewed by CBS on their “Early Show” here. This is a great video. Edwin talks about how he was shocked when he was diagnosed with Multiple Sclerosis in high school and how at first he didn’t want the stem cell treatment. I think it is safe to say he has changed his way of thinking- watch the whole video- FANTASTIC!

via Multiple Sclerosis Cured by Adult Stem Cells- Video – Stem Cell Research and Stem Cell Therapy – Zimbio.

CARDIAC STEM CELL TRIALS – THE US PLAYS “CATCH UP” – Part 3

In ALL ARTICLES, CATCH UP!, STEM CELLS - 101 on February 12, 2009 at 11:29 am
CATCH UP!

CATCH UP!

Osiris touts stem cell trial results

February 12, 2009 — 11:24am ET | By John Carroll

* Osiris shares soar on $1.38B Genzyme pact

* ALSO NOTED: Osiris files IPO; Amgen initiates kidney disease study; and much more…

* Osiris Therapeutics blueprints $80M IPO

* SPOTLIGHT: Osiris granted orphan status

Osiris Therapeutics says its final set of two-year results from a trial for Prochymal, its cutting-edge adult stem cell therapy, met its primary endpoint on safety. Prochymal demonstrated fewer adverse events compared to placebo, showed a drop in repeat hospitalizations, reduced incidents of cardiac arrhythmia and also resulted in a durable improvement in cardiac function. The placebo-controlled study enrolled 53 patients.

“This study adds convincing long-term data to the excellent safety profile of Prochymal, having now treated hundreds of patients in trials over the past decade,” said C. Randal Mills, Ph.D., president and CEO of Osiris Therapeutics. “We are excited that Prochymal demonstrated strong evidence of efficacy beyond the best cardiac care available today. We are now advancing this program into a larger Phase II trial, focusing on patients with more severe heart damage.”

Osiris, which is developing the therapy with Genzyme, recently completed enrollment in a Phase III trial of Prochymal for the treatment of steroid-refractory acute graft versus host disease. And in January the developer received clearance from the FDA to broaden its expanded access program for Prochymal.

– check out Osiris’ release

via Osiris touts stem cell trial results – FierceBiotech.

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