DAVID GRANOVSKY

Archive for February 10th, 2009|Daily archive page

STEM CELL & LYMPHOBLASTIC LEUKEMIA GENES FOUND

In ALL ARTICLES, STEM CELLS - 101, STEM CELLS IN THE NEWS on February 10, 2009 at 10:17 pm

suicide-genes-l

Sister genes maintain stem cells: Study

London (PTI): Scientists have discovered what they claim are two “sister” genes, which maintain the pool of adult stem cells destined to become blood.

An international team has found the two genes — the stem cell leukemia gene (Scl) and lymphoblastic leukemia gene 1 (Lyl1) — control transcription play often overlapping role in maintaining this pool of blood cell-forming stem cells.

“Both genes are involved in T-cell acute lymphoblastic leukemia. No one knew what role Lyl1 played in hematopoiesis (the formation of blood and related cells). The two of them have a functional redundancy. “If one is missing, the cell might be a little ‘sick’, but it survives. If both are missing, the cells die pretty quickly. Scl has been well studied and is a paradigm for hematopoiesis.

“Lyl1 was a lost sister. Only recently have a few groups studied it,” the study’s lead author Margaret Goodell of the Center of Baylor College of Medicine wrote in the Cell Stem Cell journal.

Stem cells of any kind are defined by their eternal nature, reproducing themselves and providing a pool of cells, from which more differentiated tissues arise. Previous studies had shown that when animals lacked the Scl in the embryonic stage, they did not make progenitor cells intrinsic to the formation of the blood cells and had defects in the blood vessel system.

“Up to this point, it was believed that Scl was dispensable for maintaining adult hematopoietic stem cell function after development. Our study shows that not only it’s dispensable, but it collaborates with Lyl1, and both necessary for cell survival,” co-author George Souroullas said.

According to the scientists, the study also suggests that Scl and Lyl1 are not only important in the formation of these kinds of stem cell but also for their maintenance in adults.

“While these genes are very similar and functionally redundant in adult stem cells, some molecular differences in protein structure, supported by other data in our lab, suggest that they may have distinct functions in differentiated blood cell types,” Souroullas said.

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via The Hindu News Update Service.

MUSCULAR DYSTROPHY, PART TWO – THE TREATMENT

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS - 101 on February 10, 2009 at 10:02 pm

sunset_may_2006The World-Leader in RSC treatments for neurological and autoimmune diseases is a treatment center which no center in the world can match for:

  1. Number of Diseases treated, and
  2. Number of Patients treated

The primary source of STEM CELLS used in treatments are autologous stem cells from the patient’s own body. Second is fresh cord blood stem cells that are made to order.  These cord blood stem cells are never frozen as they believe that even a cryo freeze can lower the viability and quality of the Repair Stem Cells.

Here is the list of stem cell treatments offered:

  • Alzheimer’s
  • Amyotrophic Lateral Sclerosis
  • Ataxia
  • Cerebellar Ataxia ( Includes Type 6 )
  • Hereditary Ataxias
  • Spinocerebellar Atrophy and Spinocerebellar Degeneration
  • Acquired Ataxia
  • Machado-Joseph disease
  • Olivopontocerebellar Atrophy
  • Early Stage Ataxia Telangiectasia
  • Autism Spectrum Disorders
  • Rett Syndrome
  • Absence of the Septum Pellucidum
  • Acute Disseminated Encephalomyelitis
  • Agenesis of the Corpus Callosum
  • Acquired Epileptiform Aphasia
  • Aicardi Syndrome
  • Bell’s Palsy
  • Brachial Plexus Injury
  • Brachial Plexus Birth Injuries
  • Brown-Sequard syndrome
  • Carpal Tunnel Syndrome
  • Central Cord Syndrome
  • Central Pain Syndrome
  • Central Pontine Myelinolysis
  • Cerebellar Hypoplasia
  • Cerebral Atrophy
  • Cerebral Hypoxia
  • Chiari Malformation
  • Cerebral Palsy
  • Chronic Inflammatory Demyelinating Polyneuropathy
  • Duchenne Muscular Dystrophy
  • Encephalopathy
  • Epilepsy
  • Early Infantile Epileptic
  • Encephalopathy
    (Ohtahara Syndrome)
  • Glycogen Storage Disease
    (Pompe Disease)
  • Glucose Transfer Disorders
  • Guillain-Barr? Syndrome
  • Huntington’s Disease
  • Hypertonia
  • Hypotonia
  • Infantile Spasm
  • Kennedy’s Disease (Bulbospinal Muscular Atrophy, X-Linked Spinal and Bulbar Muscular Atrophy)
  • Landau-Kleffner Syndrome
  • Lissencephaly
  • Meningitis and Encephalitis
  • Motor Neurone Disease
  • Primary Lateral Sclerosis
  • Microcephaly
  • Multisystem Atrophy
    Including Type C
  • Multiple Sclerosis
  • Myoclonus
  • Myoclonic Encephalopathy of Infants
  • Myopathies
  • Congenital Myopathy
  • Muscular Dystrophy
  • Neurotoxicity
  • Optic Nerve Disorders
  • Septo-Optic Dysplasia
  • Optic Nerve Hypoplasia
  • Optic Atrophy
  • Damage to the Optic Nerve
  • Ischemic Optic Neuropathy
  • Parkinson’s Disease
  • Perisylvian
  • Polymicrogyria
  • Post-polio Syndrome
  • Schizencephaly
  • Spastic Tetraparesis
  • Spina Bifida
  • Spinal Cord Injury
  • Spinal Muscular Atrophy
  • Stroke
  • Transverse Myelitis
  • West Nile Virus
  • West Syndrome

Whether or not you see your diagnosis listed, always write directly to this address for further information about any neurological disease:

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MUSCULAR DYSTROPHY, PART ONE – THE DISEASE

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS - 101 on February 10, 2009 at 9:49 pm

sunset_may_2006_pana1

This is a 2 part post on Muscular Dystrophy in response to the many people have recently been asking about treatments.  Part 1 defines Muscular Dystrophy (by the Doctors who treat it).  Part 2 supplys information on treatment techniques and parameters.

Muscular Dystrophy Synonyms:

* Childhood Muscular Dystrophy
* DMD
* Muscular Dystrophy, Classic X-linked Recessive
* Progressive Muscular Dystrophy of Childhood
* Pseudohypertrophic Muscular Dystrophy

General Discussion:

Duchenne Muscular Dystrophy, a hereditary degenerative disease of skeletal (voluntary) muscles, is considered the most prevalent form of childhood muscular dystrophy. The disorder typically is recognized from approximately age three to six years and has a relatively rapid, progressive disease course. Duchenne Muscular Dystrophy is initially characterized by muscle weakness and wasting (atrophy) within the pelvic area that may be followed by involvement of the shoulder muscles. With disease progression, muscle weakness and atrophy affect the trunk and forearms and gradually progress to involve most major muscles of the body.

In individuals with the disorder, initial findings may include an unusual, waddling manner of walking (gait); difficulty climbing stairs or rising from a sitting position; and repeated falling. With disease progression, additional abnormalities may develop, such as progressive curvature of the spine; wasting of thigh muscles and abnormal enlargement of the calves due to degenerative changes of muscle fibers (pseudohypertrophy); and abnormal fixation of certain joints (joint contractures) due to muscle weakness, prolonged immobility, and shortening of muscle fibers. By approximately age 10 to 12, most affected individuals require the use of a wheelchair.

Duchenne Muscular Dystrophy is also typically characterized by additional abnormalities, including involvement of heart muscle (cardiomyopathy) and varying degrees of intellectual impairment. Affected individuals may develop an increased susceptibility to respiratory infections (e.g., pneumonia), respiratory failure, impaired ability of the heart to pump blood effectively (heart failure), or other serious findings, leading to potentially life-threatening complications by late adolescence or early adulthood.

Duchenne Muscular Dystrophy is caused by changes (mutations) of a gene on the short arm (p) of chromosome X (Xp21.2). The gene regulates the production of a protein that is found in skeletal and cardiac muscle. Known as dystrophin, the protein is thought to play an important role in maintaining the structure of these muscle cells.

In most affected individuals, Duchenne Muscular Dystrophy is inherited as an X-linked recessive trait. Therefore, the disorder is usually fully expressed in males only. However, in rare instances, females who carry a copy of the mutated gene (heterozygous carriers) may develop certain, typically milder symptoms associated with the disorder. In addition, for some individuals with Duchenne Muscular Dystrophy, there is no family history of the disease. In such cases, the disorder may be caused by new (sporadic) genetic mutations that occur for unknown reasons.

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LIONS CLUB HAS MARK

In STEM CELLS IN THE NEWS on February 10, 2009 at 6:51 pm
MARK ANDERSON

DR MARK ANDERSON - U of IOWA

Advocate for stem cell research speaks to local Noon Lions Club

By ANDREW POTTER, TIMES-REPUBLICAN -POSTED: February 10, 2009

Dr. Mark Anderson of the University of Iowa spoke about stem cell research to the Noon Lions Club Monday at the American Legion hall.

Dr. Mark Anderson of the University of Iowa believes there is bright future for stem cell research.

He hopes what has become more of a political issue in recent years will go back to a focus on the science side and will eventually allow more American researchers to work with stem cells.

“Stem cells provide hope to people who don’t have any hope,” said Anderson, who spoke to the Marshalltown Noon Lions Club Monday at the American Legion hall.

The director of cardiology at the Department of Internal Medicine at UI pointed out research in animals has proven the potential stem cells can provide, whether that be replacing damaged tissue or rebuilding organs.

He described research in which a heart was rebuilt in a rat using stem cells.

“The thought that an individual can grow their own heart is very exciting,” Anderson said.

The issue many have is using embryonic cells, which many feel is already a life.

He said there are several ways to get embryonic cells and in the future they may be able to create them in ways that do not involve an embryo.

Legislation in recent years has curtailed funding and drew a line on what types of stem cell research can be done. Anderson said this has been one of the reasons the United States trails other countries such as Japan, China and Germany in stem cell research.

The research is not without drawbacks and Anderson pointed out one of the potential downsides are stem cells that are put into the body and don’t “follow the script” and end up being cancerous.

Don Crowley, vice president of the Lions Club, said there had been conversations about the stem cell issue among the members of the group and they brought in Anderson to inform them about what is going on in the field.

“This was a subject that was fascinating and interesting and that our community should learn about,” he said.

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via Advocate for stem cell research speaks to local Noon Lions Club – Times Republican.

ROVER GETS A STEM CELL “DO-OVER”

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 10, 2009 at 4:54 pm

 

DOGS AROUND THE WORLD ARE HAPPY ABOUT THE NEWS!

Stem Cells Now Curing Dogs of Leukemia

Posted 10 February, 2009 in Dogs, Leukemia |

Stem Cells curing dogs of Leukemia, an often deadly cancer? Using chemotherapy and stem cells taken from the dog’s bone marrow? Yes, it is true. While this blog has well documented stem cell therapy helping dogs with arthritis, torn muscles, hip dysplasia and joint problems among other conditions, this is the first I have heard of this stem cell treatment for Leukemia.

I did not know that dogs could be treated for Leukemia with a bone marrow transplant– the same way humans are. Maverick the dog, owned by Howie and Marna Altman, was cured of his Leukemia after undergoing a life saving bone marrow transplant with his own Adult Stem Cells. How does it work? From the article::

Stem cells were taken from Maverick’s blood and then returned to him after full-body radiation to kill the cancer cells in his bone marrow. He spent two weeks in isolation to allow time for the cells to regenerate. Aside from some follow up blood tests, doctors expect him to be back to normal.

“Maverick has done fantastic,” said Dr. Steven Suter, a veterinary oncologist at N.C. State’s College of Veterinary Medicine. “He was hardly sick at all from the radiation. He looks fantastic, he’s doing fantastic, so it’s a great day.”

It is perhaps fitting that this is happening at North Carolina State (the only place in the US that is treating dogs with bone marrow transplants), which brings back memories of Jimmy Valvano, the basketball coach who led NC State to that miraculous basketball championship in 1983 and unfortunately lost his battle with cancer.

Who can forget Jimmy running around the court looking for somebody to hug after winning that game at the buzzer? And later on, how can you forget a dying Jimmy V’s speech of “Don’t give up, Don’t EVER Give Up“??? What a wonderful and courageous man- I miss you Jimmy V. You inspired us all.

 

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via Stem Cells Now Curing Dogs of Leukemia | Adult Stem Cell Research.

SPINAL CORD INJURY (SCI) STEM CELL TRIALS – JAPAN PLAYS “CATCH UP”

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS on February 10, 2009 at 2:32 pm

SPINAL CORD TWISTS & TURNS

SPINAL CORD TWISTS & TURNS

The Headlines -COMPILED BY ARBITER STAFF -Issue date: 2/9/09 Section: News -Media Credit: MCT CAMPUS

Lured by promise of stem cells, Americans head abroad for medical treatment

World

Stem cells improve damaged spines in mice

TOKYO – A team of researchers at Keio University has succeeded in improving spinal cord damage in mice by transplanting into them neural stem cells produced with human induced pluripotent stem cells, they said.

The transplant is the first of its kind in which a therapeutic effect of human iPS cells – which can be transformed into various types of cells – has been confirmed. The results of the study are expected to pave the way for a treatment for people with spinal cord injuries.

Spinal cord injuries often cause motor function loss in victims. It is generally accepted that motor function in the legs and other body parts cannot be recovered once the central nerve in the spinal cord has been cut.

via The Headlines – News.

THERE ARE CURRENTLY REPAIR STEM CELL (RSC) TREATMENT CENTERS IN THE WORLD WHO ARE TREATING SPINAL CORD INJURY WITH YEARS OF EXPERIENCE.

This info was found here on RSCI’s site:
http://repairstemcells.org/DiseaseTreated.php#D

RSCI is a patient advocate education center that connects patients with adult stem cell treatment centers around the world:
http://repairstemcells.org

These treatment centers have met or exceeded RSCI’s rigorous guidelines and standards:
http://repairstemcells.org/RepairStemCellStandards.php

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MS STEM CELL TRIALS – THE US PLAYS “CATCH UP”

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS on February 10, 2009 at 2:11 pm

THE CHASE is on!

THE CHASE is on!

——

Treating MS Symptoms With Stem Cells –
Promising Northwestern University Trial Uses Patient’s Own Stem Cells To Treat Symptoms Of Multiple Sclerosis

(CBS) An estimated 400,000 Americans suffer from multiple sclerosis, but the findings of a new clinical trial shows promise in the fight to reverse symptoms of MS.

Researchers at Northwestern University conducted a trial using patients’ own stem cells to treat symptoms of multiple sclerosis, reports Early Show correspondent Debbye Turner Bell, and although the study group was small — only 21 patients participated in it — the findings are a huge breakthrough in the fight against MS.

Edwin McClure is strong and healthy now, but just four years ago, his life was very different.

via Treating MS Symptoms With Stem Cells, Promising Northwestern University Trial Uses Patient’s Own Stem Cells To Treat Symptoms Of Multiple Sclerosis – CBS News.

THERE ARE CURRENTLY 4 REPAIR STEM CELL (RSC) TREATMENT CENTERS IN THE WORLD WHO ARE TREATING MULTIPLE SCLEROSIS WITH YEARS OF EXPERIENCE.

This info was found here on RSCI’s site:
http://repairstemcells.org/DiseaseTreated.php#D


RSCI is a patient advocate education center that connects patients with adult stem cell treatment centers around the world:
http://repairstemcells.org


These treatment centers have met or exceeded RSCI’s rigorous guidelines and standards:
http://repairstemcells.org/RepairStemCellStandards.php

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CARDIAC STEM CELL TRIALS – THE US PLAYS “CATCH UP”

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS on February 10, 2009 at 2:04 pm
THE USA MUST GET IN LINE BEHIND DOZENS OF STEM CELL TRIALS ALREADY DONE ALL OVER THE WORLD

USA must get in line behind dozens of successful cardiac stem cell trials all over the world

I CAN SEE THERE ARE GOING TO BE A LOT OF THESE.  CARDIAC STEM CELL TRIALS HAVE BEEN TAKING PLACE ALL OVER THE WORLD FOR ALMOST A DECADE.  THE SOONER THE US RECOGNIZES THAT THE WORLD HAS PASSED THEM BY IN THE SCIENCE OF STEM CELLS, THE BETTER.

Tuesday, February 10, 2009, 10:45am EST

FIRST??? cardiac stem cell trial to take place in Louisville

The University of Louisville and Jewish Hospital will conduct the first cardiac stem cell clinical trial.

Officials with the university and Jewish Hospital & St. Mary’s HealthCare Inc., have scheduled a Wednesday morning news conference to explain the details of the trial, according to a media advisory issued by the university.

Expected to be present at the news conference, which will be held at the UofL Health Sciences Campus, are UofL President James Ramsey; Robert Shircliff, president and CEO of Jewish Hospital & St. Mary’s HealthCare; Roberto Bolli, Jewish Hospital Heart and Lung Institute distinguished chair in cardiology and Mark Slaughter, chief of the Division of Thoracic and Cardiovascular Surgery at UofL.

via First cardiac stem cell trial to take place in Louisville – Business First of Louisville:.

THERE ARE CURRENTLY MANY REPAIR STEM CELL (RSC) TREATMENT CENTERS IN THE WORLD WHO ARE TREATING CARDIOVASCULAR DISEASE WITH YEARS OF EXPERIENCE.

RSCI is a patient advocate education center that connects patients with adult stem cell treatment centers around the world:
http://repairstemcells.org

These treatment centers have met or exceeded RSCI’s rigorous guidelines and standards:
http://repairstemcells.org/RepairStemCellStandards.php

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RIGOROUSLY EXPLORING CORD OPTIONS

In ALL ARTICLES, STEM CELLS IN THE NEWS on February 10, 2009 at 11:30 am
STEM CELL BANKING ON JAPANESE CORD BLOOD

RIGOROUSLY EXPLORING CORD OPTIONS

MoU to explore adult treatment options of cord stem cells-Chennai-Cities-The Times of India – 10 Feb 2009, 0415 hrs IST, TNN

CHENNAI: Researchers will soon attempt to expand the therapeutic gains of cord blood stem cells currently used to treat diseases like blood cancer and thalassemia in children to help adults.

City-based Jeevan Stem Cell Bank inked an MoU with Nichi-In Centre for Regenerative Medicine (NCRM), Japan here on Monday to conduct joint research on expansion’ of stored cord blood stem cells and related applications. Expansion is the process of increasing the number of cells per unit of blood using laboratory methods.

“While one unit of cord blood containing 500 million stem cells is needed for a treatment of a child weighing below 40 kg, treatment of an adult needs at least two units. It is difficult to get so much blood from the same matching cord and hence the need for expansion,” said Jeeven Stem Cell Bank medical director Dr Saranya Narayan.

With research on expanded cord blood cells taking place across the world and findings being published in medical journals, it is possible to take this step in India, NCRM director Dr Samuel Abraham said.

Since NCRM remained an Indo-Japan joint venture institute, the MoU would pave the way for collaboration with Japanese hematologists who had vast experience in the clinical application of stem cells derived from the umbilical cord, Dr Abraham added.

According to Kazuo Minagawa, consul-general of Japan, the umbilical cord was preserved in Japanese tradition in memory of a newborn.

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via MoU to explore adult treatment options of cord stem cells-Chennai-Cities-The Times of India.

CARDIAC STEM CELL TRIALS – THE UK PLAYS “CATCH UP”

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS on February 10, 2009 at 3:56 am

Trials for REVOLUTIONARY stem cell surgery in UK ‘within a year’???

THEY THINK THIS IS REVOLUTIONARY?  THESE TREATMENTS HAVE BEEN GOING ON IN GERMANY, THAILAND & OTHER PLACES FOR YEARS.  HERE ARE 3 ELITE TREATMENT CENTERS – http://repairstemcells.org/TreatmentDetail.php?keyword=Heart+(Cardiovascular)+Diseases

Trials for revolutionary stem cell surgery in UK ‘within a year’

“Scientists have worked out a technique where human bone marrow cells are turned into human heart stem cells and then injected into the heart.”

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via Trials for revolutionary stem cell surgery in UK ‘within a year’ – Telegraph.

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