DAVID GRANOVSKY

Posts Tagged ‘trial’

PIONEERING??? Heart Study

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS on February 20, 2013 at 9:27 am

This makes me crazy.  Thousands, maybe tens of thousands treated to date successfully with studies going back to 2002 and they call this brand new study pioneering?  Consider the triple blind study protocol used:

  • 1/3 RECEIVE NOTHING AT ALL
  • 1/3 RECEIVE A PLACEBO
  • 1/3 RECEIVE STEM CELLS

The odds are not in his favor to even get the treatment.  It’s time to catch up to the rest of the world. – DG

DeBary man takes part in pioneering stem cell study

Dr. David Henderson, left, talks to his patient Robert Anderson, 64, of DeBary recently at Florida Hospital Memorial Medical Center in Daytona Beach. Anderson is participating in a clinical research trial that uses a patient’s own stem cells to regenerate cardiovascular tissue. He was the first patient to enroll in the clinical study that started in December at Cardiology Research Associates of Florida Hospital Memorial Medical Center.

News-Journal/STEVEN NOTARAS

By
STAFF WRITER
Published: Monday, February 18, 2013 at 5:30 a.m.
Last Modified: Sunday, February 17, 2013 at 5:41 p.m.

DAYTONA BEACH — At 44, Robert Anderson’s career as a chemical engineer was cut short due to pain in his chest and jaw.

A few years earlier doctors had performed bypass surgery on Anderson to repair the deteriorating muscle around his heart. Like 850,000 Americans, Anderson suffers from angina, which causes chest discomfort due to coronary heart disease.

But the surgery was a temporary fix for Anderson, whose diabetes worsened his heart condition. As the pain in his jaw and chest increased when he walked, the DeBary resident was forced into early retirement.

For the past 20 years, Anderson’s life has been limited by his heart condition, which has only worsened.

With no surgical options left, Anderson is hoping his participation in a clinical research trial that uses a patient’s own stem cells to regenerate cardiovascular tissue will improve his quality of life. Some patients taking part in the study also were injected with a placebo…

SPINAL INJURY CELL TREATMENTS MISINFORMATION

In STEM CELLS IN THE NEWS on November 12, 2012 at 8:50 pm

Xray of cervical spine

Unfortunately, there certainly is still a great deal of misinformation in the media today. While spinal cord injury stem cell treatments are going on successfully today, articles like the following are confusing.

http://www.newscientist.com/article/dn22235-stem-cells-bring-back-feeling-for-paralysed-patients.html

THIS ARTICLE STATES: “For the first time, people with broken spines have recovered feeling in previously paralyzed areas after receiving injections of neural stem cells.”
THE FACT IS: This is a blatant lie (or ignorance). Spinal cord injury has been successfully treated with adult stem cells for a few years now.  The following are a few of the stories.  http://repairstemcell.wordpress.com/2011/02/07/spinal-cord-injury-and-repair-stem-cell-treatments/

Some people regain sensitivity in their extremities, some gain bladder and bowel control and some are capable of walking with a walker. The limits of improvement are yet to be seen, but this is definitely NOT even close to the first.

 

THIS ARTICLE STATES:  “The cells, acquired from donated fetal brain tissue…”

THE FACT IS:  While these are not embryonic stem cells (a fetus starts at 7 weeks so they are technically ‘adult’ or non-embryonic stem cells), the back lash from the religious right on the use of fetal brain tissue, donated or not, is going to be extreme.  There should be no risk of cysts and tumors as these cells are already differentiated but let’s wait and see.

 

THE ARTICLE STATES:  “The patients also received a temporary course of immunosuppressive drugs to limit rejection of the cells.”

THE FACT IS:  Donated (or allogenic) stem cells carry the risk of graft versus-host disease (GVHD) or rejection so the immune system must be suppressed.  When you are dealing with illness or in this case, spinal cord injury, lowering the immune system with immunosuppressive drugs carries inherent risks.

 

I will take a position of cautious optimism and wait and see the results.  So the only question remaining to be asked is:  Autologous (from the aprient) stem cells carry none of these risks.  Why were they not used?

 

Stem Cells Safe for Young Traumatic Brain Injury

In SCIENCE & STEM CELLS on March 6, 2012 at 4:02 am
Image showing potential uses of stem cell research with traumatic brain injuries checked.
A Phase 1 clinical trial studying the safety of using bone marrow stem cells to treat traumatic brain injuries in children is reported. The procedures look to be safe even after 6 months of being applied. The image is adapted from a public domain image

Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients

Saturday March 3rd 2012

A procedure involving stem cells taken from patients’ own bone marrow to treat traumatic brain injury in children is safe, according to the results of a Phase 1 clinical trial.

The trial included 10 children aged 5-14 with severe traumatic brain injuries. Within 48 hours of their injuries, the children received stem cells processed from their own bone marrow.

Six months following the procedures, the children are showing no signs of further damage caused by the use of the stem cells. Though this study only points out that the procedure is safe so far, all of the children from the study had significant improvements.

Stem cell research studies such as this one are producing more and more evidence that stem cell treatments can be safe and effective.

With very few effective treatments for brain injury patients, these studies provide great promise for the future of medicine.

The University of Texas Health Science Center at Houston press release below offers more details about this and other stem cell studies.

UTHealth study: Stem cells may provide treatment for brain injuries

Preliminary results show safety of bone marrow stem cells in traumatic brain injury

Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). The results were published in this month’s issue of Neurosurgery, the journal of the Congress of Neurological Surgeons.

“Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe,” said Charles S. Cox, Jr., M.D., the study’s lead author and professor of pediatric neurosurgery at the UTHealth Medical School. The clinical trial, which included 10 children aged 5 to 14 with severe TBI, was done in partnership with Children’s Memorial Hermann Hospital, where Cox is director of the pediatric trauma program.

All the children were treated within 48 hours of their injury with their own stem cells, which were collected from their bone marrow, processed and returned to them intravenously. UTHealth’s Department of Neurology is also currently testing the same bone marrow stem cell procedure in adults with acute stroke. In a separate trial, Cox is testing the safety of using a patient’s own cord blood stem cells for traumatic brain injury in children.

As a Phase I trial designed to look at feasibility and safety, the study did not assess efficacy. However, after six months of follow-up, all of the children had significant improvement and seven of the 10 children had a “good outcome,” meaning no or only mild disability.

Children who survive severe TBI are often left with serious complications and disability. Currently, there are no effective treatments to protect or promote repair of the brain in these brain-injured children.

Read more: Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients | Neuroscience News.

ALS adult stem cell trial = safe and effective | Reuters

In VICTORIES & SUCCESS STORIES on January 19, 2012 at 9:28 am

(Reuters) – Data from the first ALS patients in a clinical trial treated with BrainStorm Cell Therapeutics adult stem cell therapy did not show significant side effects and the treatment has so far proven to be safe, the company said on Tuesday.

Israel-based BrainStorm is developing NurOwn for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease, a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

The U.S. Food and Drug Administration last year granted orphan drug designation to NurOwn. The FDA’s orphan drug program encourages the development of treatments for rare diseases by providing financial incentives.

“There have been no significant side effects in the initial patients we have treated with BrainStorm’s NurOwn technology,” said Dimitrios Karussis, the head of Israel’s Hadassah Medical Center’s Multiple Sclerosis unit, who is leading the clinical trial.

“In addition, even though we are conducting a safety trial, the early clinical follow-up of the patients treated with the stem cells shows indications of beneficial clinical effects, such as an improvement in breathing and swallowing ability as well as in muscular power.”

Patients in the trial are transplanted with stem cells derived from their own bone marrow and treated with the NurOwn stem cell technology.

The initial phase of the study is designed to establish the safety of NurOwn and will later be expanded to assess efficacy.

“Based on the interim safety report, the hospital ethical and safety committee granted the company approval to proceed with treating the next patients,” said Chaim Lebovits, president of BrainStorm.

According to the ALS Association, 5,600 people in the United States are diagnosed with the disease each year. It is estimated that as many as 30,000 Americans may have the disease — which has severely disabled British physicist Stephen Hawking — at any given time.

BrainStorm sees positive data in ALS stem cell trial | Reuters.

In the Country of the Deaf, the Hearing Man is Culturally Deprived

In STEM CELLS IN THE NEWS on January 17, 2012 at 2:25 am
While “In the Country of the Blind
the One-Eyed Man is King…”
In the Country of the Deaf,
the Hearing Man is Culturally Deprived
Image of Chuck Baird's Art No. 2, 375x337 pixels, 75 ppi depth, 11:1 compression.
A year ago I was reminded of this fact when I was trying to “help” people with hearing conditions and was set straight.  Deafness is viewed as much a culture and identity to some as it is viewed a “handicap” to others. You can read the article from last year here: HEARING LOSS – GIFT OR A DISEASE?
I have the utmost respect for the culture and identity of the deaf and only want to “help” those who want to be “helped.” (Unfortunately, even words like “help” have huge implications…it seems almost every word I use is charged with the potential for offense.) 
I do have one question which is spinning around in my brain at 2am while my tea grows cold and my back whispers conspiracies to my neck.  This is not a challenge but  merely an effort to know better and learn: 
  • If the “with hearing” child of parents “with hearing” were to suddenly go deaf, the parents would probably do everything within their means to recover the child’s hearing. 
  • If the deaf child of deaf parents were to suddenly gain audism, would the parents do everything within their means to remove the child’s hearing? 

I would love to receive people’s reactions to this. Please fee free to comment below.

Healthfully – David

AFA Denounces FDAs Approval of Newborn Stem Cell Experimentation

Audism Free America (AFA), a grassroots Deaf activist network, condemns the United States Food and Drug Administration (FDA) for its approval of a study which will use cord blood stem cells on infants as young as six weeks old in an effort to eradicate the Deaf population of the United States.

(PRWEB) January 16, 2012

Audism Free America (AFA), a grassroots Deaf activist network, condemns the United States Food and Drug Administration (FDA) for its approval of a study which will use cord blood stem cells on infants as young as six weeks old in an effort to eradicate the Deaf population of the United States.

AFA further denounces the FDA, Cord Blood Registry ®, LSL/AVT specialists,*Children’s Memorial Hospital (Houston), and the principal investigators of this study for undermining the human rights of their patients and promoting eugenic outcomes.

The newswire released on January 12, 2012 from Cord Blood Registry and Children’s Memorial Hermann Hospital states that parents of newborns and infants between six weeks to 18 months will be recruited. The infants will undergo MRIs (which frequently include sedation), blood tests, and be given their own stored stem cord blood via IV infusions. Possible health risks to the infant were not mentioned.

The newswire contained alarmist views of how being Deaf impacts language abilities and social development without describing research concerning the negative impact of withholding American Sign Language and access to cultural identification with other Deaf people.

When contacted, Dr. Harlan Lane, Distinguished Professor at Northeastern University and recipient of the MacArthur Genius Award stated: “Children who are born Deaf or early become so have a dual heritage – they have their parents’ ethnicity and also that of the sign language minority; their natural language is American Sign Language. Exclusively pathological views of Deaf children have been out of date for decades. Deaf babies are healthy babies and live fulfilling and contributing lives.”

AFA advocates for the rights of Deaf Americans, cultural resurgence, and seeks primarily to challenge the ideological foundations of audism in America. Audism is attitudes and practices based on the assumption that behaving in the ways of those who speak and hear is desired and best. It produces a system of privilege, thus resulting in stigma, bias, discrimination, and prejudice-in overt or covert ways-against Deaf culture, American Sign Language, and Deaf people of all walks of life.

AFA calls upon governmental agencies to ensure their commitment to protecting all citizens, including Deaf newborns and infants. The actions by the FDA serve to highlight the medical community’s systematic effort to threaten the culture, language, and right to life of Deaf people-and therefore, endangering linguistic and cultural diversity in the United States.

*LSL/AVT specialists (Listening and Spoken Language/Auditory Verbal Therapists) are those certified by the Alexander Graham Bell Academy and promote oral/aural only approaches to language development excluding all forms of signing.

AFA Denounces FDAs Approval of Newborn Stem Cell Experimentation.

To see if you are a candidate for adult stem cell treatment, please fill out the form at bit.ly/stemcellsnow

For more information on adult stem cells and hearing conditions: http://repairstemcell.wordpress.com/hearing-disorders/

First FDA-Approved Study of Stem Cells to Treat Hearing Loss Begins at Children’s Memorial Hermann Hospital – MarketWatch

In STEM CELLS IN THE NEWS on January 15, 2012 at 9:25 am

First FDA-Approved Study of Stem Cells to Treat Hearing Loss Begins at Children’s Memorial Hermann Hospital – MarketWatch.

First FDA-Approved Study of Stem Cells to Treat Hearing Loss Begins at Children’s Memorial Hermann Hospital

HOUSTON, Jan. 12, 2012 /PRNewswire via COMTEX/ — Children’s Memorial Hermann Hospital and Cord Blood Registry® (CBR) are launching the first FDA-approved, Phase I safety study on the use of cord blood stem cells to treat children with sensorineural hearing loss.

To view the multimedia assets associated with this release, please visit: http://www.multivu.com/mnr/53686-cord-blood-childrens-memorial-hermann-fda-approved-stem-cells-hearing-loss

The study, which will use patients’ stem cells from their own stored umbilical cord blood, is the first of its kind, and has the potential to restore hearing. This follows evidence from published laboratory studies that cord blood helps repair damaged organs in the inner ear.

The year-long study will follow 10 children, ages 6 weeks to 18 months, who have sustained post-birth hearing loss. Children who are deaf as a result of a genetic anomaly or syndrome are not eligible. To ensure consistency in cord blood stem cell processing, storage, and release for infusion, CBR is the only stem cell bank providing clients for the study..

CBS REPORTS: ADULT STEM CELL TREATMENTS WORK!

In ALL ARTICLES on November 15, 2011 at 1:23 pm
The king is dead, long live the king!
Embryonic stem cells are dead, long live Adult stem cells!

In early 2009 I wrote an article called “SCREW THE EMBRYOS, THEY’RE IRRELEVANT!

ANTHONY HOPKINS SAYS: "SCREW THE EMBRYOS!" (Legends of the Fall) :p

“…since few people can afford to travel outside the country for adult stem cell treatments, ESC-crazed America, the Bangladesh of stem cells, with its focus on “treatment useless” research, and 4-8 years behind the rest of the world (in 2009) on available adult stem cell treatments, has become exactly that, a death row prison cell for those suffering from so-called untreatable diseases.”

In “SCREW THE EMBRYOS”, I explained why Embryonic stem cells will not treat humans for decades.  I explained how embryonic research has been 100% fruitless (in regard to generating treatments) for well-funded and government supported scientists around the world for the last 13 years. I explained how Adult stem cells have been treating patients outside the USA for years and I shared what a tragic, terrible waste of life it is that Americans don’t know there are safe and effective treatment options for over 100 incurable diseases.

With Embryonic stem cell treatment research now an obvious waste of time, money and resources, where should the desperate patient with chronic or incurable disease turn?  Adult Stem Cells

Allow me to introduce you to Adult Stem Cells.

STEM CELLS 101 pic

STEM CELLS 101 – short

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM – comes from blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal neurological, breast milk, menstruation, dental pulp, and many more
  • PURPOSE IN BODY – they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS – ~zero problems (virtually zero side effects)
  • TREATMENT HISTORY – used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY – can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)

To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

cbs logoCBS has been against Adult Stem Cells for years.  They repeatedly referred to the doctors and scientists involved in adult stem cell treatments as quacks, crooks, con-men and scam artists.  They refer to adult stem cell treatments as snake oil despite a record of safety and efficacy going back to 2002! At the same time, CBS has been promoting the ‘huge potential of embryonic stem cell treatments.’  I take no pleasure in the irony that the CBS “eye” has been completely blind to the benefits of Adult stem cells for years while the rest of the world touted their benefits and the rest of the world’s patients recovered from terminal, chronic and incurable illnesses while American patients had zero options for recovery.

For a history of stem cell treatments of heart disease going back to 2002 – http://repairstemcell.wordpress.com/heart-disease-treatment/

All of this has now changed.  CBS has done a 180 degree flip and are now advocates for the benefits of Adult stem cells!

CBS VIDEO on Adult Stem Cell Success with Heart Disease

CBS ARTICLE on Adult Stem Cell Success with Heart Disease

Clinical Trial in The Lancet CBS Based Their Reporting On

Irony number 2 is that CBS uses words like “breakthrough” and “first ever.”

http://www.techbostonacademy.org/staff/english/pisano/blog/wp-content/uploads/2008/11/irony6.jpg

Do you know there are 443 clinical trials at clinicaltrials.gov with the keywords “stem cell” and “cardiac?”  There is not a single one which is a completed Embryonic stem cell trial.  Point of fact, there is not a single completed Embryonic stem cell trial for any disease anywhere. There are over 2,000 completed Adult stem cell trials.

WOW PIC

Do you know there are 5,170 peer reviewed published studies with the keywords “adult stem cell” and “cardiac?”

MAJOR WOW FACTOR!

MAJOR WOW FACTOR!

With the death of Embryonic stem cell treatments and the RE-discovery of Adult stem cell treatments, don’t you owe it to yourself to see if Adult stem cells can help you?

To see if your condition can be treated with Adult stem cells,

please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

A HISTORY OF THE GERON EMBRYONIC STEM CELL FIASCO

In BUSINESS OF STEM CELLS on November 15, 2011 at 1:27 am

http://geekcentricity.com/wp-content/uploads/2010/09/Fiasco.jpg

Embryonic stem cell treatment are now an unrealized potential.

Adult stem cell treatments are a realized potential.

To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

GERON GIVES UP on EMBRYONIC STEM CELLS!

In STEM CELLS IN THE NEWS on November 14, 2011 at 11:13 pm

THE

WAR

IS

OVER!!

GERON THROWS IN THE TOWEL!If stem cell treatments were a boxing match, Embryonic stem cell treatments would be the 500 lb Gorilla and Adult stem cell treatments would be the small, unknown underdog.   Today, that Gorilla threw in the towel!

Despite the huge disparity in their media coverage, with positive Embryonic stem cell potential articles outnumbering all Adult stem cell articles by 1,000 to one, only Adult stem cells have a proven history of safety and efficacy, only Adult stem cell treatments are available today.  Click here to see if your condition can be treated with Adult stem cells:

While Geron and the US media, big Pharma, the AMA and the FDA have all given Embryonic stem cell their full throated support, the number of patients helped with adult stem cells is in the 10s of thousands while the number of patients helped by Embryonic stem cells in zero.

HORSE FALLING DOWN DURING RACEIf Embryonic treatments were a horse race, Geron would be the strongest horse in the field.  Geron would be the horse who was 9/10 of the way around the track with all other competitors still milling about in the starting blocks.  So what would make that horse stop dead in his tracks, fall flat on his face and walk away from the race?

What does it mean for the other Embryonic focused companies when the front runner pulls out of the race?

What would cause the leading Embryonic stem cell Pharmaceutical company with multiple Embryonic stem cell products in development to end all of their Embryonic stem cell programs? 

Product Product Description Application Development Stage
GRNOPC1 Oligodendrocyte Progenitor Cells Spinal Cord Injury Phase I Clinical Trial
GRNCM1 Cardiomyocytes Heart Disease Preclinical
GRNIC1 Islets Type 1 Diabetes Research
GRNCHND1 Chondrocytes Osteoarthritis Research
Hepatocytes ADME Drug Screening Research
GRNVAC2 Mature Dendritic Cells Cancer Immunotherapy Product Research
Immature Dendritic Cells Immune Rejection Research
Osteoblasts Osteoporosis Research

via Geron.com

Perhaps their clinical trial patients developed cysts and tumors as do all Embryonic stem cell patients.  Perhaps Geron decided to end their trials before these tumors and cysts turned into cancer so they could still say their product “has been well tolerated with no serious adverse events.”

Perhaps Geron couldn’t figure out how to address the need for immunosuppressive drugs required to implant a human with ALL Embryonic stem cells when there are many Adult stem cells that have no rejection issues.

Perhaps Geron couldn’t determine how to deal with Embryonic stem cells carrying the genetic abnormalities and maladies of the donor.

Or perhaps they read some of the quotes from my articles going back to March of 2009:

  • To date, ESC research has been 100% fruitless (in regard to generating treatments) for well-funded + government supported scientists around the world for the last 11 years.
  • Dr James Thomson, father of ESC research said: “…[ESC] are not being used in any clinical applications yet, while alternatives such as adult stem cells figure in scores of therapies.”
  • Ian Wilmut, who led the team that cloned Dolly the sheep, abandoned his license to attempt human cloning, saying that the researchers “may have achieved what no politician could: an end to the [ESC] debate.”
  • Dr. Bernadine Healy, former director of the NIH in U.S. News & World Report: “…[ESC], once thought to hold the cure for Alzheimer’s, Parkinson’s, and diabetes, are obsolete….. In fact, adult stem cells, which occur in small quantities in organs throughout the body for natural growth and repair, have become stars despite great skepticism early on.
Or maybe they reviewed the timeline for Embryonic stem cell success and realized they couldn’t afford 50 YEARS OF RESEARCH!
Dr. Colin McGuckin, a noted UK embryonic research leader at Newcastle U. before departing for more useful RSC research in France announced:

  • “For me, the unnecessary row over stem cells has obscured the very real issue that patients are waiting to be treated…The best estimates of the embryonic scientists in our own university in Newcastle is that embryonic stem cells may not be able to help people this side of 50 years. That’s my lifetime. And that’s worrying. We can’t wait that long.”
I do have to applaud their spin department.  It is a brilliant move to take the news story
“GERON GIVES UP ON EMBRYONIC STEM CELLS”
and spin it into
“GERON PUTS 100% FOCUS INTO CURING CANCER.” 
Even so, we are not fooled.  The red headed step child in the family always knows when they are neglected. 
They also published their press release at 4:05 Eastern so the regular stock market was closed and couldn’t react to the news. Unfortunately for them, their stock dropped over 20% in after hours trading.
Whatever the reason for Geron abandoning Embryonic stem cells, we can now finally exalt that THE WAR IS OVER and get on with Adult Stem Cell Treatments, the only stem cells to cure a human patient.

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM•comes from blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal neurological, breast milk, menstruation, dental pulp, and many more
  • PURPOSE IN BODY•they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS•~zero problems (virtually zero side effects)
  • TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY•can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)
  • To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

via STEM CELLS 101

  • 100+ DISEASES treated around the world with adult stem cells!
  • 60-70% SUCCESS RATE typical therapeutic benefit on INCURABLE DISEASES!!
  • POTENTIAL CURES of Autism, Parkinson’s, AIDs, Diabetes, Heart Disease and more!
  • HUGE REWARDS of life extension!
  • SIGNIFICANTLY IMPROVED quality of life!

http://www.maniacworld.com/muhammad-ali-2.jpg

Geron to Focus on Its Novel Cancer Programs
Company Plans to Partner All Stem Cell Programs

MENLO PARK, Calif.–(BUSINESS WIRE)–Geron Corporation (Nasdaq: GERN) today announced that, effective immediately, the Company will focus on its first-in-class oncology programs. As a consequence, the Company will discontinue further development of its stem cell programs and is seeking partners for these novel assets.

“Our employees, collaborators and shareholders can be proud of the pioneering role they have played to advance our stem cell technology into the clinic”

“In the current environment of capital scarcity and uncertain economic conditions, we intend to focus our resources on advancing our Phase 2 clinical trials of imetelstat and GRN1005. These two novel and promising oncology drug candidates target major unmet medical needs and have important clinical development milestones occurring over the next 20 months,” said Geron’s Chief Executive Officer, John A. Scarlett, M.D. “By narrowing our focus to the oncology therapeutic area, we anticipate having sufficient financial resources to reach these important near-term value inflection points for shareholders without the necessity of raising additional capital. This would not be possible if we continue to fund the stem cell programs at the current levels.

…The decision to narrow Geron’s technology and therapeutic focus was made after a strategic review of the costs, value inflection timelines and clinical, manufacturing and regulatory complexities associated with the Company’s research and clinical-stage assets. With this decision, Geron is eliminating 66 full-time positions, representing 38% of its workforce. As a result, the Company expects one-time cash expenditures of approximately $5 million in the fourth quarter of 2011 and approximately $3 million in the first half of 2012. Geron expects to end 2011 with cash and investments in excess of $150 million.

Geron is seeking partners with the technical and financial resources to enable further development of its stem cell programs. “Our employees, collaborators and shareholders can be proud of the pioneering role they have played to advance our stem cell technology into the clinic,” said Dr. Scarlett. “Stem cells continue to hold great medical promise. We believe that our leadership role in the field and the quality of our stem cell assets — which are widely recognized as being among the most innovative, comprehensive and advanced cell therapy programs in the world — will be an important point of differentiation in our discussions to partner these assets.” In order to facilitate transfer of these programs to partners, Geron will retain a core group of employees from its stem cell operations through the end of the second quarter of 2012.

Geron plans to close the GRNOPC1 trial for spinal cord injury to further enrollment, although it will continue to follow all enrolled patients, accruing data and updating FDA and the medical community on their progress. In this trial, GRNOPC1 has been well tolerated with no serious adverse events

Read more

Related articles:

A HISTORY OF THE GERON EMBRYONIC STEM CELL FIASCO November 15, 2011

EMBRYONICS’ BLEAK FUTURE AND BOTCHED PAST November 15, 2011

To see if your condition can be treated with Adult stem cells, please fill out this form:

FAKE AND FRAUDULENT SCIENCE

In DISEASE INFO on October 27, 2011 at 2:32 am

FAKE AND FRAUDULENT SCIENCE

  • Scientific empirical data is subject to misinformation and corruption as much as what some refer to as the “soccer mom hysteria.”
    For example:  Dr Thorsen’s data on the correlation between MMR vaccines and Autism is corrupt and dependent on elements outside the study both ignored and cherry picked around:

    “Thorsen was a leading member of a Danish research group that wrote several key studies supporting CDC’s claims that the MMR vaccine and mercury-laden vaccines were safe for children. Thorsen’s 2003 Danish study reported a 20-fold increase in autism in Denmark after that country banned mercury based preservatives in its vaccines. His study concluded that mercury could therefore not be the culprit behind the autism epidemic.

    His study has long been criticized as fraudulent since it failed to disclose that the increase was an artifact of new mandates requiring, for the first time, that autism cases be reported on the national registry. This new law and the opening of a clinic dedicated to autism treatment in Copenhagen accounted for the sudden rise in reported cases rather than, as Thorsen seemed to suggest, the removal of mercury from vaccines. Despite this obvious chicanery, CDC has long touted the study as the principal proof that mercury-laced vaccines are safe for infants and young children. Mainstream media, particularly the New York Times, has relied on this study as the basis for its public assurances that it is safe to inject young children with mercury — a potent neurotoxin — at concentrations hundreds of times over the U.S. safety limits.

    Thorsen, who was a psychiatrist and not a research scientist or toxicologist, parlayed that study into a long-term relationship with CDC. He built a research empire called the North Atlantic Epidemiology Alliances (NANEA) that advertised its close association with the CDC autism team, a relationship that had the agency paying Thorsen and his research staff millions of dollars to churn out research papers, many of them assuring the public on the issue of vaccine safety.

    The discovery of Thorsen’s fraud came as the result of an investigation by Aarhus University and CDC which discovered that Thorsen had falsified documents and, in violation of university rules, was accepting salaries from both the Danish university and Emory University in Atlanta — near CDC headquarters — where he led research efforts to defend the role of vaccines in causing autism and other brain disorders. Thorsen’s center has received $14.6 million from CDC since 2002.

    Thorsen’s partner Kreesten Madsen recently came under fierce criticism after damning e-mails surfaced showing Madsen in cahoots with CDC officials intent on fraudulently cherry picking facts to prove vaccine safety.

    Leading independent scientists have accused CDC of concealing the clear link between the dramatic increases in mercury-laced child vaccinations beginning in 1989 and the epidemic of autism, neurological disorders and other illnesses affecting every generation of American children since. Questions about Thorsens’s scientific integrity may finally force CDC to rethink the vaccine protocols since most of the other key pro vaccine studies cited by CDC rely on the findings of Thorsen’s research group. These include oft referenced research articles published by the Journal of the American Medical Association, the American Journal of Preventive Medicine, the American Academy of Pediatrics, the New England Journal of Medicine and others. The validity of all these studies is now in question.”

    via http://repairstemcell.wordpress.com/2010/03/15/cdc-vaccine-cover-up-mercury-actually-does-cause-autism/

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  • PFIZER, CELEBREX, BEXTRA + VIOXX CLINICAL TRIAL RESULTS WERE FAKE- FRAUD
    February 18, 2010 at 1:55 pm “It’s being called the largest research fraud in medical history. Dr. Scott Reuben, a former member of Pfizer’s speakers’ bureau, has agreed to plead guilty to faking dozens of research studies that were published in medical journals. Now being reported across the mainstream media is the fact that Dr. Reuben accepted a $75,000 grant from Pfizer to study Celebrex in 2005. His research, which was published in a medical journal, has since been quoted by hundreds of other doctors and researchers as “proof” that Celebrex helped reduce pain during post-surgical recovery. There’s only one problem with all this: No patients were ever enrolled in the study!” http://repairstemcell.wordpress.com/2010/02/18/pfizer-celebrex-bextra-vioxx-clinical-trial-results-were-fake-fraud/


    repairstemcell.wordpress.com

    ‎”It’s being called the largest research fraud in medical history. Dr. Scott Reu…

 

  • and need I mention the Embyonic hoax perpetrated on the US populace for a decade?

    The pure and impartial and just eye of the scientist is just as susceptible to partiality as any other if not more so because they think thy can get away with it.

    The Placebo Defecthttp://naturalnews.com/030209_placebo_medical_fraud.html

    “This is the conclusion from researchers at the University of California who published their findings in the October issue of the Annals of Internal Medicine. They reviewed 167 placebo-controlled trials published in peer-reviewed medical journals in 2008 and 2009 and found that 92 percent of those trials never even described the ingredients of their placebo pills.”

    Empirical science is not a hat you take off when it is convenient. Everything has an effect and if test tubes are not sterile and compounds are contaminated and trials are screwed up then they can not be considered valid. 92%. Nuff said.

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