DAVID GRANOVSKY

Posts Tagged ‘traumatic’

TRAUMATIC BRAIN INJURY and STROKE

In DISEASE INFO on March 26, 2012 at 1:17 am

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I was told this was a con…here is my response:

My Stem Cells vs. Stroke page:
http://repairstemcell.wordpress.com/stroke-stem-cells/

Additional articles sorted by date (YEAR/MONTH/DAY):
http://repairstemcell.wordpress.com/2012/03/06/stem-cells-safe-for-young-traumatic-brain-injury/
http://repairstemcell.wordpress.com/2012/01/22/cellnews-scientists-learn-how-stem-cell-implants-help-heal-traumatic-brain-injury/

http://www.sciencedaily.com/releases/2011/08/110831160216.htm
http://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

http://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
http://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
http://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
http://repairstemcell.wordpress.com/2010/08/28/cord-blood-wakes-up-drowning-victim%e2%80%99s-brain/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
http://repairstemcell.wordpress.com/2010/07/12/stem-cell-gel-helps-repair-traumatic-brain-injuries-smartplanet/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
http://repairstemcell.wordpress.com/2010/04/28/stem-cells-from-menstrual-blood-may-benefit-stroke-patients/

http://repairstemcell.wordpress.com/2009/04/20/stem-cell-research-shows-adult-stem-cells-help-stroke-victims-adult-stem-cell-research/
http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

A con? Ok my skeptical friends, I understand. You’ve been researching stroke treatments for so long and been so disheartened you don’t believe your condition can ever improve. You’ve read all the outdated literature saying the central nervous system can not regrow (except for the most recent studies which prove it can be.) You’ve skimmed my articles and realize they are uncorroborated by “hard science.”

Fair enough. Ignore the 14 articles above which show the positive benefits of adult stem cells on stroke. You’re right, they are unsubstantiated. They are not peer reviewed medical journal articles. I appreciate your skepticism but know this:

*there are over 2,600 peer reviewed medical journal clinical trials that utilized adult stem cells with a record of safety and efficacy,
*there are many trials that cover the use of adult stem cells for stroke, ataxia, TBI, etc
*there are 60 trials that have the key words “adult stem cell” and “stroke.”
*there are 14 “Completed” trials that have the key words “adult stem cell” and “stroke.”

Research it yourself if you like. http://clinicaltrials.gov/ct2/results?term=adult+stem+cell+stroke&pg=1&show_flds=Y

Here are only the 14 “completed” trials:

Completed Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients

Conditions: Stroke;   Middle Cerebral Artery Infarction
Interventions: Procedure: Intercerebral implantation of Autulogous Stem Cells;   Drug: convention therapy
Completed Intravenous Autologous Bone Marrow-derived Stem Cells Therapy for Patients With Acute Ischemic Stroke

Condition: Acute Stroke
Intervention: Biological: Autologous bone marrow stem cell
Completed Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.

Conditions: Stroke, Acute;   Infarction, Middle Cerebral Artery
Intervention: Procedure: Infusion on autologous CD34+ stem cells into middle cerebral artery
Completed Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke

Condition: Infarction, Middle Cerebral Artery
Intervention: Other: Autologous cell transplantation
21 Completed Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke

Condition: Ischemic Stroke
Intervention: Drug: Filgrastim
31 Completed Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)

Condition: Sickle Cell Anemia
Intervention: Procedure: Angiography
34 Completed Investigating Endothelial Precursor Cells (EPCs)

Condition: Central Nervous System
Intervention:
38 Completed Immunological Mechanisms of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Condition: Multiple Sclerosis
Intervention: Procedure: Stem Cell Transplanataion
40 Completed Gene Therapy for Gaucher’s and Fabry Disease Using Viruses and Blood-Forming Cells

Condition: Gaucher’s Disease
Intervention: Genetic: human glucocerebrosidase cDNA
51 Completed Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189

Condition: Depression
Intervention: Drug: NSI-189 Phosphate
52 Completed Beta-hCG + Erythropoietin in Acute Stroke

Condition: Acute Stroke
Intervention: Drug: Beta-hCG + Erythropoietin
54 Completed Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study

Conditions: Autism;   Oxidative Stress;   Inflammation
Intervention: Drug: Hyperbaric Oxygen Therapy
59 Completed Effects of Enzyme Replacement in Gaucher’s Disease

Condition: Gaucher’s Disease
Intervention:
60 Completed Incidence of Ocular Antibodies in Patients With Sturge – Weber Syndrome (SWS)

Condition: Sturge – Weber Syndrome (SWS)
Intervention:

 

 

If you still feel this is a con, tell me what you would need to see to prove otherwise. Respectfully, David

Stem Cells Safe for Young Traumatic Brain Injury

In SCIENCE & STEM CELLS on March 6, 2012 at 4:02 am
Image showing potential uses of stem cell research with traumatic brain injuries checked.
A Phase 1 clinical trial studying the safety of using bone marrow stem cells to treat traumatic brain injuries in children is reported. The procedures look to be safe even after 6 months of being applied. The image is adapted from a public domain image

Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients

Saturday March 3rd 2012

A procedure involving stem cells taken from patients’ own bone marrow to treat traumatic brain injury in children is safe, according to the results of a Phase 1 clinical trial.

The trial included 10 children aged 5-14 with severe traumatic brain injuries. Within 48 hours of their injuries, the children received stem cells processed from their own bone marrow.

Six months following the procedures, the children are showing no signs of further damage caused by the use of the stem cells. Though this study only points out that the procedure is safe so far, all of the children from the study had significant improvements.

Stem cell research studies such as this one are producing more and more evidence that stem cell treatments can be safe and effective.

With very few effective treatments for brain injury patients, these studies provide great promise for the future of medicine.

The University of Texas Health Science Center at Houston press release below offers more details about this and other stem cell studies.

UTHealth study: Stem cells may provide treatment for brain injuries

Preliminary results show safety of bone marrow stem cells in traumatic brain injury

Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). The results were published in this month’s issue of Neurosurgery, the journal of the Congress of Neurological Surgeons.

“Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe,” said Charles S. Cox, Jr., M.D., the study’s lead author and professor of pediatric neurosurgery at the UTHealth Medical School. The clinical trial, which included 10 children aged 5 to 14 with severe TBI, was done in partnership with Children’s Memorial Hermann Hospital, where Cox is director of the pediatric trauma program.

All the children were treated within 48 hours of their injury with their own stem cells, which were collected from their bone marrow, processed and returned to them intravenously. UTHealth’s Department of Neurology is also currently testing the same bone marrow stem cell procedure in adults with acute stroke. In a separate trial, Cox is testing the safety of using a patient’s own cord blood stem cells for traumatic brain injury in children.

As a Phase I trial designed to look at feasibility and safety, the study did not assess efficacy. However, after six months of follow-up, all of the children had significant improvement and seven of the 10 children had a “good outcome,” meaning no or only mild disability.

Children who survive severe TBI are often left with serious complications and disability. Currently, there are no effective treatments to protect or promote repair of the brain in these brain-injured children.

Read more: Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients | Neuroscience News.

CellNEWS: Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury

In VICTORIES & SUCCESS STORIES on January 22, 2012 at 9:20 am

“In this study, we found that our stem cell transplantation both prevents further axonal injury and promotes axonal regrowth, through a number of previously unknown molecular mechanisms.”

http://trialx.com/curetalk/wp-content/blogs.dir/7/files/2011/06/Tramautic_Brain_Injury.jpg

Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury  
Friday, 13 January 2012

For years, researchers seeking new therapies for traumatic brain injury have been tantalized by the results of animal experiments with stem cells. In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has remained a mystery.

Now, an important part of this puzzle has been pieced together by researchers at the University of Texas Medical Branch at Galveston. In experiments with both laboratory rats and an apparatus that enabled them to simulate the impact of trauma on human neurons, they identified key molecular mechanisms by which implanted human neural stem cells — stem cells that are in the process of developing into neurons but have not yet taken their final form — aid recovery from traumatic axonal injury.
A significant component of traumatic brain injury, traumatic axonal injury involves damage to axons and dendrites, the filaments that extend out from the bodies of the neurons. The damage continues after the initial trauma, since the axons and dendrites respond to injury by withdrawing back to the bodies of the neurons.
“Axons and dendrites are the basis of neuron-to-neuron communication, and when they are lost, neuron function is lost,” said UTMB professor Ping Wu, lead author of a paper on the research appearing in the Journal of Neurotrauma.

“In this study, we found that our stem cell transplantation both prevents further axonal injury and promotes axonal regrowth, through a number of previously unknown molecular mechanisms.”

 

Read more: CellNEWS: Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury.

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