DAVID GRANOVSKY

Posts Tagged ‘STEM’

NEW HOPE FOR SOLDIERS DISFIGURED IN WAR

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on August 8, 2014 at 11:08 am
face-of-hope

Stem cells as part of every treatment protocol
What if stem cells could be used in conjunction with other treatments and in doing so, make the impossible, possible?  Well…they are starting to.  “Army surgeon Robert Hale is leading the charge to make facial reconstruction medicine ready for the wounds of 21st-century war.”

A great deal of scientific and anecdotal evidence substantiate that stem cells are a seemingly limitless potential cure-all and one of the greatest medical advancements known to man.  While the safety and efficacy of stem cell therapy when utilized as an isolated therapy is virtually undeniable, the full extent of stem cells’ healing potential is even more awe-inspiring.  Stem cells can potentially become complements to thousands of other treatments due to:

  • their regenerative capabilities
  • their flexibility
  • the fact that they are part of the body’s natural healing system

Stem cells have been used successfully to reduce symptoms and alleviate the suffering of hundreds of conditions previously believed to be incurable and they are often best utilized in isolation.  In fact, many stem cell doctors believe they work best when manipulated or modified as little as possible.  On the other hand, they have shown great success when used with other treatment protocols.  The oldest example is the 6 decades of stem cell use in the form of Bone Marrow Transplants and in coordination with chemo to mitigate Leukemia, Hodgkin’s and Non-Hodgkin’s Lymphomas and other blood cancers.  When used with an “other” effective treatment, the result is often greater than the sum of the parts as the stem cells contribute to the healing potential of the “other” protocol.

In the article below, Army surgeon Robert Hale combines multiple techniques and protocols with stem cell therapy with a patient whose injuries were so severe, they were arranging organ donation.  This “protocol stacking” of cutting edge facial reconstruction, cutting edge stem cell therapy, superclavicle flap grafting from 1917 and other techniques allowed him to accomplish what was previously impossible.  .

Used alone, stem cells have a proven history of success as the “this changes everything” element in regenerative medicine and modern healing.

Used in conjunction with other established protocols or with new technologies, stem cells may very well change everything we have come to expect from modern medicine.

By the way, we saw this coming 3 years ago in DAMN! SILENCE OF THE LAMBS MEETS STEM CELLS!

SILENCE OF THE LAMBS MEETS STEM CELLS and future transplant recipients win big!!  Remember in Silence of the Lambs, at the end of the movie, when Hannibal Lechter cuts off the guards face and then wears it out to escape?  It turns out, if he had some stem cells to go with that face transplant, he could have just kept on wearing it.  Surgical researchers did exactly that on four dogs and all 4 of the dogs tolerated the face transplants for over one year without immunosuppressive drugs after the first month.

New Hope for Soldiers Disfigured in War

Army surgeon Robert Hale is leading the charge to make facial reconstruction medicine ready for the wounds of 21st-century war.

Col. Robert Hale shows a prototype of a mask that would speed healing and help prevent infection in treatment of facial injuries in soldiers. The design and function of the biomask has evolved as Hale has worked with research teams at Fort Sam Houston in San Antonio…

http://discovermagazine.com/2014/sept/11-face-of-hope

STEM CELLS ARE OUT OF THIS WORLD

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on July 21, 2014 at 4:38 pm

The potential of stem cells to regrow and/or prevent the deterioration of muscle and bone cells over time when subjected to zero gravity has garnered an enormous amount of interest from NASA and the entire space travel industry.   This has lead NASA to send stem cells into space to be researched in low or zero gravity on the space station.   The findings are extraordinary.  “The team discovered that 64 percent of the proteins found in the stem cells grown in simulated microgravity were not in control samples. In particular, the bioreactor cells contained several proteins involved in the breakdown of bone and in the regulation of calcium, neither type of which were found in stem cells grown in regular, Earth gravity.” 

We’ve know for some time that stem cells are smart and capable of:

  • differentiating into whatever cell types are needed without direction
  • growing every cell in a heart and organizing those cells perfectly into where they need to be
  • retro-differentiate into other cell types after finishing work on a particular organ or tissue type
  • traveling back through the umbilical cord from fetus in womb to mother with heart disease to aid the mother in the healing process
  • and many more incredible capabilities

But those actions took place in the patient’s body where the stem cells are able to read the needs of the body with the help of  numerous cues, messenger cells and the entire physiological road map of the patient to guide them.   Essentially, they have an awesome GPS system and just have to follow the directions they are given on roads the GPS “knows” very well.  Conversely, the astro-stem cells (stem cell-nauts?) are able to grow better in space than on earth and to grow with “space relevant capabilities.”  This is incredible.  Imagine going to space for the first time and knowing intrinsically what to do and further, knowing what to do to help your host body better survive and thrive in the conditions of space.  The astro-stem cells are taking cues from their external environment from factors they have never even been exposed to (unless you adhere to the ancient aliens theories) and modifying their proteins and genetic make up to accommodate for the difference in gravity.

What else can they do? If we assume the stem cells will react to the external cues as well as the internal cues, what other factors will they respond to?  We know they grow better in space and in a hyperbaric chamber; what type of response would they have to being underground, on the ocean or under it (long submarine voyages or sub-oceanic colonization), in the dark (increased optic nerve proliferation?), in radioactive areas (radiation resistance)?  Time will tell.  I would say the sky is the limit but apparently, it’s not.

Are we witnessing evolution?
evo·lu·tion  noun \ˌe-və-ˈlü-shən, ˌē-və-\ biology : a theory that the differences between modern plants and animals are because of changes that happened by a natural process over a very long time.  the process by which changes in plants and animals happen over time, a process of slow change and development

No.  Not evolution.  This is faster than the classic definition of evolution.  This is accelerated and positive mutation as a response to external and internal environmental factors.   This is…adaption, rapid adaption…”  Lending support to my analogy that stem cells are born Marines because “Marines are taught to adapt, improvise, overcome…” via

…and the line between science fiction and science reality grows ever thinner.
- David

Growing-stem-cells-in-space

Growing stem cells in space: Medicine’s next big thing

“When challenged by microgravity, living organisms’ genes can ‘turn on,’ transforming growth. Scientists at Zero Gravity Solutions work to direct cells toward healthier, hardier strains. It’s not genetic engineering, but accelerated hybridization.” via http://www.space.com/21885-stem-cells-in-space-can-solve-plant-and-animal-problems-video.html

Date:
March 31, 2014
Source:
Ivanhoe / Powered by NewsLook.com
Summary:
Currently, treatments for hemorrhagic stroke aim to control swelling but not regeneration of the damaged tissue. Now, researchers are using an out of this world idea to help stroke survivors. Video provided by Ivanhoe

http://www.sciencedaily.com/videos/58f619e8b7a37890f1857c84110e7e91.htm

RELATED/SOURCES:

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

- See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

- See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

 

Angel Di Maria gets stem cells for World Cup final

In ALL ARTICLES, CELEBRITIES & STEM CELLS, STEM CELLS IN THE NEWS on July 8, 2014 at 11:07 am

Angel di Maria now joins the ranks of professional athletes who turned to stem cell treatments for healing from injury or performance enhancement.  This long list includes such notables as Peyton Manning, Bartolo Colon, Jarvis Green, Kobe Bryant, Andrew Bynum, Tiger Woods (if you believe the rumors) and many more.

 

Atletico Madrid Barcelona Real Madrid Athletic Bilbao Sevilla Villarreal Real Sociedad Valencia Celta Vigo Levante Malaga Rayo Vallecano Getafe Espanyol Granada Elche Almeria Deportivo La Coruña Eibar Córdoba

2014 World Cup / News

Angel Di Maria to undergo stem cell treatment to play the 2014 World Cup final

by Tom Conn | Posted on Monday, July 7th, 2014

Argentine international winger, Angel Di Maria suffered a torn right hamstring in Friday’s 1-0 win over Belgium and despite being ruled out of action for the remainder of the tournament, Di Maria Is undergoing stem-cell treatment in hopes of making the 2014 World Cup final next weekend.

DiMaria

According to Spanish sports daily, AS, Di Maria is so determined to join his teammates, should they reach the World Cup final, that he has decided to undergo stem cell treatment, similar to that used by Diego Costa ahead of the Champions League final, in order to fight for football’s grandest prize.

The medical procedure is used to regenerate damaged cells using the patient’s own healthy cells, with the primary object being to reduce inflammation and repair the torn muscle tissue.

In addition to the treatment, Di Maria will also undergo the standard treatment for this injury; ice, kinesiology, electro pulse stimulation and some rehabilitation exercises in the swimming pool.

LATE STAGE OVARIAN CANCER CURED WITH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 7, 2014 at 1:03 pm

ovarian-cancer-symptoms
Hue Hospital Succeeds in Treating Cancer with Stem Cell

Saigon – Doctors of Hue Central Hospital have used stem cell transplantation to successfully treat a cancer patient of the last stage. The Hue Central Hospital announced on June 26 that its doctors have cured Le Thi Sau, 52, who was suffering ovarian cancer in the last stage, with stem cell transplant. The operation is the success of the scientific project “Using stem cell in breast cancer and cervical cancer” managed by Professor Nguyen Duy Thang, deputy head of the hospital. Adult stem cells have been used to treat certain cancers through bone marrow transplants. In this therapy, the stem cells that give rise to the different blood cells in the body are transplanted into the bone marrow of the patient, where they regenerate the blood. The project was given green light to carry out in the Hue Central Hospital by the Ministry of Science and Technology. Professor Nguyen Duy Thang said the success of this method will pave the way for next operations on breast and ovarian cancer patients. In the time ahead, the hospital continues to treat two other cancer female patients with the stem cell treatment. It is hoped that the treatment will save many cancer patients. (www.saigon-gpdaily.com.vn June 27)

DO ADULT STEM CELLS CAUSE CANCER?

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 1, 2014 at 4:31 pm

NO!

cancer-free-zone

What do you get when you add 1,100 ADULT STEM CELL PATIENTS studied over 5 years,

plus another 1,873 ADULT STEM CELL PATIENTS studied over an average 12.5 years,

plus another ~7,000 ADULT STEM CELL PATIENTS in studies and FDA clinical trials data?

~10,000 ADULT STEM CELL TREATMENT PATIENTS showing NO CANCER!

 

“A total of 1873 patients were treated from 1990 to 2006 with bone marrow-derived concentrated cells. Patients were monitored for cancer incidence from the date of the first operation (1990) until death, or until December 31, 2011. The mean follow-up time was 12.5 years (range, five to twenty-two years)…No tumor formation was found at the treatment sites on the 7306 magnetic resonance images and 52,430 radiographs among the 1873 patients…This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.

The upshot? This most recent study, as well as others, FDA clinical trials data, and the data we have published now amounts to about 10,000 patients who have been treated with adult stem cells and extensively tracked for this issue. There is no evidence that adult stem cells cause cancer. There is no rational reason for the fear, other than a completely different type of cell (ESC) that happens to have a similar name (stem cell) can cause teratomas – hence the confusion!”

Tumors, cancers and teratomas may result from Embryonic stem cell (ESC) treatments or Induced Pluripotent stem cell (iPSC) treatments

but NOT FROM ADULT STEM CELL TREATMENTS.

Sources:

RADIATION AND CANCER (MUST READ)

In ALL ARTICLES, DISEASE INFO on June 29, 2014 at 12:23 pm

RADIATION AND CANCER (MUST READ)

radiotherapy_malignancy

“Researchers from the Department of Radiation Oncology at the UCLA Jonsson Comprehensive Cancer Center report that radiation treatment TRANSFORMS CANCER CELLS INTO TREATMENT-RESISTANT BREAST CANCER STEM CELLS, even as it kills half of all tumor cells.”

“…In some cases, CANCER STEM CELLS ARE GENERATED by the therapy…”

“… if tumors are challenged by certain stressors that threaten them (such as radiation), they generate iBCSCs that may, along with surviving cancer stem cells, PRODUCE MORE TUMORS…”

For more info: http://www.greenmedinfo.com/blog/study-radiation-therapy-can-make-cancers-30x-more-malignant
Study: http://onlinelibrary.wiley.com/doi/10.1002/cncr.27701/full

STEM CELLS HIT MAIN STREAM MEDIA!

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 27, 2014 at 9:03 pm

STEM CELLS HIT MAIN STREAM MEDIA! 
On NBC tonight at 8pm EST!

The first stem cell generated windpipe was implanted in 2008.
Six long years later, the technique has been improved significantly and has hit main stream media. 

Image

“Macchiarini’s team began by collecting stem cells from Beyene’s bone marrow. Those cells were mixed with special growth factors and then poured onto a scaffold made from plastic — in fact, the very same plastic that is used to make soda bottles — which had been made to mimic the shape of a real windpipe.  In just a matter of days, the scaffold began to transform into an actual functioning windpipe.”

Some attack those pushing the boundaries, citing that the surgery is experimental and unproven.  But the Dr can’t stand by as patients die when he can do something about it and can’t ignore their pleas for a chance at the hope of recovery.  This is cutting edge of medicine and there are thousands of clinical trials and studies and 10s to 100s of thousands of patients treated, most outside of the US.  There are no guarantees.  There are always risks, even with rigorously tested pharmaceutical drugs and treatment protocols that have been used for decades.  But for chronic and terminal patients who are given no chance for recovery, experimental sounds like a pretty great option.

Historically, new treatments have always been met with resistance.

“Tom Starzl, when he started doing liver transplants, the first seven, eight, nine patients all died. Everybody said he was nuts, OK? Christian Barnard, when he started doing heart transplants, everyone threw rocks at him. This is how we’re going to treat diseases in the future and this is the start of it.”

Anything which pushes the envelop of contemporary knowledge will be rejected by those clinging to traditional concepts…but without pioneering doctors and even more pioneering patients, willing to take risks, medical protocols can not advance.  I salute the doctor and the patients who are the ground-breaking pioneers in the new land of regenerative medicine.  And what can their mutual risk do for the patient and millions to follow?

“One of Macchiarini’s most promising success stories is Claudia Castillo, a Spanish mother who is doing so well six years after her transplant that an increasing number of Macchiarini’s colleagues are beginning to see him in a new light.”

Thank you!

To watch the video and learn more:

http://www.nbcnews.com/health/health-news/leap-faith-desperate-patients-look-lab-grown-organs-n142036

PANCREATIC CANCER TUMORS DEFEATED WITH CORD BLOOD STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, VICTORIES & SUCCESS STORIES on June 25, 2014 at 11:42 am

fight pancreatic cancer FPC_shirt


PANCREATIC CANCER TUMORS DEFEATED WITH CORD BLOOD STEM CELLS

What happens when you “genetically engineer MSCs isolated from human umbilical cord blood so that they expressed IL-15” (which fights cancer tumors) and inject them into mice with pancreatic  tumors?

  • The IL-15 migrate to the tumor
  • Other cancer and tumor fighting immune cells migrate to the tumor
  • The IL-15 attack the tumor
  • Other cancer and tumor fighting immune cells attack the tumor
  • Tumors show cell death
  • Tumor growth is significantly inhibited
  • Survival is prolonged
  • The mice immune systems are effectively vaccinated against future tumor growth

Scientists “used these souped-up cells to treat In mice afflicted with pancreatic tumors. Pancreatic cancer is an indiscriminate killer, since by the time it causes any symptoms, it is usually so advanced, that there is little to be done in order to treat it. Thus new strategies to treat this type of cancer are eagerly being sought. Systemic administration of IL-15-expressing MSCs significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. The tumors of these mice showed extensive cell death, and other types of immune cells known to fight tumor cells (NK and T cells) had also accumulated around the tumor. Other experiments confirmed that the injected MSCs did indeed migrate toward the tumors and secrete IL-15 at the site of the tumors…Interestingly, those mice that were cured from the pancreatic tumors, appeared to have a kind of resistance of these tumors. Namely, when Fan and his colleagues tried to reintroduce the same tumor cells back into the cured mice, the tumor cells would not grow. Thus the engineered MSCs not only tuned the immune system against the tumor, but they effectively vaccinated the mice against it as well.”

via http://beyondthedish.wordpress.com/2014/06/23/engineered-stem-cels-from-human-umbilical-cord-blood-eradicates-pancreatic-tumor/

 

 

Thanks Squeeky!

mouse-grown-from-stem-cells

HEMATOPOIETIC STEM CELLS PROTECT AGAINST MYELOPROLIFERATIVE NEOPLASIA

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on June 25, 2014 at 9:14 am

​WHAT CAN’T STEM CELLS DO?

HEMATOPOIETIC STEM CELLS PROTECT AGAINST MYELOPROLIFERATIVE NEOPLASIA

After over 15 years of main stream research around the world (with 50 years of bone marrow/stem cell transplant research and therapies), most people still believe there are only a few sources for stem cells; embryonic, adult and induced pluripotent.

Adult stem cells in particular though, consist of a huge number of stem cell sources: embryos, fetuses, placentas, umbilical cord blood, Wharton’s jelly, endometria, peripheral blood, umbilical cord blood, bone marrow, placentas, adipose or fat tissue, skeletal and cardiac muscle, olfactoric mucosal (nasal neurological), breast milk, dental pulp, lungs and many other sources. Chinese scientists have even generated human teeth from the stem cells found in urine.

 

clip_image002

Each stem cell source appears to have unique qualities and characteristics which scientists are barely beginning to fully understand. The blood or bone marrow have what are called “hematopoietic stem cells.”

“A hematopoietic stem cell is a cell isolated from the blood or bone marrow that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood…” via

As if hematopoietic stem cells weren’t awesome enough due to their ability to produce cells of the blood and the immune system and destroy unneeded cells, they have an additional benefit which may be even more impressive. Hematopoietic stem cells introduced into the patient’s body also protects against myeloproliferative neoplasia.

Myeloproliferative neoplasm is “a type of disease in which the bone marrow makes too many red blood cells, platelets, or certain white blood cells. Myeloproliferative neoplasms usually get worse over time as the number of extra cells build up in the blood and/or bone marrow. This may cause bleeding problems, anemia, infection, fatigue, or other signs and symptoms. Certain myeloproliferative neoplasms may become acute myeloid leukemia (AML). Myeloproliferative neoplasms include chronic myelogenous leukemia (CML), polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. Also called chronic myeloproliferative neoplasm.” via

As research continues, we learn more and more about the abilities of stem cells and their role as one of the most important healing systems in the human body.

clip_image004

HEMATOPOIETIC STEM CELLS

Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders

Posted: 22 Jun 2014 11:22 AM PDT

“The protective microenvironment of the hematopoietic stem cell niche, which produces cells of the blood and the immune system, also protects against myeloproliferative neoplasia. Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment…”

 

 

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING

In ALL ARTICLES, BUSINESS OF STEM CELLS, SCIENCE & STEM CELLS on June 23, 2014 at 2:55 pm

broken-bone-cast

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING
“Stem cells are smart and will only stay in one place to repair damaged cells and tissues until called away for more dire situations requiring attention.  Like little ADHD multi-tasking mechanics/repairmen, they run all over the body where the body has decided (through a very complex set of devices) they are most needed.  This results in stem cells dedicated to mending bones, suddenly running off to fix the heart, pancreas, etc before finishing the job on the broken bone.  While this is a great holistic and triage approach (paying attention and dedicating resources to that which needs it most), it makes it difficult to access how powerful and successful stem cells are at resolving a single issue/condition in the body.

A lot can be said for repairing many areas in the entire body simultaneously, in fact, this is one of stem cells’ greatest strengths…but it doesn’t sit well with the concept of “completing one job before moving on to another.”  Scientists have devised a new way to make stem cells stay put and finish the job they were directed to do.  No more stem cell ADHD.

keep-calm-and-oh-look-a-squirrel-1

In the case of serious and terminal diseases, this is an excellent innovation.  If you can fix that which is going to fail first, you can then move on to what’s next.  It also makes commercialization of stem cells easier.  Nobody picks up their car with the damaged exhaust from the mechanic and he says: ‘I got the exhaust half done but realized your distributor, struts and alternator were shot so I fixed them instead.’  But your body is not a car.

This may be a wonderful innovation or it may be another instance of scientists trying to aggressively control a natural healing system in the body.  I think it’s both and the result is we now have one more extraordinary tool for fighting disease…and like any tool, it will be used well and for the right reasons and results and also used poorly for the wrong reasons and results.  Ultimately, our understanding of the modus operandi of stem cells has increased, our ability to manipulate stem cells has increased and the everyday miracles of stem cell treatment results are getting better and better understood and more common place all the time.” – David Granovsky

 ——————-

Delivering Capsules of Stem Cells Helps Repair Injured Bones

“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.

Researchers, and a couple of renegade doctors in Colorado, have shown that stem cells do help bones heal. While bones, even the intricately shaped jawbone, have been grown in the lab, researchers have been somewhat stymied in their efforts at the seemingly more banal task of using stem cells and grafts to help heal major fractures, bones removed in surgery and other hard-to-fix injuries inside the body.

That’s where materials science comes in.

University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone…”

via
​http://singularityhub.com/2014/06/23/delivering-capsules-of-stem-cells-helps-repair-injured-bones/

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