DAVID GRANOVSKY

Posts Tagged ‘SCLEROSIS’

MS patient to take part in pioneering experiment – CBS News

In STEM CELLS IN THE NEWS on January 21, 2014 at 1:42 pm

No mention of the words “stem cell” in the headline.  No mention of stem cells until the 6th paragraph.  Why make it so difficult for patients to find these articles? In any case, we eagerly await the results! -dg

“Stem cells can be morphed into any cell in the body. Patients like Quinn have bone marrow removed and the stem cells inside are then changed in the kind of stem cells found in the brain and spinal cord.

Those cells will then be injected directly into the spinal cord. The hope is that they will repair the insulation and perhaps even the wires underneath.”

via MS patient to take part in pioneering experiment – CBS News.

 

RELATED ARTICLES:

  • FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis

“To my knowledge, this is the first FDA-approved stem cell trial in the United States to investigate direct injection of stem cells into the cerebrospinal fluid of MS patients, and represents an exciting advance in MS research and treatment,” said Dr. Saud A. Sadiq, Senior Research Scientist at Tisch MS Research Center of New York and the study’s principal investigator.

The groundbreaking study will investigate a regenerative strategy using stem cells harvested from the patient’s own bone marrow.  These stem cells will be injected intrathecally (into the cerebrospinal fluid surrounding the spinal cord) in 20 participants who meet the inclusion criteria for the trial.  This will be an open label safety and tolerability study.  All study activities will be conducted at the Tisch MS Research Center and affiliated International Multiple Sclerosis Management Practice (IMSMP).”  via http://www.prnewswire.com/news-releases/fda-approves-stem-cell-clinical-trial-for-multiple-sclerosis-219553021.html

  • Meredith Vieira’s Family Health Battle

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?

WHAT PRICE HEALTH?

In STEM CELLS IN THE NEWS on April 2, 2013 at 4:02 pm

http://www.defendingfoodsafety.com/uploads/image/FDA%20-%20Grant%20Money.jpg

Greg said:

“Dave, word on the grapevine is a few stem cell professionals almost or did come to blows over the FDA nonsense. They couldn’t understand how the FDA has been stonewalling them when the FDA has okayed dangerous drugs with far less data and safety.”

I responded:

“This has been going on for some time. Simply put, there are a number of docs and treatment centers that are leading the charge, a full frontal assault on the FDA to obtain the right (which should not be something they need to petition for) to use autologous (from the patient’s own body) adult stem cells for treatment. There are a number of regulations that need to be met and federal, state and local law before one can treat in the USA. Almost nobody knows how to do this. Even those that do, can still come under fire and spend their entire war chest battling in the courts. Even if you win over and over, you still can waste valuable time, money and energy better spent treating patients and researching protocols and developing ideas.

There are also many patient groups who are actively lobbying for these rights and numerous petitions floating around. The call to arms I recently wrote which I am putting the finishing touches on, entitled “The Public Wants Stem Cell Treatments” addresses these issues directly. These are the front lines my friends and the docs and patients are on one side and the FDA and upstart regulatory bureaus trying to get a market share of stem cell regulation are on the other. Welcome to the wild west. The mortars and shrapnel are flying and anyone who sticks their head out of the fox hole will incur a mortal wound.

The number of hoops required to jump through are daunting and almost nobody knows how and fewer are willing to take the chance but the potential upside is thousands, tens of thousands, hundreds of thousands, millions of chronic and terminally ill patients with incurable disease recovering, going into remission, reclaiming their health and their lives.

What’s the value of that? What price can we put on our health? I’m reminded of the old credit card commercials…

Chronic disease = $30-150,000 per year
Loss of income from inability to work = $30-150,000 per year
Adult stem cell treatment = $8 – 10,000
Living without symptoms after treatment = Priceless
Living to see your daughter married = Priceless
Living to see your grandchild born = Priceless
Living without pain = Pricelesshttp://www.statusant.com/large/Today-be-thankful-and-think-how-rich-you-are.-Your-family-is-priceless%7C2C-your-time-is-gold-and-your-health-is-wealth.-status.jpgRelated articles

STEM CELL TREATMENTS FOR MULTIPLE SCLEROSIS SISTERS?

In ALL ARTICLES, OFF THE BEATEN PATH, STEM CELLS - 101 on January 3, 2013 at 3:13 pm

Two sisters have MS.  I thought it would be interesting to see them both get stem cell treatments to see how their body’s and the stem cells reacted differently in such genetically similar people.- DG

A friend intelligently made the following comment:
“Even twins would have unique MS experiences. You have to consider multiple factors at play with MS symptoms. I know fraternal twins who experience the MS differently and have to be treated in different ways. There is no one-size-fits-all with having and treating MS.”

My response:
I agree there is no one treatment fits all but that is one of the unique attributes of stem cell treatments.  Stem cells work within the systems of your own body, utilizing your own cells to regenerate and rejuvenate necrotic and damaged tissue, to create new tissue and to pull your own body’s healing elements into play to fix what is wrong.  Stem cells, especially autologous (from your own body) stem cells used in therapy are a highly personalized individual treatment which will not only heal twins differently but will actually result in a different therapy each time the same person receives them depending upon what is currently needed by the body.

By analogy: 
truck

Imagine a drug is a big mack truck, driving along and crashing through anything in it’s way to attain it’s destination.  Now imagine your own stem cells follow all of the rules of the road and even stop and fix damaged roadway on it’s way to it’s destination.  The stem cells recruit helpers and construction workers and healers along the way and they will even build new roads if the area is too damaged to support the healing activity required.

advanced-nav-header

Now imagine a batch of stem cells in a different country with different roads, signs, ailments etc and because they are part of the original healing system of that body, they are able to navigate, fix, recruit and heal there as well.

I agree 100%.  THERE IS NO ONE TREATMENT FITS ALL.  There is also no such thing as ONE STEM CELL TREATMENT.

snowflake3w

Each stem cell treatment is unique to each individual.  As they should be.
At least, the treatments I advocate are.

STEM CELLS FOR MS – HOW THEY WORK DISCOVERED

In VICTORIES & SUCCESS STORIES on September 5, 2012 at 2:32 pm

 

Cleveland researchers find key to stem-cell therapy for MS patients: Discoveries
Published: Tuesday, September 04, 2012, 7:21 AM     Updated: Tuesday, September 04, 2012, 2:02 PM

CLEVELAND, Ohio — …Figuring out why the mice improved could help researchers see if the MSC injection will work well in a particular patientbefore the patient is injected, and possibly augment or improve the treatment as well.

In May, the research group atCWRU, headed up by neurosciences professor Robert Miller, discovered exactly what it is in the stem-cell soup that has a healing effect: a large molecule called hepatocyte growth factor, or HGF. The team published their results in Nature Neuroscience.

Miller’s group knew that it could be the stem cells themselves, by coming in physical contact with the myelin damage, that were having a healing effect. Or it could be something the stem cells secreted into the surrounding liquid culture, or media, they were grown in, that was key. HGF is secreted by the stem cells, Miller said.

The team identified the HGF by first injecting only the liquid the stem cells were grown in, but not the stem cells themselves, into the mice they were studying. The mice got better, so the team knew whatever was helping was in the media.

Next, they isolated the small, medium and large molecules from the media and tried each size on the mice. Only the large-molecule treatment had the healing effect, meaning that whatever was helping was somewhere in that mix, Miller said.

“The molecule that jumped out at us was HGF,” he said, because it is the right size, is made by MSCs, and in a couple ofstudies had been shown to be involved in myelin repair.

So the scientists took a purified sample of HGF and injected it into the sick mice. They got better. When they blocked the receptor for HGF in the mice, they stayed sick. It was pretty compelling evidence that they’d found what they’d been looking for, Miller said.

“We went on to show that HGF, like the MSCs, is regulating both the immune response, and it is independently promoting myelin repair in the brain,” he said.

MSCs, taken from the bone marrow, are currently being tested in more than 150 clinical trials in the United States and around the world to treat conditions such as osteoarthritis, diabetes, emphysema and stroke.

JEFFREY-COHEN-CLEVELAND-CLINIC.JPG

The local Phase 1 trial has enrolled 16 of 24 total patients, and eight of them have completed the trial protocol, said Dr. Jeffrey Cohen, Cleveland Clinic neurologist and lead investigator of the trial.

So far, the treatment seems to be working, Cohen said.

“It’s a little early to be saying it, but things have looked encouraging.”

And there have been no safety concerns and almost no side effects. There has also been no activation — an aggravation or return of symptoms — of this relapsing disease in the patients involved, which has happened unexpectedly with other types of MS treatments.

Miller’s discovery won’t change the course of the trial currently under way at the Clinic and UH, but it may change the future of MSC treatment.

While they don’t know yet what the outcome of that trial will be, it’s possible that if a patient doesn’t respond to the treatment, it could mean that hisstem cells aren’t producing enough HGF to be effective at healing, Miller said. Miller will be studying MSC samples from all the patients in the trial to find out if those who are better at producing HGF fare better.

He’ll also be trying to see if they can predict how well a patient will do based on hisHGF levels in the MSC sample…

“Finally, though we’re a long way from this, maybe we could augment the expression of HGF in patients whose stem cells aren’t that effective to enhance their effectiveness,” he said.

But why not just inject the HGF alone? Miller said there are two reasons. First, the receptor for HGF in the cells, called c-MET, has been implicated in liver and breast cancer. Injecting HGF by itself into the body may stimulate the c-MET pathway, he said, and the research team is not willing to risk that.

“The stem cells have the advantage that they tend to home to the area of insult, so they don’t stick around in other parts of the body,” he said. “They target the treatment where it’s needed.”

http://www.cleveland.com/healthfit/index.ss

Stem Cell Injections in Lou Gehrig’s Disease can be Given Safely

In VICTORIES & SUCCESS STORIES on April 11, 2012 at 12:16 am

WELCOME US MEDIA!!! WOO HOO!!

11 YEARS LATE TO THE PARTY:

A history of Amyotrophic Lateral Sclerosis (ALS) aka Lou Gehrig’s disease and stem cell treatments for humans going back to 2001.

http://repairstemcell.wordpress.com/amyotrophic-lateral-sclerosis-als/

http://upload.wikimedia.org/wikipedia/commons/thumb/2/2f/GehrigCU.jpg/200px-GehrigCU.jpg

Stem Cell Injections in Lou Gehrig’s Disease can be Given Safely, New Research Shows

ANN ARBOR, Mich., April 10, 2012 /PRNewswire-USNewswire/ – The first published results from an early-stage clinical trial show that spinal cord stem cells can be delivered safely into the spines of patients with the condition commonly known as Lou Gehrig‘s disease, opening the door for further research on this innovative approach.

In a paper published online ahead of print publication in the peer-reviewed journal Stem Cells, a team from the University of Michigan, Emory University and study sponsor NeuralStem, Inc. report the results from 12 patients who took part in a study being conducted at Emory.

All had amyotrophic lateral sclerosis, the inevitably fatal degenerative disease of the nervous system that many call Lou Gehrig‘s disease. None experienced any long-term complications related to either the surgical procedure or the implantation of stem cells, or showed signs of rejecting the cells. And in the months following the surgery to inject the cells, none showed evidence that their ALS progression was accelerating..

Stem Cell Injections in Lou Gehrig’s Disease can be Given Safely,… — ANN ARBOR, Mich., April 10, 2012 /PRNewswire-USNewswire/ –.


Can MS be treated with stem cells?

In ALL ARTICLES on October 25, 2011 at 2:13 pm

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

I did some digging and would like to present the preliminary results to answer the question:

Can MS be treated with stem cells?

http://www.msconnections.org/ms-myelin.gifSOME MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” - January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – http://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

————————————-

Can MS be treated with stem cells?

You decide. Here are 11 articles from my blog,  28,000 from google news and there are a total of 20 clinical trials from clinicaltrials.gov

From my blog…

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

***http://repairstemcell.wordpress.com/2010/05/18/ms-and-stem-cells-time-is-brain-in-ms/

*** http://repairstemcell.wordpress.com/2009/09/02/my-ms-pain-is-gone/

* * * http://repairstemcell.wordpress.com/2009/04/26/fat-derived-stem-cells-might-treat-ms-us-news-and-world-report/

* * * http://repairstemcell.wordpress.com/2009/04/15/britt%e2%80%99s-fight-against-multiple-sclerosis-hits-home-for-uncw-starnewsonlinecom-star-news-wilmington-nc/

* * * http://repairstemcell.wordpress.com/2009/04/09/stem-cell-breakthrough-may-lead-to-ms-treatments-forbescom/

* * * http://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-2/

* * * http://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-1/

* * * http://repairstemcell.wordpress.com/2009/03/07/study-stem-cell-transplants-could-reverse-ms-cloning-and-stem-cells-msnbccom/

* * * http://repairstemcell.wordpress.com/2009/02/23/foxnewscom-college-student-with-multiple-sclerosis-symptom-free-after-stem-cell-treatment-health-news-current-health-news-medical-news/

* * * http://repairstemcell.wordpress.com/2009/02/12/stem-cells-ms-multiple-sclerosis-cured-by-adult-stem-cells-video-stem-cell-research-and-stem-cell-therapy/

* * * http://repairstemcell.wordpress.com/2009/02/11/multiple-sclerosis-ms-stem-cell-trials-us-is-starting-to-%e2%80%9ccatch-up%e2%80%9d/

* * * http://repairstemcell.wordpress.com/2009/02/10/the-us-is-playing-catch-up-with-stem-cells-ms/

* * * http://repairstemcell.wordpress.com/2009/02/08/stem-cell-transplants-help-ms-victims/

…and about 28,000 scholarly papers/studys on “MS stem cell” here:
http://scholar.google.com/scholar?q=multiple%20sclerosis%20trial%20stem%20cell&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=ws\

…and 20 responses from clinicaltrials.gov on “multiple sclerosis stem cell”
http://clinicaltrial.gov/ct2/results?term=multiple+sclerosis+stem+cell

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

Method weeds out best stem cells for MS

In STEM CELLS IN THE NEWS on October 21, 2011 at 9:18 am

“The scientists then injected the cells into the brains of mice that were born without the ability to make myelin. Twelve weeks later, the cells had become oligodendrocytes and had coated more than 40 percent of the brain’s neurons with myelin—a four-fold improvement over their earlier results.”

This is why stem cell treatments for MS work! – David

Method weeds out best stem cells for MS

U. BUFFALO/ U. ROCHESTER (US) — Scientists have discovered a precise way to isolate the specific stem cells needed to treat multiple sclerosis and a variety of childhood diseases caused by the brain’s inability to make myelin.

Twelve weeks after scientists injected specific stem cells into the brains of mice that were born without the ability to make myelin, the cells had coated more than 40 percent of the brain’s neurons with myelin (areas in red)—a four-fold improvement over earlier results. (Credit: University at Buffalo)

Myelin is the crucial fatty material that coats neurons and allows them to signal effectively. The research, reported online in Nature Biotechnology, overcomes an important barrier to using stem cells to treat demyelinating diseases.

Until now, it has been difficult to separate out the right progenitor cells—the ones that will develop into cells that make myelin—says Fraser Sim, assistant professor of pharmacology and toxicology at the University at Buffalo and the study’s first and co-corresponding author. He conducted most of the work as a researcher at the University of Rochester.

Straight from the Source:Read the original study – DOI: 10.1038/nbt.1972

…Sim and Rochester graduate student Crystal McClain ran extensive analyses looking at gene activity in different types of stem cells, leading to the conclusion that stem cells carrying a protein known as CD140a on their surface seemed to be most likely to become oligodendrocytes—the type of brain cell that makes myelin.

The scientists then injected the cells into the brains of mice that were born without the ability to make myelin. Twelve weeks later, the cells had become oligodendrocytes and had coated more than 40 percent of the brain’s neurons with myelin—a four-fold improvement over their earlier results.

…“These cells migrate more effectively throughout the brain, and they myelinate other cells more quickly and more efficiently than any other cells assessed thus far. Now we finally have a cell type that we think is safe and effective enough to propose for clinical trials.”
…The new approach may also be applicable to Krabbe’s Disease, Sim says, which also involves the breakdown of myelin. Sim, who came to UB in 2009, is actively collaborating on related work with researchers at the Hunter James Kelly Research Institute, a partnership between UB and the Hunter’s Hope Foundation and located in UB’s New York State Center of Excellence in Bioinformatics and Life Sciences.

The work was supported by the National Institute of Neurological Disorders and Stroke, the National Multiple Sclerosis Society, the New York State Stem Cell Research Board, the Adelson Medical Research Foundation and the Mathers Charitable Foundation.

NEW MS TREATMENT INFO!!!

In BEST OF THE BEST on October 6, 2011 at 1:02 am

NEW MULTIPLE SCLEROSIS TREATMENT INFO!!!!

For those interested, I just received 13 pages of Stem Cell Treatments of MS info. There is editing and translation and I am trying to get fully substantiated results for these treatments. I will have it to those of you who are interested shortly.

http://www.quicktrimbody.com/wp-content/uploads/2011/02/multiple-sclerosis-and-sunshine8.gif

MS MS MS MS MS MS MS MS MS MS MS

In DISEASE INFO on September 19, 2011 at 9:36 am

some info on stem cell treatments for MS.

I can tell you where to go, costs, protocols, etc. No charge for my help, just trying to give you some info.

STEM CELLS FOR MS

In STEM CELLS IN THE NEWS on September 17, 2011 at 9:42 am

MORE CONFIRMATION IT WORKS!

Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2 Suppl 2):72-6.

[Transplantation of mesenchymal

stem cells in multiple sclerosis].

Abstract

To assess safety and tolerability of treatment with autologic multipotent mesenchymal stem cells (MSC) in multiple sclerosis (MS), we have obtained autologic red bone marrow-derived MSC from 8 patients. Proliferation, immunophenotype and caryotype of MSC, their sterility, the absence of hemopoetic cells, chromosomal aberrations and signs of aging were controlled during the cell growth. The inverse injection of MSC in patient’s blood was conducted in accordance to the elaborated protocol in a short intravenous infusion in dose 2.0 x 10(6)/kg of body mass once in 30 days.

  • The duration of treatment was from 4 to 8 months.
  • The efficacy of treatment was assessed after 4, 8 and 12 months.
  • All patients tolerated repeated intravenous infusions of autologic MSC well with no significant side-effects as in the early as well in the remote periods of treatment.
  • The distinct positive effect was seen in some cases 2 months after the beginning of treatment.
  • The improvement of 0.5 point on EDSS was seen in 5/8 patients after 4 months.
  • After 12 months, the improvement of 0.5-1 point on EDSS was seen in 6/8, stabilization in 1/8, progression in 1/8.
  • These results revealed the safety of the elaborated protocol of treatment and the moderate clinical efficacy of treatment in non-curable patients or those with poor response to treatment that suggested continuing the study and enrollment of new patients.
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