DAVID GRANOVSKY

Posts Tagged ‘REPAIR’

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING

In ALL ARTICLES, BUSINESS OF STEM CELLS, SCIENCE & STEM CELLS on June 23, 2014 at 2:55 pm

broken-bone-cast

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING
“Stem cells are smart and will only stay in one place to repair damaged cells and tissues until called away for more dire situations requiring attention.  Like little ADHD multi-tasking mechanics/repairmen, they run all over the body where the body has decided (through a very complex set of devices) they are most needed.  This results in stem cells dedicated to mending bones, suddenly running off to fix the heart, pancreas, etc before finishing the job on the broken bone.  While this is a great holistic and triage approach (paying attention and dedicating resources to that which needs it most), it makes it difficult to access how powerful and successful stem cells are at resolving a single issue/condition in the body.

A lot can be said for repairing many areas in the entire body simultaneously, in fact, this is one of stem cells’ greatest strengths…but it doesn’t sit well with the concept of “completing one job before moving on to another.”  Scientists have devised a new way to make stem cells stay put and finish the job they were directed to do.  No more stem cell ADHD.

keep-calm-and-oh-look-a-squirrel-1

In the case of serious and terminal diseases, this is an excellent innovation.  If you can fix that which is going to fail first, you can then move on to what’s next.  It also makes commercialization of stem cells easier.  Nobody picks up their car with the damaged exhaust from the mechanic and he says: ‘I got the exhaust half done but realized your distributor, struts and alternator were shot so I fixed them instead.’  But your body is not a car.

This may be a wonderful innovation or it may be another instance of scientists trying to aggressively control a natural healing system in the body.  I think it’s both and the result is we now have one more extraordinary tool for fighting disease…and like any tool, it will be used well and for the right reasons and results and also used poorly for the wrong reasons and results.  Ultimately, our understanding of the modus operandi of stem cells has increased, our ability to manipulate stem cells has increased and the everyday miracles of stem cell treatment results are getting better and better understood and more common place all the time.” – David Granovsky

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Delivering Capsules of Stem Cells Helps Repair Injured Bones

“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.

Researchers, and a couple of renegade doctors in Colorado, have shown that stem cells do help bones heal. While bones, even the intricately shaped jawbone, have been grown in the lab, researchers have been somewhat stymied in their efforts at the seemingly more banal task of using stem cells and grafts to help heal major fractures, bones removed in surgery and other hard-to-fix injuries inside the body.

That’s where materials science comes in.

University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone…”

via
​http://singularityhub.com/2014/06/23/delivering-capsules-of-stem-cells-helps-repair-injured-bones/

STEM CELLS MAKE VAGINAS!!

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on April 11, 2014 at 12:44 pm

MAKING VAGINAS FROM STEM CELLS, YES…ENTIRE VAGINAS, WORKING VAGINAS, ANATOMICALLY CORRECT IN FORM AND FUNCTION. WOW!

Georgia O'Keeffe

Georgia O’Keeffe

“Four women have had new vaginas grown in the laboratory and implanted by doctors in the US.

A tissue sample and a biodegradable scaffold were used to grow vaginas in the right size and shape for each woman as well as being a tissue match.

They all reported normal levels of “desire, arousal, lubrication, orgasm, satisfaction” and painless intercourse.

Experts said the study, published in the Lancet, was the latest example of the power of regenerative medicine.”
http://www.bbc.com/news/health-26885335

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:20 pm
http://repairstemcell.files.wordpress.com/2013/11/8c5a1-strokebrainimage.jpg?w=249&h=332
Stem Cells Improve Cognition After Brain Injury

Research led by Charles Cox at the University of Texas Health Science Center has shown that stem cell therapy given during the critical time window after traumatic brain injury promotes lasting cognitive improvement. These experiments, which were published in the latest issue of the journal Stem Cells Translational Medicine, provide a pre-clinical model for experiments with larger animals.

After the brain has suffered a traumatic injury, there are few treatment options. Damage to the brain can be severe, and can also cause ongoing neurological impairment. Approximately half of all patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

In this work from Cox’s lab, stem cells from bone marrow known as multipotent adult progenitor cells (MAPCs) were used. MAPCs seem to be a subpopulation of mesenchymal stem cells, and they have a documented ability to reduce inflammation in mice immediately after traumatic brain injury. Unfortunately, no one has measured the ability of MAPCs to improve the condition of the brain over time.

Cox, Distinguished Professor of Pediatric Surgery at the UTHealth Medical School and in collaboration with the Children’s Fund, Inc., injected two groups of brain-injured mice with MAPCs two hours after injury and then once again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times greater.

After four months, those mice that had received the stronger dose not only continued to have less inflammation, but they also showed significant gains in cognitive function. Laboratory examination of the brains of these rodents confirmed that those that had received the higher dose of MAPCs had better brain function than those that had received the lower dose.

According to Cox, “Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs.” Cox also indicated that this study indicates that intravenous injection of MAPCs might very well become a viable treatment for people with traumatic brain injury in the future.

 

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish.

AMNIOTIC STEM CELLS HEAL INTESTINAL DISORDER

In STEM CELLS IN THE NEWS on March 27, 2013 at 9:00 am

shutterstock_20325178

Amniotic stem cells heal intestinal disorder that afflicts premature babies

A new study published in GUT (An International Journal of Gastroenterology and Hepatology) has shown that amniotic fluid stem cells can reverse intestinal damage in rats caused by necrotising enterocolitis — an often fatal disorder that afflicts premature babies.

Paolo De Coppi had already proved that amniotic fluid could be reprogrammed in a similar way to how we reprogram embryonic stem cells, and without introducing potentially damaging genes to instigate the transformation (how adult cells are made pluripotent). Though not quite as versatile as the embryonic version, De Coppi showed that they could be converted into liver, bone and nerve cells.

What’s interesting about this latest study is that the stem cells calmed the intestinal inflammation, healed and reversed damage done to the gut far better than bone marrow stem cells (used in a rate control group), and in an unexpected way. After being injected, the cells travelled to the tiny villi that line the intestinal walls and absorb nutrients, where it then released an unknown substance that triggered progenitor cells to calm the inflammation and instigate tissue and villi regrowth. The team is unsure exactly how it released a growth factor to kick the progenitor cells into action, but it’s hoping further studies could clear this up — that knowledge could then be used to develop drugs that replicate the same action.

In the meantime, De Coppi says, “we hope that stem cells found in amniotic fluid will be used more widely in therapies and in research, particularly for the treatment of congenital malformations”.

Necrotising enterocolitis is common in premature babies, with inflammation rapidly leading to tissue death and a perforated intestine if antibiotics have no effect. At that point, an operation is the only option and these have a 70 percent survival rate due to related risks of surgery at such a young age, and can leave infants with a shortened intestine and trouble eating for the rest of their lives. This latest study gives hope for an injectable, non-invasive solution.

Stem cells have already been shown to have some incredible properties for regenerative medicine — most recently baboon embryonic stem cells were used to repair damaged arteries. However, due the ethical grey area embryonic experiments reside in, progress has inevitably been slower, with the first official human trials only recently beginning to take place. Stem cells derived from amniotic fluid have huge potential, but would mainly still rely on donors given the impracticalities of storing fluid from every birth. Nevertheless, according to estimates published in a 2005 study, just 150 donors would provide a match for 38 percent of the population.

De Coppi, who in 2010 made headlines when he built an 11-year-old boy a trachea replacement from his own bone marrow stem cells, is currently raising funding for his research into building rejection-free transplants from stem cells.

http://www.wired.co.uk/news/archive/2013-03/25/amniotic-fluid

Image: Shutterstock

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BROADCAST JOURNALIST SON TREATED WITH STEM CELLS

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 17, 2013 at 9:33 am

Daren DaviLa and son

Karen Davila resorts to stem-cell therapy for son’s autism

Broadcast journalist Karen Davila’s firstborn, David, was 3½ years old when he was diagnosed with Pervasive Developmental Disorder, Not Otherwise Specified (PDD/NOS) in the Autism Spectrum, a severe form of autism. The development pediatrician said there was no cure for David’s condition.   “David didn’t have the classic signs of autism, but clearly he wasn’t developing like other children his age,” says Davila. “At the age of 3, he wasn’t speaking spontaneously, although he could read. He had tantrums, couldn’t express his needs, whether he was hungry or sad, and didn’t reach out to other children his age.”

Like most kids in the autism spectrum, the boy had attention difficulties. “He was spaced out most of the time, and was rigid. It was so heartbreaking to see my eldest this way,” she adds.   Davila refused to accept that there was no answer to her son’s condition. “I researched endlessly and devoted myself to making sure my son got the best possible treatment,” she says. She quickly put her son on a casein- and gluten-free diet and biomedical treatment, under the care of Defeat Autism Now (DAN)-licensed doctors.

Early last year, Davila was offered an opportunity to try the fresh cell therapy being offered by a clinic in Germany.  The stem cells are harvested from lamb fetus and injected into the patient. By then, the journalist-mom had read up on the supposed benefits of stem cell on children with special needs.  In March, mother and son flew to Frankfurt.

“I didn’t consult with David’s doctors,” Davila admits. “But I have an aggressive-progressive approach to David’s condition. I’m willing to try anything that could help my son.  Doctors will frown upon this (lamb stem cell) since it is not accepted in the medical field, but I did try it for David’s sake.”

Around June last year, Dr. Z Teo and his wife, dermatologist Aivee Aguilar-Teo, introduced autologous fat stem-cell therapy or fat stem-cell therapy in their clinic.   Dr. Teo has been performing fat stem cell repair therapy or FSCR in his clinic in Singapore for a few years.

 Unlike the sheep stem cell, FSCR harvests fat from the patient’s tummy or thigh; a machine then isolates the stem cells from the fat. The fresh stem cell is then injected back into the patient’s body to stimulate the production of new, healthy cells. In patients who are too old or too sick, or have autism like David, fat stem cells are taken from a close blood kin.

Speaking to her son’s autism specialists, Davila says they have “no strong opposition against autologous fat stem-cell therapy.”

David’s procedure is deemed safe, “but blood screening, infectious screening, and compatibility testing and complete physical checkup must be performed prior to the procedure,” says Dr. Aguilar-Teo. Compatibility testing is vital to determine which of the parents is a better-match donor, she adds.  The clinic has performed 50-60 FSCRs since last year, only a handful of which share the same case as David’s.

As for its effect on David, “after just a week or two, the results were dramatic,” Davila says. “We noticed that David was quicker in question-and-answer response. He was visibly more aware, more in the moment, and he was bantering more at home and in school.

“Earlier that year, I brought David to Germany for fresh cell therapy. The effects were quite different. I believe that stem cell coming from the human body is clearly more powerful and potent.”

The surgeons in the Teos’ clinic also injected back some of Davila’s fat stem cells into her body. Apart from its purported benefits for people with neurodegenerative and cardiovascular disorders, and diseases like diabetes and asthma, FSCR is largely touted for its anti-aging and aesthetic benefits.  Prominent personalities who have admitted undergoing stem-cell therapy include former Presidents Joseph Estrada and Gloria Macapagal-Arroyo, and Senate President Juan Ponce Enrile.

Speaking to her son’s autism specialists, Davila says they have “no strong opposition against autologous fat stem-cell therapy.”

To read full article, click HERE.

“When considering stem cell treatment you are taking your own health and well being in your hands. Do yourself a favor and surround yourself with positive open minded people who want you to recover. Is this how you describe your doctor, Your family?  Talk to patients who have been treated successfully. Embrace their health, passion and optimism and make it your own. The fastest way to greater health is to want it, believe it can happen, surround yourself with other like minded people and make it happen.”

- DG

 “Be the change u want to see in the world” – Gandhi

‘Brimming with energy’ after $20K stem cell treatment

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 20, 2013 at 3:04 pm

A great example of the benefits of adult stem cells.  Treatments are now in the $8-10,000 range with even more advanced treatment techniques. – David

‘Brimming with energy’ after $20K stem cell treatment

Jennifer Vasilakos got the shocking surprise of her life after helping a man who stopped to ask her for directions. That man happened to be the billionaire founder of the Beanie Baby company and what he did may have saved her life. NBC’s Kristen Dahlgren reports.

By Kristen Dahlgren and Erica Ayisi, NBC News

COVERAGE OF STORY ON NBC NEWS – VIDEO

JENNIFER’S STORY IN HER OWN WORDS – VIDEO

What started out as a modest fundraising event held in a Santa Barbara, Calif., parking lot has turned into a life-changing moment for Jennifer Vasilakos, thanks to a chance meeting with Beanie Baby billionaire Ty Warner.

It all began in a parking lot in July of last year. Vasilakos, 42, set up a table near her hometown’s annual Santa Barbara French Festival to raise money for stem cell treatment, displaying signs and flyers that explained her cause. She also brought a small moneybox to stash cash made from parking cars for festival-goers.

Equipped with sunglasses, a water bottle and coffee, Vasilakos was prepared to spend the day raising awareness and telling people her personal story – that she was diagnosed with acute renal failure in 2011 and had received dialysis three times a day, three times a week. It was a grueling regimen that she would endure the rest of her life. A kidney transplant wasn’t an option; she had been rejected as a candidate because of a previous bout with cancer.

Vasilakos, a Reiki teacher and herbalist, decided her only option was to save up for stem cell treatment – a costly procedure that is not performed in the United States.

But as the day wore on, her moneybox largely remained empty. The festival, she said, “was completely dead.”

That’s when a lost driver in a “small little car” drove up, looking for directions. Jennifer chatted him up.

Ty Warner, Beanie Baby creator and chief executive of Ty Inc., arrives at the Toy Fair to sign

“The man rolls down the window, has a piece of paper in his hand and he’s looking for a local business,” she recalled. “I provide him instructions and because I am fundraising that day to get my stem cell treatment, I hand him my flyer.”

The man gave her $50.

About an hour later, the driver returned, looked her in the eye and asked if she was the woman in the flyer raising money for stem cell treatment. She confirmed that she was.

Courtesy of Jennifer Vasilakos

Jennifer Vasilakos received this note from Ty Warner, accompanied by a check for $20,000. It reads: “Dear Jennifer, Someone up there loves you because I was guided to meet you on Saturday. I never lose my way, but fate had me lost and ask you for direction. The rest of the story I hope will be a wonderful new life for you. God bless you Jennifer. Ty.”

The man replied, “I’m Ty Warner, and I’d like to help you with this and take care of it for you.”

Yes, that Ty Warner – of Ty Inc., the billionaire brain behind the Beanie Babies collectibles craze. Vasilakos said she recognized his name but had no idea he would ultimately make a huge donation.

“I was hoping to raise a few hundred dollars that day by the generosity of my community for the stem cell treatment that I needed to get,” she said. “I had no idea I would meet Ty Warner that day.”

On her blog, Vasilakos wrote: “I listened as he repeated over and over that he was going to help me. That my fundraising was done. That I didn’t need to worry any longer. He said he would send a check after he returned to his offices during the week.”

Several days after they met, Vasilakos received a $20,000 check from Warner along with a handwritten note. She said she hopes it “was a little birdy in his ear that said, ‘You should help this woman.’”

Vasilakos had the stem cell treatment last year…

Warner, according to a prepared statement, was enlightened by their chance encounter.

“After I serendipitously met Jennifer, I further educated myself on her stem cell needs. I was shocked that this particular type of treatment wasn’t available to her in the U.S.,” Warner said. “My hope is that we can bring this lifesaving treatment to the forefront so that it can become more readily available and provide alternatives for people like Jennifer.”

Vasilakos underwent the treatment in September 2012 and now, after months of recovery, she says she feels great.

“The day the length of my dialysis treatment was reduced to two and half hours per treatment was an exciting day. I regained three hours of freedom per month! My blood pressure has dropped down to normal with lower and lower levels of medication,” she wrote recently on her blog. “The biggest change is how amazing I feel, and I am brimming with energy. My immune system has become resilient, and I can feel the difference in my body.”

via ‘Brimming with energy’ after $20K stem cell treatment – The Daily Nightly.

http://video.msnbc.msn.com/nightly-news/50485093#50485093

 

Stem cell agency needs to shed conflicts

In BUSINESS OF STEM CELLS, STEM CELLS IN THE NEWS on December 18, 2012 at 4:20 pm

ImageStem cell agency needs to shed conflicts
California‘s stem cell agency understands the importance of attacking chronic problems. So if it wants to survive beyond 2014, it should heed the Institutes of Medicine‘s advice to eliminate conflicts of interest on its board — and do it before awarding the remaining $1.2 billion of the $3 billion voters approved for stem cell research.

The California Institute for Regenerative Medicine asked the prestigious Institutes of Medicine, the health arm of the National Academy of Sciences, to evaluate its operations. One of the findings was that the vast majority of the agency’s 29 board members stand to benefit in various ways from their decisions on awarding research grants.

This has been suggested before, but the new report leaves no question of the ethical issue. To justify its continuation in some form, perhaps as a nonprofit or a foundation, the agency needs a majority of independent board members to make funding decisions.

The stem cell institute’s public funding window closes in 2014. It commissioned the review in part to help figure out how it might survive after that to sustain progress in stem cell research.

Even if there were no concerns about independence, another voter-approved bond would be out of the question.

Long-term funding was never the intent when Proposition 71 passed in 2004. It was supposed to kick-start research at a time when federal funding was blocked and to establish California as a major player in the rapidly advancing medical field.

http://www.mercurynews.com/opinion/ci_22216395/mercury-news-editorial-stem-cell-agency-needs-shed

 

SWEAT GLANDS PLAY NEW ROLE TO AID WOUND HEALING

In STEM CELLS IN THE NEWS on December 5, 2012 at 9:00 am

excessive-sweating

Sweat glands have been historically known for their ability to regulate the core temperature of the human body and to secrete unwanted toxins.   Recent research has discovered that sweat glands contain an abundance of stem cells and the potential to aid wound healing.

-DG

Human skin is rich with millions of eccrine sweat glands that help your body cool down after a trip to the gym or on a warm day. These same glands, new University of Michigan Health System research shows, also happen to play a key role in providing cells for recovering skin wounds — such as scrapes, burns and ulcers.  The findings were released online ahead of print in the American Journal of Pathology.

“Skin ulcers — including those caused by diabetes or bed sores — and other non-healing wounds remain a tremendous burden on health services and communities around the world,” says lead author Laure Rittié, Ph.D., research assistant professor of dermatology at the University of Michigan Medical School.  “Treating chronic wounds costs tens of billions of dollars annually in the United States alone, and this price tag just keeps rising. Something isn’t working.”  Now, U-M researchers believe they have discovered one of the body’s most powerful secret weapons in healing.

“By identifying a key process of wound closure, we can examine drug therapies with a new target in mind: sweat glands, which are very under-studied,” Rittié says. “We’re hoping this will stimulate research in a promising, new direction.”  Previous understanding of wound closure was that new skin cells originate from hair follicles and from intact skin at the edge of the wound. The U-M findings demonstrate that cells arise from beneath the wound, and suggest that human eccrine sweat glands also store an important reservoir of adult stem cells that can quickly be recruited to aid wound healing.

“It may be surprising that it’s taken until now to discover the sweat glands’ vital role in wound repair,” Rittié says. “But there’s a good reason why these specific glands are under-studied — eccrine sweat glands are unique to humans and absent in the body skin of laboratory animals that are commonly used for wound healing research.  “We have discovered that humans heal their skin in a very unique way, different from other mammals,” Rittié adds. “The regenerative potential of sweat glands has been one of our body’s best-kept secrets. Our findings certainly advance our understanding of the normal healing process and will hopefully pave the way for designing better, targeted therapies.”

Additional authors include Dana L. Sachs, M.D.; Jeffrey S. Orringer, M.D.; John J. Voorhees, M.D.; and Gary J. Fisher, Ph.D., all of the University of Michigan Department of Dermatology.

http://www.sciencedaily.com/releases/2012/11/121120100432.htm

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STRANGERS STEM CELLS REPAIR HEART MUSCLE

In STEM CELLS IN THE NEWS on November 5, 2012 at 8:54 pm

English: Solution to repair heart muscle using...

Study: Stem cells from strangers can repair hearts

LOS ANGELES (AP) — Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients’ own cells for helping restore heart tissue.

The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone’s cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.

Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.

The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study’s leader, Dr. Joshua Hare of the University of Miami.

The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that they grew large and flabby, unable to pump blood effectively.

Researchers advertised for people to supply marrow, which is removed using a needle into a hip bone. The cells were taken from the marrow and amplified for about a month in a lab at Baltimore’s Johns Hopkins University, then returned to Miami to be used for treatment, which did not involve surgery.

The cells were delivered through a tube pushed through a groin artery into the heart near the scarred area. Fifteen patients were given cells from their own marrow and 15 others, cells from strangers.

About a year later, scar tissue had been reduced by about one-third. Both groups had improvements in how far they could walk and in quality of life. There was no significant difference in one measure of how well their hearts were able to pump blood, but doctors hope these patients will continue to improve over time, or that refinements in treatment will lead to better results.

The big attraction is being able to use cells supplied by others, with no blood or tissue matching needed.

“You could have the cells ready to go in the blood bank so when the patient comes in for a therapy — there’s no delay,” Hare said. “It’s also cheaper to make the donor cells,” and a single marrow donor can supply enough cells to treat as many as 10 people.

Dr. Elliott Antman of Harvard-affiliated Brigham and Women’s Hospital in Boston who heads the heart conference, praised the work.

“That opens up an entire new avenue for stem cell therapy, like a sophisticated version of a blood bank,” he said. There’s an advantage in not having to create a cell therapy for each patient, and it could spare them the pain and wait of having their own marrow harvested, he said.

The study was sponsored by the National Institutes of Health. Hare owns stock in a biotech company working on a treatment using a mixture of cells.

Juan Lopez received his own cells in the study, and said it improved his symptoms so much that at age 70, he was able to return to his job as an engineer and sales manager for a roofing manufacturer and ride an exercise bike.

“It has been a life-changing experience,” said Lopez, who lives in Miami. “I can feel day by day, week by week, month by month, my improvement. I don’t have any shortness of breath and my energy level is way up there. I don’t have any fluid in my lungs.

And, he said happily, “My sex drive has improved!”

Marilynn Marchione – Associated Press

http://news.yahoo.com/study-stem-cells-strangers-repair-hearts-205105872.html

Heart Association: http://www.heart.org

JAMA: http://www.jama.ama-assn.org

 

 

HEARTS and KNEES – Patient, heal thyself | sciencebuz

In VICTORIES & SUCCESS STORIES on January 21, 2012 at 9:20 am

“The first study…uses stem cell therapy to repair heart tissue damaged by coronary heart disease. Of the 16 patients injected with autologous CSCs, 14 showed an increase in Left Ventricular Ejection Fraction (LVEF)…In seven of the patients, infarct (dead tissue) size decreased by 24 % at the end of 4 months, and a further 6 % at the end of a year. Both these results indicate CSCs had a positive impact on heart tissue regeneration.

The second study…focuses on using autologous stem cell therapy for repair of torn meniscal tissue…The “Cell Bandage” from Azellon will use patients own, expanded stem cells, harvested from the bone marrow…will grow into new menisci-type cells and heal the tear. The results of in vitro trials have so far been very promising. Phase I clinical trials are set to begin May 2012.”

http://www.designmom.com/wp-content/uploads/2011/02/5417124292_6a49ef3983.jpg

Two reports in the press this week focus on the use of autologous (patient’s own) stem cells for repair of damaged tissue.

The first study, led by Professor Roberto Bolli, of the University of Louisville, reports on early findings of a phase I clinical trial, which uses stem cell therapy to repair heart tissue damaged by coronary heart disease. Cardiac tissue, harvested from the patient during surgery, was used to  isolate autologous cardiac stem cells (CSCs). CSCs were grown in the laboratory till their numbers reached around 2 million cells. At this stage the cells were re-injected back at the site of tissue damage.

Of the 16 patients injected with autologous CSCs, 14 showed an increase in Left Ventricular Ejection Fraction (LVEF) – the amount of blood a left ventricle pumps through the aorta during each contraction of the heart, 4 months after infusion. In seven of the patients, infarct (dead tissue) size decreased by 24 % at the end of 4 months, and a further 6 % at the end of a year. Both these results indicate CSCs had a positive impact on heart tissue regeneration.

The second study, led by Professor Anthony Hollander, of Azellon Ltd, a University of Bristol spin-out company, focuses on using autologous stem cell therapy for repair of torn meniscal tissue. The menisci are found at the knee joints, and they act as shock absorbers for the knee. This tissue is often damaged as a result of sport-related injury, especially contact sports such as football or rugby.

Current treatment options include knee arthroscopy surgery, which involves removing part or whole of the damaged meniscal tissue. This reduces the shock-absorbing properties at the knee joint and leaves the patient vulnerable to early-onset osteoarthritis, eventually followed by total knee replacement.

The “Cell Bandage” from Azellon will use patients own, expanded stem cells, harvested from the bone marrow. These cells are seeded onto a special biocompatible membrane, which will be inserted at the site of damage using a simple surgical procedure.  Given the right conditions, the hope is that stem cells will grow into new menisci-type cells and heal the tear. The results of in vitro trials have so far been very promising. Phase I clinical trials are set to begin May 2012.

Patient, heal thyself | sciencebuz.

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