DAVID GRANOVSKY

Posts Tagged ‘red’

Chicago Woman Cured of Sickle Cell Disease

In VICTORIES & SUCCESS STORIES on June 20, 2012 at 11:14 pm
Chicago Woman Cured of Sickle Cell Disease

Posted: June  18, 2012 by Sherri McGinnis Gonzalez

Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant. University of Illinois Hospital & Health Sciences System physicians performed the procedure using medication to suppress her immune system and one small dose of total body radiation right before the transplant.The transplant technique is relatively uncommon and is a much more tolerable treatment for patients with aggressive sickle cell disease who often have underlying organ disease and other complications, says Dr. Damiano Rondelli, professor of medicine at UIC, who performed Thomas’s transplant.

The procedure initially allows a patient’s own bone marrow to coexist with that of the donor. Since the patient’s bone marrow is not completely destroyed by chemotherapy or radiation prior to transplant, part of the immune defense survives, lessening the risk of infection. The goal is for the transplanted stem cells to gradually take over the bone marrow’s role to produce red blood cells — normal, healthy ones…

Search and Rescue Dog in 9/11 Attacks Receives Stem Cell Treatment in Burke – Lorton, VA Patch

In STEM CELLS IN THE NEWS on March 20, 2012 at 3:12 am

Search and Rescue Dog in 9/11 Attacks Receives Stem Cell Treatment in Burke

Treatment should help alleviate aches and pains for “Red,” a 12-year-old black Labrador retriever.

 March 19, 2012

    

 

A decade ago, “Red,” a black Labrador search and rescue dog, was deployed in the 9/11 attacks at the Pentagon in Arlington.

Many of the hundreds of search and rescue dogs sent to the Pentagon, World Trade Center in New York City and Shanksville, Pa., have since passed away.

On Monday, Red, who is now 12 years old, received a breakthrough stem cell regenerative treatment from Dr. John Herrity, D.V.M., at the Burke Animal Clinic to help ease crippling arthritis and live out her days in greater comfort.

Red was sent to the Pentagon on Sept. 16, 2001, with her owner and handler, Heather Roche of Annapolis, Md. They worked at the site for 11 days, finding remains of victims in the Pentagon’s north parking-lot area. Red later helped in the aftermath of Hurricanes Katrina and Rita.

No longer able to handle tasks like climbing a two-story ladder, Red retired in July 2011. “She still wants to work, but her body just can’t do it anymore,” Roche said.

“This dog gave a lot to us,” Herrity said Monday afternoon after performing the treatment on Red. “They do searches for remains in burned out buildings. It’s the least we can do for these guys.”

Procedure Lets Old Dogs Run, Play Again

The two-part procedure takes a little over an hour and normally costs $2,000 to $2,400. Two other 9/11 dogs that recently received the same stem cell therapy are able to run, climb and play again. The treatment mainly helps larger breed dogs ages 9 and older with hip and arthritis problems.

Herrity has experience with more than two-dozen stem cell operations. MediVet-America, which developed the in-clinic stem cell technology, donated the cost of the procedure and cryogenic banking of additional stem cells.

Veterinarians and researchers describe stem cell regenerative therapy as a major scientific development in the treatment of arthritis, hip dysplasia, ligament and cartilage injuries and other degenerative joint diseases in dogs, cats, horses and other animals. The technology uses an adult animals’ own stem cells to heal itself.

MediVet-America’s treatment involves removing fat tissue from the animal, separating the stem cells from the fat, activating and injecting the cells into the affected areas. Within four to six weeks, animals who were in severe pain with a restricted range of motion are able to walk, run and even jump again. Key to the procedure is an advanced, patented L.E.D. technology that activates millions of dormant stem cells present in fat tissue.

MediVet donated the test kit system for Red’s procedure on Monday.

Two other Sept. 11 search and rescue dogs also have been treated with stem cell therapy and are doing well, according to MediVet. Bailey, a 15 year-old black Lab, underwent the procedure in November. Hoke, a 14 year-old yellow Lab, was treated in December. Both are doing well, according to their handlers, and have resumed normal activity in retirement.

“We are proud to help the unsung canine heroes of 9/11 more than a decade after the attacks,” said MediVet-America CEO Jeremy Delk. “They deserve the very best stem cell therapeutic care that is now being received by animals across the nation.”

Herrity said the recovery process takes about two to three months. “Our society today wants everything done yesterday,” he said. “But that’s not how the body works.”

 

Search and Rescue Dog in 9/11 Attacks Receives Stem Cell Treatment in Burke – Lorton, VA Patch.

The Great Beyond: Blood farm to satiate vampires, accountant

In ALL ARTICLES on March 21, 2009 at 8:03 pm

Blood farm to satiate vampires, accountant – August 20, 2008

Scientists say they’ve worked out how to make blood by the gallon, and maybe just in time to save their company.

The development “promises to provide an almost limitless supply suitable for transfusion into any patient” say the Times, which “would also eliminate the risk of transmitting the pathogens that cause hepatitis, HIV and Creutzfeldt-Jakob disease (CJD) through transfusions”. This means that “blood donations and vampire bites may one day be a thing of the past” according to one blogger.

Blood has published the paper as an advance online publication, and according to the abstract Shi-Jiang Lu, of Advanced Cell Technology, and colleagues show that it is feasible that embryonic stem cells can be used to create functional oxygen carrying red blood cells at high yields (1010 to1011 red blood cells per six-well plate of embryonic stem cells). They are not the first group to create red blood cells this way, but they are the first to do it on this scale.

Medical News Today highlighted that “stem-cell originated red blood cells were more like fetal and embryonic blood cells than adult cells, they did show some adult cell characteristics after maturing in vitro.” Similarly, the American Red Cross told Scientific American that while the work is “pioneering,” the technique “has not progressed to the stage where the cultured cells are fully equivalent “to real red blood cells”. This is just one of the issues to sort out before this blood can be used for transfusions.

Susan Shurin, from the National Heart, Lung and Blood Institute in Bethesda, Maryland, also explained to Scientific American that there are sugars on the surface of the cells and if the immune system sees them as risky, it could kill the cells. But she called the new work an “important first step”.

The researchers are now trying to make blood cells using reprogrammed adult cells, called induced pluripotent stem cells, while according to Reuters Advanced Cell Technology, which is one of a few commercial ventures trying to make a business out of the emerging stem cell field, “is desperately seeking investors to keep it afloat”.

“The team at Massachusetts-based Advanced Cell Technology hopes the finding might help save the struggling company,” says the wire service.

via The Great Beyond: Blood farm to satiate vampires, accountant.

STEM CELL SCIENCE – New technology sheds light on rise of blood cells | Science | Reuters

In ALL ARTICLES, STEM CELLS IN THE NEWS on February 11, 2009 at 5:55 pm

red-blood-cells

LONDON (Reuters) – German scientists using new imaging technology said on Wednesday they have watched a single cell give rise to blood cells, bolstering understanding of stem cells.

The findings could one day allow scientists to create blood in the laboratory that hospitals could give to patients needing transfusions, said Timm Schroeder of the Institute of Stem Cell research in Munich.

“What we are looking at is where blood really comes from during development,” he said in a telephone interview. “Blood cells are born during the embryo development and we wanted to know from what type of cells they came from.”

The researchers, who published their findings in the journal Nature, developed technology that allowed them to track hundreds of thousands of cells in real time over a week.

Homing in thousands of endothelial cells, which line blood vessels, the researchers discovered that a subset was able to form blood cells.

“It is important to know the exact cell type that produces blood,” Schroeder said. “This is the prerequisite to tweak the system to produce blood cells from embryonic stem cells in a lab.”

Stem cells are the body’s master cells, giving rise to various tissues and the blood. Some types are found throughout organs, blood and tissue and are in immature form until they generate needed cell types.

Doctors hope to use them some day in a new field called regenerative medicine in which tailor-made transplants of tissues and perhaps organs can be grown from a patient’s own cells.

(Reporting by Michael Kahn; Editing by Maggie Fox)

via New technology sheds light on rise of blood cells | Science | Reuters.

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