DAVID GRANOVSKY

Posts Tagged ‘parkinson’

Parkinson’s patients fund their own stem cell research

In BUSINESS OF STEM CELLS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 19, 2013 at 9:00 am

parkinsons

Healing Parkinson’s patients with their own stem cells

Up to 1 million Americans have Parkinson’s, according to the Parkinson’s Disease Foundation. Because aging is the chief risk factor for the disease, the patient population is expected to increase as the baby boom generation gets older.  Parkinson’s selectively kills brain cells that make the neurotransmitter dopamine, which enables movement. No one knows how it happens, or how to stop it. Researchers expect that transplanted dopamine-producing brain cells will eventually die, but perhaps not for 10 to 15 years.

The most visible symptoms of Parkinson’s include tremors, slowed movement, stooped posture and loss of balance, and trouble speaking. People sometimes walk with a shuffling gait, and they may experience severe and chronic pain. Patients’ faces can assume a mask-like expression.  Drugs that provide dopamine or mimic its effects can partially relieve the symptoms, but they produce side effects such as uncontrolled movement. Also, their effectiveness decreases over time.

A groundbreaking stem cell treatment for Parkinson’s disease is getting close to moving from lab research in La Jolla to therapy for patients. The research, funded by the patients and their supporters, could also pioneer a new model for moving medical advances from the lab into the clinic.

Eight Parkinson’s patients have allied with scientists from The Scripps Research Institute and medical professionals from Scripps Clinic for the project, which involves creating new brain cells from other cells in their own bodies. Because of the unusual, personalized nature of the research, the patients are participating with scientists and doctors as equals, meeting regularly to review the progress.

The ambitious goal is to relieve the movement difficulties Parkinson’s causes by replacing the brain cells the disease destroys. In theory, it would restore near-normal movement for a decade or more, and the procedure could be repeated as needed.

Research is far enough along that scientists and health care professionals in the project are talking to regulators about beginning clinical trials, perhaps as soon as next year.

The replacement brain cells are now being grown in a lab at The Scripps Research Institute. Patches of skin the diameter of a pencil eraser were removed from the patients’ arms and turned into a new kind of stem cell that acts like embryonic stem cells. Called induced pluripotent stem cells, they were discovered in 2006, a feat honored by a Nobel Prize last year.

These IPS cells can become nearly any kind of cell in the body… Another potential advantage of IPS cells over embryonic stem cells is that they should be less prone to rejection by the patients’ immune systems, because the transplanted cells come from the individuals themselves.

Patient Cassandra Peters, 57, learned of the reality of Parkinson’s and the hope of a new treatment in a visit with Dr. Houser, her neurologist.  “Interestingly, when I first had a conversation with her, when she definitively told me I had Parkinson’s, she said to me, quote, “You will have a stem cell procedure in your lifetime.”  I took that ball and held it in my heart, thinking, this is going to be my ‘get out of jail free’ card.  Not a day goes by when I don’t have an opportunity to share what I’m going through now and what the future might hold,” Peters said.

Ileana Slavin, a research associate in the lab of Jeanne Loring, and Suzanne Peterson, a staff scientist, discuss what it means for scientists to directly meet the people they’re trying to help.  Diabetes researcher Matthias von Herrath of the La Jolla Institute for Allergy & Immunology said the work could help scientists developing stem cell therapies for diabetics,” von Herrath said. “And that’s going to open the door for these type of stem cells.”

Loring’s researchers are reaching the final stages of their part of the project. They have made induced pluripotent stem cells from all eight patients, and have turned those into the needed brain cells for two of them. The work continues for the other six.

Parkinson’s represents the “low-hanging fruit” of neurological diseases for stem cell therapy.  We know what cell types are lost in Parkinson’s disease,” Bratt-Leal said in a March 8 meeting of the group. “We can make them from stem cells.  And now we can make stem cells from adult tissues.  The next logical step is to make these cells from people and put them back into them.”

“With IPS cells grown from the patient, rejection should be less of a worry”, Bratt-Leal said.

Now that the research side of the project has overcome its greatest hurdles, the focus is shifting to medicine, Loring said. The replacement brain cells will be grown in a clinical grade facility at the City of Hope in Los Angeles.  As part of the transition to the medical side, Houser will provide expertise in setting up the clinical trial, assuming approval is granted by the U.S. Food and Drug Administration.

Beyond the potential benefit to the eight patients, the project may provide an answer to what Loring and other researchers call the “Valley of Death,” the period that halts promising research before it can become a medical treatment.  Most scientific research is federally funded, but commercialization is left to the private sector. If companies don’t see a way to make money, they won’t pursue a therapy, even if it works.  This problem is especially forbidding for treatments customized to individual patients. These don’t produce economies of scale, and hence are not attractive to pharmaceutical companies.  Advocates of the customized Parkinson’s therapy said it will pay off in the long run. Patients will require less medical care, and find it easier to maintain their jobs.

To Read Full Article click HERE.

DENTAL STEM CELLS CARRY GREAT POTENTIAL

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 21, 2013 at 9:00 am

ed_helms

Dental pulp stem cells: a promising tool for bone regeneration.

Human tissues are different in term of regenerative properties. Stem cells are a promising tool for tissue regeneration, thanks to their particular characteristics of proliferation, differentiation and plasticity. Several “loci” or “niches” within the adult human body are colonized by a significant number of stem cells. However, access to these potential collection sites often is a limiting point. The interaction with biomaterials is a further point that needs to be considered for the therapeutic use of stem cells. Dental pulp stem cells (DPSCs) have been demonstrated to answer all of these issues: access to the collection site of these cells is easy and produces very low morbidity; extraction of stem cells from pulp tissue is highly efficiency; they have an extensive differentiation ability; and the demonstrated interactivity with biomaterials makes them ideal for tissue reconstruction. SBP-DPSCs are a multipotent stem cell subpopulation of DPSCs which are able to differentiate into osteoblasts, synthesizing 3D woven bone tissue chips in vitro and that are capable to synergically differentiate into osteoblasts and endotheliocytes.  Several studies have been performed on DPSCs and they mainly found that these cells are multipotent stromal cells that can be safety cryopreserved, used with several scaffolds, that can extensively proliferate, have a long lifespan and build in vivo an adult bone with Havers channels and an appropriate vascularization.

http://www.ncbi.nlm.nih.gov/pubmed/18300003

Dental stem cell banking facility launched by Stemade Biotech this week in Punjab, India with the intent to expand across the county.    “This will help the people to secure their healthy future. Like timely monetary investments help plan future financial security, dental stem cell banking can help plan for a disease- free body.” said Dr Vikas Jindal.

“Stem cells have a defining property to self- regenerate, which can be used to treat serious ailments. Unlike bone marrow stem cells, extracting dental cells is a noninvasive procedure. Dental pulp contains stem cells, known as dental pulp stem cells. The finest dental pulp stem cells are found in baby teeth or milk teeth. Dental stem cells can generate solid structures such as bone, new dental tissue, cartilage and muscle. Dental pulp stem cell banking can be done on milk teeth of children in the age group of five to 12. Teens that are undergoing orthodontic procedures, such as getting braces, have the opportunity to bank their premolars that are often extracted during the procedure. Adults on the other hand have the opportunity to bank on their dental pulp stem cells through wisdom teeth.”

dental-pulp-stem-cell

“Dental Stem cells are Mesenchymal (tissue-related) stem cells whilst umbilical cord blood provides hematopoietic (blood-related) stem cells. Hematopoietic stem cells have the potential to treat only blood-related disorders such as leukemia etc whereas, mesenchymal stem cells have potential applications in all other tissues of our body such as brain for treatment of Alzheimer’s, Parkinson’s, eye for corneal reconstruction and liver for cirrhosis, said Shailesh Gadre Managing Director, Stemade Biotech.”

Embryonic Pluripotency May Give Up Secrets – But So What?

In STEM CELLS IN THE NEWS on July 20, 2012 at 4:07 am

More forward looking statements (without any of the standard legalese on risks, assumptions and uncertainty) regarding the great mystery of embryonic stem cells maybe, sort of, perhaps, soon to give up it’s secrets.

So what’s the deal? 

“Pluripotency is defined as the capacity of individual cells to initiate all lineages of the mature organism in response to signals from the embryo or cell culture environment.”1

Embryonic stem cells have pluripotency.  Discovery of the methods and aspects which allow for pluripotency in embryonic stem cells are definitely a research milestone and one which will advance many lines of inquiry in various fields of medicine…but…there are a few major issues, particularly in the USA.

  • There are already ADULT stem cells which ARE PLURIPOTENT and can be used for treatment. 
  • The US is in a bitter tug of war in both accurate media coverage of stem cells and research and use of adult versus embryonic stem cells. 
  • Pharma is trying to make drugs out of this stuff and get patents on it.
  • In most cases, your own body can supply the necessary stem cells for your own treatment. 
  • And of course, the controversy issues of utilizing embryonic stem cells which will cause the religious right to exert huge resistance on any advancement of embryonic stem cell research in the US.

While the US is still playing a game of catch up in adult and embryonic research and especially treatment; please remember, embryonic stem cell research was fully funded with government backing in many countries around the world for over a decade resulting in…

ZERO EMBRYONIC STEM CELL TREATMENTS.

So don’t get your hopes up for embryonic treatment anytime soon, but then again,

SO WHAT!

ADULT stem cells are here, now, powerful, safe and effective.  What are you waiting for?

Mechanisms That Allow Embryonic Stem Cells to Become Any Cell in the Human Body Identified

ScienceDaily (July 18, 2012) — New research at the Hebrew University of Jerusalem sheds light on pluripotency — the ability of embryonic stem cells to renew themselves indefinitely and to differentiate into all types of mature cells. Solving this problem, which is a major challenge in modern biology, could expedite the use of embryonic stem cells in cell therapy and regenerative medicine.

If scientists can replicate the mechanisms that make pluripotency possible, they could create cells in the laboratory which could be implanted in humans to cure diseases characterized by cell death, such as Alzheimer’s, Parkinson’s, diabetes and other degenerative diseases.

To shed light on these processes, researchers in the lab of Dr. Eran Meshorer, in the Department of Genetics at the Hebrew University’s Alexander Silberman Institute of Life Sciences, are combining molecular, microscopic and genomic approaches. Meshorer’s team is focusing on epigenetic pathways — which cause biological changes without a corresponding change in the DNA sequence — that are specific to embryonic stem cells.

The molecular basis for epigenetic mechanisms is chromatin, which is comprised of a cell’s DNA and structural and regulatory proteins. In groundbreaking research performed by Shai Melcer, a PhD student in the Meshorer lab, the mechanisms which support an “open” chromatin conformation in embryonic stem cells were examined. The researchers found that chromatin is less condensed in embryonic stem cells, allowing them the flexibility or “functional plasticity” to turn into any kind of cell.

A distinct pattern of chemical modifications of chromatin structural proteins (referred to as the acetylation and methylation of histones) enables a looser chromatin configuration in embryonic stem cells. During the early stages of differentiation, this pattern changes to facilitate chromatin compaction.

But even more interestingly, the authors found that a nuclear lamina protein, lamin A, is also a part of the secret. In all differentiated cell types, lamin A binds compacted domains of chromatin and anchors them to the cell’s nuclear envelope. Lamin A is absent from embryonic stem cells and this may enable the freer, more dynamic chromatin state in the cell nucleus. The authors believe that chromatin plasticity is tantamount to functional plasticity since chromatin is made up of DNA that includes all genes and codes for all proteins in any living cell. Understanding the mechanisms that regulate chromatin function will enable intelligent manipulations of embryonic stem cells in the future.

“If we can apply this new understanding about the mechanisms that give embryonic stem cells their plasticity, then we can increase or decrease the dynamics of the proteins that bind DNA and thereby increase or decrease the cells’ differentiation potential,” concludes Dr. Meshorer. “This could expedite the use of embryonic stem cells in cell therapy and regenerative medicine, by enabling the creation of cells in the laboratory which could be implanted in humans to cure diseases characterized by cell death, such as Alzheimer’s, Parkinson’s, diabetes and other degenerative diseases.”

PARKINSON’S – FREDDIE ROACH

In ALL ARTICLES on February 9, 2012 at 1:22 pm

http://fightnetwork.com/wp-content/uploads/2011/11/FreddieRoach1.jpg

For those that don’t know him, Freddie Roach is the greatest boxing coach of all time.  He has accomplished this incredible feat with slurred speech and tremors.  Freddie Roach has Parkinson’s.  On the HBO special about him, in a conversation with another Parkinson’s patient Roach says:

“That’s why Muhammad Ali shakes so much.  He doesn’t take the medication.”

The side effects of the medication are worse than the symptoms of the disease.

http://www.maniacworld.com/muhammad-ali-2.jpg

In a special on Muhammad Ali’s daughter, a brilliant fighter in her own right, she says:

Ali is perfectly coherent and easy to talk to in the morning before he takes his meds.  After he takes his meds you can’t talk to him.

http://www.sportsclb.com/wp-content/uploads/laila-ali-picture-1.jpg

What have we learned here?

http://repairstemcell.wordpress.com/2011/03/17/gene-therapy-shows-promise-for-parkinsons-reuters/

http://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

Autologous Bone Marrow Stem Cells Transplant into Parkinson’s Disease Patients – Safe + Improve
http://repairstemcell.wordpress.com/2010/03/11/autologous-bone-marrow-stem-cells-transplant-into-parkinson%e2%80%99s-disease-patients-safe-improve/

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!
http://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

Do Stem Cells Repair Damaged Brain Cells
http://repairstemcell.wordpress.com/2009/08/25/mesenchymal-stem-cells-may-repair-damaged-brain-cells-%c2%ab-adult-stem-cell-awareness/

* OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD! –http://tinyurl.com/DEBATEisDEAD

OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD!

In VICTORIES & SUCCESS STORIES on October 22, 2011 at 9:15 am

The debate ended 2.5 years ago but the battle still wages on! SO much has changed in 2.5 years  yet so much remains the same. 

The world has embraced the knowledge that adult stem cells can treat almost anything with safety and success but nobody in the USA knows about it because they are not available here and considered “unapproved by the FDA.”

Maybe we can enlist the “Occupy Wall Street” peeps to make some huge needed changes in our health care and available treatments.  – David

Originally from: http://repairstemcell.wordpress.com/2009/03/31/oprah-michael-j-fox-dr-mehmet-oz-the-stem-cell-debate-is-over/

The Stem Cell Debate Is Over! ...sort of...

The Wisdom of Oz

Visualize the surreal image of Oprah Winfrey, Michael J Fox and Dr. Mehmet Oz, wearing purple surgical gloves, sitting on stage around a human brain. Dr. Oz explains the absence of Nigro-Striatal Neurons in the brain of Parkinson’s patients while lifting out partially dissected chunks of brain and placing them into Michael’s shaking hand.

The camera zooms in as Dr. Oz steadies Michael’s hand in his. Dr. Oz weaves an intimidating, steel needle between Michael’s gloved and trembling fingers and illustrates the procedure for injecting stem cells into the brain by plunging it both into and through the quivering cerebellum. Michael’s legs spasm and contort and my stomach clenches empathetically with what I sense is Michael’s extreme discomfort, but is really a symptom of his condition.

And yet, NOTHING could have prepared me for what happened next as Dr. Oz, unbelievably and without prelude or warning, makes the stunning statement:
“I think, Oprah, the stem cell debate is dead.”

“The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it’s very hard to control them and so they can become cancer.”

While astonished by his public announcement, I soon began to wonder: “why did Dr Oz only briefly allude to the potential of iPS cells and the proven benefits of adult stem cell treatments?” And then it became clear.

Dr Oz recognizes that the average person on an American street is led to believe, “a stem cell is an embryo is a stem cell”. Due to years of misleading media saturation, as far most Americans know, there are no other stem cells besides embryonic. Walk down the street and ask someone “what is an adult stem cell…what is an iPS cell”, and your inquiries will surely be met by blank stares.

So in retrospect, what Oz DID do, was truly…amazing.

Shunning the history of the love/hate affair Americans have with Embryonic stem cell research and ignoring the majority of US media over the past 5 years, the decrees of President Obama’s funding policies, the positions of the FDA and AMA and the fruitless decade long public pursuit of embryonic cures undertaken by Michael J Fox (with the benevolent and optimistic spirit of Christopher Reeve hovering over him) and before the bewildered eyes of Michael, Oprah and ~7.2 million viewers, Dr Mehmet Oz nailed the coffin shut on ESC treatments:
“I think, Oprah, the stem cell debate is dead.”

With this one simple statement on national TV, Dr Oz has taken the first step towards educating the American public about the current insurmountable limitations of embryonic stem cells and cracked open the door to the American collective mind-set regarding the potential of iPS cells and the reality that Repair stem cells (RSC) have been treating diseases around the world successfully for a decade. Despite the fact that thousands of American doctors refer to RSC as “snake oil,” more and more American patients are realizing that the US medical system is faltering, dated and just not working while the greatest medicine the world has ever seen is available just beyond the borders of their own country.

The seeds planted by Dr Oz will take a long time to find purchase in the collective American mind-set. There is too much embryonic momentum, media and drama, and America loves drama. Embryonic stem cells will not go away and like Romeo and Juliet, this love/hate affair may have to run its course for most, despite Dr Oz stealing the “distilled liquor” and Romeo’s poison and dagger in an attempt to avoid all of the deaths at the end of this play.

To read more about this grim fairy tale: http://repairstemcell.wordpress.com/2009/03/30/a-grim-fairy-tale-americas-doomed-love-affair-with-embryonic-stem-cell-research-intro-the-romance-is-an-illusion/

One step at a time we will climb this mountain and slowly open American eyes to improve their knowledge of treatment options so all can intelligently exercise the freedom of choice in their individual medical care. One inch at a time, Oz wisely created a pathway to an amazing new world of available medical treatments for what were previously believed to be incurable diseases and are in fact treating patients successfully around the world.

Dr Oz took this first step and it was a HUGE first step!

So from where I am sitting, I would like to express my heartfelt and sincerest appreciation for Dr Oz’s bravery, statements and actions. Thank you, Dr. Oz and thank you Oprah; for allowing this sage doctor the forum to break the walls restricting millions of Americans from the knowledge of the medical treatment options they so unquestionably deserve.

Here is the actual transcript based on my ears and fingers and a lot of patient rewinding:

“I think, Oprah, the stem cell debate is dead.”

“The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it’s very hard to control them and so they can become cancer.”

“I can take a little bit of your skin, take those cells, get them to go back in time so they are like they were when you were first made, and then they will start to make that dopamine & I think those cells, because they won’t be as prone to cancer & because they’re your genes will be the ones that are ultimately used to cure Parkinsons.”

“I think we are single digit years away from making a big impact in the lives of Parkinson’s disease but also diabetics, heart disease, people who have had a lot of problems.”

To see the original video: http://www.oprah.com/media/20090319-tows-dr-oz-brain

APATHY, IGNORANCE OR BLINDNESS?

In CELEBRITIES & STEM CELLS on October 6, 2011 at 1:27 am

I posted this on Montel William’s Facebook page:

“I just received 13 pages of new Stem Cell Treatments for MS info. There is editing and translation and I am trying to get fully substantiated results for these treatments…if you are interested in reviewing the info.”

http://img2.timeinc.net/people/i/2008/specials/fall_tv/blog/080211/montel_williams_240x320.jpg

SO SAD!: 

It was removed within 10 seconds of my posting it on Montel’s page.  Why would they not want to know about new treatments?  Don’t they have a responsibility as leaders of social media to share new treatment info with their followers?

It’s really a damn shame.  Christopher Reeves died chasing embryonic stem cells while adult stem cells have given the ability to walk to paraplegics.  Michael J Fox chases embryonic stem cells while adult stem cells have 60-70% success treating Parkinson’s disease.  The brilliant visionary Steve Jobs died of pancreatic cancer never knowing about a number of successful cancer treatments.  The blind can now see.  Diabetics are off insulin.  Heart transplant patients play tennis with their own heart healed.

It’s time people!!  If you know any leaders in media, corporate or politics; please refer them to me and I will personally explain to them why so many people do not have to die today.

Be the change in the world you want to see – Ghandi
…before it’s too late.

Celeb Dad We Love: Michael J. Fox Discouraged About Parkinson’s Disease But Fights On

In STEM CELLS IN THE NEWS on June 8, 2011 at 10:23 pm

Michael J. Fox Discouraged About Parkinson’s Disease

POSTED BY MICHELLE LAMAR ON JUNE 2ND, 2011 AT 12:38 AM

michael j fox 280x300 Celeb Dad We Love: Michael J. Fox Discouraged About Parkinson’s Disease But Fights On

Michael J Fox is an awesome celeb dad and I admire him so much for his brave fight against Parkinson’s disease in addition to his busy family life and career.  But reports surfaced today that Fox is realizing that he will likely never see a cure for Parkinson’s disease in his lifetime.

Michael J. Fox will celebrate his 50th birthday in June but sources close to the actor say he has been devastated by a recent setback in Parkinson’s research.

New research showed certain stem cells won’t be effective in treating Parkinson’s because they will be rejected by patients’ immune systems.  A source told the National Enquirer that the actor is crushed about the research findings:

“Michael is seeing his life ebb away. Turning 50 is a wake-up call. He wonders if he’ll be able to dance at his kids’ weddings. Michael had such high hopes for this potentially miraculous stem cell therapy, but now it’s back to the drawing board.”

 

Why has it taking him so long to figure out that only adult stem cells, not embryonic, are the key to Parkinson’s patients recovery.

Autologous Bone Marrow Stem Cells Transplant into Parkinson’s Disease Patients – Safe + Improve
http://repairstemcell.wordpress.com/2010/03/11/autologous-bone-marrow-stem-cells-transplant-into-parkinson%e2%80%99s-disease-patients-safe-improve/

 

 

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!
http://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

 

Do Stem Cells Repair Damaged Brain Cells
http://repairstemcell.wordpress.com/2009/08/25/mesenchymal-stem-cells-may-repair-damaged-brain-cells-%c2%ab-adult-stem-cell-awareness/

 

* OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD! –http://tinyurl.com/DEBATEisDEAD

More evidence links diabetes, Parkinson’s disease

In DISEASE INFO on April 15, 2011 at 11:24 am
More evidence links diabetes, Parkinson’s disease

Parkinson’s Improvements with stem cell treatment

NEW YORK | Fri Apr 15, 2011 9:29am EDT

(Reuters) – People with diabetes may be more likely to also develop Parkinson’s disease – and this seems particularly true for younger patients, a new study suggests.

The findings, published online by the journal Diabetes Care, add to evidence linking diabetes and Parkinson’s. One recent report said that U.S. adults with diabetes had a slightly higher risk of developing Parkinson’s over a 15-year period, compared to nondiabetics.

Neither study, however, proves that diabetes itself causes Parkinson’s.

Instead, researchers think it’s more likely that the two disorders share some common underlying causes.

The new findings are from Denmark, where researchers compared close to 2,000 adults with Parkinson’s disease and nearly 10,000 people the same age but without the disease (the “control” group).

Overall, 6.5 percent of the Parkinson’s patients had diabetes for at least 2 years before they were diagnosed with the movement disorder. By comparison, just 5 percent of people in the control group had diabetes for at least 2 years.

Overall, the study found, having diabetes was linked to a roughly one-third higher risk of developing Parkinson’s. That was after the researchers accounted for participants’ age and sex, and any diagnoses of emphysema – which was considered a proxy for heavy smoking. (Studies have found cigarette smokers to be at lower risk of Parkinson’s, for reasons that are not clear.)

In particular, diabetes was related to a higher risk of developing Parkinson’s before the age of 60 — which is about the average age at diagnosis.

Exactly what the findings mean is unclear, according to the researchers, who were led by Dr. Eva Schernhammer of Harvard Medical School in Boston.

But they say that for now, the “most plausible” explanation would be that diabetes and Parkinson’s have some of the same biological underpinnings.

One possibility is continuous low-level inflammation throughout the body, which is suspected of contributing to a number of chronic diseases by damaging cells. There might also be a common genetic susceptibility.

However, even if people with diabetes have a relatively bigger risk of Parkinson’s, that does not mean it is a high risk. For example, the recent U.S. study that tracked patients for 15 years involved nearly 289,000 older adults. The proportion of people who eventually developed Parkinson’s disease was 0.8 percent among diabetics and 0.5 percent among nondiabetics – less than 1 percent in either case.

The researchers on that study said that people with diabetes should simply continue to do the things already recommended for their overall health — eating a well-balanced diet and getting regular exercise.

More studies are needed, they said, to understand why diabetes is related to a higher Parkinson’s risk, and what, if anything, can be done about it.

Diabetes arises when the body can no longer properly use the blood-sugar-regulating hormone insulin. Parkinson’s occurs when movement-regulating cells in the brain die off or become disabled, leading to symptoms like tremors, rigidity in the joints, slowed movement and balance problems.

Researchers say it’s possible that something about diabetes — like a problem regulating insulin — might somehow contribute to Parkinson’s. But that remains unproven.

Gene therapy shows promise for Parkinson’s | Reuters

In VICTORIES & SUCCESS STORIES on March 17, 2011 at 11:02 am

I’m glad to see other therapies are producing benefits to Parkinson’s patients.

There now seems to be 3 options for Parkinson’s patients:
Gene therapy = 23.1 % improvement
Placebo effect = 12.7 % improvement

Adult Stem Cells = 60 % improvement*

* 60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS! http://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

-dg

Gene therapy article below pic


“The treated group showed a 23.1 percent improvement on a scale of Parkinson’s symptoms six months after treatment, compared to a 12.7 percent improvement for patients who received sham surgery, according to the published research.”

Gene therapy shows promise for Parkinson’s | Reuters.

THE WHOLE IS GREATER THAN THE SUM OF THE PARTS

In OFF THE BEATEN PATH on September 28, 2010 at 7:53 pm

Completely random, caffeine infused, unedited rant

(not really random, actually in response to this comment on facebook:

” Breaking news: Alzheimer’s is a whole body disease. Insulin, glucose, neurological system + nutrition all affect it. Breaking news? So…the entire body works holistically…diseases should be treated holistically? This is only breaking news in USA now, it was breaking news in Asia + India 3,000 years ago. Western med …always seems look through the wrong end of the binoculars + try to kill a fly with a shot gun.”

alexgrey33ri.gif alex grey image by breando

THE WHOLE IS GREATER THAN THE SUM OF THE PARTS

As I spend time with specialists I find more and more of them are either realizing or “able to empirically prove” that diabetes, Alzheimer’s, Parkinson’s, etc etc are a disease of the entire body. The evidence is all there.

SO the drugs that target a single chemical interaction, a single organ, a single anything…even if they work, will not fix the body, they will only fix that specific problem. So then 6-12 months later when that part is no longer screaming for fixing and the next part makes itself heard, you will then take a new drug in Act 2 of “my whole body is broken but I am going to treat it one problem at a time.”

Segue to car analogy: Go put 100,000 miles on your car. Don’t change the oil, don’t fill the tires, don’t put fuel line cleaner in the gas tank, don’t maintain it all. Wait until it is smoking, shaking, coughing and stalling. Wait until every turn produces squeals of protest from the tie rods, axle, wheels and steering column. Wait until every hill cause it to wheeze, belch smoke, shudder and shake. Then and only then, go out and buy your self a brand new carburetor or exhaust, or fuel injector. In fact, you can buy any one thing, brand new and replace it. Any one thing but just one thing. Then question why your car doesn’t drive like when it was new.

Now back to the movie analogy – Act 2 of “my whole body is broken and I am going to treat it one problem at a time.” ……… Now here’s the fun part. Act 2 assessment – problem 1 (antagonist #1) is fixed via drug #1 (savior #1), problem 2 (antagonist #2) enters the scene and drug #2 (savior #2) is introduced to quell problem #2…but as in all dramas, drug #1 (savior #1) is not so pure of heart. This hero is flawed and now there is a new problem (antagonist #3) generated by the introduction of savior #1. And so on and so on. COnfusing? Depressing? You’re damn right! Now here’s the b*tch of it…this tragic movie will go on for the rest of your life.

Here’s an interesting analogy: I envision the plot as a snake eating it’s own tail. The more he eats, the less hungry he is and the less body he has to sustain…but the more he eats, the more he is using up his own body…until when he has finally eaten himself all the way from tail to head, there is nothing left to sustain but there is also nothing left of his body. If this isn’t clear, feel free to go to the chemo or radiation ward. I think the analogy will absolutely be clear as day to you then.

And please understand that I truly mean no disrespect to these docs and scientists who are calling attention to the fact that diseases, once believed to be isolated events in the body; are actually system wide organisms within an organism and through circulation, electric-neurological exchange or associative influence actually interact with every other cell in your body. These docs and scientists who through empirical western analysis are trying to draw attention to a holistic approach of treatment are lone forces crying out for change in an industry of rigidity…they are often the sole open minded wise person in a forest full of old rooted dead trees…they are working in a centuries old system that is anti-free thought, anti- radical concept and anti “anything that challenges the status quo.”

These docs and scientists who are challenging their industry thinking deserve our support. They need our help to get the word out and more importantly, we as patients have a responsibility to ourselves and our loved ones to question what else is out there, what else is involved in this problem, what other factors are contributing to my illness. So do it!

…and that’s my rant.

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