DAVID GRANOVSKY

Posts Tagged ‘NERVE’

Milan, Italy study used stem cells derived from mouse skin tissue to treat MS – Lima multiple sclerosis | Examiner.com

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:25 pm
Milan, Italy study used stem cells derived from mouse skin tissue to treat MS

 

An experiment was published Tuesday in Nature Communications by researchers at San Raffaele Scientific Institute in Milan and the University of Milan in Italy, that showed they were able to reduce nervous system damage in mice.

Milan, Italy study used stem cells derived from mouse skin tissue to treat MS – Lima multiple sclerosis | Examiner.com.

BLOOD, HEART AND BRAIN STEM CELLS

In STEM CELLS IN THE NEWS on April 11, 2013 at 10:40 am

stem cell science

Science daily is an excellent source for medical article and studies.  I’ve received their feed for quite a while now.  Here, are 3 stem cell articles from today.

  1. Blood stem cells, besides turning into hema type cells can also become white blood cells.
  2. Cardiac stem cells from bone marrow can heal the heart.  This we’ve known since the late 90’s but additional confirmation is always appreciated.
  3. Brain stem cells not only can turn into brain and nerve cells but they also clear out the garbage in the brain and keep the cells in a perpetual stem cell state.

These are 3 good stem cell articles but also of note…

This is the first time Science Daily has had three stem cell articles in their feed.  The world is turning to stem cells.  Are you?

———————————————-

Surprising ability of blood stem cells to respond to emergencies

http://www.sciencedaily.com/releases/2013/04/130410131227.htm 

Posted: 10 Apr 2013 10:12 AM PDT

Scientists have revealed an unexpected role for hematopoietic stem cells: They do not merely ensure the continuous renewal of our blood cells; in emergencies they are capable of producing white blood cells “on demand” that help the body deal with inflammation or infection. This property could be used to protect against infections in patients undergoing bone marrow transplants, while their immune system reconstitutes itself.

 

Cardiopoietic ‘smart’ stem cells show promise in heart failure patients

 http://www.sciencedaily.com/releases/2013/04/130410103349.htm

Posted: 10 Apr 2013 07:33 AM PDT

Therapy with cardiopoietic (cardiogenically-instructed) or “smart” stem cells can improve heart health for people suffering from heart failure. This is the first application in patients of lineage-guided stem cells for targeted regeneration of a failing organ, paving the way to development of next generation regenerative medicine solutions.

 

Spring cleaning in your brain’s stem cells?

http://www.sciencedaily.com/releases/2013/04/130410094120.htm

Posted: 10 Apr 2013 06:41 AM PDT

Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells when you need them. New research shows the vital role of a type of internal “spring cleaning” that both clears out garbage inside the cells, and keeps them in their perpetual stem-cell state.

BENNY HILL IS ALIVE AND WELL AS BRITAIN GOES BLIND

In ALL ARTICLES on September 23, 2011 at 7:00 am

Remember in the final scene of every episode of Benny Hill where he does something really scandalous and then gets chased by the entire cast around and around in circles?  Turns out, Benny Hill is ALIVE AND WELL and advising Britain on their medical protocols!  http://www.webtvwire.com/wp-content/uploads/2010/06/the-benny-hill-show-logo.jpg

You see, Britain, like the USA, is chasing this fleet footed “embryonic stem cell treatment comedy of errors” around and around in circles just like in the Benny Hill episodes.  Every week, the same scene is played out with Benny running, the entire cast chasing and he never gets caught.  So in Art, so in life.  Britain is chasing embryonic stem cells used for treatment of optic diseases.  And remember…

  • Embryonic stem cells STILL have ZERO successful clinical trials
  • Embryonic stem cells STILL cause cysts and tumors that can become cancerous (wait 20 years and ask again though)
  • Embryonic stem cells STILL have rejection issues that require immunosuppressive drugs
  • Embryonic stem cells STILL carry the genetic anomalies of the donor
ON THE OTHER HAND…

So on top of wasting time chasing a cure with no prior history of success and huge negative side effects, thy are running right past a treatment with a huge history of success and safety and trials.

So cue up the cameras, get everyone in costume and let’s start that famous music going as everyone chases embryonic stem cell treatments around and around.  Wait! STOP! Hold it! CUT!

How on earth can we explain the entire medical community and government running right past what already works?  Got it! Give them all blindfolds!  That way they can be assured to miss the forest but they will hit every damn tree in it and so will the patients, patiently waiting for treatments which will never come!

…annndddd   ACTION!!!

Iris of a human eye

First trial of embryonic stem cell treatment in Europe gets green light

Patients in Britain with an eye disease that leads to blindness will take part in Europe’s first human embryonic stem cell trial

British surgeons are to take part in the first trial in patients of a human embryonic stem cell therapy to gain approval from regulators in Europe.

Surgeons at Moorfields Eye Hospital in London will inject cells into the eyes of 12 patients with an incurable eye disease called Stargardt’s macular dystrophy, one of the main causes of blindness in young people…

Read more

OPTIC NERVE HYPOPLASIA, SEPTO-OPTIC DYSPLASIA, MACULAR DEGENERATION and OPTIC CHEMICAL BURNS

In VICTORIES & SUCCESS STORIES on February 11, 2011 at 9:41 am

Until she was 15, Morse had 20/4,000 vision in one eye and only light perception in the other due to optic nerve hypoplasia, or an underdevelopment of the nerve that transmits vision signals from the eye to the brain. She could make out human figures but not see details, could only read if the paper was within inches of her eye, and could only watch TV standing with her nose pressed to the glass…

After raising $15,000 from community donations, the mother and daughter set out for China on July 4…

She received spinal injections of cord blood stem cells each week for six weeks. After her third treatment, she realized she could read and knew the treatments were working…

More info on OPTIC NERVE HYPOPLASIA, SEPTO-OPTIC DYSPLASIA, MACULAR DEGENERATION and OPTIC CHEMICAL BURNS:

Treatment with adult stem cells, due to the amazing transformation from blindness to sight, are some of the most powerful success stories in adult stem cell treatments.

·         Macie Morse from Colorado before stem cells had 20/4000 vision in one eye and in the other eye she only had “light perception,” she could only make out light.  Also, she could only watch TV with her nose pressed against the glass. After treatment she had 20/80 vision in one eye and the other is 20/400+.  She is now driving her family’s van and enjoying her new driving permit. http://repairstemcell.wordpress.com/2009/02/16/stem-cells-optic-nerve-hypoplasia-victory/

·         Jakob Bielski from Canada received stem cell treatment because he couldn’t see at all and had no response to light.  After the Cord Blood Stem Cells Were Implanted he has some vision, can respond to visual information and responds to light.

·         Dakota Clarke’s mother said “It’s been worth every single penny to see the changes in her.”

·         Coby Fend’s mother said ““We are talking about going back — we’d almost be crazy not to, because right now it’s the best thing going in the entire world.”

·         Connor Corkern’s mother said: “He’s doing great. He is doing wonderful. It’s like we’ve got a totally new baby.”

·         Cameron Petersen’s Grandma said: “There was nothing for Cameron before this treatment. Now, his world is limitless.”

·         Lydia Black’s father said: “the treatment is already having a huge effect on her life, and he is glad that she was able to receive stem cell treatment…”

·         Savannah Watring’s mother said: “She said hello to herself in an elevator (after seeing her reflection). It blew everyone away. We weren’t expecting that.”

·         Xavier Carballo’s ophthalmologist, Dr. Jack Guggino of Tampa, said he did a baseline exam on the boy before the trip to China and after his return. Before the treatment Xavier could only detect hand motion at 1 to 2 feet, and after the treatment he could count fingers at 3 to 4 feet.  “As far as Xavier is concerned, there has been definite and measurable improvement, neurologically and ophthalmologically,” Guggino said.

·         Lawrence Brown III looks at the number “10” on a family laptop and tells his mother Georgina Brown what the number is as part of a daily exercise to see if his sight is improving. For most people, it is insignificant.  But for Lawrence, 16, who has been blind since birth, it was an exceptional moment.“They call it a really good placebo effect,” Lawrence said. “Whatever, if it’s a placebo effect, I want some more.” http://repairstemcell.wordpress.com/2009/08/09/stem-cell-therapy-shows-results-el-paso-times/

·         Blind Man Can See Again After Stem Cell Therapy – A man blinded after having ammonia squirted in his eye is now able to see again thanks to adult stem cells taken from his own body.  Russell Turnbull, 38, from England had therapy using stem cells taken from his other eye in a research study in London.

·         A study in the New England Journal of Medicine on 112 patients with corneal damage from chemical burns whom received treatment.  After adult stem cell treatment, a permanent restoration of a transparent, renewing corneal epithelium was attained in 76.6% of eyes. The restored eyes remained stable over time, with up to 10 years of follow-up (mean, 2.91±1.99; median, 1.93).  http://repairstemcell.wordpress.com/2010/06/24/chemically-burned-eyes-repaired-with-stem-cells/

VIDEO: Meet Sam, a visual artist who was confronted with the one thing a man in his profession fears most: Compromised vision. In his case his ability to see clearly was being undermined by age-related macular degeneration (AMD.) His Doctor harvests and uses a patient’s own stem cell-rich bone marrow to help effect healing. Sam discerned improvements in his vision within the first ten days following his treatment and siz weeks later the vision in his left eye had improved while that in his right eye was now normal.

If you or a loved one interested in receiving FREE information on currently available stem cell treatments for OPTIC NERVE HYPOPLASIA, SEPTO-OPTIC DYSPLASIA, MACULAR DEGENERATION and OPTIC CHEMICAL BURNS, please contact me at dsgrano@gmail.com or for other options, go to: CONTACT ME

SCOTLAND JUMPS INTO STEM CELL CLINICAL TRIALS

In ALL ARTICLES on July 29, 2010 at 12:11 pm

This video shows the Health Minister of Scotland discussing current stem clinical trials in Scotland for stroke and for eye repair.  It’s significant that they are in the stem cell game.  One more country recognizing the power of stem cells.

p.s.  It’s a short video and armed with my explanation above, you probably know everything you need to know without even watching it – http://video.forbes.com/fvn/tech/scotland-stem-cell-edge

 

And now for your viewing pleasure…a pic of Cuillin Mountains in Scotland

http://www.1adventure.com/archives/images/cuillin-mountains-scotland-backside.jpg

Other STROKE articles:

  1. http://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
  2. http://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
  3. http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
  4. http://www.sciencedaily.com/releases/2011/08/110831160216.htm

JAMA — Stem Cells Boost Dopamine – to help Parkinson’s

In VICTORIES & SUCCESS STORIES on June 23, 2010 at 6:06 pm

Stem Cells Boost Dopamine

Bridget M. Kuehn

JAMA. 2010;303(24):2464.

JAMA: The  Journal Of the American Medical Association.  To Promote the Science and  Art of Medicine and the Betterment of the Public Health

  Vol. 303 No. 24, June 23/30, 2010

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Transplantation of human endometrial–derived stem cells (HEDSC) [HEDSC ARE ADULT STEM CELLS FROM THE ENDOMETRIUM] into mice with a Parkinson disease-like disorder boosted the animals’ dopamine production, according to a study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The findings provide preliminary evidence that such transplantation may have therapeutic benefits in Parkinson disease.

In the study, a team of researchers from Yale University first demonstrated that HEDSC could differentiate into dopaminergic neurons in vitro (Wolff EF et al. J Cell Mol Med. 10.1111/j.1582-4934.2010.01068.x [published ahead April 7, 2010). Next, the investigators transplanted HEDSC into both immunodeficient and immunocompetent mice with a Parkinson-like disorder. They found that the transplanted cells survived at the transplant site and also migrated to damaged brain regions and differentiated into neural cells. Both immunodeficient and immunocompetent animals that had undergone such transplants showed no sign of rejecting the transplanted cells and experienced increased . . .

via JAMA — Stem Cells Boost Dopamine, June 23/30, 2010, Kuehn 303 (24): 2464.

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg

In VICTORIES & SUCCESS STORIES on June 22, 2010 at 3:00 am

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows

Patients blinded in one or both eyes by chemical burns regained their vision after healthy stem cells were extracted from their eyes and reimplanted, according to a report by Italian researchers at a scientific meeting.

Patient's Own Stem Cells Fix Damaged Eyes

The tissue was drawn from the limbus, an area at the junction of the cornea and white part of the eye. It was grown on a fibrous tissue, then layered onto the damaged eyes. The cells grew into healthy corneal tissue, transforming disfigured, opaque eyes into functioning ones with normal appearance and color, said researchers led by Graziella Pellegrini of the University of Modena’s Center for Regenerative Medicine.

The stem-cell treatment restored sight to more than three- quarters of the 112 patients treated, Pellegrini said yesterday in a presentation at the International Society for Stem Cell Research meeting. She estimated the work may benefit 1,000 to 2,000 patients in Europe whose eyes have been damaged by chemical burns and many more in developing countries where the use of chemicals is less regulated. Her patients were followed for an average of three years and some for as long as a decade…..

via Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg.

BBC News – Frenchay Hospital trials offer MS stem cell hopes

In VICTORIES & SUCCESS STORIES on June 16, 2010 at 12:22 pm

Almost missed this article from May 5th.  Good results. Confirms what we already know.  Bone marrow stem cells…

“increased nerve function by up to 20%.”

This is backed up by 58 articles from http://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/ (There are more. This list is as of Sept, 09′) and a number of clinical trials. – dg

Frenchay Hospital trials offer MS stem cell hopes

Scientist examining tissue culture

The study has been carried out at the Burden Centre in Frenchay Hospital

Clinical trials on six multiple sclerosis (MS) patients who have had stem cell injections have produced “encouraging” results, scientists say.

The trials, which are thought to be a world first,

World first??!! What about the 23 MS/Stem Cell trials listed here: http://clinicaltrial.gov/ct2/results?term=multiple+sclerosis+stem+cell – dg

are taking place at Frenchay Hospital in Bristol.

The six were injected with stem cells harvested from their own bone marrow. Research found this increased nerve function by up to 20%.

…Liz Allison, one of the volunteers being studied, said: “My long-term hope is that stem cell research will be a cure for MS and will be available for everyone who is afflicted with this disease.

“It has the added benefit of being a relatively pain-free procedure and having no side effects.”

via BBC News – Frenchay Hospital trials offer MS stem cell hopes.

NEW STEM CELL FOUND IN THE BRAIN

In SCIENCE & STEM CELLS on May 26, 2010 at 3:08 am

Discovery of Stem Cell Illuminates Human Brain Evolution, Points to Therapies

ScienceDaily (May 24, 2010) — UCSF scientists have discovered a new stem cell in the developing human brain. The cell produces nerve cells that help form the neocortex — the site of higher cognitive function — and likely accounts for the dramatic expansion of the region in the lineages that lead to humans, the researchers say.

Future studies of these cells are expected to shed light on developmental diseases such as autism and schizophrenia and malformations of brain development, including microcephaly, lissencephaly and neuronal migration disorders, they say, as well as age-related illnesses, such as Alzheimer’s disease…

via Discovery of stem cell illuminates human brain evolution, points to therapies.

“OPTIC NERVE TREATMENT ABANDONED” or “HOW TO REGRET FOR THE REST OF YOUR LIFE”

In STEM CELLS IN THE NEWS on January 21, 2010 at 11:45 am
“OPTIC NERVE TREATMENT ABANDONED” or
“HOW TO REGRET FOR THE REST OF YOUR LIFE”

It saddens me to see people who are on the brink of improvement for their child’s condition are turned away at the door by anti-adult stem cell nay-saying UK doctors. This event will reverberate in their lives for years to come…and unfortunately I believe the parents will regret their choice for years to come. (my comments in red) -dg

Imogen James

Imogen James has a condition known as Optic Nerve Hypoplasia

The parents of a girl with sight problems have given up plans to take their daughter  for stem cell therapy.

Lauren and Nick James’ daughter Imogen suffers from an underdeveloped optic nerve which makes her virtually blind.  Her parents believed this treatment would work miracles on their daughter’s sight.  They raised over £28,000 to pay for the operation but will now return the money and give the rest to charity.

‘Former Optic Nerve Hypoplasia Patient and Stem Cell Recipient Dakota Clark is Doing fantastic’

Imogen James was born with Optic Nerve Hypoplasia which is congenital condition (i.e. present at birth). It means that Imogen is virtually blind and can only see things if they are extremely close to her. Lauren first heard about the stem cell treatment a year ago which filled her with hope.  “A year ago we met with Dakota Clark’s family who’d just been to China for stem cell therapy and they had given rave reviews, [saying] how fantastic it was and how Dakota had started walking, her eyesight was better, her speech was better and she was doing fantastic. “I’ll admit at the time I thought, ‘wow this is unbelievable’ so that gave us the boost.”

Stem cell therapy aims to replace or repair damaged cells but according to the NHS ”the range of diseases where stem cell treatment is proven treatment option is still quite small”.

A few comments about this:

  • Adult or Repair “stem cell treatment is (a) proven treatment option” in over 170 diseases (not very small)…in about ~2000 clinical trials, ~30-40,000 scientific papers and thousands of success stories.
  • Nat’l Health Services or NHS provides treatments to patients so their commenting on competing medical options  is extremely suspect and a conflict of interest.
  • I recently commented on an NHS article on MS with “More Info about MS and Stem Cells – http://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/My comments were removed.

They needed to raise £30,000 to pay for the operation and the flights.  After raising £28,000 in a matter of months, the family was all set to go ahead and had booked flights for December 2009.  So close…so close…

But then the doubts set in. “Obviously during that time we were doing a lot of research ourselves but the more and more we dug into the stem cell therapy the more answers I wasn’t finding.  “I was finding a lot of questions, but I wasn’t finding any answers and unfortunately the company we were going to see, they were sort of evasive with the answers in a way, but I found out from speaking to doctors in the UK that they don’t have the answers either – no-one has.”  The treatment itself involves using an intravenous drip to feed the stem cells into the body, or by using a lumbar puncture .

I have seen the answers that this treatment center (one of the most reputable treatment centers in the world) gives.  They are respectful and honest and they are unwilling to make forward looking or optimistic statements.  Interested patients receive the facts and nothing more.  They will give you the results and experiences and data but no guarantees or promises because they can not and will not out of responsibility to their patients and their own integrity.  This is not evasive, this is the way it should be!

I feel terrible for the Jameses.  I wish them the best and hope Imogen’s condition improves every day.  I hope they don’t regret this decision for the rest of her life…but I’m afraid they will.  I hope they don’t become convinced in 2 months that stem cells are the way to go…but I’m afraid they will.  I hope they have read everything available on stem cell treatment of optic nerve hypoplasia [ http://repairstemcell.wordpress.com/?s=optic+nerve ] …the story of Macie Morse who went from legally blind to driving a car, the story of American Idol candidate Devin Riley, the story of the 40 or 50 more (and counting) ONH, SOH and MD (macular degeneration) patients whose sight has improve considerably since stem cell treatment and whose quality of life improvements are off the charts.

In retrospect, I hope they haven’t.  If they have seen all of this evidence and come so close and then still turned away is as bewildering to me as it is tragic. Sigh… I wish I could help them…maybe I still can. I don’t know… Perhaps they will see this and read all of the information available.  I’d like to help if I can…

“But few have spoken of the actual pleasure derived from giving to someone, from creating something, from finishing a task, from offering unexpected help almost invisibly and anonymously.”  Paul Wiener quotes

-David

http://img180.imageshack.us/img180/7520/youcanleadahorsetowateran2.jpgYou can lead a horse to water, but you can’t make him drink.

[something that you say which means you can give someone the opportunity to do something, but you cannot force them to do it if they do not want to - Cambridge Idioms Dictionary, 2nd ed. ]

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