DAVID GRANOVSKY

Posts Tagged ‘MS’

MS patient to take part in pioneering experiment – CBS News

In STEM CELLS IN THE NEWS on January 21, 2014 at 1:42 pm

No mention of the words “stem cell” in the headline.  No mention of stem cells until the 6th paragraph.  Why make it so difficult for patients to find these articles? In any case, we eagerly await the results! -dg

“Stem cells can be morphed into any cell in the body. Patients like Quinn have bone marrow removed and the stem cells inside are then changed in the kind of stem cells found in the brain and spinal cord.

Those cells will then be injected directly into the spinal cord. The hope is that they will repair the insulation and perhaps even the wires underneath.”

via MS patient to take part in pioneering experiment – CBS News.

 

RELATED ARTICLES:

  • FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis

“To my knowledge, this is the first FDA-approved stem cell trial in the United States to investigate direct injection of stem cells into the cerebrospinal fluid of MS patients, and represents an exciting advance in MS research and treatment,” said Dr. Saud A. Sadiq, Senior Research Scientist at Tisch MS Research Center of New York and the study’s principal investigator.

The groundbreaking study will investigate a regenerative strategy using stem cells harvested from the patient’s own bone marrow.  These stem cells will be injected intrathecally (into the cerebrospinal fluid surrounding the spinal cord) in 20 participants who meet the inclusion criteria for the trial.  This will be an open label safety and tolerability study.  All study activities will be conducted at the Tisch MS Research Center and affiliated International Multiple Sclerosis Management Practice (IMSMP).”  via http://www.prnewswire.com/news-releases/fda-approves-stem-cell-clinical-trial-for-multiple-sclerosis-219553021.html

  • Meredith Vieira’s Family Health Battle

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?

Milan, Italy study used stem cells derived from mouse skin tissue to treat MS – Lima multiple sclerosis | Examiner.com

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:25 pm
Milan, Italy study used stem cells derived from mouse skin tissue to treat MS

 

An experiment was published Tuesday in Nature Communications by researchers at San Raffaele Scientific Institute in Milan and the University of Milan in Italy, that showed they were able to reduce nervous system damage in mice.

Milan, Italy study used stem cells derived from mouse skin tissue to treat MS – Lima multiple sclerosis | Examiner.com.

STEM CELL TRAIL BLAZER RICHARD HUMPHRIES WILL BE MISSED

In ALL ARTICLES, STEM CELLS IN THE NEWS on February 21, 2013 at 4:44 pm

richard humphries

Richard Davis Humphries was a trail blazer in the area of adult stem cell treatments and his strength and passion will be missed. His successful treatment and recovery from secondary progressive multiple sclerosis in 2007 enlightened untold numbers to the benefits and safety of adult stem cell treatments. If you didn’t know him, here’s a small piece of his battle and recovery from MS:

In March of 2007, “Humphries, a 54-year-old Alexandria native who lives in Fort Worth, Texas, was bedridden and suffering from excruciating pain with secondary progressive multiple sclerosis.

“Very few people know this,” he said, “but I prayed to die every day and night, for the pain was off the charts.”…

…”The night after the second injection, I started to feel better and the fog had lifted. The time was midnight, and I had not been able to stay up that late in some time. The pain was gone….

HUMPHRIES WAS THE FIRST ADIPOSE (FAT TISSUE) DERIVED STEM CELL RECIPIENT IN THE WORLD.  STEM CELLS FROM FAT HAVE SOME OF THE HIGHEST REGENERATIVE CAPABILITIES AND ARE FOUND IN SUPER ABUNDANCE, MAKING THEM AN IDEAL SOURCE FOR TREATMENT.


…In February (2008?), Humphries underwent another experimental stem cell treatment to regrow inner ear nerve hairs. It not only improved his hearing but helped him tolerate heat, which can be a problem for people with MS…

“It’s an amazing recovery,” Ichem said (Dr. Tom Ichem of San Diego, a scientist). “I was with him in (Washington) D.C. and spent three days with him, and I was, honestly, bona fide flabbergasted. It’s one thing to read about recoveries like this, but to see it first hand — I hate to say ‘miracle,’ but it was absolutely something very, very stunning. Usually when we develop new treatments, we see results with some impact, but I’ve never seen this kind of stunning impact. It literally shocked me.”

Rest In Peace my friend. You will be missed.

STEM CELL TREATMENTS FOR MULTIPLE SCLEROSIS SISTERS?

In ALL ARTICLES, OFF THE BEATEN PATH, STEM CELLS - 101 on January 3, 2013 at 3:13 pm

Two sisters have MS.  I thought it would be interesting to see them both get stem cell treatments to see how their body’s and the stem cells reacted differently in such genetically similar people.- DG

A friend intelligently made the following comment:
“Even twins would have unique MS experiences. You have to consider multiple factors at play with MS symptoms. I know fraternal twins who experience the MS differently and have to be treated in different ways. There is no one-size-fits-all with having and treating MS.”

My response:
I agree there is no one treatment fits all but that is one of the unique attributes of stem cell treatments.  Stem cells work within the systems of your own body, utilizing your own cells to regenerate and rejuvenate necrotic and damaged tissue, to create new tissue and to pull your own body’s healing elements into play to fix what is wrong.  Stem cells, especially autologous (from your own body) stem cells used in therapy are a highly personalized individual treatment which will not only heal twins differently but will actually result in a different therapy each time the same person receives them depending upon what is currently needed by the body.

By analogy: 
truck

Imagine a drug is a big mack truck, driving along and crashing through anything in it’s way to attain it’s destination.  Now imagine your own stem cells follow all of the rules of the road and even stop and fix damaged roadway on it’s way to it’s destination.  The stem cells recruit helpers and construction workers and healers along the way and they will even build new roads if the area is too damaged to support the healing activity required.

advanced-nav-header

Now imagine a batch of stem cells in a different country with different roads, signs, ailments etc and because they are part of the original healing system of that body, they are able to navigate, fix, recruit and heal there as well.

I agree 100%.  THERE IS NO ONE TREATMENT FITS ALL.  There is also no such thing as ONE STEM CELL TREATMENT.

snowflake3w

Each stem cell treatment is unique to each individual.  As they should be.
At least, the treatments I advocate are.

STEM CELLS FOR MS – HOW THEY WORK DISCOVERED

In VICTORIES & SUCCESS STORIES on September 5, 2012 at 2:32 pm

 

Cleveland researchers find key to stem-cell therapy for MS patients: Discoveries
Published: Tuesday, September 04, 2012, 7:21 AM     Updated: Tuesday, September 04, 2012, 2:02 PM

CLEVELAND, Ohio — …Figuring out why the mice improved could help researchers see if the MSC injection will work well in a particular patientbefore the patient is injected, and possibly augment or improve the treatment as well.

In May, the research group atCWRU, headed up by neurosciences professor Robert Miller, discovered exactly what it is in the stem-cell soup that has a healing effect: a large molecule called hepatocyte growth factor, or HGF. The team published their results in Nature Neuroscience.

Miller’s group knew that it could be the stem cells themselves, by coming in physical contact with the myelin damage, that were having a healing effect. Or it could be something the stem cells secreted into the surrounding liquid culture, or media, they were grown in, that was key. HGF is secreted by the stem cells, Miller said.

The team identified the HGF by first injecting only the liquid the stem cells were grown in, but not the stem cells themselves, into the mice they were studying. The mice got better, so the team knew whatever was helping was in the media.

Next, they isolated the small, medium and large molecules from the media and tried each size on the mice. Only the large-molecule treatment had the healing effect, meaning that whatever was helping was somewhere in that mix, Miller said.

“The molecule that jumped out at us was HGF,” he said, because it is the right size, is made by MSCs, and in a couple ofstudies had been shown to be involved in myelin repair.

So the scientists took a purified sample of HGF and injected it into the sick mice. They got better. When they blocked the receptor for HGF in the mice, they stayed sick. It was pretty compelling evidence that they’d found what they’d been looking for, Miller said.

“We went on to show that HGF, like the MSCs, is regulating both the immune response, and it is independently promoting myelin repair in the brain,” he said.

MSCs, taken from the bone marrow, are currently being tested in more than 150 clinical trials in the United States and around the world to treat conditions such as osteoarthritis, diabetes, emphysema and stroke.

JEFFREY-COHEN-CLEVELAND-CLINIC.JPG

The local Phase 1 trial has enrolled 16 of 24 total patients, and eight of them have completed the trial protocol, said Dr. Jeffrey Cohen, Cleveland Clinic neurologist and lead investigator of the trial.

So far, the treatment seems to be working, Cohen said.

“It’s a little early to be saying it, but things have looked encouraging.”

And there have been no safety concerns and almost no side effects. There has also been no activation — an aggravation or return of symptoms — of this relapsing disease in the patients involved, which has happened unexpectedly with other types of MS treatments.

Miller’s discovery won’t change the course of the trial currently under way at the Clinic and UH, but it may change the future of MSC treatment.

While they don’t know yet what the outcome of that trial will be, it’s possible that if a patient doesn’t respond to the treatment, it could mean that hisstem cells aren’t producing enough HGF to be effective at healing, Miller said. Miller will be studying MSC samples from all the patients in the trial to find out if those who are better at producing HGF fare better.

He’ll also be trying to see if they can predict how well a patient will do based on hisHGF levels in the MSC sample…

“Finally, though we’re a long way from this, maybe we could augment the expression of HGF in patients whose stem cells aren’t that effective to enhance their effectiveness,” he said.

But why not just inject the HGF alone? Miller said there are two reasons. First, the receptor for HGF in the cells, called c-MET, has been implicated in liver and breast cancer. Injecting HGF by itself into the body may stimulate the c-MET pathway, he said, and the research team is not willing to risk that.

“The stem cells have the advantage that they tend to home to the area of insult, so they don’t stick around in other parts of the body,” he said. “They target the treatment where it’s needed.”

http://www.cleveland.com/healthfit/index.ss

Recovery From Multiple Sclerosis By Growth Factor In Stem Cells

In VICTORIES & SUCCESS STORIES on June 21, 2012 at 1:54 pm

http://static.ddmcdn.com/gif/multiple-sclerosis-demyelinization.gif

Recovery From Multiple Sclerosis By Growth Factor In Stem Cells
http://www.medicalnewstoday.com/articles/245816.php

Multiple Sclerosis and stem cells – need more info?
http://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

ADULT STEM CELLS AND RADIATION?

In SCIENCE & STEM CELLS on November 16, 2011 at 6:51 pm

The question of radiation during adult stem cell treatments came up today:

radiation pic

N says: “Touting adult stem cells as the way to salvation, even with donor human hematopoietic stem cells (hHESCs) (adult stem cells), used in the treatment of leukemia patients, a patient must undergo a radiation treatment to suppress their immune system prior to receiving the donor hHESCs. StemCellBlogger commented on the need for immunosuppression when using hESCs in clinical translational therapy. Given that a patient must receive a near lethal dose of radiation, knocking out their immune system BEFORE receiving hHESCs from a registered DONOR, flies in the face of reason when compared to the immunosuppression required for hESC infusion. A patient receivng either a liver, kidney, pancreas or dual kidney pancreas organ transplant receives immunosuppression in the form of Campath as a prophylactic prior to the transplant and then must either receive Prograf, Cyclosporin, or Sirolimus (depending on the tissue transplanted) in order to suppress the patients immune system, allowing the graft to survive while avoiding graft-vs-host rejection. If we are going to talk about translational therapies, then let’s get into the meat and stop chewing the fat.

regen medicine

My response: I’m not talking about bone marrow transplants for leukemia patients, I’m talking about adult stem cell treatments used in regenerative medicine.  For example, CBS who have called adult stem cells snake oil for years just did a very positive piece on a recent heart trial:

CBS VIDEO on Adult Stem Cell Success with Heart Disease

CBS ARTICLE on Adult Stem Cell Success with Heart Disease

“This study is still in progress. 16 patients were assigned to the treatment group and seven to the control group; no CSC-related adverse effects were reported. In 14 CSC-treated patients who were analysed, LVEF increased from 30·3% (SE 1·9) before CSC infusion to 38·5% (2·8) at 4 months after infusion (p=0·001). By contrast, in seven control patients, during the corresponding time interval, LVEF did not change (30·1% [2·4] at 4 months after CABG vs 30·2% [2·5] at 8 months after CABG). Importantly, the salubrious effects of CSCs were even more pronounced at 1 year in eight patients (eg, LVEF increased by 12·3 ejection fraction units [2·1] vs baseline, p=0·0007). In the seven treated patients in whom cardiac MRI could be done, infarct size decreased from 32·6 g (6·3) by 7·8 g (1·7; 24%) at 4 months (p=0·004) and 9·8 g (3·5; 30%) at 1 year (p=0·04).”

via Clinical Trial in The Lancet CBS Based Their Reporting On

While the study is still in prgress and the results are preliminary, I find it extremely ironic that CBS uses words like “breakthrough” and “first ever” and N acts as if he doesn’t know about the 443 clinical trials at clinicaltrials.gov with the keywords “stem cell” and “cardiac?,” over 2,000 completed Adult stem cell trials, thousands of patients treated safely and effectively around the world and over 5,170 peer reviewed published studies with the keywords “adult stem cell” and “cardiac?”

The results are great the history is extensive and no radiation is needed.In fact, even MS which used to need radiation to treat with adult stem cells no longer needs radiation.

Can MS be treated with stem cells?

In ALL ARTICLES on October 25, 2011 at 2:13 pm

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

I did some digging and would like to present the preliminary results to answer the question:

Can MS be treated with stem cells?

http://www.msconnections.org/ms-myelin.gifSOME MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” - January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – http://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

————————————-

Can MS be treated with stem cells?

You decide. Here are 11 articles from my blog,  28,000 from google news and there are a total of 20 clinical trials from clinicaltrials.gov

From my blog…

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

***http://repairstemcell.wordpress.com/2010/05/18/ms-and-stem-cells-time-is-brain-in-ms/

*** http://repairstemcell.wordpress.com/2009/09/02/my-ms-pain-is-gone/

* * * http://repairstemcell.wordpress.com/2009/04/26/fat-derived-stem-cells-might-treat-ms-us-news-and-world-report/

* * * http://repairstemcell.wordpress.com/2009/04/15/britt%e2%80%99s-fight-against-multiple-sclerosis-hits-home-for-uncw-starnewsonlinecom-star-news-wilmington-nc/

* * * http://repairstemcell.wordpress.com/2009/04/09/stem-cell-breakthrough-may-lead-to-ms-treatments-forbescom/

* * * http://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-2/

* * * http://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-1/

* * * http://repairstemcell.wordpress.com/2009/03/07/study-stem-cell-transplants-could-reverse-ms-cloning-and-stem-cells-msnbccom/

* * * http://repairstemcell.wordpress.com/2009/02/23/foxnewscom-college-student-with-multiple-sclerosis-symptom-free-after-stem-cell-treatment-health-news-current-health-news-medical-news/

* * * http://repairstemcell.wordpress.com/2009/02/12/stem-cells-ms-multiple-sclerosis-cured-by-adult-stem-cells-video-stem-cell-research-and-stem-cell-therapy/

* * * http://repairstemcell.wordpress.com/2009/02/11/multiple-sclerosis-ms-stem-cell-trials-us-is-starting-to-%e2%80%9ccatch-up%e2%80%9d/

* * * http://repairstemcell.wordpress.com/2009/02/10/the-us-is-playing-catch-up-with-stem-cells-ms/

* * * http://repairstemcell.wordpress.com/2009/02/08/stem-cell-transplants-help-ms-victims/

…and about 28,000 scholarly papers/studys on “MS stem cell” here:
http://scholar.google.com/scholar?q=multiple%20sclerosis%20trial%20stem%20cell&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=ws\

…and 20 responses from clinicaltrials.gov on “multiple sclerosis stem cell”
http://clinicaltrial.gov/ct2/results?term=multiple+sclerosis+stem+cell

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

In STEM CELLS IN THE NEWS on October 25, 2011 at 1:49 pm

Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible progress, measured in terms of the scale of their disability.”

With these “encouraging” results, the researchers decided to perform another study involving more patients, and compared their results with traditional treatments. The experiment involved the removal and freezing of bone marrow after treating the marrow with drugs to remove the lymphocytes of the immune system which are responsible for attacking nerve system fibers in MS patients.

At the end of the process, doctors implanted stem cells, which proved to be able to give the MS patients a normally functioning immune system. The time factor, underlined neurologists, seems crucial in the efficiency for stem cells because “if we intervene quickly, we are able to exploit the body’s ability to repair itself, which in the long term is lost”. In any case, scientists say that “ it is not a definitive cure for muscular sclerosis”.

OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD!

In VICTORIES & SUCCESS STORIES on October 22, 2011 at 9:15 am

The debate ended 2.5 years ago but the battle still wages on! SO much has changed in 2.5 years  yet so much remains the same. 

The world has embraced the knowledge that adult stem cells can treat almost anything with safety and success but nobody in the USA knows about it because they are not available here and considered “unapproved by the FDA.”

Maybe we can enlist the “Occupy Wall Street” peeps to make some huge needed changes in our health care and available treatments.  – David

Originally from: http://repairstemcell.wordpress.com/2009/03/31/oprah-michael-j-fox-dr-mehmet-oz-the-stem-cell-debate-is-over/

The Stem Cell Debate Is Over! ...sort of...

The Wisdom of Oz

Visualize the surreal image of Oprah Winfrey, Michael J Fox and Dr. Mehmet Oz, wearing purple surgical gloves, sitting on stage around a human brain. Dr. Oz explains the absence of Nigro-Striatal Neurons in the brain of Parkinson’s patients while lifting out partially dissected chunks of brain and placing them into Michael’s shaking hand.

The camera zooms in as Dr. Oz steadies Michael’s hand in his. Dr. Oz weaves an intimidating, steel needle between Michael’s gloved and trembling fingers and illustrates the procedure for injecting stem cells into the brain by plunging it both into and through the quivering cerebellum. Michael’s legs spasm and contort and my stomach clenches empathetically with what I sense is Michael’s extreme discomfort, but is really a symptom of his condition.

And yet, NOTHING could have prepared me for what happened next as Dr. Oz, unbelievably and without prelude or warning, makes the stunning statement:
“I think, Oprah, the stem cell debate is dead.”

“The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it’s very hard to control them and so they can become cancer.”

While astonished by his public announcement, I soon began to wonder: “why did Dr Oz only briefly allude to the potential of iPS cells and the proven benefits of adult stem cell treatments?” And then it became clear.

Dr Oz recognizes that the average person on an American street is led to believe, “a stem cell is an embryo is a stem cell”. Due to years of misleading media saturation, as far most Americans know, there are no other stem cells besides embryonic. Walk down the street and ask someone “what is an adult stem cell…what is an iPS cell”, and your inquiries will surely be met by blank stares.

So in retrospect, what Oz DID do, was truly…amazing.

Shunning the history of the love/hate affair Americans have with Embryonic stem cell research and ignoring the majority of US media over the past 5 years, the decrees of President Obama’s funding policies, the positions of the FDA and AMA and the fruitless decade long public pursuit of embryonic cures undertaken by Michael J Fox (with the benevolent and optimistic spirit of Christopher Reeve hovering over him) and before the bewildered eyes of Michael, Oprah and ~7.2 million viewers, Dr Mehmet Oz nailed the coffin shut on ESC treatments:
“I think, Oprah, the stem cell debate is dead.”

With this one simple statement on national TV, Dr Oz has taken the first step towards educating the American public about the current insurmountable limitations of embryonic stem cells and cracked open the door to the American collective mind-set regarding the potential of iPS cells and the reality that Repair stem cells (RSC) have been treating diseases around the world successfully for a decade. Despite the fact that thousands of American doctors refer to RSC as “snake oil,” more and more American patients are realizing that the US medical system is faltering, dated and just not working while the greatest medicine the world has ever seen is available just beyond the borders of their own country.

The seeds planted by Dr Oz will take a long time to find purchase in the collective American mind-set. There is too much embryonic momentum, media and drama, and America loves drama. Embryonic stem cells will not go away and like Romeo and Juliet, this love/hate affair may have to run its course for most, despite Dr Oz stealing the “distilled liquor” and Romeo’s poison and dagger in an attempt to avoid all of the deaths at the end of this play.

To read more about this grim fairy tale: http://repairstemcell.wordpress.com/2009/03/30/a-grim-fairy-tale-americas-doomed-love-affair-with-embryonic-stem-cell-research-intro-the-romance-is-an-illusion/

One step at a time we will climb this mountain and slowly open American eyes to improve their knowledge of treatment options so all can intelligently exercise the freedom of choice in their individual medical care. One inch at a time, Oz wisely created a pathway to an amazing new world of available medical treatments for what were previously believed to be incurable diseases and are in fact treating patients successfully around the world.

Dr Oz took this first step and it was a HUGE first step!

So from where I am sitting, I would like to express my heartfelt and sincerest appreciation for Dr Oz’s bravery, statements and actions. Thank you, Dr. Oz and thank you Oprah; for allowing this sage doctor the forum to break the walls restricting millions of Americans from the knowledge of the medical treatment options they so unquestionably deserve.

Here is the actual transcript based on my ears and fingers and a lot of patient rewinding:

“I think, Oprah, the stem cell debate is dead.”

“The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it’s very hard to control them and so they can become cancer.”

“I can take a little bit of your skin, take those cells, get them to go back in time so they are like they were when you were first made, and then they will start to make that dopamine & I think those cells, because they won’t be as prone to cancer & because they’re your genes will be the ones that are ultimately used to cure Parkinsons.”

“I think we are single digit years away from making a big impact in the lives of Parkinson’s disease but also diabetics, heart disease, people who have had a lot of problems.”

To see the original video: http://www.oprah.com/media/20090319-tows-dr-oz-brain

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