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Posts Tagged ‘medicine’

STEM CELLS 101 – short

In ALL ARTICLES, SCIENCE & STEM CELLS on April 11, 2013 at 12:50 am

Transplanted adult dermal stem cells / Cellule...

STEM CELLS 101 – short

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM•comes from
    blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal
    neurological, breast milk, menstruation, dental pulp, lungs (new source!) and many more
  • PURPOSE IN BODY•they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS•~zero problems (virtually zero side effects)
  • TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY•can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)

EMBRYONIC STEM CELL = ESC

  • SOURCE/DERIVED FROM•comes from embryos
  • PURPOSE IN BODY•split for 7 weeks until you have a fetus the size of a thumbnail
  • OBSTACLES+SIDE EFFECTS•they create
    cysts and tumors, rejection requires immunosuppressive drugs for the ill
    patient, they carry the genetic anomalies of the donor, etc
  • TREATMENT HISTORY•can currently treat zero diseases, probably need to cure cancer first to use them

INDUCED PLURIPOTENT STEM CELL = iPSC (“Embryonic Stem Cell Lite”)

  • SOURCE/DERIVED FROM•comes from regular adult cells like skin cells that are then transformed by scientists into stem cells
  • PURPOSE IN BODY•to be a skin cell or other tissue
  • OBSTACLES+SIDE EFFECTS•they create
    cysts and tumors, rejection requires immunosuppressive drugs for the ill
    patient, they carry the genetic anomalies of the donor…
  • TREATMENT HISTORY•no treatments to date, probably need to cure cancer first to use them

STEPHEN HAWKING VISITS STEM CELL LAB

In ALL ARTICLES, STEM CELLS IN THE NEWS on April 10, 2013 at 4:57 pm
Stephen Hawking Visits LA Stem Cell Lab

Stephen Hawking toured a stem cell laboratory Tuesday where scientists are studying ways to slow the progression of Lou Gehrig’s disease, a neurological disorder that has left the British cosmologist almost completely paralyzed.

After the visit, the 71-year-old Hawking urged doctors, nurses and staff at Cedars-Sinai Medical Center to support the research.

Hawking recalled how he became depressed when he was diagnosed with the disease 50 years ago and initially didn’t see a point in finishing his doctorate. But his attitude changed when his condition didn’t progress quickly and he was able to concentrate on his studies.

“Every new day became a bonus,” he told a packed room.

Cedars-Sinai received nearly $18 million last year from California’s taxpayer-funded stem cell institute to study the debilitating disease also known as amyotrophic lateral sclerosis. ALS attacks nerve cells in the brain and spinal cord that control the muscles. People gradually have more and more trouble breathing and moving as muscles weaken and waste away.

There’s no cure and no way to reverse the disease’s progression. Few people with ALS live longer than a decade.

Diagnosed at age 21 while a student at Cambridge University, Hawking has survived longer than most. He receives around-the-clock care, can only communicate by twitching his cheek, and relies on a computer mounted to his wheelchair to convey his thoughts in a distinctive robotic monotone.

A Cedars-Sinai patient who was Hawking’s former student spurred doctors to invite the physicist to glimpse their stem cell work.

“We decided it was a great opportunity for him to see the labs and for us to speak to one of the preeminent scientists in the world,” said Dr. Robert Baloh, who heads the hospital’s ALS program.

During the tour, Hawking viewed microscopic stem cells through a projector screen and asked questions about the research, Baloh said.

Cedar-Sinai scientists have focused on engineering stem cells to make a protein in hopes of preventing nerve cells from dying. The experiment so far has been done in rats. Baloh said he hopes to get governmental approval to test it in humans, which would be needed before any therapy can be approved.

Renowned for his work on black holes and the origins of the universe, Hawking is famous for bringing esoteric physics concepts to the masses through his best-selling books including “A Brief History of Time,” which sold more than 10 million copies worldwide. Hawking titled his speech to Cedars-Sinai employees “A Brief History of Mine.”

Despite his diagnosis, Hawking has remained active. In 2007, he floated like an astronaut on an aircraft that creates weightlessness by making parabolic dives.

Space exploration is important “for the future of humanity,” he told the audience.

Hawking said he did not think Earthlings would survive “without escaping beyond your fragile planet.”

And he gave some advice: Look up at the stars. Stay curious.

“However difficult life may seem, there is always something you can do and succeed at,” he said.

Doctors don’t know why some people with Lou Gehrig’s disease fare better than others. Baloh said he has treated patients who lived for 10 years or more.

“But 50 years is unusual, to say the least,” he said.

 

RELATED ARTICLES:

Stem Cells from Human Adipose Tissue Used to Chase Migrating Cancer Cells

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on March 15, 2013 at 11:21 am
Stemness of primary AMSC lines demonstrated with differentiation along three mesenchymal lineages, Adipocyte (a, d [48], g), Osteocyte (b [48], e, h), and Chondrocyte (c [48], f, i), documented via lineage specific staining with Oil Red O, Alizarin Red, and Collagen II, respectively. (Credit: Pendleton et al. Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas. PLoS ONE, 2013; 8 (3): e58198 DOI: 10.1371/journal.pone.0058198)
Using Fat to Fight Brain Cancer: Stem Cells from Human Adipose Tissue Used to Chase Migrating Cancer Cells

Mar. 12, 2013 — In laboratory studies, Johns Hopkins researchers say they have found that stem cells from a patient’s own fat may have the potential to deliver new treatments directly into the brain after the surgical removal of a glioblastoma, the most common and aggressive form of brain tumor.


The investigators say so-called mesenchymal stem cells (MSCs) have an unexplained ability to seek out damaged cells, such as those involved in cancer, and may provide clinicians a new tool for accessing difficult-to-reach parts of the brain where cancer cells can hide and proliferate anew. The researchers say harvesting MSCs from fat is less invasive and less expensive than getting them from bone marrow, a more commonly studied method.

ADULT STEM CELLS USED TO CREATE CARDIAC TISSUE

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 19, 2013 at 9:08 am

abc_weir_heart_130118_wg

Adult Stem Cells: A Piece of My Heart, From Cells in My Arm

Doctors have dreamed of a day when science could grow healthy spare parts in a lab for the human body.  A pivotal moment in this search came in the late ’90s when the first embryonic stem cells were isolated. These cells are the biological “seeds” that divide, differentiate and grow into the myriad parts of the human body.  While it was a thrilling discovery, it was also the start of an ethical and political firestorm, since an embryo had to be destroyed in order to isolate its stem cells. In 2001, President George W. Bush signed an executive order to restrict further research.

The move forced scientists to search for other ways and in 2007, researchers in Japan and Wisconsin figured out a way to reprogram adult cells into stem cells. Word of the discovery reached Mayo, and Dr. Tim Nelson and his colleagues at the Center for Regenerative Medicine were intrigued. This could be a way to help all those kids, born with deformed hearts, who sit on transplant waiting lists at Mayo each year.

“This is one technology that allows us to understand disease, but it also allows us to dream about the day we apply that therapeutically.” And as he described his work, he made me a tantalizing offer. If I would agree to partake in their research, he said I “could be the first person to ever see his own heart tissue beat outside his body.”

It began with a biopsy of the skin under my left bicep, all the better to hide the tiny scar. With a small round knife, Dr. Nelson dug out a pencil eraser-sized chunk of my flesh and plopped it into a jar of pink liquid. I flew home and they went to work, using a combination of genes to bioengineer these bits of flesh into pluripotent (“many potentials”) stem cells. At that stage, they could’ve nudged them into becoming neurons or lung cells or even parts of my eyeball, but in keeping with Dr. Nelson’s promise, the Mayo team turned them into cardiac tissue. Months later, I returned for a one-of-a-kind reunion and gazing through that microscope, I could see pumping proof why this kind of medical science just won the Nobel Prize.

Dr. Nelson got most excited when he showed me a tiny piece of my cardiac tissue that had dramatically formed into the shape of a heart — a pumping, three-dimensional glimpse into a future when this kind of cell could theoretically be injected into a heart-attack victim or a diseased child and literally mend the person from within.

See the full story of Bill Weir’s experience

http://abcnews.go.com/Nightline/video/human-heart-tissue-bill-weirs-arm-18253132

STEM CELL TREATMENTS FOR MULTIPLE SCLEROSIS SISTERS?

In ALL ARTICLES, OFF THE BEATEN PATH, STEM CELLS - 101 on January 3, 2013 at 3:13 pm

Two sisters have MS.  I thought it would be interesting to see them both get stem cell treatments to see how their body’s and the stem cells reacted differently in such genetically similar people.- DG

A friend intelligently made the following comment:
“Even twins would have unique MS experiences. You have to consider multiple factors at play with MS symptoms. I know fraternal twins who experience the MS differently and have to be treated in different ways. There is no one-size-fits-all with having and treating MS.”

My response:
I agree there is no one treatment fits all but that is one of the unique attributes of stem cell treatments.  Stem cells work within the systems of your own body, utilizing your own cells to regenerate and rejuvenate necrotic and damaged tissue, to create new tissue and to pull your own body’s healing elements into play to fix what is wrong.  Stem cells, especially autologous (from your own body) stem cells used in therapy are a highly personalized individual treatment which will not only heal twins differently but will actually result in a different therapy each time the same person receives them depending upon what is currently needed by the body.

By analogy: 
truck

Imagine a drug is a big mack truck, driving along and crashing through anything in it’s way to attain it’s destination.  Now imagine your own stem cells follow all of the rules of the road and even stop and fix damaged roadway on it’s way to it’s destination.  The stem cells recruit helpers and construction workers and healers along the way and they will even build new roads if the area is too damaged to support the healing activity required.

advanced-nav-header

Now imagine a batch of stem cells in a different country with different roads, signs, ailments etc and because they are part of the original healing system of that body, they are able to navigate, fix, recruit and heal there as well.

I agree 100%.  THERE IS NO ONE TREATMENT FITS ALL.  There is also no such thing as ONE STEM CELL TREATMENT.

snowflake3w

Each stem cell treatment is unique to each individual.  As they should be.
At least, the treatments I advocate are.

STEM CELLS – MAGIC OR SCIENCE?

In STEM CELLS IN THE NEWS on July 26, 2012 at 11:28 am

 

A friend asked:

“I would like nothing more than to beleive adult stem cell working for different diseases, however I don’t. How can you take a sick cell and replant it and it becomes healthy.”

—————————————————————————

My answer:

HIGH TURNOVER RATE
This is not magic, it is biological fact. Let’s start with your body. “Just like us, cells grow old and die. When old cells die, new ones replace them. For example, a blood cell in our body lives for about 120 days. Another example is our skin cells. We shed our skin cells about every 35 days.” That’s the outer layer which is why tattoos fade over time and why tattoos go deep into the lower levels of skin.

I’M DYING! YES, WE ALL ARE…
So our cells are in a constant state of “getting older” or “getting sick” or moving towards “impaired function.” I’m dying says the soldier with the sucking chest wound. Yes, we all are, says his philosopher friend. And we are indeed. “He not busy being born is busy dying.” says Bob Dylan. Perhaps this is too philosophical but the point is this: our body and every one of the 5-50 trillion cells is either getting older and weaker and dying or is currently being born or repaired. It’s a dynamic entity, this shell we reside in and it is constantly changing.

GETTING DOWN WITH THE SICKNESS
If you have too many cells with impaired function, especially in a specific area, which are damaged, necrotic, not getting enough nutrients, minerals etc and are getting exposure to too many toxins, inflammation, infections, etc which it can not eliminate, then something will go wrong and you will get sick with the capital ‘S’ and it is time to call in the workers to fix you up.

BOB THE BUILDER HAS SOME COMPETITION
Stem cells are the body’s construction workers. They do both renovations and they do ground up construction. Renovations amount to taking dead tissue and cells – necrotic – and re-energizing them so they come back to life (no zombie jokes please). This can be seen in hundreds of heart studies and trials and thousands of congestive heart failure patients where necrotic heart tissue implanted with stem cells was found to be living and beating a few weeks later. Ground up construction is where they set up shop on a blank field and build something new. This can be seen when stem cells create mini bypasses where stents were implanted. They are actually smart enough to know the “stent area” is a dangerous heavy traffic area and even if the stent is working, they will create offramps and onramps around the stent or bypasses with capillaries. Pretty cool huh?

YOU CAN’T ALWAYS GET WHAT YOU WANT
Not magic, just plain old science and if your body was able to produce enough stem cells to run to the heart, it could do it by itself. In fact, it is trying, desperately to do exactly that but the body in congestive heart failure is like a single mother with 6 kids, 3 jobs and 2 dogs standing on one foot and juggling chain saws. She just can’t do it all, she is stretched to the limits of her endurance, something has to give…and it does. So while your body is sending stem cells to the heart, and the feet and the pancreas, liver, kidney, brain, endocrine and lymphatic and circulatory system infrastructure, RIGHT NOW, to renovate and build new cells and tissues, it is not sending ENOUGH and the fact that our single mom smokes and lives near a factory and does other people’s laundries, exposing herself to multiple chemical toxins, doesn’t sleep much, can only afford McD’s and is highly stressed, etc etc just taxes her body all the more.

RIGHT HERE, RIGHT NOW
So YOU have stem cells in YOUR body RIGHT NOW which are running around, differentiating into different cell types and healing you. All the time. So while our bodies are in a constant state of degradation, our stem cells are constantly fighting that degradation.

WANT THE SCIENCE?
If you would like trials and studies to back this up there are about 2,600 at last count and I can refer you to some that address a specific condition.

 

Cardiac muscle patches made from stem cells

In VICTORIES & SUCCESS STORIES on June 21, 2012 at 2:01 pm
Old news but good news~!
http://www.ouhsc.edu/histology/Glass%20slides/64_05.jpg
Cardiac muscle patches made from stem cells

A cutting-edge method developed at the University of Michigan Center for Arrhythmia Research successfully uses stem cells to create heart cells capable of mimicking the heart’s crucial squeezing action.

The cells displayed activity similar to most people’s resting heart rate. At 60 beats per minute, the rhythmic electrical impulse transmission of the engineered cells in the U-M study is 10 times faster than in most other reported stem cell studies.

An image of the electrically stimulated cardiac cells is displayed on the cover of the current issue of Circulation Research, a publication of the American Heart Association.

For those suffering from common, but deadly, heart diseases, stem cell biology represents a new medical frontier…

Recovery From Multiple Sclerosis By Growth Factor In Stem Cells

In VICTORIES & SUCCESS STORIES on June 21, 2012 at 1:54 pm

http://static.ddmcdn.com/gif/multiple-sclerosis-demyelinization.gif

Recovery From Multiple Sclerosis By Growth Factor In Stem Cells
http://www.medicalnewstoday.com/articles/245816.php

Multiple Sclerosis and stem cells – need more info?
http://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

Chicago Woman Cured of Sickle Cell Disease

In VICTORIES & SUCCESS STORIES on June 20, 2012 at 11:14 pm
Chicago Woman Cured of Sickle Cell Disease

Posted: June  18, 2012 by Sherri McGinnis Gonzalez

Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant. University of Illinois Hospital & Health Sciences System physicians performed the procedure using medication to suppress her immune system and one small dose of total body radiation right before the transplant.The transplant technique is relatively uncommon and is a much more tolerable treatment for patients with aggressive sickle cell disease who often have underlying organ disease and other complications, says Dr. Damiano Rondelli, professor of medicine at UIC, who performed Thomas’s transplant.

The procedure initially allows a patient’s own bone marrow to coexist with that of the donor. Since the patient’s bone marrow is not completely destroyed by chemotherapy or radiation prior to transplant, part of the immune defense survives, lessening the risk of infection. The goal is for the transplanted stem cells to gradually take over the bone marrow’s role to produce red blood cells — normal, healthy ones…

POT, SMOKING AND THC ARE ALL THE DEVIL!!!

In Medical Marijuana on June 12, 2012 at 12:16 am

The title is facetious and the following is in response to this comment:

“…I can tell you SMOKE of any kind is not good for you. Pot smoke is not magic. Anyone saying otherwise is spreading propaganda.” Bob (we’ll call him Bob)
 
My response:
Propoganda? Interesting word choice given the history of anti-marijuana propaganda, but ok, here we go…
DAMN THOSE HARVARD UNIVERSITY PROPAGANDISTS!!!
DAMN THEM TO HELL!!!

Marijuana Cuts Lung Cancer Tumor Growth In Half, [Harvard] Study Shows
http://www.sciencedaily.com/releases/2007/04/070417193338.htm
But if Bob is still vehemently against SMOKING marijuana…
 
Lighting up giving you aches? Try some MJ space cakes!!
THC is your friend…weed tinctures will help you mend!!
Smoke make you recoil? Try hemp oil!!
Don’t criticize…vap-o-rize!!
 
Perhaps our friend Bob is anti smoke,not anti marijuana’s benefits?

You see Bob, just because I enjoyed drinking a relaxing tea made out of stinging nettles today doesn’t mean I want to rub those same stinging nettles on my private parts. What’s my point? Hate the bad delivery system, not the incredibly beneficial plant.

You site Tommy Chong getting prostate cancer as an anti0marijuana anecdote…

and since we are trying to see the forest and not the trees by exploring the many methods of ingesting marijuana other than smoking it, maybe you can’t connect marijuana use to prostate cancer (unless he put it in his rear, which some people do).  In fact, perhaps if Tommy Chong took marijuana enemas he would have avoided prostate cancer or could heal it now…WHAT!?  Marijuana enemas, does such a thing exist?  Apparently, yes:

“Marijuana tea enema solution causes a particular kind of relaxation that is extremely helpful in aiding those who have chronic pain-related illnesses (especially adult colic), loss of appetite (especially from HIV or AIDS), multiple sclerosis (MS), or are suffering through chemotherapy or opiate withdraws.” http://enemasolutions.com/marijuana-enema/marijuana-tea-enema-solution-recipe.html

But since Chong is a singular example and an anecdotal (not clinically relevant) example and he is indeed now actually TREATING HIS PROSTATE CANCER WITH HEMP OIL http://www.cbsnews.com/8301-31749_162-57450353-10391698/tommy-chong-using-pot-to-treat-prostate-cancer/ maybe he is a bad example for your position in the argument and even better, a solid example for my side of the argument (thanks!).

Pot isn’t the devil Bob, ignorance is.

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