DAVID GRANOVSKY

Posts Tagged ‘MARROW’

LATE STAGE OVARIAN CANCER CURED WITH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 7, 2014 at 1:03 pm

ovarian-cancer-symptoms
Hue Hospital Succeeds in Treating Cancer with Stem Cell

Saigon – Doctors of Hue Central Hospital have used stem cell transplantation to successfully treat a cancer patient of the last stage. The Hue Central Hospital announced on June 26 that its doctors have cured Le Thi Sau, 52, who was suffering ovarian cancer in the last stage, with stem cell transplant. The operation is the success of the scientific project “Using stem cell in breast cancer and cervical cancer” managed by Professor Nguyen Duy Thang, deputy head of the hospital. Adult stem cells have been used to treat certain cancers through bone marrow transplants. In this therapy, the stem cells that give rise to the different blood cells in the body are transplanted into the bone marrow of the patient, where they regenerate the blood. The project was given green light to carry out in the Hue Central Hospital by the Ministry of Science and Technology. Professor Nguyen Duy Thang said the success of this method will pave the way for next operations on breast and ovarian cancer patients. In the time ahead, the hospital continues to treat two other cancer female patients with the stem cell treatment. It is hoped that the treatment will save many cancer patients. (www.saigon-gpdaily.com.vn June 27)

DO ADULT STEM CELLS CAUSE CANCER?

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 1, 2014 at 4:31 pm

NO!

cancer-free-zone

What do you get when you add 1,100 ADULT STEM CELL PATIENTS studied over 5 years,

plus another 1,873 ADULT STEM CELL PATIENTS studied over an average 12.5 years,

plus another ~7,000 ADULT STEM CELL PATIENTS in studies and FDA clinical trials data?

~10,000 ADULT STEM CELL TREATMENT PATIENTS showing NO CANCER!

 

“A total of 1873 patients were treated from 1990 to 2006 with bone marrow-derived concentrated cells. Patients were monitored for cancer incidence from the date of the first operation (1990) until death, or until December 31, 2011. The mean follow-up time was 12.5 years (range, five to twenty-two years)…No tumor formation was found at the treatment sites on the 7306 magnetic resonance images and 52,430 radiographs among the 1873 patients…This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.

The upshot? This most recent study, as well as others, FDA clinical trials data, and the data we have published now amounts to about 10,000 patients who have been treated with adult stem cells and extensively tracked for this issue. There is no evidence that adult stem cells cause cancer. There is no rational reason for the fear, other than a completely different type of cell (ESC) that happens to have a similar name (stem cell) can cause teratomas – hence the confusion!”

Tumors, cancers and teratomas may result from Embryonic stem cell (ESC) treatments or Induced Pluripotent stem cell (iPSC) treatments

but NOT FROM ADULT STEM CELL TREATMENTS.

Sources:

GUT BACTERIA = STRONGER STEM CELL RESPONSE

In ALL ARTICLES, STEM CELLS IN THE NEWS on June 23, 2014 at 4:03 pm

Aliens or martians cartoon illustration

Gut Bacteria= Stronger Stem Cell Response

“The diversity of bacteria in the gastrointestinal tract of patients receiving stem cell transplants may be an important predictor of their post-transplant survival, researchers report. Researchers found a strong connection between post-transplant gut microbiota diversity and outcomes, observing overall survival rates of 36 percent, 60 percent, and 67 percent among the low, intermediate, and high diversity groups, respectively.” – ‘Gut bacteria predict survival after stem cell transplant, study shows.’ ScienceDaily

I always believed it, now there’s proof!
http://www.sciencedaily.com/releases/2014/06/140617112226.htm

WHY? Maybe because…
Stem cells are a natural healing system in the body that regenerate dead and damaged tissue and create new tissue– they require nutrients to do so. Gut bacteria helps digest food and derive nutrients for the entire body. More gut bacteria means a stronger immune system which means a greater ability to fight infection; more nutrients available for use as building blocks, to repair nutrients, etc. This results in increased potential benefits from stem cell therapy.

 

Stem Cell Transplantation in Traumatic Spinal Cord Injury

In STEM CELLS IN THE NEWS on January 23, 2014 at 5:59 pm

Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

http://www.accesssportsmed.com/wp-content/uploads/2011/03/spine_large.jpg

From http://www.plosbiology.org – January 6, 7:09 AM

Spinal cord injury is an important cause of disability in young adults, and stem cells have been proposed as a possible treatment. Here we systematically assess the evidence in the scientific literature for the effectiveness of stem-cell–based therapies in animal models of spinal cord injury.

Ella Buzhor\’s insight:

The comparison between multiple allogeneic stem cell treatments revealed improved both motor and sensory function in SCI animal models. Differentiation prior to implantation and IV route of cell administration yielded better outcomes.

via Cell Therapy & Regenerative Medicine | Scoop.it.

Pluristem stem cell trial to treat muscle injury meets main goal | Reuters

In STEM CELLS IN THE NEWS on January 22, 2014 at 5:32 pm
  • cells were safe and well tolerated
  • one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group.
  • Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.
  • An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated…versus the placebo group.

Pluristem stem cell trial to treat muscle injury meets main goal

TEL AVIV Tue Jan 21, 2014 3:07am EST

(Reuters) – Pluristem Therapeutics Inc said results from its early/mid-stage clinical trial indicated its placenta-derived stem cells for the treatment of muscle injury were safe and provided evidence the cells might be effective in treating orthopedic injuries.

\”Patients treated with PLX-PAD had a greater improved change of maximal voluntary muscle contraction force than the placebo group,\” Israel-based Pluristem said in a statement on Tuesday.

The trial was conducted at the Orthopedic Clinic of the Charite University Medical School under the auspices of the Paul-Ehrlich-Institute, Germany\’s health authority.

\”This was a very important study not only for Pluristem but for the cell therapy industry in general,\” Pluristem chief executive Zami Aberman said. \”Based on these results, we intend to move forward with implementing our strategy towards using PLX cells in orthopedic indications and muscle trauma.\”

The injured muscle studied was the gluteus medius muscle in the buttock. Total hip replacement surgery via the standard transgluteal approach necessitates injury of the gluteus medius muscle, and post-operative healing is crucial for joint stability and function.

\”The study showed that PLX-PAD cells were safe and well tolerated,\” the statement said.

The primary efficacy endpoint of the study was the change in maximal voluntary isometric contraction force of the gluteal muscle six months after surgery.

Efficacy was shown in two groups treated with the cells, with one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group. Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.

An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated with PLX-PAD cells versus the placebo group.

via Pluristem stem cell trial to treat muscle injury meets main goal | Reuters.

MS patient to take part in pioneering experiment – CBS News

In STEM CELLS IN THE NEWS on January 21, 2014 at 1:42 pm

No mention of the words “stem cell” in the headline.  No mention of stem cells until the 6th paragraph.  Why make it so difficult for patients to find these articles? In any case, we eagerly await the results! -dg

“Stem cells can be morphed into any cell in the body. Patients like Quinn have bone marrow removed and the stem cells inside are then changed in the kind of stem cells found in the brain and spinal cord.

Those cells will then be injected directly into the spinal cord. The hope is that they will repair the insulation and perhaps even the wires underneath.”

via MS patient to take part in pioneering experiment – CBS News.

 

RELATED ARTICLES:

  • FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis

“To my knowledge, this is the first FDA-approved stem cell trial in the United States to investigate direct injection of stem cells into the cerebrospinal fluid of MS patients, and represents an exciting advance in MS research and treatment,” said Dr. Saud A. Sadiq, Senior Research Scientist at Tisch MS Research Center of New York and the study’s principal investigator.

The groundbreaking study will investigate a regenerative strategy using stem cells harvested from the patient’s own bone marrow.  These stem cells will be injected intrathecally (into the cerebrospinal fluid surrounding the spinal cord) in 20 participants who meet the inclusion criteria for the trial.  This will be an open label safety and tolerability study.  All study activities will be conducted at the Tisch MS Research Center and affiliated International Multiple Sclerosis Management Practice (IMSMP).”  via http://www.prnewswire.com/news-releases/fda-approves-stem-cell-clinical-trial-for-multiple-sclerosis-219553021.html

  • Meredith Vieira’s Family Health Battle

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?

Two More Patients HIV-Free After Bone Marrow Transplants – ABC News

In VICTORIES & SUCCESS STORIES on September 12, 2012 at 5:08 pm

Read the story on the first man to recover from HIV Positive with a stem cell transplant who is now symptom free for 5 years! http://repairstemcell.wordpress.com/2010/12/10/man-appears-free-of-hiv-after-stem-cell-transplant-for-3-years/

And with these 2 more men now HIV free, perhaps the dream of an HIV Free Generation is one step closer to reality!

Two More Patients HIV-Free After Bone Marrow Transplants

Researchers at Brigham and Women’s Hospital in Boston have discovered that, following bone marrow transplants, two men no longer have detectable HIV in their blood cells.

The finding is significant because it suggests that by giving these patients transplants while they were on anti-retroviral therapy, they may have been cured of the AIDS-causing virus.

“We expected HIV to vanish from the patients’ plasma, but it is surprising that we can’t find any traces of HIV in their cells,” said Dr. Timothy Henrich, one of the researchers studying the two men. “It suggests that under the cover of anti-retroviral therapy, the cells that repopulated the patient’s immune system appear to be protected from becoming re-infected with HIV.”…


Two More Patients HIV-Free After Bone Marrow Transplants – ABC News
.

STEM CELLS, AUTISM and stuff

In STEM CELLS IN THE NEWS on August 29, 2012 at 3:48 pm

http://www.nh-di.org/nh/wp-content/uploads/2010/11/clarifications290.jpg

First a disclaimer.  I am a stem cell writer/author/advocate.  While you may think this means I have an agenda (I do, to help patients get better), I am very careful to site real data sources for my info.  My “opinions” are based on science.  [For example, I am uninterested in embryonic stem cells because they will not produce treatments for decades, they cause cysts and tumors and they require immunosuppressive drugs.]

Many of my sources are from my own blog so if you find this too self-referential or if you find any data lacking on a specific subject, please ask and I will tell you where I got my original data from.  Please feel free to comment on my blog.  It is an open forum on the benefits of adult stem cell treatments.  I welcome all intelligent and rational communication and my site is not monetized so I make no money if you go there, comment or otherwise.

Ok, there’s a lot of misinformation out there. Let’s clear it up.

ADULT STEM CELLS or ASC – https://repairstemcell.wordpress.com/stem-cells-for-newbies/
SOURCE/DERIVED FROM•comes from blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal neurological, breast milk, menstruation, dental pulp, lungs, eyes, brain and many more
PURPOSE IN BODY•they are the body’s natural healing cells
OBSTACLES+SIDE EFFECTS•virtually zero side negative effects, many positive side effects
TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years, can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)

For example, blood derived stem cells are a very valid source of stem cells and many treatment centers and clinical trials using blood derived stem cells for years with extremely positive results.  The first stem cell treatment center in the world generated significant therapeutic benefit for over 62% of their congestive heart failure patients.  These are called no option CHF patients because their only recourse is a heart transplant.  62% of “no option” CHF patients derived significant therapuetic benefit, sometimes doubling their Ejection Fractions (amount of blood pumped out by the heart).  But this is anecdotal, let’s talk data.

What data is their showing that stem cell treatments work?
Anecdotal and 10’s of thousands of patients treated aside…as of late 2009, according to the National Institutes of Health, there were and are ~2600 stem cell clinical trials around the world – http://www.clinicaltrials.gov/
Of those ~2600, there are ~2591 mentions of adult stem cells.
Of those ~2591, about half of them (~1300) are actual adult stem cell clinical trials.

Currently, as of today, there are 3,989 clinical trials under keyword search “stem cell” illustrating the safety and efficacy of utilizing stem cells to treat chronic and terminal diseases. Many are from reputable colleges and hospitals around the world, some in the US like Duke U., Northwestern, etc.

How about for Autism? (I apologize, my data has not kept current but as of late 2009)
https://repairstemcell.wordpress.com/2009/10/26/stem-cells-for-autism/
and https://repairstemcell.wordpress.com/2009/10/16/potential-of-stem-cell-treatments-for-autism/

Please also look at the 29,500 scholarly papers submitted on “stem cell” plus “autism” minus embryonic.  These are up to date:
http://scholar.google.com/scholar?as_q=autism&as_epq=stem+cell&as_oq=&as_eq=embryonic&as_occt=any&as_sauthors=&as_publication=&as_ylo=&as_yhi=&btnG=&hl=en&as_sdt=1%2C39&as_vis=1

I hope this was informative. If I can be of any assistance on specific diseases or questions, please feel free to ask.

STEM CELLS – MAGIC OR SCIENCE?

In STEM CELLS IN THE NEWS on July 26, 2012 at 11:28 am

 

A friend asked:

“I would like nothing more than to beleive adult stem cell working for different diseases, however I don’t. How can you take a sick cell and replant it and it becomes healthy.”

—————————————————————————

My answer:

HIGH TURNOVER RATE
This is not magic, it is biological fact. Let’s start with your body. “Just like us, cells grow old and die. When old cells die, new ones replace them. For example, a blood cell in our body lives for about 120 days. Another example is our skin cells. We shed our skin cells about every 35 days.” That’s the outer layer which is why tattoos fade over time and why tattoos go deep into the lower levels of skin.

I’M DYING! YES, WE ALL ARE…
So our cells are in a constant state of “getting older” or “getting sick” or moving towards “impaired function.” I’m dying says the soldier with the sucking chest wound. Yes, we all are, says his philosopher friend. And we are indeed. “He not busy being born is busy dying.” says Bob Dylan. Perhaps this is too philosophical but the point is this: our body and every one of the 5-50 trillion cells is either getting older and weaker and dying or is currently being born or repaired. It’s a dynamic entity, this shell we reside in and it is constantly changing.

GETTING DOWN WITH THE SICKNESS
If you have too many cells with impaired function, especially in a specific area, which are damaged, necrotic, not getting enough nutrients, minerals etc and are getting exposure to too many toxins, inflammation, infections, etc which it can not eliminate, then something will go wrong and you will get sick with the capital ‘S’ and it is time to call in the workers to fix you up.

BOB THE BUILDER HAS SOME COMPETITION
Stem cells are the body’s construction workers. They do both renovations and they do ground up construction. Renovations amount to taking dead tissue and cells – necrotic – and re-energizing them so they come back to life (no zombie jokes please). This can be seen in hundreds of heart studies and trials and thousands of congestive heart failure patients where necrotic heart tissue implanted with stem cells was found to be living and beating a few weeks later. Ground up construction is where they set up shop on a blank field and build something new. This can be seen when stem cells create mini bypasses where stents were implanted. They are actually smart enough to know the “stent area” is a dangerous heavy traffic area and even if the stent is working, they will create offramps and onramps around the stent or bypasses with capillaries. Pretty cool huh?

YOU CAN’T ALWAYS GET WHAT YOU WANT
Not magic, just plain old science and if your body was able to produce enough stem cells to run to the heart, it could do it by itself. In fact, it is trying, desperately to do exactly that but the body in congestive heart failure is like a single mother with 6 kids, 3 jobs and 2 dogs standing on one foot and juggling chain saws. She just can’t do it all, she is stretched to the limits of her endurance, something has to give…and it does. So while your body is sending stem cells to the heart, and the feet and the pancreas, liver, kidney, brain, endocrine and lymphatic and circulatory system infrastructure, RIGHT NOW, to renovate and build new cells and tissues, it is not sending ENOUGH and the fact that our single mom smokes and lives near a factory and does other people’s laundries, exposing herself to multiple chemical toxins, doesn’t sleep much, can only afford McD’s and is highly stressed, etc etc just taxes her body all the more.

RIGHT HERE, RIGHT NOW
So YOU have stem cells in YOUR body RIGHT NOW which are running around, differentiating into different cell types and healing you. All the time. So while our bodies are in a constant state of degradation, our stem cells are constantly fighting that degradation.

WANT THE SCIENCE?
If you would like trials and studies to back this up there are about 2,600 at last count and I can refer you to some that address a specific condition.

 

Chicago Woman Cured of Sickle Cell Disease

In VICTORIES & SUCCESS STORIES on June 20, 2012 at 11:14 pm
Chicago Woman Cured of Sickle Cell Disease

Posted: June  18, 2012 by Sherri McGinnis Gonzalez

Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant. University of Illinois Hospital & Health Sciences System physicians performed the procedure using medication to suppress her immune system and one small dose of total body radiation right before the transplant.The transplant technique is relatively uncommon and is a much more tolerable treatment for patients with aggressive sickle cell disease who often have underlying organ disease and other complications, says Dr. Damiano Rondelli, professor of medicine at UIC, who performed Thomas’s transplant.

The procedure initially allows a patient’s own bone marrow to coexist with that of the donor. Since the patient’s bone marrow is not completely destroyed by chemotherapy or radiation prior to transplant, part of the immune defense survives, lessening the risk of infection. The goal is for the transplanted stem cells to gradually take over the bone marrow’s role to produce red blood cells — normal, healthy ones…

Follow

Get every new post delivered to your Inbox.

Join 2,981 other followers

%d bloggers like this: