DAVID GRANOVSKY

Posts Tagged ‘injury’

Pluristem stem cell trial to treat muscle injury meets main goal | Reuters

In STEM CELLS IN THE NEWS on January 22, 2014 at 5:32 pm
  • cells were safe and well tolerated
  • one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group.
  • Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.
  • An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated…versus the placebo group.

Pluristem stem cell trial to treat muscle injury meets main goal

TEL AVIV Tue Jan 21, 2014 3:07am EST

(Reuters) – Pluristem Therapeutics Inc said results from its early/mid-stage clinical trial indicated its placenta-derived stem cells for the treatment of muscle injury were safe and provided evidence the cells might be effective in treating orthopedic injuries.

\”Patients treated with PLX-PAD had a greater improved change of maximal voluntary muscle contraction force than the placebo group,\” Israel-based Pluristem said in a statement on Tuesday.

The trial was conducted at the Orthopedic Clinic of the Charite University Medical School under the auspices of the Paul-Ehrlich-Institute, Germany\’s health authority.

\”This was a very important study not only for Pluristem but for the cell therapy industry in general,\” Pluristem chief executive Zami Aberman said. \”Based on these results, we intend to move forward with implementing our strategy towards using PLX cells in orthopedic indications and muscle trauma.\”

The injured muscle studied was the gluteus medius muscle in the buttock. Total hip replacement surgery via the standard transgluteal approach necessitates injury of the gluteus medius muscle, and post-operative healing is crucial for joint stability and function.

\”The study showed that PLX-PAD cells were safe and well tolerated,\” the statement said.

The primary efficacy endpoint of the study was the change in maximal voluntary isometric contraction force of the gluteal muscle six months after surgery.

Efficacy was shown in two groups treated with the cells, with one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group. Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.

An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated with PLX-PAD cells versus the placebo group.

via Pluristem stem cell trial to treat muscle injury meets main goal | Reuters.

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:20 pm
http://repairstemcell.files.wordpress.com/2013/11/8c5a1-strokebrainimage.jpg?w=249&h=332
Stem Cells Improve Cognition After Brain Injury

Research led by Charles Cox at the University of Texas Health Science Center has shown that stem cell therapy given during the critical time window after traumatic brain injury promotes lasting cognitive improvement. These experiments, which were published in the latest issue of the journal Stem Cells Translational Medicine, provide a pre-clinical model for experiments with larger animals.

After the brain has suffered a traumatic injury, there are few treatment options. Damage to the brain can be severe, and can also cause ongoing neurological impairment. Approximately half of all patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

In this work from Cox’s lab, stem cells from bone marrow known as multipotent adult progenitor cells (MAPCs) were used. MAPCs seem to be a subpopulation of mesenchymal stem cells, and they have a documented ability to reduce inflammation in mice immediately after traumatic brain injury. Unfortunately, no one has measured the ability of MAPCs to improve the condition of the brain over time.

Cox, Distinguished Professor of Pediatric Surgery at the UTHealth Medical School and in collaboration with the Children’s Fund, Inc., injected two groups of brain-injured mice with MAPCs two hours after injury and then once again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times greater.

After four months, those mice that had received the stronger dose not only continued to have less inflammation, but they also showed significant gains in cognitive function. Laboratory examination of the brains of these rodents confirmed that those that had received the higher dose of MAPCs had better brain function than those that had received the lower dose.

According to Cox, “Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs.” Cox also indicated that this study indicates that intravenous injection of MAPCs might very well become a viable treatment for people with traumatic brain injury in the future.

 

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish.

CHRISTOPHER REEVE’S STEM CELL SPINAL CORD MISTAKE

In CELEBRITIES & STEM CELLS, STEM CELLS IN THE NEWS on September 25, 2012 at 1:07 pm

spinal

A SAD BIRTHDAY FOR CHRISTOPHER REEVE

Christopher Reeve would most likely have reached his 60th birthday today had he focused on adult stem cell treatments instead of embryonic.

Adult stem cell treatments have produced significant therapeutic benefits in Spinal cord injury patients for years.  Patients have regained sensation in the extremities, bladder and bowel control and even the ability to walk.  It is sad that a misinformed or misguided and certainly limited focus on embryonic stem cells resulted in the loss of potential for this iconic actor to recover from spinal cord injury.

HISTORY OF STEM CELL TREATMENTS FOR SPINAL CORD INJURY

SPINAL CORD INJURY vs ASC HISTORY OF TREATMENT – http://tinyurl.com/SCIvsASC

REGENERATING THE CENTRAL NERVOUS SYSTEM  http://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

Stepping Towards A Paralysis Cure, A Tale Of Two Supermen Stem Cells Cure 23 Year Old Male of Paralysis – C6…-C7 injury
http://repairstemcell.wordpress.com/2009/03/28/stepping-towards-a-paralysis-cure-a-tale-of-two-supermen-stem-cells-cure-23-year-old-male-of-paralysis-c6-c7-injury/

Paraplegic – Adult Stem Cell Success Stories – Laura Dominguez
http://repairstemcell.wordpress.com/2010/05/05/paraplegic-adult-stem-cell-success-stories-laura-dominguez/

PARALYZED COUSINS PLEASED WITH STEM CELL TREATMENT
http://repairstemcell.wordpress.com/2010/02/15/paralyzed-cousins-pleased-with-stem-cell-treatment/

Successful Stem Cell Treatment of Spinal Cord Injury in Dogs
http://repairstemcell.wordpress.com/2010/02/08/successful-stem-cell-treatment-of-spinal-cord-injury-in-dogs/

Spinal Cord Injury Patient Wins…and Loses
http://repairstemcell.wordpress.com/2010/02/08/spinal-cord-injury-patient-wins-and-loses/

STEM CELLS FOR SPINAL CORD INJURY
http://repairstemcell.wordpress.com/2009/12/31/stem-cells-for-spinal-cord-injury/

Adult Stem Cell Grafts Help Paralyzed Heal
http://repairstemcell.wordpress.com/2009/10/21/adult-stem-cell-grafts-help-paralyzed-heal/

Medical hope as paralysed dog cured by stem cell therapy – mirror.co.ukhttp://repairstemcell.wordpress.com/2009/10/08/medical-hope-as-paralysed-dog-cured-by-stem-cell-therapy-mirror-co-uk/

Major the Roseville police dog gets stem cell treatment – http://blogs.citypages.com/blotter/2011/01/major_police_dog_stem_cell.php

 

http://www.myhero.com/ReadingRoom/books/Christopher%20Reeve%20-%20Nothing%20Is%20Impossible.jpg

Christopher D’Olier Reeve[1] (September 25, 1952 – October 10, 2004) was an American actor, film director, producer, screenwriter, author and activist. He achieved stardom for his acting achievements, in particular his motion-picture portrayal of the fictional superhero Superman.

On May 27, 1995, Reeve became a quadriplegic after being thrown from a horse during an equestrian competition in Virginia. He required a wheelchair and breathing apparatus for the rest of his life. He lobbied on behalf of people with spinal-cord injuries and for human embryonic stem cell research, founding the Christopher Reeve Foundation and co-founding the Reeve-Irvine Research Center.[2]

NEW STEM CELL FOUND IN THE BRAIN

In STEM CELLS IN THE NEWS on April 23, 2012 at 10:08 pm

http://www.bio.miami.edu/~cmallery/150/neuro/brain_stem_cells2.jpg

New stem cell found in the brain

Researchers at Lund University have discovered a new stem cell in the adult brain. These cells can proliferate and form several different cell types – most importantly, they can form new brain cells. Now the researchers hope to put the discovery to use to develop methods that can repair diseases and injury to the brain.

Analysing brain tissue from biopsies, the researchers for the first time found stem cells located around small blood vessels in the brain. The cell’s specific function is still unclear, but its plastic properties suggest great potential. A similar cell type has been identified in several other organs where it can promote regeneration of muscle, bone, cartilage and adipose tissue.

In other organs, researchers have shown clear evidence that these types of cells contribute to repair and wound healing. Scientists suggest that the curative properties may also apply to the brain. The next step is to try to control and enhance stem cell self-healing properties with the aim of carrying out therapies targeted to a specific area of the brain.

“Our findings show that the cell capacity is much larger than we originally thought, and that these cells are very versatile,” said Gesine Paul-Visse, Ph.D., Associate Professor of Neuroscience at Lund University.

“Most interesting is their ability to form neuronal cells, but they can also be developed for other cell types. The results contribute to better understanding of how brain cell plasticity works and opens up new opportunities to exploit these very features.”

The study, published in the journal PLoS ONE, is of interest to a broad spectrum of brain research. Future possible therapeutic targets range from neurodegenerative diseases to stroke.

“We hope that our findings may lead to a new and better understanding of the brain’s own repair mechanisms,” said Dr. Paul-Visse. “Ultimately the goal is to strengthen these mechanisms and develop new treatments that can repair the diseased brain.”

###

Link to the study here:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0035577

The study:

Title: The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells Published in: PLoS ONE, 16 April, 2012.

New stem cell found in the brain.

TRAUMATIC BRAIN INJURY and STROKE

In DISEASE INFO on March 26, 2012 at 1:17 am

TO SEE IF YOU ARE A CANDIDATE FOR STEM CELL TREATMENT, PLEASE FILL OUT THE FOLLOWING FORM:  STEM CELL PATIENT QUESTIONNAIRE

I was told this was a con…here is my response:

My Stem Cells vs. Stroke page:
http://repairstemcell.wordpress.com/stroke-stem-cells/

Additional articles sorted by date (YEAR/MONTH/DAY):
http://repairstemcell.wordpress.com/2012/03/06/stem-cells-safe-for-young-traumatic-brain-injury/
http://repairstemcell.wordpress.com/2012/01/22/cellnews-scientists-learn-how-stem-cell-implants-help-heal-traumatic-brain-injury/

http://www.sciencedaily.com/releases/2011/08/110831160216.htm
http://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

http://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
http://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
http://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
http://repairstemcell.wordpress.com/2010/08/28/cord-blood-wakes-up-drowning-victim%e2%80%99s-brain/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
http://repairstemcell.wordpress.com/2010/07/12/stem-cell-gel-helps-repair-traumatic-brain-injuries-smartplanet/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
http://repairstemcell.wordpress.com/2010/04/28/stem-cells-from-menstrual-blood-may-benefit-stroke-patients/

http://repairstemcell.wordpress.com/2009/04/20/stem-cell-research-shows-adult-stem-cells-help-stroke-victims-adult-stem-cell-research/
http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

A con? Ok my skeptical friends, I understand. You’ve been researching stroke treatments for so long and been so disheartened you don’t believe your condition can ever improve. You’ve read all the outdated literature saying the central nervous system can not regrow (except for the most recent studies which prove it can be.) You’ve skimmed my articles and realize they are uncorroborated by “hard science.”

Fair enough. Ignore the 14 articles above which show the positive benefits of adult stem cells on stroke. You’re right, they are unsubstantiated. They are not peer reviewed medical journal articles. I appreciate your skepticism but know this:

*there are over 2,600 peer reviewed medical journal clinical trials that utilized adult stem cells with a record of safety and efficacy,
*there are many trials that cover the use of adult stem cells for stroke, ataxia, TBI, etc
*there are 60 trials that have the key words “adult stem cell” and “stroke.”
*there are 14 “Completed” trials that have the key words “adult stem cell” and “stroke.”

Research it yourself if you like. http://clinicaltrials.gov/ct2/results?term=adult+stem+cell+stroke&pg=1&show_flds=Y

Here are only the 14 “completed” trials:

Completed Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients

Conditions: Stroke;   Middle Cerebral Artery Infarction
Interventions: Procedure: Intercerebral implantation of Autulogous Stem Cells;   Drug: convention therapy
Completed Intravenous Autologous Bone Marrow-derived Stem Cells Therapy for Patients With Acute Ischemic Stroke

Condition: Acute Stroke
Intervention: Biological: Autologous bone marrow stem cell
Completed Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.

Conditions: Stroke, Acute;   Infarction, Middle Cerebral Artery
Intervention: Procedure: Infusion on autologous CD34+ stem cells into middle cerebral artery
Completed Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke

Condition: Infarction, Middle Cerebral Artery
Intervention: Other: Autologous cell transplantation
21 Completed Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke

Condition: Ischemic Stroke
Intervention: Drug: Filgrastim
31 Completed Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)

Condition: Sickle Cell Anemia
Intervention: Procedure: Angiography
34 Completed Investigating Endothelial Precursor Cells (EPCs)

Condition: Central Nervous System
Intervention:
38 Completed Immunological Mechanisms of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Condition: Multiple Sclerosis
Intervention: Procedure: Stem Cell Transplanataion
40 Completed Gene Therapy for Gaucher’s and Fabry Disease Using Viruses and Blood-Forming Cells

Condition: Gaucher’s Disease
Intervention: Genetic: human glucocerebrosidase cDNA
51 Completed Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189

Condition: Depression
Intervention: Drug: NSI-189 Phosphate
52 Completed Beta-hCG + Erythropoietin in Acute Stroke

Condition: Acute Stroke
Intervention: Drug: Beta-hCG + Erythropoietin
54 Completed Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study

Conditions: Autism;   Oxidative Stress;   Inflammation
Intervention: Drug: Hyperbaric Oxygen Therapy
59 Completed Effects of Enzyme Replacement in Gaucher’s Disease

Condition: Gaucher’s Disease
Intervention:
60 Completed Incidence of Ocular Antibodies in Patients With Sturge – Weber Syndrome (SWS)

Condition: Sturge – Weber Syndrome (SWS)
Intervention:

 

 

If you still feel this is a con, tell me what you would need to see to prove otherwise. Respectfully, David

Stem Cells Safe for Young Traumatic Brain Injury

In SCIENCE & STEM CELLS on March 6, 2012 at 4:02 am
Image showing potential uses of stem cell research with traumatic brain injuries checked.
A Phase 1 clinical trial studying the safety of using bone marrow stem cells to treat traumatic brain injuries in children is reported. The procedures look to be safe even after 6 months of being applied. The image is adapted from a public domain image

Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients

Saturday March 3rd 2012

A procedure involving stem cells taken from patients’ own bone marrow to treat traumatic brain injury in children is safe, according to the results of a Phase 1 clinical trial.

The trial included 10 children aged 5-14 with severe traumatic brain injuries. Within 48 hours of their injuries, the children received stem cells processed from their own bone marrow.

Six months following the procedures, the children are showing no signs of further damage caused by the use of the stem cells. Though this study only points out that the procedure is safe so far, all of the children from the study had significant improvements.

Stem cell research studies such as this one are producing more and more evidence that stem cell treatments can be safe and effective.

With very few effective treatments for brain injury patients, these studies provide great promise for the future of medicine.

The University of Texas Health Science Center at Houston press release below offers more details about this and other stem cell studies.

UTHealth study: Stem cells may provide treatment for brain injuries

Preliminary results show safety of bone marrow stem cells in traumatic brain injury

Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). The results were published in this month’s issue of Neurosurgery, the journal of the Congress of Neurological Surgeons.

“Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe,” said Charles S. Cox, Jr., M.D., the study’s lead author and professor of pediatric neurosurgery at the UTHealth Medical School. The clinical trial, which included 10 children aged 5 to 14 with severe TBI, was done in partnership with Children’s Memorial Hermann Hospital, where Cox is director of the pediatric trauma program.

All the children were treated within 48 hours of their injury with their own stem cells, which were collected from their bone marrow, processed and returned to them intravenously. UTHealth’s Department of Neurology is also currently testing the same bone marrow stem cell procedure in adults with acute stroke. In a separate trial, Cox is testing the safety of using a patient’s own cord blood stem cells for traumatic brain injury in children.

As a Phase I trial designed to look at feasibility and safety, the study did not assess efficacy. However, after six months of follow-up, all of the children had significant improvement and seven of the 10 children had a “good outcome,” meaning no or only mild disability.

Children who survive severe TBI are often left with serious complications and disability. Currently, there are no effective treatments to protect or promote repair of the brain in these brain-injured children.

Read more: Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients | Neuroscience News.

CellNEWS: Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury

In VICTORIES & SUCCESS STORIES on January 22, 2012 at 9:20 am

“In this study, we found that our stem cell transplantation both prevents further axonal injury and promotes axonal regrowth, through a number of previously unknown molecular mechanisms.”

http://trialx.com/curetalk/wp-content/blogs.dir/7/files/2011/06/Tramautic_Brain_Injury.jpg

Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury  
Friday, 13 January 2012

For years, researchers seeking new therapies for traumatic brain injury have been tantalized by the results of animal experiments with stem cells. In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has remained a mystery.

Now, an important part of this puzzle has been pieced together by researchers at the University of Texas Medical Branch at Galveston. In experiments with both laboratory rats and an apparatus that enabled them to simulate the impact of trauma on human neurons, they identified key molecular mechanisms by which implanted human neural stem cells — stem cells that are in the process of developing into neurons but have not yet taken their final form — aid recovery from traumatic axonal injury.
A significant component of traumatic brain injury, traumatic axonal injury involves damage to axons and dendrites, the filaments that extend out from the bodies of the neurons. The damage continues after the initial trauma, since the axons and dendrites respond to injury by withdrawing back to the bodies of the neurons.
“Axons and dendrites are the basis of neuron-to-neuron communication, and when they are lost, neuron function is lost,” said UTMB professor Ping Wu, lead author of a paper on the research appearing in the Journal of Neurotrauma.

“In this study, we found that our stem cell transplantation both prevents further axonal injury and promotes axonal regrowth, through a number of previously unknown molecular mechanisms.”

 

Read more: CellNEWS: Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury.

A HISTORY OF THE GERON EMBRYONIC STEM CELL FIASCO

In BUSINESS OF STEM CELLS on November 15, 2011 at 1:27 am

http://geekcentricity.com/wp-content/uploads/2010/09/Fiasco.jpg

Embryonic stem cell treatment are now an unrealized potential.

Adult stem cell treatments are a realized potential.

To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

GERON GIVES UP on EMBRYONIC STEM CELLS!

In STEM CELLS IN THE NEWS on November 14, 2011 at 11:13 pm

THE

WAR

IS

OVER!!

GERON THROWS IN THE TOWEL!If stem cell treatments were a boxing match, Embryonic stem cell treatments would be the 500 lb Gorilla and Adult stem cell treatments would be the small, unknown underdog.   Today, that Gorilla threw in the towel!

Despite the huge disparity in their media coverage, with positive Embryonic stem cell potential articles outnumbering all Adult stem cell articles by 1,000 to one, only Adult stem cells have a proven history of safety and efficacy, only Adult stem cell treatments are available today.  Click here to see if your condition can be treated with Adult stem cells:

While Geron and the US media, big Pharma, the AMA and the FDA have all given Embryonic stem cell their full throated support, the number of patients helped with adult stem cells is in the 10s of thousands while the number of patients helped by Embryonic stem cells in zero.

HORSE FALLING DOWN DURING RACEIf Embryonic treatments were a horse race, Geron would be the strongest horse in the field.  Geron would be the horse who was 9/10 of the way around the track with all other competitors still milling about in the starting blocks.  So what would make that horse stop dead in his tracks, fall flat on his face and walk away from the race?

What does it mean for the other Embryonic focused companies when the front runner pulls out of the race?

What would cause the leading Embryonic stem cell Pharmaceutical company with multiple Embryonic stem cell products in development to end all of their Embryonic stem cell programs? 

Product Product Description Application Development Stage
GRNOPC1 Oligodendrocyte Progenitor Cells Spinal Cord Injury Phase I Clinical Trial
GRNCM1 Cardiomyocytes Heart Disease Preclinical
GRNIC1 Islets Type 1 Diabetes Research
GRNCHND1 Chondrocytes Osteoarthritis Research
Hepatocytes ADME Drug Screening Research
GRNVAC2 Mature Dendritic Cells Cancer Immunotherapy Product Research
Immature Dendritic Cells Immune Rejection Research
Osteoblasts Osteoporosis Research

via Geron.com

Perhaps their clinical trial patients developed cysts and tumors as do all Embryonic stem cell patients.  Perhaps Geron decided to end their trials before these tumors and cysts turned into cancer so they could still say their product “has been well tolerated with no serious adverse events.”

Perhaps Geron couldn’t figure out how to address the need for immunosuppressive drugs required to implant a human with ALL Embryonic stem cells when there are many Adult stem cells that have no rejection issues.

Perhaps Geron couldn’t determine how to deal with Embryonic stem cells carrying the genetic abnormalities and maladies of the donor.

Or perhaps they read some of the quotes from my articles going back to March of 2009:

  • To date, ESC research has been 100% fruitless (in regard to generating treatments) for well-funded + government supported scientists around the world for the last 11 years.
  • Dr James Thomson, father of ESC research said: “…[ESC] are not being used in any clinical applications yet, while alternatives such as adult stem cells figure in scores of therapies.”
  • Ian Wilmut, who led the team that cloned Dolly the sheep, abandoned his license to attempt human cloning, saying that the researchers “may have achieved what no politician could: an end to the [ESC] debate.”
  • Dr. Bernadine Healy, former director of the NIH in U.S. News & World Report: “…[ESC], once thought to hold the cure for Alzheimer’s, Parkinson’s, and diabetes, are obsolete….. In fact, adult stem cells, which occur in small quantities in organs throughout the body for natural growth and repair, have become stars despite great skepticism early on.
Or maybe they reviewed the timeline for Embryonic stem cell success and realized they couldn’t afford 50 YEARS OF RESEARCH!
Dr. Colin McGuckin, a noted UK embryonic research leader at Newcastle U. before departing for more useful RSC research in France announced:

  • “For me, the unnecessary row over stem cells has obscured the very real issue that patients are waiting to be treated…The best estimates of the embryonic scientists in our own university in Newcastle is that embryonic stem cells may not be able to help people this side of 50 years. That’s my lifetime. And that’s worrying. We can’t wait that long.”
I do have to applaud their spin department.  It is a brilliant move to take the news story
“GERON GIVES UP ON EMBRYONIC STEM CELLS”
and spin it into
“GERON PUTS 100% FOCUS INTO CURING CANCER.” 
Even so, we are not fooled.  The red headed step child in the family always knows when they are neglected. 
They also published their press release at 4:05 Eastern so the regular stock market was closed and couldn’t react to the news. Unfortunately for them, their stock dropped over 20% in after hours trading.
Whatever the reason for Geron abandoning Embryonic stem cells, we can now finally exalt that THE WAR IS OVER and get on with Adult Stem Cell Treatments, the only stem cells to cure a human patient.

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM•comes from blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal neurological, breast milk, menstruation, dental pulp, and many more
  • PURPOSE IN BODY•they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS•~zero problems (virtually zero side effects)
  • TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY•can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)
  • To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

via STEM CELLS 101

  • 100+ DISEASES treated around the world with adult stem cells!
  • 60-70% SUCCESS RATE typical therapeutic benefit on INCURABLE DISEASES!!
  • POTENTIAL CURES of Autism, Parkinson’s, AIDs, Diabetes, Heart Disease and more!
  • HUGE REWARDS of life extension!
  • SIGNIFICANTLY IMPROVED quality of life!

http://www.maniacworld.com/muhammad-ali-2.jpg

Geron to Focus on Its Novel Cancer Programs
Company Plans to Partner All Stem Cell Programs

MENLO PARK, Calif.–(BUSINESS WIRE)–Geron Corporation (Nasdaq: GERN) today announced that, effective immediately, the Company will focus on its first-in-class oncology programs. As a consequence, the Company will discontinue further development of its stem cell programs and is seeking partners for these novel assets.

“Our employees, collaborators and shareholders can be proud of the pioneering role they have played to advance our stem cell technology into the clinic”

“In the current environment of capital scarcity and uncertain economic conditions, we intend to focus our resources on advancing our Phase 2 clinical trials of imetelstat and GRN1005. These two novel and promising oncology drug candidates target major unmet medical needs and have important clinical development milestones occurring over the next 20 months,” said Geron’s Chief Executive Officer, John A. Scarlett, M.D. “By narrowing our focus to the oncology therapeutic area, we anticipate having sufficient financial resources to reach these important near-term value inflection points for shareholders without the necessity of raising additional capital. This would not be possible if we continue to fund the stem cell programs at the current levels.

…The decision to narrow Geron’s technology and therapeutic focus was made after a strategic review of the costs, value inflection timelines and clinical, manufacturing and regulatory complexities associated with the Company’s research and clinical-stage assets. With this decision, Geron is eliminating 66 full-time positions, representing 38% of its workforce. As a result, the Company expects one-time cash expenditures of approximately $5 million in the fourth quarter of 2011 and approximately $3 million in the first half of 2012. Geron expects to end 2011 with cash and investments in excess of $150 million.

Geron is seeking partners with the technical and financial resources to enable further development of its stem cell programs. “Our employees, collaborators and shareholders can be proud of the pioneering role they have played to advance our stem cell technology into the clinic,” said Dr. Scarlett. “Stem cells continue to hold great medical promise. We believe that our leadership role in the field and the quality of our stem cell assets — which are widely recognized as being among the most innovative, comprehensive and advanced cell therapy programs in the world — will be an important point of differentiation in our discussions to partner these assets.” In order to facilitate transfer of these programs to partners, Geron will retain a core group of employees from its stem cell operations through the end of the second quarter of 2012.

Geron plans to close the GRNOPC1 trial for spinal cord injury to further enrollment, although it will continue to follow all enrolled patients, accruing data and updating FDA and the medical community on their progress. In this trial, GRNOPC1 has been well tolerated with no serious adverse events

Read more

Related articles:

A HISTORY OF THE GERON EMBRYONIC STEM CELL FIASCO November 15, 2011

EMBRYONICS’ BLEAK FUTURE AND BOTCHED PAST November 15, 2011

To see if your condition can be treated with Adult stem cells, please fill out this form:

Spinal membrane (meninges) is a Source of Stem Cells

In ALL ARTICLES, SCIENCE & STEM CELLS on November 10, 2011 at 9:56 am

SPINAL MENINGES

“…meninges, the membrane which envelops the central nervous system, is a potential source of self-renewing stem cells…”  

Let’s consider:

IF, “Stem cells…serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. ” via NIH

AND, there are stem cells in the spinal membrane (meninges).

THEN, the spinal column has it’s own repair system, ie. can repair itself.

Did you think the central nervous system couldn’t repair itself? Wrong. REGENERATING THE CENTRAL NERVOUS SYSTEM

Did you think spinal cord injuries would not respond to stem cell treatments? Wrong.  SPINAL CORD INJURY + STEM CELL TREATMENTS

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New Evidence for Spinal Membrane as a Source of Stem Cells May Advance Treatment of Spinal Cord Injuries

ScienceDaily (Oct. 28, 2011) — Italian and Spanish scientists studying the use of stem cells for treating spinal cord injuries have provided the first evidence to show that meninges, the membrane which envelops the central nervous system, is a potential source of self-renewing stem cells. The research, published in Stem Cells, develops the understanding of cell activation in central nervous system injuries; advancing research into new treatments for spinal injuries and degenerative brain disorders.


The team focused their research on spinal cord injuries, caused when the spinal cord is damaged by trauma rather than disease. Depending on the severity a spinal injury can lead from pain to full paralysis, with high social and medical care costs. As the spinal cord lacks the ability to regenerate, the potential for patient recovery is severely limited.

“Our research offers the first evidence that the spinal cord meninges, the system of membranes which cover the surface of the brain and the spinal cord, contains stem cells which are capable of self-renewal and proliferation,” said lead authors Dr Ilaria Decimo and Dr Francesco Bifari, at the University of Verona.

Following a spinal injury meningeal cells increase in number and migrate to form glial scars and the team believe this process explains part of the mechanism of stem cell activation in central nervous system diseases; a mechanism which could in turn be used for treatments. Dr Decimo’s team microdissected samples of spinal cord meninges from adult rats revealing that meningeal cells contain crucial stem cell properties. It is these properties which increase following a spinal cord injury.

“Our research emphasizes the role of meninges cells in the reaction to spinal cord trauma and indicates for the first time that spinal cord meninges harbour stem cells which are activated by injury,” concluded Dr, Decimo. “Further testing could result in a strategic turnaround for advancing regenerative medicine for treating neurological disorders and spinal cord injuries.”

“This study underlines the importance of endogenous stem cells,” said Stem Cells Editor Dr Miodrag Stojkovic. “Identification of these cells is crucial for understanding the basic mechanisms of cell biology and tissue repair, but also to identify drugs and chemicals which might be used to mobilize meningeal stem cells.”

Journal Reference:

  1. Ilaria Decimo, Francesco Bifari, Francisco Javier Rodriguez, Giorgio Malpeli, Sissi Dolci, Valentina Lavarini, Silvia Pretto, Sandra Vasquez, Marina Sciancalepore, Alberto Montalbano, Valeria Berton, Mauro Krampera, Guido Fumagalli. Nestin- and DCX-Positive Cells Reside in Adult Spinal Cord Meninges and Participate to Injury-Induced Parenchymal Reaction. Stem Cells, 2011; DOI: 10.1002/stem.766

New evidence for spinal membrane as a source of stem cells may advance treatment of spinal cord injuries.

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