DAVID GRANOVSKY

Posts Tagged ‘heal’

LATE STAGE OVARIAN CANCER CURED WITH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 7, 2014 at 1:03 pm

ovarian-cancer-symptoms
Hue Hospital Succeeds in Treating Cancer with Stem Cell

Saigon – Doctors of Hue Central Hospital have used stem cell transplantation to successfully treat a cancer patient of the last stage. The Hue Central Hospital announced on June 26 that its doctors have cured Le Thi Sau, 52, who was suffering ovarian cancer in the last stage, with stem cell transplant. The operation is the success of the scientific project “Using stem cell in breast cancer and cervical cancer” managed by Professor Nguyen Duy Thang, deputy head of the hospital. Adult stem cells have been used to treat certain cancers through bone marrow transplants. In this therapy, the stem cells that give rise to the different blood cells in the body are transplanted into the bone marrow of the patient, where they regenerate the blood. The project was given green light to carry out in the Hue Central Hospital by the Ministry of Science and Technology. Professor Nguyen Duy Thang said the success of this method will pave the way for next operations on breast and ovarian cancer patients. In the time ahead, the hospital continues to treat two other cancer female patients with the stem cell treatment. It is hoped that the treatment will save many cancer patients. (www.saigon-gpdaily.com.vn June 27)

WHAT DOES THE FOXO1 SAY? HERE’S MORE INSULIN!

In ALL ARTICLES, BUSINESS OF STEM CELLS on July 5, 2014 at 10:20 am
It May Take Guts to Cure Diabetes -Human GI Cells Retrained to Produce Insulin

Imagine taking cells from your gastrointestinal tract and then switching off one gene, the FOXO1 gene, and then ending up with insulin producing cells.  From gut cell to diabetes fighter in one easy gene switch-off.  Scientists did this successfully in 2012 in mice and recently in humans.  What does the FOXO1 say? ‘Here’s more insulin!’  Awesome.

The next step is where it gets…awkward.  I’d like this information to generate a gene therapy protocol or to improve success rates in stem cell/Diabetes treatment protocols,  etc.  But that’s not the way our system works.  The next step is to find a drug that inhibits the FOXO1 gene so it “…could retrain cells inside a person’s GI tract to produce insulin…”  Unfortunately, this drug will also have side effects as all drugs do which will create other symptoms requiring other drugs to mitigate.  And so it goes.

When will US Diabetes patients be able to benefit from a medical protocol based on this discovery?  An educated guess puts it at:
7-10 years for clinical trials and drug development for a name brand Pharma product and then 10-15 years for the drug patent to open up to an affordable generic.
Sorry Diabetes patients.

New York, NY (June 30, 2014) “By switching off a single gene, scientists at Columbia University’s Naomi Berrie Diabetes Center have converted human gastrointestinal cells into insulin-producing cells, demonstrating in principle that a drug could retrain cells inside a person’s GI tract to produce insulin…The Columbia researchers were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells’ FOXO1 gene.”

STEM CELLS HIT MAIN STREAM MEDIA!

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 27, 2014 at 9:03 pm

STEM CELLS HIT MAIN STREAM MEDIA! 
On NBC tonight at 8pm EST!

The first stem cell generated windpipe was implanted in 2008.
Six long years later, the technique has been improved significantly and has hit main stream media. 

Image

“Macchiarini’s team began by collecting stem cells from Beyene’s bone marrow. Those cells were mixed with special growth factors and then poured onto a scaffold made from plastic — in fact, the very same plastic that is used to make soda bottles — which had been made to mimic the shape of a real windpipe.  In just a matter of days, the scaffold began to transform into an actual functioning windpipe.”

Some attack those pushing the boundaries, citing that the surgery is experimental and unproven.  But the Dr can’t stand by as patients die when he can do something about it and can’t ignore their pleas for a chance at the hope of recovery.  This is cutting edge of medicine and there are thousands of clinical trials and studies and 10s to 100s of thousands of patients treated, most outside of the US.  There are no guarantees.  There are always risks, even with rigorously tested pharmaceutical drugs and treatment protocols that have been used for decades.  But for chronic and terminal patients who are given no chance for recovery, experimental sounds like a pretty great option.

Historically, new treatments have always been met with resistance.

“Tom Starzl, when he started doing liver transplants, the first seven, eight, nine patients all died. Everybody said he was nuts, OK? Christian Barnard, when he started doing heart transplants, everyone threw rocks at him. This is how we’re going to treat diseases in the future and this is the start of it.”

Anything which pushes the envelop of contemporary knowledge will be rejected by those clinging to traditional concepts…but without pioneering doctors and even more pioneering patients, willing to take risks, medical protocols can not advance.  I salute the doctor and the patients who are the ground-breaking pioneers in the new land of regenerative medicine.  And what can their mutual risk do for the patient and millions to follow?

“One of Macchiarini’s most promising success stories is Claudia Castillo, a Spanish mother who is doing so well six years after her transplant that an increasing number of Macchiarini’s colleagues are beginning to see him in a new light.”

Thank you!

To watch the video and learn more:

http://www.nbcnews.com/health/health-news/leap-faith-desperate-patients-look-lab-grown-organs-n142036

PANCREATIC CANCER TUMORS DEFEATED WITH CORD BLOOD STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, VICTORIES & SUCCESS STORIES on June 25, 2014 at 11:42 am

fight pancreatic cancer FPC_shirt


PANCREATIC CANCER TUMORS DEFEATED WITH CORD BLOOD STEM CELLS

What happens when you “genetically engineer MSCs isolated from human umbilical cord blood so that they expressed IL-15” (which fights cancer tumors) and inject them into mice with pancreatic  tumors?

  • The IL-15 migrate to the tumor
  • Other cancer and tumor fighting immune cells migrate to the tumor
  • The IL-15 attack the tumor
  • Other cancer and tumor fighting immune cells attack the tumor
  • Tumors show cell death
  • Tumor growth is significantly inhibited
  • Survival is prolonged
  • The mice immune systems are effectively vaccinated against future tumor growth

Scientists “used these souped-up cells to treat In mice afflicted with pancreatic tumors. Pancreatic cancer is an indiscriminate killer, since by the time it causes any symptoms, it is usually so advanced, that there is little to be done in order to treat it. Thus new strategies to treat this type of cancer are eagerly being sought. Systemic administration of IL-15-expressing MSCs significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. The tumors of these mice showed extensive cell death, and other types of immune cells known to fight tumor cells (NK and T cells) had also accumulated around the tumor. Other experiments confirmed that the injected MSCs did indeed migrate toward the tumors and secrete IL-15 at the site of the tumors…Interestingly, those mice that were cured from the pancreatic tumors, appeared to have a kind of resistance of these tumors. Namely, when Fan and his colleagues tried to reintroduce the same tumor cells back into the cured mice, the tumor cells would not grow. Thus the engineered MSCs not only tuned the immune system against the tumor, but they effectively vaccinated the mice against it as well.”

via http://beyondthedish.wordpress.com/2014/06/23/engineered-stem-cels-from-human-umbilical-cord-blood-eradicates-pancreatic-tumor/

 

 

Thanks Squeeky!

mouse-grown-from-stem-cells

HEMATOPOIETIC STEM CELLS PROTECT AGAINST MYELOPROLIFERATIVE NEOPLASIA

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on June 25, 2014 at 9:14 am

​WHAT CAN’T STEM CELLS DO?

HEMATOPOIETIC STEM CELLS PROTECT AGAINST MYELOPROLIFERATIVE NEOPLASIA

After over 15 years of main stream research around the world (with 50 years of bone marrow/stem cell transplant research and therapies), most people still believe there are only a few sources for stem cells; embryonic, adult and induced pluripotent.

Adult stem cells in particular though, consist of a huge number of stem cell sources: embryos, fetuses, placentas, umbilical cord blood, Wharton’s jelly, endometria, peripheral blood, umbilical cord blood, bone marrow, placentas, adipose or fat tissue, skeletal and cardiac muscle, olfactoric mucosal (nasal neurological), breast milk, dental pulp, lungs and many other sources. Chinese scientists have even generated human teeth from the stem cells found in urine.

 

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Each stem cell source appears to have unique qualities and characteristics which scientists are barely beginning to fully understand. The blood or bone marrow have what are called “hematopoietic stem cells.”

“A hematopoietic stem cell is a cell isolated from the blood or bone marrow that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood…” via

As if hematopoietic stem cells weren’t awesome enough due to their ability to produce cells of the blood and the immune system and destroy unneeded cells, they have an additional benefit which may be even more impressive. Hematopoietic stem cells introduced into the patient’s body also protects against myeloproliferative neoplasia.

Myeloproliferative neoplasm is “a type of disease in which the bone marrow makes too many red blood cells, platelets, or certain white blood cells. Myeloproliferative neoplasms usually get worse over time as the number of extra cells build up in the blood and/or bone marrow. This may cause bleeding problems, anemia, infection, fatigue, or other signs and symptoms. Certain myeloproliferative neoplasms may become acute myeloid leukemia (AML). Myeloproliferative neoplasms include chronic myelogenous leukemia (CML), polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. Also called chronic myeloproliferative neoplasm.” via

As research continues, we learn more and more about the abilities of stem cells and their role as one of the most important healing systems in the human body.

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HEMATOPOIETIC STEM CELLS

Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders

Posted: 22 Jun 2014 11:22 AM PDT

“The protective microenvironment of the hematopoietic stem cell niche, which produces cells of the blood and the immune system, also protects against myeloproliferative neoplasia. Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment…”

 

 

FOR BEST RESULTS: INCREASE GUT BACTERIA

In ALL ARTICLES, OFF THE BEATEN PATH on June 23, 2014 at 4:04 pm

http://clearlykombucha.com/2014/03/wtf-are-probiotics/

 For Best Results: Increase Gut Bacteria

 

“A healthy and balanced diet, as well as probiotics, have been known to be helpful in preserving gastrointestinal health for quite a long time. But it is only recently that the underlying mechanisms have become somewhat clearer. A rapidly increasing body of knowledge promises to further clarify the effects of our daily food on the gut microbiota and to indicate more targeted applications of probiotics in the near future. This was one of the topics presented at the Gut Microbiota for Health World Summit in Miami, FL, USA. On March 8-9, 2014, internationally leading experts discussed the latest advances in gut microbiota research and its impact on health.”  -‘Feeding gut microbiota: Nutrition, probiotics key factors for digestive health.’ ScienceDaily

We’ve all heard of probiotics and their dietary benefits. Now let’s use that knowledge and put it to good use when it comes to stem cell transplantation. According to the article we posted earlier, increased gut microbiota can increase the success and survival rate of patients post transplant. Now here’s the big question… ‘how do we increase these helpful suckers early and get them working ASAP?!’ Well, you probably guessed it–  eating foods rich in probiotics (such as yogurt)  is one way to do this! Click the links and find out why you should be feeding the little helpers alive in your gut and how to increase their diversity– and increase your chances of success!!

http://helivac.co.za/2014/04/25/probiotics-and-your-gut/

Other benefits of increased gut microbiota and why that’s good

Related Links:

Exercise and healthy diet and how that helps

What are probiotics anyway?

 

GUT BACTERIA = STRONGER STEM CELL RESPONSE

In ALL ARTICLES, STEM CELLS IN THE NEWS on June 23, 2014 at 4:03 pm

Aliens or martians cartoon illustration

Gut Bacteria= Stronger Stem Cell Response

“The diversity of bacteria in the gastrointestinal tract of patients receiving stem cell transplants may be an important predictor of their post-transplant survival, researchers report. Researchers found a strong connection between post-transplant gut microbiota diversity and outcomes, observing overall survival rates of 36 percent, 60 percent, and 67 percent among the low, intermediate, and high diversity groups, respectively.” – ‘Gut bacteria predict survival after stem cell transplant, study shows.’ ScienceDaily

I always believed it, now there’s proof!
http://www.sciencedaily.com/releases/2014/06/140617112226.htm

WHY? Maybe because…
Stem cells are a natural healing system in the body that regenerate dead and damaged tissue and create new tissue– they require nutrients to do so. Gut bacteria helps digest food and derive nutrients for the entire body. More gut bacteria means a stronger immune system which means a greater ability to fight infection; more nutrients available for use as building blocks, to repair nutrients, etc. This results in increased potential benefits from stem cell therapy.

 

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING

In ALL ARTICLES, BUSINESS OF STEM CELLS, SCIENCE & STEM CELLS on June 23, 2014 at 2:55 pm

broken-bone-cast

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING
“Stem cells are smart and will only stay in one place to repair damaged cells and tissues until called away for more dire situations requiring attention.  Like little ADHD multi-tasking mechanics/repairmen, they run all over the body where the body has decided (through a very complex set of devices) they are most needed.  This results in stem cells dedicated to mending bones, suddenly running off to fix the heart, pancreas, etc before finishing the job on the broken bone.  While this is a great holistic and triage approach (paying attention and dedicating resources to that which needs it most), it makes it difficult to access how powerful and successful stem cells are at resolving a single issue/condition in the body.

A lot can be said for repairing many areas in the entire body simultaneously, in fact, this is one of stem cells’ greatest strengths…but it doesn’t sit well with the concept of “completing one job before moving on to another.”  Scientists have devised a new way to make stem cells stay put and finish the job they were directed to do.  No more stem cell ADHD.

keep-calm-and-oh-look-a-squirrel-1

In the case of serious and terminal diseases, this is an excellent innovation.  If you can fix that which is going to fail first, you can then move on to what’s next.  It also makes commercialization of stem cells easier.  Nobody picks up their car with the damaged exhaust from the mechanic and he says: ‘I got the exhaust half done but realized your distributor, struts and alternator were shot so I fixed them instead.’  But your body is not a car.

This may be a wonderful innovation or it may be another instance of scientists trying to aggressively control a natural healing system in the body.  I think it’s both and the result is we now have one more extraordinary tool for fighting disease…and like any tool, it will be used well and for the right reasons and results and also used poorly for the wrong reasons and results.  Ultimately, our understanding of the modus operandi of stem cells has increased, our ability to manipulate stem cells has increased and the everyday miracles of stem cell treatment results are getting better and better understood and more common place all the time.” – David Granovsky

 ——————-

Delivering Capsules of Stem Cells Helps Repair Injured Bones

“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.

Researchers, and a couple of renegade doctors in Colorado, have shown that stem cells do help bones heal. While bones, even the intricately shaped jawbone, have been grown in the lab, researchers have been somewhat stymied in their efforts at the seemingly more banal task of using stem cells and grafts to help heal major fractures, bones removed in surgery and other hard-to-fix injuries inside the body.

That’s where materials science comes in.

University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone…”

via
​http://singularityhub.com/2014/06/23/delivering-capsules-of-stem-cells-helps-repair-injured-bones/

SHE WASN’T DEAD ENOUGH FOR STEM CELLS IN THE US

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 19, 2014 at 9:22 am

Finding no promising treatment programs in the United States, and nothing that would be covered by her health insurance, Cristy traveled to Istanbul, Turkey, in 2011 for a life-saving stem-cell transplant

WHY!

CRISTY SCT
University of Hawaii Professor, Stem Cell Transplant Surgery Survivor and author of “5 Steps To Being Your Own Patient Advocate” is taking her “5 Steps Movement” on the road in July….

Cristy Kessler, Ed.D., NBCT

With over 19 years of teaching experience, Dr. Cristy Kessler has been motivating audiences of all ages with her message of determination, survival, faith, and hope. Cristy has a natural ability for speaking to large groups of people of all ages and a style of speaking that helps them feel like they’re sitting in her living room.

Cristy Kessler has been a role model for countless students from 5th grade through university whose lives she has touched as a social studies teacher, coach, and associate professor in education at the University of Hawaii. This, in spite of a lifetime of pain and a constant battle with health issues throughout her life.

A three-sport standout in high school, Cristy coached both soccer and basketball, including a five-year stint as coach for TourneySport USA in Hawaii. She earned her doctorate in educational leadership and innovation in 2003, and as part of her commitment to being the best teacher and role model she could be, she achieved certification through the National Board for Professional Teaching Standards (NBPTS), even though this certification is generally recognized as a program for K-12 teachers. Rarely has a university professor sought (or achieved) this recognition, but Cristy did exactly that in 2005, even as she was recovering from cancer surgery. In her role as an associate professor at the university, she has guided scores of teachers through successful achievement of NBPTS certification.

Plagued by constant pain and fatigue, Cristy was finally diagnosed in 2006 with a constellation of auto-immune diseases: scleroderma, ankylosing spondylitis, and vasculitis, any one of which is ultimately fatal. Following years of treatment for the symptoms of these disorders, it became clear that the only way to save her life was to somehow tackle the diseases themselves, not just the symptoms. Finding no promising treatment programs in the United States, and nothing that would be covered by her health insurance, Cristy traveled to Istanbul, Turkey, in 2011 for a life-saving stem-cell transplant at Anadolu Hospital, an affiliate of Johns Hopkins University. Extensive fund-raising efforts by friends and family helped make this incredible journey a reality.

The transplant succeeded such that Cristy has a brand-new immune system and has resumed her work with university students and teachers. She continues to look for opportunities to inspire and encourage others through the story of her determination to live, even in the face of chronic pain and imminent death.

Dr. Kessler recently released a new book, “5 Steps To Being Your Own Patient Advocate” and is touring in July in support of the book.

Check out the current tour schedule at:
http://www.5stepstobeingyourownpatientadvocate.com

“My Health. My Body. My Voice….Learning To Live Tour” campaign:
https://www.indiegogo.com/projects/my-health-my-body-my-voice-learning-to-live-tour/x/3387656

You can read Cristy’s compelling story at:
http://www.cristykessler.com

Youtube Channel:
https://www.youtube.com/channel/UCoL–mQB2KXhcVkJXxMZwFg

YOUR BRAIN, THE EMPTY CUP

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 4, 2014 at 8:40 am

empty-cup  819px-Complete_neuron_cell_diagram_en.svg

15 years ago, modern science was confronted with the premise that HEART type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results (The first clinical trial of a novel therapy was conducted unintentionally by the Renaissance surgeon Ambroise Parè in 1537).  Ask your doctor if heart cells can regenerate.  There is still ENORMOUS resistance.

10 years ago, modern science was confronted with the premise that BRAIN type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results.  Ask your doctor if brain cells can regenerate.  There is still ENORMOUS resistance.

3 days ago Duke researchers published a study in the peer reviewed journal Nature about how they “found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons.”

While this is incredible news, science is still moving too slowly for those suffering from chronic and terminal diseases, dementia, TBI and other neurological disorders.  Is it time to revamp the system?  Is it time to approach healing and science with the premise that the human body has regenerative capabilities and we should tap into those systems to heal disorders instead of treating symptoms far removed from the original disorders?  What other premises are in place which are blocking medical advancements?

A story from Zen Buddhism:
Nan-in served tea. He poured his visitor’s cup full, and then kept on pouring.  The professor watched the overflow until he no longer could restrain himself. “It is overfull. No more will go in!”  “Like this cup,” Nan-in said, “you are full of your own opinions and speculations. How can I show you Zen unless you first empty your cup?”

Regenerative medicine is a new frontier.  Already around for decades, most have yet to recognize it as the huge paradigm shift which necessitates our emptier our cups and approaching medicine from a completely new perspective.  A new perspective which includes an empty cup.

Is your thinking, holding you back?

via
http://www.sciencedaily.com/releases/2014/06/140602102006.htm
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3734.html

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