DAVID GRANOVSKY

Posts Tagged ‘EMBRYONIC’

MULTIPOTENT STROMAL STEM CELLS FROM PLACENTAL TISSUE DEMONSTRATE HIGH THERAPEUTIC POTENTIAL

In STEM CELLS IN THE NEWS on December 11, 2012 at 9:00 am

placenta

Scientists at Children’s Hospital Oakland Research Institute (CHORI) led by Vladimir Serikov, MD, PhD, and Frans Kuypers, PhD, report in the current Epub issue of Stem Cells Translational Medicine that placental stem cells with important therapeutic properties can be harvested in large quantities from the fetal side of human term placentas called the chorion.

The chorion is a part of the afterbirth and is normally discarded after delivery, but it contains stem cells of fetal origin that appear to be pluripotent — i.e., they can differentiate into different types of human cells, such as lung, liver, or brain cells. Since these functional placental stem cells can be isolated from either fresh or frozen term human placentas, this implies that if each individual’s placenta is stored at birth instead of thrown away, these cells can be harvested in the future if therapeutic need arises. This potential represents a major breakthrough in the stem cell field.

In previous work, Drs. Serikov and Kuypers reported a novel technology to harvest blood-forming stem cells from the placenta to augment cord blood cells. These cells are “siblings” of the cord blood derived stem cells. Cord blood stem cells, unlike embryonic stem cells, have been used for many hundreds of successful bone marrow transplants. These transplants are mainly performed in children, as the amount of cells that can be harvested from cord blood is usually not sufficient for a successful transplant in adults. Adding placental-derived stem cells to the cord blood stem cells could make successful adult bone marrow transplants routinely possible.

The current report demonstrates that placental stem cells have much broader therapeutic potential than bone-marrow transplants, because they are pluripotent — i.e. able to differentiate into many different cell types — and they also generate growth factors that help in tissue repair. These cells are shown to integrate into different tissues when transplanted into mice, but like cord blood stem cells, and in contrast to embryonic pluripotent stem cells, they do not form tumor-like structures in mice.

Placental-derived stem cells are often viewed as “adult” stem cells in contrast to “embryonic” stem cells, which are the dominant focus in the stem cell research field. However, this report shows that these fetal stem cells can be harvested in large numbers, and without the ethical concerns attached to the use of embryonic stem cells. These stem cells may thus be a more practical source for regenerative medicine, particularly since, if placentas are routinely saved instead of thrown away, each individual will be able to draw on their own fetal stem cells if future therapeutic needs arise.

Placental stem cells are only 9 months old, and in contrast to adult stem cells, do not need to be reprogrammed to become pluripotent. Placental-derived stem cells have characteristics of young and vigorous cells, including young mitochondria. Future research will be aimed to bring this to the clinic and to test their efficacy in translational therapeutic applications.

 

http://www.sciencedaily.com/releases/2012/05/120518132250.htm

A DIFFERENT KIND OF STEM CELL

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on November 26, 2012 at 8:05 am

Human fibroblast

A research team at Georgetown Lombardi Comprehensive Cancer Center say the new and powerful cells they first created in the laboratory a year ago constitute a new stem-like state of adult epithelial cells. They say these cells have attributes that may make regenerative medicine truly possible.”  This advancement could potentially guide research into a new era of personalized medicine.

-DG

In the November 19 online early edition of the Proceedings of the National Academy of Sciences (PNAS), they report that these new stem-like cells do not express the same genes as embryonic stem cells and induced pluripotent stem cells (iPSCs) do. That explains why they don’t produce tumors when they grow in the laboratory, as the other stem cells do, and why they are stable, producing the kind of cells researchers want them to.  “These seem to be exactly the kind of cells that we need to make regenerative medicine a reality,” says the study’s senior investigator, Richard Schlegel, M.D., Ph.D., chairman of the department of pathology at Georgetown Lombardi, a part of Georgetown University Medical Center.

This study is a continuation of work that led to a breakthrough in December 2011 when Schlegel and his colleagues demonstrated that he and his team had designed a laboratory technique that keep both normal as well as cancer cells alive indefinitely — which previously had not been possible.  They had discovered that adding two different substances to these cells (a Rho kinase inhibitor and fibroblast feeder cells) pushes them to morph into stem-like cells that stay alive indefinitely. When the two substances are withdrawn from the cells, they revert back to the type of cell that they once were. They dubbed these cells conditionally reprogrammed cells (CRCs).

The advance was seen as an exciting demonstration of personalized cancer medicine. In fact, a case study authored by Schlegel and his team, reported in the September 27 issue of the New England Journal of Medicine (NEJM), demonstrated how CRCs derived from normal and tumor cells of a 24-year-old man with a rare type of lung tumor allowed physicians to identify an effective cancer therapy. These cells were used to screen potential treatments and in this way, the scientists were able to see which therapies were active against the tumor cells and less harmful to the normal cells.

“Our first clinical application utilizing this technique represents a powerful example of individualized medicine,” Schlegel said in September. But he cautioned, “It will take an army of researchers and solid science to figure out if this technique will be the advance we need to usher in a new era of personalized medicine.”

This study was designed to see how the CRCs compared to known properties of embryonic stem cells and iPSCs, which are adult cells that have been manipulated by addition of genes to make them capable of differentiating (morphing into new adult cell types).  Both embryonic stem cells and iPSCs have been investigated for use in regenerative medicine, but each can form tumors when injected into mice and “it is difficult to control what kind of cells these cells differentiate into,” Schlegel says.  “You may want them to be a lung cell, but they could form a skin cell instead.”

In contrast, cells derived from the lung will develop stem-like properties when the conditions are added, allowing expansion of the lung cell population. However, when the conditions are withdrawn, they will revert to differentiated lung cells, he says. Schlegel added that they do this rapidly — within three days of adding the inhibitor and feeder cells, they efficiently generated large numbers of stem-like cells. It is also completely reversible: when the conditions are taken away, the cells lose their stem-like properties and potentially can be safely implanted into tissue.

The researchers compared gene expression between the three cell types and found that while some of the same genes are expressed in all the cells, CRCs don’t over express the same critical genes that embryonic stem cells and iPSCs do. “Because they don’t express those genes, they don’t form tumors and they are lineage committed, unlike the other cells,” Schlegel says. “That shows us that CRCs are a different kind of stem-like cell.”  As part of the study, the research team showed that when cervical cells are conditioned and placed on a three-dimensional platform, they start to form cells that “look like the cervix,” Schlegel says. The same is true from cells in the trachea — on a 3-D platform, they begin to look like a trachea, he says.

If and when use of CRCs are perfected for the clinic — and that will take considerable work, Schlegel says — they potential could be used in a wide variety of novel ways.  “Perhaps they could be used more broadly for chemosensitivity, as we demonstrated in the NEJM study, for regenerative medicine to replace organ tissue that is damaged, for diabetes — we could remove remaining islet ells in the pancreas, expand them, and implant them back into the pancreas —and to treat the many storage diseases caused by lack of liver enzymes. In those cases, we can take liver cells out, expand them and insert normal genes in them, and put them back in patients,” Schlegel says.  “The potential of these cells are vast, and exciting research to help define their ability is ongoing,” he says.
The research described was funded by a grant to Schlegel from the National Institutes of Health (R01 CA106400) with additional support from an additional NIH grant (5 U42 RR006042). Georgetown University has filed a patent application on the technology described in this paper. Schlegel is an inventor for the patent application.

http://explore.georgetown.edu/news/?ID=67774&PageTemplateID=295

PLURUIPOTENT STEM CELLS, A POTENTIALLY INVALUABLE THERAPEUTIC RESOURCE

In SCIENCE & STEM CELLS on November 21, 2012 at 7:44 am

B0007671 Mouse embryonic stem cells

Pluripotent stem cells are potentially an invaluable therapeutic resource, as shown in a recent study conducted by the Stanford University School of Medicine.  Within this study, researchers found that with appropriate initial coaching of cells and through the use of environmental cues, the human body has the ability to direct differentiation of cells.

 

Pluripotent stem cells are nature’s double-edged sword. Because they can develop into a dizzying variety of cell types and tissues, they are a potentially invaluable therapeutic resource. However, that same developmental flexibility can lead to dangerous tumors called teratomas if the stem cells begin to differentiate out of control in the body.

To prevent this outcome, researchers must first give the cells a not-so-subtle shove toward their final developmental fate before transplanting them into laboratory animals or humans. But exactly how to do so can vary widely among laboratories. Now researchers at the Stanford University School of Medicine have used an experiment in mice to hit upon a way to possibly skip this fiddly step by instead relying mostly on signals within the body to keep the stem cells in line.

“Before we can use these cells, we have to differentiate, or ‘coach,’ them down a specific developmental pathway,” said Michael Longaker, MD, the Deane P. and Louise Mitchell Professor in the School of Medicine. “But there’s always a question as to exactly how to do that, and how many developmental doors we have to close before we can use the cells. In this study, we found that, with appropriate environmental cues, we could let the body do the work.”

Allowing the body to direct differentiation could speed the U.S. Food and Drug Administration’s approval of using such pluripotent stem cells, Longaker believes, by eliminating the extended periods of laboratory manipulation required during the forced differentiation of the cells.

Longaker, who co-directs Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, is the senior author of the research, published online Nov. 19 in the Proceedings of the National Academy of Sciences. Postdoctoral scholars Benjamin Levi, MD, and Jeong Hyun, MD, and research assistant Daniel Montoro are co-first authors of the work. Longaker is also a member of the Stanford Cancer Institute.

“Once we identify the key proteins and signals coaching the tissue within the body, we can try to mimic them when we use the stem cells,” said Longaker. “Just as the shape of water is determined by its container, cells respond to external cues. For example, in the future, if you want to replace a failing liver, you could put the cells in a scaffold or microenvironment that strongly promotes liver cell differentiation and place the cell-seeded scaffold into the liver to let them differentiate in the optimal macroenvironment

http://med.stanford.edu/ism/2012/november/longaker.html

Cambridge Academics Will Bypass European Embryonic Stem Cells Ruling

In STEM CELLS IN THE NEWS on January 16, 2012 at 7:39 am

I am amazed that Cambridge seems unaware of the benefits of adult stem cells, their record of safety and efficacy, over 2000 clinical trials and many thousands more studies, 20,000 patients treated successfully to date, their bio-availability and no need for immunosuppressive drugs/no rejection issues and their pluripotency. Yes, I said pluripotency.  There ARE adult stem cells that ARE pluripotent. Didn’t you know? Hmmm… I wonder why not? – David

Ellee Seymour: Cambridge Academics Will Bypass European Stem Cells Ruling.

http://kara.allthingsd.com/files/2007/11/cambridge1.jpg
Cambridge Academics Will Bypass European Embryonic Stem Cells Ruling

Posted: 12/1/12 18:51 GMT

The Vice-Chancellor of Cambridge University, Professor Sir Leszek Borysiewicz, has vowed to bypass a European Court of Justice ruling that bans patents on embryonic stem cells by turning to the United States or India instead.

There are 26 laboratories in Cambridge using stem cells; it has the largest aggregate of stem cell scientists in Europe. However, their future research, which is hoped will lead to vital medical discoveries, remains uncertain if they comply with the court ruling announced last October.

Sir Leszek, a former lecturer in medicine and Chief Executive of the UK’s Medical Research Council, told a Cambridge Network gathering of hi-tech business leaders, that the ruling may be “politically incorrect”, and that the government was “trying to play this down”.

He said: “I believe embryonic stem cells have to be the way forward. We do have a problem in the European area, but I’ve been very clear, both to ministers and others about how Cambridge is going to tackle that. We will continue to do a lot of research here, we will engage with whatever development we can locally and further forward, but the university itself will look at ways of ensuring that patenting can actually occur, and, if necessary, be run through the US, and, if necessary, the Indian sub-continent.”

He added: “There is no way we can actually block the development of potential therapeutics which will have a major impact.”

Sir Leszek, who earlier in the week had been speaking to David Cameron and his “prime ministerial team” about innovation, along with Intel and Hermann Hauser, feels passionately about the potential revolutionary treatments which embryonic stem cell research could provide for those suffering from blindness, spinal cord injury and stroke, as well as Alzheimer’s disease and Parkinson’s.

“There is a fundamental issue that Europe has got involved, and frankly, I don’t think we should stand back and prevent major opportunities from actually reaching completion as quickly as possible.”

When the European Court of Justice announced the ban on patents, David Willetts, the Science Minister, told The Times that the government remained committed to stem cell research, despite the court’s decision:

“It does look disappointing because we want to see the effective development of cell therapies that could alleviate and tackle serious medical conditions. It could inhibit this research and development.

“If Europe wants to remain as productive and creative in scientific discovery as it historically has been, it can’t regulate innovation out of existence.”

Back in Cambridge, Sir Leszek was in no doubt about the major contribution this fine academic city could provide:

“Here we have the brains and the means and the ideas to change to world; frankly, we should have the ambition too. Cambridge is a unique environment with the best ideas and the best implementation. If the answers to pressing questions facing humanity don’t come from here, where will they come from?”

OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD!

In VICTORIES & SUCCESS STORIES on October 22, 2011 at 9:15 am

The debate ended 2.5 years ago but the battle still wages on! SO much has changed in 2.5 years  yet so much remains the same. 

The world has embraced the knowledge that adult stem cells can treat almost anything with safety and success but nobody in the USA knows about it because they are not available here and considered “unapproved by the FDA.”

Maybe we can enlist the “Occupy Wall Street” peeps to make some huge needed changes in our health care and available treatments.  – David

Originally from: http://repairstemcell.wordpress.com/2009/03/31/oprah-michael-j-fox-dr-mehmet-oz-the-stem-cell-debate-is-over/

The Stem Cell Debate Is Over! ...sort of...

The Wisdom of Oz

Visualize the surreal image of Oprah Winfrey, Michael J Fox and Dr. Mehmet Oz, wearing purple surgical gloves, sitting on stage around a human brain. Dr. Oz explains the absence of Nigro-Striatal Neurons in the brain of Parkinson’s patients while lifting out partially dissected chunks of brain and placing them into Michael’s shaking hand.

The camera zooms in as Dr. Oz steadies Michael’s hand in his. Dr. Oz weaves an intimidating, steel needle between Michael’s gloved and trembling fingers and illustrates the procedure for injecting stem cells into the brain by plunging it both into and through the quivering cerebellum. Michael’s legs spasm and contort and my stomach clenches empathetically with what I sense is Michael’s extreme discomfort, but is really a symptom of his condition.

And yet, NOTHING could have prepared me for what happened next as Dr. Oz, unbelievably and without prelude or warning, makes the stunning statement:
“I think, Oprah, the stem cell debate is dead.”

“The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it’s very hard to control them and so they can become cancer.”

While astonished by his public announcement, I soon began to wonder: “why did Dr Oz only briefly allude to the potential of iPS cells and the proven benefits of adult stem cell treatments?” And then it became clear.

Dr Oz recognizes that the average person on an American street is led to believe, “a stem cell is an embryo is a stem cell”. Due to years of misleading media saturation, as far most Americans know, there are no other stem cells besides embryonic. Walk down the street and ask someone “what is an adult stem cell…what is an iPS cell”, and your inquiries will surely be met by blank stares.

So in retrospect, what Oz DID do, was truly…amazing.

Shunning the history of the love/hate affair Americans have with Embryonic stem cell research and ignoring the majority of US media over the past 5 years, the decrees of President Obama’s funding policies, the positions of the FDA and AMA and the fruitless decade long public pursuit of embryonic cures undertaken by Michael J Fox (with the benevolent and optimistic spirit of Christopher Reeve hovering over him) and before the bewildered eyes of Michael, Oprah and ~7.2 million viewers, Dr Mehmet Oz nailed the coffin shut on ESC treatments:
“I think, Oprah, the stem cell debate is dead.”

With this one simple statement on national TV, Dr Oz has taken the first step towards educating the American public about the current insurmountable limitations of embryonic stem cells and cracked open the door to the American collective mind-set regarding the potential of iPS cells and the reality that Repair stem cells (RSC) have been treating diseases around the world successfully for a decade. Despite the fact that thousands of American doctors refer to RSC as “snake oil,” more and more American patients are realizing that the US medical system is faltering, dated and just not working while the greatest medicine the world has ever seen is available just beyond the borders of their own country.

The seeds planted by Dr Oz will take a long time to find purchase in the collective American mind-set. There is too much embryonic momentum, media and drama, and America loves drama. Embryonic stem cells will not go away and like Romeo and Juliet, this love/hate affair may have to run its course for most, despite Dr Oz stealing the “distilled liquor” and Romeo’s poison and dagger in an attempt to avoid all of the deaths at the end of this play.

To read more about this grim fairy tale: http://repairstemcell.wordpress.com/2009/03/30/a-grim-fairy-tale-americas-doomed-love-affair-with-embryonic-stem-cell-research-intro-the-romance-is-an-illusion/

One step at a time we will climb this mountain and slowly open American eyes to improve their knowledge of treatment options so all can intelligently exercise the freedom of choice in their individual medical care. One inch at a time, Oz wisely created a pathway to an amazing new world of available medical treatments for what were previously believed to be incurable diseases and are in fact treating patients successfully around the world.

Dr Oz took this first step and it was a HUGE first step!

So from where I am sitting, I would like to express my heartfelt and sincerest appreciation for Dr Oz’s bravery, statements and actions. Thank you, Dr. Oz and thank you Oprah; for allowing this sage doctor the forum to break the walls restricting millions of Americans from the knowledge of the medical treatment options they so unquestionably deserve.

Here is the actual transcript based on my ears and fingers and a lot of patient rewinding:

“I think, Oprah, the stem cell debate is dead.”

“The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it’s very hard to control them and so they can become cancer.”

“I can take a little bit of your skin, take those cells, get them to go back in time so they are like they were when you were first made, and then they will start to make that dopamine & I think those cells, because they won’t be as prone to cancer & because they’re your genes will be the ones that are ultimately used to cure Parkinsons.”

“I think we are single digit years away from making a big impact in the lives of Parkinson’s disease but also diabetics, heart disease, people who have had a lot of problems.”

To see the original video: http://www.oprah.com/media/20090319-tows-dr-oz-brain

BENNY HILL IS ALIVE AND WELL AS BRITAIN GOES BLIND

In ALL ARTICLES on September 23, 2011 at 7:00 am

Remember in the final scene of every episode of Benny Hill where he does something really scandalous and then gets chased by the entire cast around and around in circles?  Turns out, Benny Hill is ALIVE AND WELL and advising Britain on their medical protocols!  http://www.webtvwire.com/wp-content/uploads/2010/06/the-benny-hill-show-logo.jpg

You see, Britain, like the USA, is chasing this fleet footed “embryonic stem cell treatment comedy of errors” around and around in circles just like in the Benny Hill episodes.  Every week, the same scene is played out with Benny running, the entire cast chasing and he never gets caught.  So in Art, so in life.  Britain is chasing embryonic stem cells used for treatment of optic diseases.  And remember…

  • Embryonic stem cells STILL have ZERO successful clinical trials
  • Embryonic stem cells STILL cause cysts and tumors that can become cancerous (wait 20 years and ask again though)
  • Embryonic stem cells STILL have rejection issues that require immunosuppressive drugs
  • Embryonic stem cells STILL carry the genetic anomalies of the donor
ON THE OTHER HAND…

So on top of wasting time chasing a cure with no prior history of success and huge negative side effects, thy are running right past a treatment with a huge history of success and safety and trials.

So cue up the cameras, get everyone in costume and let’s start that famous music going as everyone chases embryonic stem cell treatments around and around.  Wait! STOP! Hold it! CUT!

How on earth can we explain the entire medical community and government running right past what already works?  Got it! Give them all blindfolds!  That way they can be assured to miss the forest but they will hit every damn tree in it and so will the patients, patiently waiting for treatments which will never come!

…annndddd   ACTION!!!

Iris of a human eye

First trial of embryonic stem cell treatment in Europe gets green light

Patients in Britain with an eye disease that leads to blindness will take part in Europe’s first human embryonic stem cell trial

British surgeons are to take part in the first trial in patients of a human embryonic stem cell therapy to gain approval from regulators in Europe.

Surgeons at Moorfields Eye Hospital in London will inject cells into the eyes of 12 patients with an incurable eye disease called Stargardt’s macular dystrophy, one of the main causes of blindness in young people…

Read more

STEM CELLS 101 – making sense of the mess

In ALL ARTICLES on September 23, 2011 at 4:21 am

STEM CELLS MAKING YOU CRAZY?!!!

http://www.thedogandthediva.com/wp-content/uploads/confused.bmp

Embryonic? Adult? induced Pluripotent? Omnipotent? Tutipotent? Umbilical? Fetal? Placental? Mesynchymal? Adipose?  Are you confused by it all?

CAN ANYONE MAKE SENSE OF THIS MESS OF INFORMATION!?!?!

STEM CELLS 101

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM•comes from blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal neurological, breast milk, menstruation, dental pulp, and many more
  • PURPOSE IN BODY•they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS•~zero problems (virtually zero side effects)
  • TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY•can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)

EMBRYONIC STEM CELL = ESC

  • SOURCE/DERIVED FROM•comes from embryos
  • PURPOSE IN BODY•split for 7 weeks until you have a fetus the size of a thumbnail
  • OBSTACLES+SIDE EFFECTS•they create cysts and tumors, rejection requires immunosuppressive drugs for the ill patient, they carry the genetic anomalies of the donor, etc
  • TREATMENT HISTORY•can currently treat zero diseases, probably need to cure cancer first to use them

INDUCED PLURIPOTENT STEM CELL = iPSC (“Embryonic Stem Cell Lite”)

  • SOURCE/DERIVED FROM•comes from regular adult cells like skin cells that are then transformed by scientists into stem cells
  • PURPOSE IN BODY•to be a skin cell or other tissue
  • OBSTACLES+SIDE EFFECTS•they create cysts and tumors, rejection requires immunosuppressive drugs for the ill patient, they carry the genetic anomalies of the donor…
  • TREATMENT HISTORY•no treatments to date, probably need to cure cancer first to use them
FOR MORE INFORMATION ABOUT A SPECIFIC DISEASE OR STEM CELL TREATMENT COSTS AND INFORMATION OR TO LEARN WHERE PATIENTS CAN BE TREATED TODAY, PLEASE CONTACT ME: dsgrano@gmail.com

 

GERON’S EMBRYONIC “WASTE OF TIME” CONTINUES…

In ALL ARTICLES on September 21, 2011 at 9:51 pm

Here’s an 867 word article I’d like to not waste your time with.

http://www.epiphanymarketing.com/blog/wp-content/uploads/2010/03/waste-of-time-283x300.jpg

The premise is:  “The study is not meant to determine whether the stem cells can cure or even improve the patients’ condition, but to find out if the treatment itself is safe. Researchers will be monitoring patients over the following months and years to look for side effects, including possible benign tumor growth if the stem cells start to replicate, or adverse immune reactions.”

So let’s not waste your time, I’ll give you the results right now:

EMBRYONIC STEM CELL = ESC

  • SOURCE/DERIVED FROM•comes from embryos
  • PURPOSE IN BODY•split for 7 weeks until you have a fetus the size of a thumbnail
  • OBSTACLES+SIDE EFFECTS•they create cysts and tumors, rejection requires immunosuppressive drugs for the ill patient, they carry the genetic anomalies of the donor, etc
  • TREATMENT HISTORY•can currently treat zero diseases, probably need to cure cancer first to use them

Read it if you want but that’s really “all she wrote.”  Then again, this will allow billions to be pumped into embryonic research for treatments over “the following months and years” despite this fact…

SCREW THE EMBRYOS, THEY’RE IRRELEVANT!

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Paralyzed patient in major Geron stem cell study

Erin Allday, Chronicle Staff Writer, Wednesday, September 21, 2011

A Bay Area patient who recently suffered a serious spinal cord injury and is now paralyzed from the waist down joined the world’s first-ever embryonic stem cell study in humans last week, when Stanford doctors injected 2 million cells designed to replace damaged neurons in the patient’s spine.

The patient, who is not being identified, is the fourth person to be enrolled in the clinical trial being run by Menlo Park’s Geron Corp. and the first person in California. The patient, whose participation in the trial was revealed Tuesday, received the stem cell injection Saturday at Santa Clara Valley Medical Center and is now at the rehabilitation center there.

The study is not meant to determine whether the stem cells can cure or even improve the patients’ condition, but to find out if the treatment itself is safe. Researchers will be monitoring patients over the following months and years to look for side effects, including possible benign tumor growth if the stem cells start to replicate, or adverse immune reactions…

Read more

ADULT CELLS, STEM CELLS & CANCER

In ALL ARTICLES on September 21, 2011 at 2:19 pm

Wow, this one was devious!! Some of these articles must be read very carefully as they are misleading and confusing, perhaps even intentionally so.

http://elrodsgodisney.files.wordpress.com/2011/07/confused_mickey_mouse_poster-p228990749419197094vhwx0_328-e1309635341795.jpg?w=197&h=281They start by telling you ‘adult stem cells‘ may fight cancer….

but later in the article refer to them as ‘adult cells…’

and even later as ‘induced pluripotent stem cells.’

But don’t be fooled by this semantic sleight of hand.

Induced pluripotent stem cells are semantically ‘adult cells’ only in the sense that all cells in an adult can be referred to as adult cells.  Perhaps this is the author’s attempt to make them distinct from embryonic cells. In any case, if your friend asks you for an APPLE from the MARKET, it is not acceptable to bring him back a BAG OF FLOUR just because they both can be “found at a MARKET.”

ANd let’s be clear.  Only ADULT STEM CELLS have thousands of studies and trials and thousands of patients treated safely and effectively.  Induced pluripotent stem cells have NONE.  And while Induced pluripotent stem cells ARE a manipulated type of ‘stem cell,’ they have a lot of problems too, as the article owns up to (one of the problems) in the end:

potential side effects need to be considered. iPS cells may develop into other harmful cells in the body.”

              “other harmful cells in the body”  =  tumors, cysts, cancer

THEY HAVE TO SOLVE THE ISSUES OF REJECTION & CANCER BEFORE THEY CAN

  1. USE THESE CELLS TO COMBAT CANCER!!
  2. USE THESE CELLS IN STEM CELL TREATMENTS!!

(dichotomy? I think so, makes me think of vaccines where you get injected with the disease to build anti-bodies to the disease.)

But the good news is, there are cancer treatments out there with high results and low or virtually no side effects that make chemo and radiation look ineffective and barbaric by comparison!

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Stem cells, potential source of cancer-fighting T cells

ScienceDaily (Sep. 20, 2011) — Adult stem cells from mice converted to antigen-specific T cells — the immune cells that fight cancer tumor cells — show promise in cancer immunotherapy and may lead to a simpler, more efficient way to use the body’s immune system to fight cancer, according to Penn State College of Medicine researchers.

“Cancer immunotherapy is a promising method to treat cancer patients,” said Jianxsun Song, Ph.D., assistant professor, microbiology and immunology. “Tumors grow because patients lack the kind of antigen-specific T cells needed to kill the cancer. An approach called adoptive T cell immunotherapy generates the T cells outside the body, which are then used inside the body to target cancer cells.”

It is complex and expensive to expand T cell lines in the lab, so researchers have been searching for ways to simplify the process. Song and his team found a way to use induced pluripotent stem (iPS) cells, which are adult cells that are genetically changed to be stem cells.

“Any cell can become a stem cell,” Song explained. “It’s a very good approach to generating the antigen-specific T cells and creates an unlimited source of cells for adoptive immunotherapy.”

By inserting DNA, researchers change the mouse iPS cells into immune cells and inject them into mice with tumors. After 50 days, 100 percent of the mice in the study were still alive, compared to 55 percent of control mice, which received tumor-reactive immune cells isolated from donors.

Researchers reported their results and were featured as the cover story in a recent issue of the journal Cancer Research.

A limitation of this potential therapy is that it currently takes at least six weeks for the iPS cells to develop into T cells in the body. In addition, potential side effects need to be considered. iPS cells may develop into other harmful cells in the body.

Researchers are now studying how to use the process in human cells.

Other researchers on this paper are Fengyang Lei, and Rizwanul Haque, Department of Microbiology and Immunology; Lynn Budgeon and Neil D. Christensen, Ph.D., Department of Pathology, Penn State College of Medicine.

This study was funded through the Pennsylvania Department of Health using Tobacco Settlement Funds, the W.W. Smith Charitable Trust and the Melanoma Research Foundation.

Celeb Dad We Love: Michael J. Fox Discouraged About Parkinson’s Disease But Fights On

In STEM CELLS IN THE NEWS on June 8, 2011 at 10:23 pm

Michael J. Fox Discouraged About Parkinson’s Disease

POSTED BY MICHELLE LAMAR ON JUNE 2ND, 2011 AT 12:38 AM

michael j fox 280x300 Celeb Dad We Love: Michael J. Fox Discouraged About Parkinson’s Disease But Fights On

Michael J Fox is an awesome celeb dad and I admire him so much for his brave fight against Parkinson’s disease in addition to his busy family life and career.  But reports surfaced today that Fox is realizing that he will likely never see a cure for Parkinson’s disease in his lifetime.

Michael J. Fox will celebrate his 50th birthday in June but sources close to the actor say he has been devastated by a recent setback in Parkinson’s research.

New research showed certain stem cells won’t be effective in treating Parkinson’s because they will be rejected by patients’ immune systems.  A source told the National Enquirer that the actor is crushed about the research findings:

“Michael is seeing his life ebb away. Turning 50 is a wake-up call. He wonders if he’ll be able to dance at his kids’ weddings. Michael had such high hopes for this potentially miraculous stem cell therapy, but now it’s back to the drawing board.”

 

Why has it taking him so long to figure out that only adult stem cells, not embryonic, are the key to Parkinson’s patients recovery.

Autologous Bone Marrow Stem Cells Transplant into Parkinson’s Disease Patients – Safe + Improve
http://repairstemcell.wordpress.com/2010/03/11/autologous-bone-marrow-stem-cells-transplant-into-parkinson%e2%80%99s-disease-patients-safe-improve/

 

 

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!
http://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

 

Do Stem Cells Repair Damaged Brain Cells
http://repairstemcell.wordpress.com/2009/08/25/mesenchymal-stem-cells-may-repair-damaged-brain-cells-%c2%ab-adult-stem-cell-awareness/

 

* OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD! –http://tinyurl.com/DEBATEisDEAD

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