DAVID GRANOVSKY

Posts Tagged ‘ADULT’

DO ADULT STEM CELLS CAUSE CANCER?

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 1, 2014 at 4:31 pm

NO!

cancer-free-zone

What do you get when you add 1,100 ADULT STEM CELL PATIENTS studied over 5 years,

plus another 1,873 ADULT STEM CELL PATIENTS studied over an average 12.5 years,

plus another ~7,000 ADULT STEM CELL PATIENTS in studies and FDA clinical trials data?

~10,000 ADULT STEM CELL TREATMENT PATIENTS showing NO CANCER!

 

“A total of 1873 patients were treated from 1990 to 2006 with bone marrow-derived concentrated cells. Patients were monitored for cancer incidence from the date of the first operation (1990) until death, or until December 31, 2011. The mean follow-up time was 12.5 years (range, five to twenty-two years)…No tumor formation was found at the treatment sites on the 7306 magnetic resonance images and 52,430 radiographs among the 1873 patients…This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.

The upshot? This most recent study, as well as others, FDA clinical trials data, and the data we have published now amounts to about 10,000 patients who have been treated with adult stem cells and extensively tracked for this issue. There is no evidence that adult stem cells cause cancer. There is no rational reason for the fear, other than a completely different type of cell (ESC) that happens to have a similar name (stem cell) can cause teratomas – hence the confusion!”

Tumors, cancers and teratomas may result from Embryonic stem cell (ESC) treatments or Induced Pluripotent stem cell (iPSC) treatments

but NOT FROM ADULT STEM CELL TREATMENTS.

Sources:

STEM CELLS MAKE VAGINAS!!

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on April 11, 2014 at 12:44 pm

MAKING VAGINAS FROM STEM CELLS, YES…ENTIRE VAGINAS, WORKING VAGINAS, ANATOMICALLY CORRECT IN FORM AND FUNCTION. WOW!

Georgia O'Keeffe

Georgia O’Keeffe

“Four women have had new vaginas grown in the laboratory and implanted by doctors in the US.

A tissue sample and a biodegradable scaffold were used to grow vaginas in the right size and shape for each woman as well as being a tissue match.

They all reported normal levels of “desire, arousal, lubrication, orgasm, satisfaction” and painless intercourse.

Experts said the study, published in the Lancet, was the latest example of the power of regenerative medicine.”
http://www.bbc.com/news/health-26885335

Stem Cell-based Baldness Cure One Step Closer | Beyond the Dish

In STEM CELLS IN THE NEWS on January 29, 2014 at 3:01 pm

Stem Cell-based Baldness Cure One Step Closer

http://www.mensfitness.com/sites/mensfitness.com/files/imagecache/node_page_image/article_images/male-pattern-baldness-main_0.jpg

January 28, 2014 – by mburatov

Scientists might be able to offer people with less that optimal amounts of hair new hope when it comes to reversing baldness. Researchers from the University of Pennsylvania say they’ve moved closer to using stem cells to treat thinning hair — at least in mice.

This group said that the use of stem cells to regenerate missing or dying hair follicles is considered a potential way to reverse hair loss. However, the technology did not exist to generate adequate numbers of hair-follicle-generating stem cells.

But new findings indicate that this may now be achievable. “This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles,” Dr. Xiaowei Xu, an associate professor of dermatology at Penn’s Perelman School of Medicine, said in a university news release.

According to Xu, those cells have many potential applications that extend to wound healing, cosmetics and hair regeneration.In their new study, Xu’s team converted induced pluripotent stem cells iPSCs – reprogrammed adult stem cells with many of the characteristics of embryonic stem cells – into epithelial stem cells. This is the first time this has been done in either mice or people.

The epithelial stem cells were mixed with certain other cells and implanted into mice. They produced the outermost layers of the skin and hair follicles that are similar to human hair follicles.

This study was published in the Jan. 28 edition of the journal Nature Communications.This suggests that these cells might eventually help regenerate hair in people.

Xu said this achievement with iPSC-derived epithelial stem cells does not mean that a treatment for baldness is around the corner. Hair follicles contain both epithelial cells and a second type of adult cells called dermal papillae.

“When a person loses hair, they lose both types of cells,” Xu said. “We have solved one major problem — the epithelial component of the hair follicle. We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet.”

Experts also note that studies conducted in animals often fail when tested in humans.

via Stem Cell-based Baldness Cure One Step Closer | Beyond the Dish.

Vitamin C boosts the reprogramming of adult cells into stem cells « Health Research Report

In STEM CELLS IN THE NEWS on January 24, 2014 at 8:05 am

November 8, 2012

Vitamin C boosts the reprogramming of adult cells into stem cells 1

http://www.nutraingredients-usa.com/var/plain_site/storage/images/publications/food-beverage-nutrition/nutraingredients-usa.com/research/vitamin-c-rda-should-be-doubled-says-linus-pauling-institute-researcher/6914603-1-eng-GB/Vitamin-C-RDA-should-be-doubled-says-Linus-Pauling-Institute-researcher_strict_xxl.jpg

Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells.

Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes. Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.

“The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it. Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated,” explains senior study author Dr. Duanqing Pei from the South China Institute for Stem Cell Biology and Regenerative Medicine at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.

Dr. Pei and colleagues measured the production of reactive oxygen species or ROS during reprogramming and discovered a potential link between high ROS and low reprogramming efficiency. They became particularly interested in antioxidants, hypothesizing that they might suppress ROS and cell senescence, which seems to be a major roadblock for the generation of iPSCs.

The researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells. Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state. Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence.

“Our results highlight a simple way to improve iPSC generation and provide additional insight into the mechanistic basis of reprogramming,” concludes Dr. Pei. “It is also of interest that a vitamin with long-suspected anti-aging effects has such a potent influence on reprogramming, which can be considered a reversal of the aging process at the cellular level. It is likely that our work may stimulate further research in this area as well.”

via Vitamin C boosts the reprogramming of adult cells into stem cells « Health Research Report.

Stem Cell Transplantation in Traumatic Spinal Cord Injury

In STEM CELLS IN THE NEWS on January 23, 2014 at 5:59 pm

Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

http://www.accesssportsmed.com/wp-content/uploads/2011/03/spine_large.jpg

From http://www.plosbiology.org – January 6, 7:09 AM

Spinal cord injury is an important cause of disability in young adults, and stem cells have been proposed as a possible treatment. Here we systematically assess the evidence in the scientific literature for the effectiveness of stem-cell–based therapies in animal models of spinal cord injury.

Ella Buzhor\’s insight:

The comparison between multiple allogeneic stem cell treatments revealed improved both motor and sensory function in SCI animal models. Differentiation prior to implantation and IV route of cell administration yielded better outcomes.

via Cell Therapy & Regenerative Medicine | Scoop.it.

Pluristem stem cell trial to treat muscle injury meets main goal | Reuters

In STEM CELLS IN THE NEWS on January 22, 2014 at 5:32 pm
  • cells were safe and well tolerated
  • one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group.
  • Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.
  • An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated…versus the placebo group.

Pluristem stem cell trial to treat muscle injury meets main goal

TEL AVIV Tue Jan 21, 2014 3:07am EST

(Reuters) – Pluristem Therapeutics Inc said results from its early/mid-stage clinical trial indicated its placenta-derived stem cells for the treatment of muscle injury were safe and provided evidence the cells might be effective in treating orthopedic injuries.

\”Patients treated with PLX-PAD had a greater improved change of maximal voluntary muscle contraction force than the placebo group,\” Israel-based Pluristem said in a statement on Tuesday.

The trial was conducted at the Orthopedic Clinic of the Charite University Medical School under the auspices of the Paul-Ehrlich-Institute, Germany\’s health authority.

\”This was a very important study not only for Pluristem but for the cell therapy industry in general,\” Pluristem chief executive Zami Aberman said. \”Based on these results, we intend to move forward with implementing our strategy towards using PLX cells in orthopedic indications and muscle trauma.\”

The injured muscle studied was the gluteus medius muscle in the buttock. Total hip replacement surgery via the standard transgluteal approach necessitates injury of the gluteus medius muscle, and post-operative healing is crucial for joint stability and function.

\”The study showed that PLX-PAD cells were safe and well tolerated,\” the statement said.

The primary efficacy endpoint of the study was the change in maximal voluntary isometric contraction force of the gluteal muscle six months after surgery.

Efficacy was shown in two groups treated with the cells, with one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group. Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.

An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated with PLX-PAD cells versus the placebo group.

via Pluristem stem cell trial to treat muscle injury meets main goal | Reuters.

MS patient to take part in pioneering experiment – CBS News

In STEM CELLS IN THE NEWS on January 21, 2014 at 1:42 pm

No mention of the words “stem cell” in the headline.  No mention of stem cells until the 6th paragraph.  Why make it so difficult for patients to find these articles? In any case, we eagerly await the results! -dg

“Stem cells can be morphed into any cell in the body. Patients like Quinn have bone marrow removed and the stem cells inside are then changed in the kind of stem cells found in the brain and spinal cord.

Those cells will then be injected directly into the spinal cord. The hope is that they will repair the insulation and perhaps even the wires underneath.”

via MS patient to take part in pioneering experiment – CBS News.

 

RELATED ARTICLES:

  • FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis

“To my knowledge, this is the first FDA-approved stem cell trial in the United States to investigate direct injection of stem cells into the cerebrospinal fluid of MS patients, and represents an exciting advance in MS research and treatment,” said Dr. Saud A. Sadiq, Senior Research Scientist at Tisch MS Research Center of New York and the study’s principal investigator.

The groundbreaking study will investigate a regenerative strategy using stem cells harvested from the patient’s own bone marrow.  These stem cells will be injected intrathecally (into the cerebrospinal fluid surrounding the spinal cord) in 20 participants who meet the inclusion criteria for the trial.  This will be an open label safety and tolerability study.  All study activities will be conducted at the Tisch MS Research Center and affiliated International Multiple Sclerosis Management Practice (IMSMP).”  via http://www.prnewswire.com/news-releases/fda-approves-stem-cell-clinical-trial-for-multiple-sclerosis-219553021.html

  • Meredith Vieira’s Family Health Battle

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?

STEM CELLS FIX HEART 5 YEARS AGO

In VICTORIES & SUCCESS STORIES on November 17, 2013 at 9:18 am

AN UPDATE ON JAMES 11/17/2013

 “i have been doing manual labor with my dads company the heart is doing well im getting in better shape every week.

im to the piont now i can carry 5 gallon buckets of concrete up hills lol, pretty cool still
in a few days it will be my 6 year anniversary and still no reversion!!”
success

2006

Case Study: James Eilert, 34 years old, presents with a “widowmaker” [100 % blockage of the left ascending coronary artery]. His ejection fraction (EF – volume of blood his heart pumps out) was between 20 and 25 percent (55 is normal). His cardiologist told him he has about 5 years left to live.  James left the country in order to receive Adult Stem Cell treatment.

1 1/2 weeks after treatment – Echocardiogram revealed that his completely dead apex was beating again.

6 months after treatment – Sidewalls of heart beat normally.  Septum went from 100% damage to 30% damage. Cardiologist confirms James’ heart is 50 percent more elastic than the year before Repair Stem Cell therapy.

6 – 9 months after treatment – James’ total dead heart tissue is down to about 10%.  EF is up to 50%!

4 years later – James’ heart and health continue to improve. He continues to push himself and his limits.  He runs regularly, works 7 days a week and can bike 20 miles .

Summation:

James went from Class III congestive heart failure to Class I with an ejection fraction (EF) increase from ~20-25% to his current EF of 50%.  His doctors have lifted all restrictions and limitations on his physical activities.

James is only one of many adult stem cell treatment success stories…

November 17, 2011 Update:

A letter from James.  How is he doing today?

“its amazing how fast reality can change, the differences that you see in others that they dont notice themselves. the changes in attitudes and perceptions that the “new” was never in doubt and is accepted as if it were always true. the new studies showing the truth about adult stem cell heart treatments the last few months have proven that we the few pioneers that have made huge financial sacrifices to try and save our lives were not crazy, stupid or otherwise deluded!

it was a risk and for the last four years despite proving over and over by running uphill on so many treadmills my improvments were basically ignored by cardiologists, general practitioners, and even my own wife and stepdaughters.

that i am happy to say has changed!!!!

i went to see my doctor yesterday, he told me to start heavy weight training and interval running, to help me lose weight better. what was differnet? nobody has told me to do that since my heart attack, there was no mention of taking it easy, in fact before i was told to only do light weights and take it easy, watch my heart rate, dont push past 150bpm ever.

it was like i never even had a heart attack.

i asked in disbelief if i should watch my heart rate, keep it a safe zone. the answer “no, stick to 85 to 90 percent and youll be fine, your exercise scores and echos show you can handle it”

vindication, no longer an unexplained anamoly, just a patient that responded better than average to a new treatment – like it was always true in thier minds, never a doubt.

what a feeling!! it has taken ten years to go from the “fringe” to the mainstream - i look forward to getting treatments here in america, and i’m so happy i took the risk that now ensures i will be alive to reap the benifits when it becomes available here!

have a good day david – it nice to be right once in a while!
jim eilert

Congratulations as always Jim!  On your heart recovery success and on having the courage to be a pioneer with an adult stem cell treatment that was cutting edge around the world 5 years ago and is still barely know today in the USA! – David

Stem cell scarring aids recovery from spinal cord injury

In VICTORIES & SUCCESS STORIES on November 5, 2013 at 2:45 pm

Scarring created by stem cells at the site of spinal cord injury actually assists in healing, instead of impeding it as previously thought! -dg

Stem Cell Scarring Aids Recovery from Spinal Cord Injury

Oct. 31, 2013 — In a new study, researchers at Karolinska Institutet in Sweden show that the scar tissue formed by stem cells after a spinal cord injury does not impair recovery; in fact, stem cell scarring confines the damage. The findings, which are published in the scientific journal Science, indicate that scar tissue prevents the lesion from expanding and helps injured nerve cells survive…

Stem cell scarring aids recovery from spinal cord injury.

DOES GOD WANT ME TO HEAL?

In OFF THE BEATEN PATH, STEM CELLS IN THE NEWS on April 17, 2013 at 12:53 pm

To Heal jesus

ARE ADULT STEM CELLS, GOD’S HEALING POWER?

VERBOSE AND RANDOM MUSINGS ON GOD, RELIGION, STEM CELLS, HEALTH & THE INEVITABLE

(A 1/4 baked secular and slightly irreverent but meaning no disrespect hypothesis of what God wants us to do when we get sick)

—————————————————-

A religious friend questions her activity in a group on Longevity:
“I really don’t know why I’m in this. Aging is a natural thing. We are all meant to die when god chooses.. anything we do or say will never change that. Life goes how it wants to, and no research is going to change that.”

I responded:

You bring up an interesting question.  I respect your opinion and share my own. For the sake of this exploration, let’s assume God exists and we all agree on how to define him…

You wrote, “We die when God chooses.”

If God brings us into life and chooses our death then I would guess you are presuming that God is omniscient and omnipotent.  If that’s the case, then your entire life too is pre-destined and you have no choice in any of your decisions.  This is fatalism.  In fact, this is absolute fatalism when you give it all up and allow God to take responsibility for everything that happens to you.  This takes all responsibility out of our hands.

The next are controversial hot buttons no doubt but we can only assess the value in a philosophy or “ism” if we push ourselves and them to the extreme.  So, with an omniscient and omnipotent God and a fatalist interpretation, everything happens as it was fated.  The woman gets an abortion only as she was fated to do.  The serial murderer kills again only as he was fated to do.  The Uncle rapes the niece as it was fated.  And we can all just sit back and take no responsibility for anything that happens to us or around us.  That can’t be right.

Perhaps you feel you can interpret God’s intentions and make decisions on behalf of his intentions for yourself.  On the one hand you have no say, on the other you can not only see the pattern in God’s mysterious works but also interpret them and affect change in your life based on your interpretations of them.  So you feel you can analyze and understand the intentions of an omniscient and omnipotent being?  Do you know how limited our vision is, figuratively and literally?  DO you know that we see less than 1% of the electromagnetic spectrum.  In fact, we see only about 0.00018% of it in our limited visible spectrum.  The rest of our senses are equally pathetic. SO we are “aware” of an infinitesimal amount of what is really going on. We are completely unprepared and incapable.  For sure, God works in mysterious ways because we only see a trillionth of a fraction of  what he does in the universe.  Einstein said: “trying to understand the universe is like trying to understand an entire deck of cards when you can only see one.”  He understood the folly of that hubris-tic exercise and he was pretty smart by any standards. The narcissism inherent in this is mind boggling. So that can’t be right.

Should we accept our fates or should we try to change them?  Fatalism is a philosophical construct that fails when applied to practical living.  Will you lie down in traffic, secure in your knowledge that if God intended you get run over by a bus, you will get run over by a bus?  Conversely, if God’s intent is for you to live, no number of buses running over you will cause your demise?  No?  Then you are already choosing to abandon fatalism and partaking in actions which hedge your bets against God’s intended destiny for you or fate.  So that can’t be right.

Are you so special that God spends his time on deciding your fate?  Is it the big stuff, like life or death with a big empty space in the middle or does he decide every single event, like if you get a dust mote in your eye or an uncomfortable wedgie from sitting on the bus too long?  Has God put that pimple on your nose before Church?  Don’t use make up, your are covering God’s intent.  So that can’t be right.

“Life goes how it wants to.”

Do you mean God created your life which proceeds according to his plan?  You are giving up all free choice and we are back to the fatalism argument.  Did God intend for a child to be born with a disease or contract a disease and if so, should we allow that to proceed without intervening.  Should a simple infection from a splinter be allowed to spread, become gangrenous and cause death.  The next time you trip, should you keep your hands at your sides and take that concrete curb full in the teeth?  No.  You can’t.  Your survival instincts kick in, as God intended, one might surmise.  We intervene at every level of every day.  God brought you to this group with it’s interests in Longevity.  Was that not his intention?  Does he intend for you to survive only instinctively or also with forethought and planning and the utilization of that grey matter in your head? I’m thinking the latter.

You remind me of a story:

A man lived by the river. He heard a radio report that the river was going to rush up and flood the town. And that all the residents should evacuate their homes. But the man said, ‘I’m religious. I pray. God loves me. God will save me.’

The waters rose up. A guy in a row boat came along and he shouted, ‘Hey, hey you! You in there. The town is flooding. Let me take you to safety.’ But the man shouted back, ‘I’m religious. I pray. God loves me. God will save me.’

A helicopter was hovering overhead. And a guy with a megaphone shouted, ‘Hey you, you down there. The town is flooding. Let me drop this ladder and I’ll take you to safety.’ But the man shouted back that he was religious, that he prayed, that God loved him and that God will take him to safety.

Well… the man drowned. And standing at the gates of St. Peter, he demanded an audience with God. ‘Lord,’ he said, ‘I’m a religious man, I pray. I thought you loved me. Why did this happen?’

God said, ‘I sent you a radio report, a helicopter, and a guy in a rowboat. What the hell are you doing here?

 ——————————————————————————

I don’t think we should assume everything is pre-destined

I don’t think we should assume we know God’s plan

I don’t think we should assume we should hand over responsibility for our lives

I don’t think we should assume we should hand over responsibility for the manner in which we die

I don’t think we should assume we are so important as to warrant divine intervention

I don’t think we should take a pass on what God has put before us

Perhaps God’s intent was for us to do everything in our power to live well and to live long.  When a child is struck ill with a deadly disease , it is “God’s will.”  Then, when a child is healed from a deadly disease, it is a miracle.  Is it less of a miracle if a motorcycle accident donates the heart needed or a new treatment cures the previously incurable?  Should we not partake of those things because God has a plan?  Shall we make no effort to assist in the extension of a healthy lifestyle?

Adult stem cells are the body’s natural healing system, presumable put there by God.  Shouldn’t we use them?

Doesn’t God want us to live and prosper? He did give us the equipment for it.  A body that heals and a mind that reasons, a world full of healing plants and doctors and scientists who were put here, also by God.  Is it not God’s intent for you to utilize all of the resources at our disposal, including perhaps, the 76,000,000 hits when you google “God” and “healing.”  The Vatican has given their full throated support to adult stem cells and they know a thing or two about God.  Is it not God’s intent for you to eat, to breath, to love, to connect, to perpetuate the species and to live as best as we can for as long as we can, if for no other reason, then to share and illuminate the word and beauty of God to as many as we can for as long as possible.

So this is your radio report, your row boat  and your helicopter.  If you embrace God, you must embrace food, embrace breathing, embrace health, embrace healing, embrace science and embrace longevity.  They are all put here by God for you to enjoy and benefit from.  To ignore them or turn away is as to turn your back on a gift from God.

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