DAVID GRANOVSKY

CROHN’s DISEASE

CROHN’s DISEASE

Autologous haemopoietic stem cell transplantation for autoimmune diseases

M Zeher, G Papp… – Expert Opinion on …, 2011 – informahealthcare.com

in 24 patients with severe, refractory CD [47], The patients‘ symptoms and Crohn’s disease activity
index Cardiovascular disease complications in systemic lupus erythematosus Burt RK, Traynor
A, Statkute L, Nonmyeloablative hematopoietic stem cell transplantation for systemic

Cited by 2Related articlesAll 3 versions

Stem-Cell Transplantation for Refractory Crohn’s Disease

RM Craig… – … , Volume 2: IBD and Crohn’s Disease, 2011 – books.google.com

Regardless of the therapy employed, many patients remain very sick in spite of therapy, after
all therapeutic options have been exhausted.””19 Although not well characterized, a distinct exces
45. hematopoietic stem cell transplantation in severe Crohn’s disease refractory to

 

Hematopoietic stem cell transplantation for curing children with severe autoimmune diseases: Is this a valid option?

A Pession, D Zama, R Masetti… – … Transplantation, 2012 – Wiley Online Library

Diabetes mellitus type 1 (DM1) DM1 is a disease in which pancreatic beta-cells are Mobilization
of peripheral hematopoietic stem cells was performed by the infusion of CY (2 g/ m2 CD34+ cells,
after immunoablative conditioning with CY and ATG followed by stem cell infusion.

 

Various types of stem cells, including a population of very small embryonic‐like stem cells, are mobilized into peripheral blood in patients with Crohn’s disease

W Marlicz, E Zuba‐Surma, M Kucia… – Inflammatory Bowel …, 2012 – Wiley Online Library

Crohn’s disease (CD) is a complex multifactorial inflammatory bowel disease (IBD) and
Interestingly, the autologous hematopoietic bone marrow (BM) SCs transplants as well as infusions
of mesenchymal stem cells (MSCs) turned out to have benefi- cial effects in

Cited by 2Related articlesAll 2 versions

 

Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation

P Hematti, J Kim… – Stem Cells and Human Diseases, 2012 – Springer

2010) Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal
Crohn’s disease: results of 5 Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation
in pediatric patients with severe refractory acute graft-versus-host disease in a

Related articles

 

Cell therapies for inflammatory bowel disease.

J Panés, O García-Bosch, A Salas… – Current drug delivery, 2011 – ukpmc.ac.uk

new biologic agents, the need for intestinal resection in Crohn’s disease (CD)has remained include
stem cell therapies, and selected/conditioned immune cell therapy, such last decade, significant
responses have been documented to hematopoietic stem cells transplantation

CachedAll 2 versions

 

Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation

[PDF] from ebmt.org

JA Snowden, R Saccardi, M Allez… – … Transplantation, 2011 – nature.com

23, 25, 26, 124, 125, 126, 127, 128 The Autologous Stem cell Transplantation International MS
Trial is III study for adult patients with CD supported by European Crohn’s and Colitis the following
consensus criteria for refractory disease (a) corticosteroid-resistant disease, with no

Cited by 6Related articlesAll 4 versions

 

Clinical course of Crohn’s disease following treatment of lymphoma

M El Mourabet, JG Hashash, NH Sun… – Inflammatory Bowel …, 2011 – Wiley Online Library

We sought to characterize the course and recurrence of CD following a diagnosis of lymphoma
to help define prognostic factors and treatment options in this rare but Autologous hematopoietic
stem cell transplantation in patients with refractory Crohn’s disease.

Related articlesAll 2 versions

 

Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease-Implications for Diagnosis and Therapy

[HTML] from gastrojournal.org

D Kotlarz, R Beier, D Murugan, J Diestelhorst… – Gastroenterology, 2012 – Elsevier

options 34. Scime R, Cavallaro AM, Tringali S, et al. Complete clinical remission after high-dose
immune suppression and autologous hematopoietic stem cell transplantation in severe Crohn’s
disease refractory to immunosuppressive and immunomodulator therapy.

 

STEM CELL S & CROHN’S DISEASE

http://repairstemcell.wordpress.com/2009/02/11/stem-cell-s-crohns-disease/

 

New therapy with stem cells to treat Crohn’s disease

http://www.eurekalert.org/pub_releases/2009-02/i-id-ntw021909.php

 

After adult stem-cell treatment, several patients with severe Crohn’s disease at Chicago’s Northwestern Hospital have shown remarkable progress. The patients had failed to respond to standard treatments.

via “Crohn’s Disease: Hematopoietic Stem Cell Transplantation is Option for Patients with Severe CD,” from Blood Weekly, 13 November 2003, p. 23.

Hematopoietic stem cell transplantation for severe Crohn’s disease

RM Craig, A Traynor, Y Oyama… – Bone marrow transplantation, 2003 – nature.com

… group of patients, intense immune suppression followed by autologous hematopoietic stem cell
transplantation (HSCT … each patient entering clinical remission in terms of the Crohn’s Disease
Activity Index … the colon on colonoscopic evaluation persist up to 1 year post-transplant. …

Cited by 78Related articlesBL DirectAll 7 versions

High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease

[HTML] from hematologylibrary.org

RK Burt, A Traynor, Y Oyama… – Blood, 2003 – bloodjournal.hematologylibrary.org

… Farmer RG,; Whelan G,; Fazio VW. . Long-term follow-up of patients with Crohn’s disease. … Medline.
↵: Burt RK,; Slavin S,; Burns WH,; Marmont A. . Induction of tolerance in autoimmune disease
by hematopoietic stem cell transplantation: getting closer to a cure? …

Cited by 71Related articlesBL DirectAll 5 versions

Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells

[HTML] from hematologylibrary.org

A Al-toma, OJ Visser, HM van Roessel… – …, 2007 – bloodjournal.hematologylibrary.org

… Autologous hematopoietic stem cell transplantation (ASCT) is an increasingly accepted effective
treatment option for patients with severe autoimmune diseases refractory to … Autologous
hematopoietic stem cell transplantation in patients with refractory Crohn’s disease. …

Cited by 79Related articlesBL DirectAll 5 versions

Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation

M Ditschkowski, H Einsele, R Schwerdtfeger… – …, 2003 – journals.lww.com

… stem-cell transplantation (SCT) for severe hematologic diseases indicate allogeneic hematopoietic
SCT as a … are consistent with previous case reports of patients with Crohn’s disease or ulcerative …
if allogeneic SCT using innovative conditioning regimens or stem-cell purified, T …

Cited by 118Related articlesBL DirectAll 6 versions

Complete remission of Crohn’s disease after high-dose cyclophosphamide and autologous stem cell transplantation

W Kreisel, K Potthoff, H Bertz… – … marrow transplantation, 2003 – nature.com

… were difficult to treat, we discussed high-dose chemotherapy and aPBSCT with the patient as
a therapeutic option. … Burt RK, Traynor A, Oyama Y, Craig R. High dose immune suppression and
autologous hematopoietic stem cell transplantation in refractory Crohn’s disease. …

Cited by 35Related articlesBL DirectAll 5 versions

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