DAVID GRANOVSKY

Archive for the ‘STEM CELLS IN THE NEWS’ Category

STEM CELLS ARE OUT OF THIS WORLD

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on July 21, 2014 at 4:38 pm

The potential of stem cells to regrow and/or prevent the deterioration of muscle and bone cells over time when subjected to zero gravity has garnered an enormous amount of interest from NASA and the entire space travel industry.   This has lead NASA to send stem cells into space to be researched in low or zero gravity on the space station.   The findings are extraordinary.  “The team discovered that 64 percent of the proteins found in the stem cells grown in simulated microgravity were not in control samples. In particular, the bioreactor cells contained several proteins involved in the breakdown of bone and in the regulation of calcium, neither type of which were found in stem cells grown in regular, Earth gravity.” 

We’ve know for some time that stem cells are smart and capable of:

  • differentiating into whatever cell types are needed without direction
  • growing every cell in a heart and organizing those cells perfectly into where they need to be
  • retro-differentiate into other cell types after finishing work on a particular organ or tissue type
  • traveling back through the umbilical cord from fetus in womb to mother with heart disease to aid the mother in the healing process
  • and many more incredible capabilities

But those actions took place in the patient’s body where the stem cells are able to read the needs of the body with the help of  numerous cues, messenger cells and the entire physiological road map of the patient to guide them.   Essentially, they have an awesome GPS system and just have to follow the directions they are given on roads the GPS “knows” very well.  Conversely, the astro-stem cells (stem cell-nauts?) are able to grow better in space than on earth and to grow with “space relevant capabilities.”  This is incredible.  Imagine going to space for the first time and knowing intrinsically what to do and further, knowing what to do to help your host body better survive and thrive in the conditions of space.  The astro-stem cells are taking cues from their external environment from factors they have never even been exposed to (unless you adhere to the ancient aliens theories) and modifying their proteins and genetic make up to accommodate for the difference in gravity.

What else can they do? If we assume the stem cells will react to the external cues as well as the internal cues, what other factors will they respond to?  We know they grow better in space and in a hyperbaric chamber; what type of response would they have to being underground, on the ocean or under it (long submarine voyages or sub-oceanic colonization), in the dark (increased optic nerve proliferation?), in radioactive areas (radiation resistance)?  Time will tell.  I would say the sky is the limit but apparently, it’s not.

Are we witnessing evolution?
evo·lu·tion  noun \ˌe-və-ˈlü-shən, ˌē-və-\ biology : a theory that the differences between modern plants and animals are because of changes that happened by a natural process over a very long time.  the process by which changes in plants and animals happen over time, a process of slow change and development

No.  Not evolution.  This is faster than the classic definition of evolution.  This is accelerated and positive mutation as a response to external and internal environmental factors.   This is…adaption, rapid adaption…”  Lending support to my analogy that stem cells are born Marines because “Marines are taught to adapt, improvise, overcome…” via

…and the line between science fiction and science reality grows ever thinner.
- David

Growing-stem-cells-in-space

Growing stem cells in space: Medicine’s next big thing

“When challenged by microgravity, living organisms’ genes can ‘turn on,’ transforming growth. Scientists at Zero Gravity Solutions work to direct cells toward healthier, hardier strains. It’s not genetic engineering, but accelerated hybridization.” via http://www.space.com/21885-stem-cells-in-space-can-solve-plant-and-animal-problems-video.html

Date:
March 31, 2014
Source:
Ivanhoe / Powered by NewsLook.com
Summary:
Currently, treatments for hemorrhagic stroke aim to control swelling but not regeneration of the damaged tissue. Now, researchers are using an out of this world idea to help stroke survivors. Video provided by Ivanhoe

http://www.sciencedaily.com/videos/58f619e8b7a37890f1857c84110e7e91.htm

RELATED/SOURCES:

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

- See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

- See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

 

AUTISM TRIAL AT DUKE UNIVERSITY

In STEM CELLS IN THE NEWS on July 18, 2014 at 1:00 pm

http://clinicaltrials.gov/ct2/show/record/NCT02176317
“Umbilical cord blood (UCB) has been shown to lessen the clinical and radiographic impact of hypoxic brain injury and stroke in animal models and in infants with hypoxic ischemic encephalopathy. UCB also engrafts and differentiates in the brain, facilitating neural cell repair in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation. Infusion of autologous UCB does not require immunosuppression and has been shown to be safe in young children with brain injuries such as cerebral palsy and stroke. In this study, the investigators hypothesize that infusion of a patient’s own umbilical cord blood cells (UCB) can offer neural protection/repair in the brain and reduction of inflammation associated with this disorder.”

DUKE STEM CELL AUTISM TRIAL

There’s a lot of skepticism surrounding this trial using cord blood stem cells to treat autism.  Apparently, the concerns are:

1.  Autism is a name given to a whole host of diseases yet to be named, ie. many different symptoms.
Stem cells are part of the natural healing system in the body.  They are smart and migrate to fix damaged tissue and cells.  Stem cells work within your body in conjunction with your physiology.  You can try to train and control them but they have a mind of their own.  For ex: When cardiac stem cells are injected into the heart, they often finish their work and then migrate down to the Pancreas and fix it.  IV implantation is very much in keeping with this idea and relies on the stem cells smart capabilities.  On a certain level, we don’t need to know what is broken.  They do.  A soldier is trained to respond to orders, then told what to do and they damn well do it.  Marines are taught to adapt, improvise, overcome and often sent into battle with limited intel.  When faced with an obstacle, they change their strategy and create a new one to succeed.  Both are very valuable.  Stem cells are born Marines.

2.  We don’t know what causes Autism so we can’t treat it.
The people saying we don’t “know” what causes Autism are the same people who “knew” cardiac cells don’t regenerate, central nervous system cells don’t regenerate, only Embryonic stem cells have value, Margarine is better than Butter, etc. Wrong, wrong, wrong, wrong. 

There are more things in heaven and earth, Horatio,
Than are dreamt of in your philosophy.
– Hamlet (1.5.167-8), Hamlet to Horatio

Our knowledge is incredibly limited.  As time goes on, we learn more and everything we held as inviolate becomes…violated.   Taking into consideration that everything we “know” will be proven wrong in a few decades and then wrong again in another few after that as we learn more…people should probably stop blocking treatments because of what they “know” or in this case, don’t “know.”

This just popped up and I had to add it. Regulation of developmental gene expression occurs in the reverse order to that expected   http://phys.org/news/2014-07-developmental-gene-reverse.html – “…modifications involving Polycomb proteins occur in a manner that contradicts existing models.” 

3.  Stem cells can’t make it into the brain where the damage is.
This is a test for safety of stem cells in Autistic children so efficacy is only a secondary consideration.  Let’s see if they tolerate a small amount of stem cells first before giving them a full dose, though I see no reason why they wouldn’t.   Duke U. is where a number of successful pediatric cord blood/Cerebral Palsy trials were held. http://repairstemcell.wordpress.com/2012/04/10/cerebral-palsy-and-stem-cells/  CP involves the brain.  Stem cells have a history of success with Ataxia, Traumatic Brain injury, etc. etc.

Conclusion:

  • Proof of concept with brain injury and stroke symptoms in animals and infants with hypoxic ischemic encephalopathy.
  • Proof of concept with facilitating neural cell repair in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation.
  • Autologous UCB means no immunosuppression required. 
  • Shown to be safe in young children with brain injuries such as cerebral palsy and stroke.
  • Stem cells are “smart” Marines.
  • Not knowing what causes a problem is no reason to not try to fix it.

That’s a lot of good reasons to forge ahead. 
Plus, tragically, it’s only getting worse out there.

Photo: Prevalence of ASDs with 8 Year olds

 

ADULT STEM CELL EVOLUTION AT A GLANCE

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on July 16, 2014 at 11:03 am

“Beginning in about 1990, the treatment of cardiovascular disease experienced major conceptual expansions through the application of new therapeutic paradigms targeted to angiogenesis and tissue healing. Initial strategies involved administering proteins involved in healing processes, then the genes that encoded them, and then, by the end of the decade, the use of stem cells to better achieve these objectives.” -‘Stem Cell Therapy in Cardiovascular Disease: Past Obstacles and Promising New Directions‘, genengnews.com

Stem Cell Therapy in Cardiovascular Disease: Past Obstacles and Promising New Directions

Adult Stem Cell Evolution At A Glance
Author: Sarah Hoffman

I know many people think that what we know about stem cells is all we have ever known. This is a misconception arising from the fact that people in the United States do not discuss the topic because it could be considered a political no-no-topic. In reality, many scientists from all over the earth research adult stem cells and are finding ways to use them that was never before imaginable. They are also perfecting ways in which we use them to treat patience with varying ailments. This article focuses on cardiovascular diseases.

Scientists began by trying varying methods of stem cell treatment, from utilizing many different types of cells at a time to using very specific cells. Through many studies and trial and error, scientists found that intravenous injection of stem cells to treat many cardiac ailments was effective, efficient, and affordable.

So it seems to me that a routine stem cell treatment may soon be available to cardiac patients.

Take a gander at the whole article and I know some more of your questions are sure to be answered!

Angel Di Maria gets stem cells for World Cup final

In ALL ARTICLES, CELEBRITIES & STEM CELLS, STEM CELLS IN THE NEWS on July 8, 2014 at 11:07 am

Angel di Maria now joins the ranks of professional athletes who turned to stem cell treatments for healing from injury or performance enhancement.  This long list includes such notables as Peyton Manning, Bartolo Colon, Jarvis Green, Kobe Bryant, Andrew Bynum, Tiger Woods (if you believe the rumors) and many more.

 

Atletico Madrid Barcelona Real Madrid Athletic Bilbao Sevilla Villarreal Real Sociedad Valencia Celta Vigo Levante Malaga Rayo Vallecano Getafe Espanyol Granada Elche Almeria Deportivo La Coruña Eibar Córdoba

2014 World Cup / News

Angel Di Maria to undergo stem cell treatment to play the 2014 World Cup final

by Tom Conn | Posted on Monday, July 7th, 2014

Argentine international winger, Angel Di Maria suffered a torn right hamstring in Friday’s 1-0 win over Belgium and despite being ruled out of action for the remainder of the tournament, Di Maria Is undergoing stem-cell treatment in hopes of making the 2014 World Cup final next weekend.

DiMaria

According to Spanish sports daily, AS, Di Maria is so determined to join his teammates, should they reach the World Cup final, that he has decided to undergo stem cell treatment, similar to that used by Diego Costa ahead of the Champions League final, in order to fight for football’s grandest prize.

The medical procedure is used to regenerate damaged cells using the patient’s own healthy cells, with the primary object being to reduce inflammation and repair the torn muscle tissue.

In addition to the treatment, Di Maria will also undergo the standard treatment for this injury; ice, kinesiology, electro pulse stimulation and some rehabilitation exercises in the swimming pool.

LATE STAGE OVARIAN CANCER CURED WITH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 7, 2014 at 1:03 pm

ovarian-cancer-symptoms
Hue Hospital Succeeds in Treating Cancer with Stem Cell

Saigon – Doctors of Hue Central Hospital have used stem cell transplantation to successfully treat a cancer patient of the last stage. The Hue Central Hospital announced on June 26 that its doctors have cured Le Thi Sau, 52, who was suffering ovarian cancer in the last stage, with stem cell transplant. The operation is the success of the scientific project “Using stem cell in breast cancer and cervical cancer” managed by Professor Nguyen Duy Thang, deputy head of the hospital. Adult stem cells have been used to treat certain cancers through bone marrow transplants. In this therapy, the stem cells that give rise to the different blood cells in the body are transplanted into the bone marrow of the patient, where they regenerate the blood. The project was given green light to carry out in the Hue Central Hospital by the Ministry of Science and Technology. Professor Nguyen Duy Thang said the success of this method will pave the way for next operations on breast and ovarian cancer patients. In the time ahead, the hospital continues to treat two other cancer female patients with the stem cell treatment. It is hoped that the treatment will save many cancer patients. (www.saigon-gpdaily.com.vn June 27)

DO ADULT STEM CELLS CAUSE CANCER?

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 1, 2014 at 4:31 pm

NO!

cancer-free-zone

What do you get when you add 1,100 ADULT STEM CELL PATIENTS studied over 5 years,

plus another 1,873 ADULT STEM CELL PATIENTS studied over an average 12.5 years,

plus another ~7,000 ADULT STEM CELL PATIENTS in studies and FDA clinical trials data?

~10,000 ADULT STEM CELL TREATMENT PATIENTS showing NO CANCER!

 

“A total of 1873 patients were treated from 1990 to 2006 with bone marrow-derived concentrated cells. Patients were monitored for cancer incidence from the date of the first operation (1990) until death, or until December 31, 2011. The mean follow-up time was 12.5 years (range, five to twenty-two years)…No tumor formation was found at the treatment sites on the 7306 magnetic resonance images and 52,430 radiographs among the 1873 patients…This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.

The upshot? This most recent study, as well as others, FDA clinical trials data, and the data we have published now amounts to about 10,000 patients who have been treated with adult stem cells and extensively tracked for this issue. There is no evidence that adult stem cells cause cancer. There is no rational reason for the fear, other than a completely different type of cell (ESC) that happens to have a similar name (stem cell) can cause teratomas – hence the confusion!”

Tumors, cancers and teratomas may result from Embryonic stem cell (ESC) treatments or Induced Pluripotent stem cell (iPSC) treatments

but NOT FROM ADULT STEM CELL TREATMENTS.

Sources:

A SIGHT FOR SORE EYES

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on June 28, 2014 at 1:45 pm

20140628-143215-52335093.jpg
A Sight for Sore Eyes
Author: Sarah Hoffman

“Researchers have grown part of an eye in a lab dish, using a type of stem cell made from a piece of skin.

They said the little retina started growing and developing on its own — an important step towards creating custom-tailored organs in the lab.”

Earlier this month scientists successfully created a functioning human retina using iPSCs (induced pluripotent stem cells). But that’s not the cool part. What’s actually amazing is that they did very little to make this happen.

Wait what?! Ok let me explain. These researchers took some of these cells from a tiny little piece of human skin, basically rewound time as far as these cells are concerned and pushed them back to a more-or-less embryonic state, sent signals to some genes manipulating them to form a retina, and then let it do it’s thing. And it was a success! This little retina is living in a dish just sensing light and being a badass little organ. Even the scientists didn’t realize this would happen so naturally

STEM CELLS HIT MAIN STREAM MEDIA!

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 27, 2014 at 9:03 pm

STEM CELLS HIT MAIN STREAM MEDIA! 
On NBC tonight at 8pm EST!

The first stem cell generated windpipe was implanted in 2008.
Six long years later, the technique has been improved significantly and has hit main stream media. 

Image

“Macchiarini’s team began by collecting stem cells from Beyene’s bone marrow. Those cells were mixed with special growth factors and then poured onto a scaffold made from plastic — in fact, the very same plastic that is used to make soda bottles — which had been made to mimic the shape of a real windpipe.  In just a matter of days, the scaffold began to transform into an actual functioning windpipe.”

Some attack those pushing the boundaries, citing that the surgery is experimental and unproven.  But the Dr can’t stand by as patients die when he can do something about it and can’t ignore their pleas for a chance at the hope of recovery.  This is cutting edge of medicine and there are thousands of clinical trials and studies and 10s to 100s of thousands of patients treated, most outside of the US.  There are no guarantees.  There are always risks, even with rigorously tested pharmaceutical drugs and treatment protocols that have been used for decades.  But for chronic and terminal patients who are given no chance for recovery, experimental sounds like a pretty great option.

Historically, new treatments have always been met with resistance.

“Tom Starzl, when he started doing liver transplants, the first seven, eight, nine patients all died. Everybody said he was nuts, OK? Christian Barnard, when he started doing heart transplants, everyone threw rocks at him. This is how we’re going to treat diseases in the future and this is the start of it.”

Anything which pushes the envelop of contemporary knowledge will be rejected by those clinging to traditional concepts…but without pioneering doctors and even more pioneering patients, willing to take risks, medical protocols can not advance.  I salute the doctor and the patients who are the ground-breaking pioneers in the new land of regenerative medicine.  And what can their mutual risk do for the patient and millions to follow?

“One of Macchiarini’s most promising success stories is Claudia Castillo, a Spanish mother who is doing so well six years after her transplant that an increasing number of Macchiarini’s colleagues are beginning to see him in a new light.”

Thank you!

To watch the video and learn more:

http://www.nbcnews.com/health/health-news/leap-faith-desperate-patients-look-lab-grown-organs-n142036

I WISH I WAS PART SALAMANDER

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 25, 2014 at 1:47 pm

http://assets2.motherboard.tv/content-images/contentimage/no-slug/2ca519d978ecda38a2da800fa4c5ab14.jpg

I Wish I Was Part Salamander

Author: Sarah Hoffman

“The secret of how salamanders successfully regrow body parts is being unravelled by UCL researchers in a bid to apply it to humans.

For the first time, researchers have found that the ‘ERK pathway’ must be constantly active for salamander cells to be reprogrammed, and hence able to contribute to the regeneration of different body parts.” -Limb Regeneration: Do Salamanders Hold the Key?‘ ucl.ac.uk

Mystery no more! Scientists now know why us humans are unable to regrow limbs when we lose one, unlike salamanders who are able to regenerate cells and limbs very successfully. The reason has been linked to something called the ERK Pathway, which is basically like one of those tubes you use to pass documents between yourself and the teller at the bank drive-through– except this biological “tube”  is made up of proteins which pass information from the surface of the cell to the DNA at the nucleus. The difference between our ERK Pathway and the salamanders’ is that ours has bank hours, while the salamander has 24/7 fast-food-chain hours. Our pathway is open for a limited time, while the ERK Pathway of a salamander is capable of working all day every day which results in constant cell growth and ultimate limb regeneration. Pretty cool, right?! What’s even cooler is that researchers are trying to figure out if we can force this in humans and other mammals. And so far so good! While we are unable at this point to regrow our limbs like a salamander, these researchers have found out that when our ERK Pathway is forced open our bodies are capable of continuing to grow these cells with the intention of regeneration. But here’s where it takes a turn– our cells become dedifferentiated, meaning that these cells lack the blueprint to turn into a limb, but could potentially be programmed and manipulated into one. In other words, we can get the process going but the process requires further manipulation in order to complete it.

Imagine not having to worry about shutting your fingers in the car door, or accidentally putting your hand in the garbage disposal… pretty neat!

Tens to hundreds of thousands of patients have already been treated with stem cells and the treatments have a high ratio of success but stem cell therapy and regenerative medicine is a relatively new science.  We know a great deal more about WHAT stem cells can fix than we know HOW they fix things on the molecular level…but we are learning very quickly and the therapeutic and healing potential is incredible! 

Sources:

http://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2814%2900150-7

http://www.ucl.ac.uk/news/news-articles/0614/200614-salamander-limb-regeneration

HEMATOPOIETIC STEM CELLS PROTECT AGAINST MYELOPROLIFERATIVE NEOPLASIA

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on June 25, 2014 at 9:14 am

​WHAT CAN’T STEM CELLS DO?

HEMATOPOIETIC STEM CELLS PROTECT AGAINST MYELOPROLIFERATIVE NEOPLASIA

After over 15 years of main stream research around the world (with 50 years of bone marrow/stem cell transplant research and therapies), most people still believe there are only a few sources for stem cells; embryonic, adult and induced pluripotent.

Adult stem cells in particular though, consist of a huge number of stem cell sources: embryos, fetuses, placentas, umbilical cord blood, Wharton’s jelly, endometria, peripheral blood, umbilical cord blood, bone marrow, placentas, adipose or fat tissue, skeletal and cardiac muscle, olfactoric mucosal (nasal neurological), breast milk, dental pulp, lungs and many other sources. Chinese scientists have even generated human teeth from the stem cells found in urine.

 

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Each stem cell source appears to have unique qualities and characteristics which scientists are barely beginning to fully understand. The blood or bone marrow have what are called “hematopoietic stem cells.”

“A hematopoietic stem cell is a cell isolated from the blood or bone marrow that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood…” via

As if hematopoietic stem cells weren’t awesome enough due to their ability to produce cells of the blood and the immune system and destroy unneeded cells, they have an additional benefit which may be even more impressive. Hematopoietic stem cells introduced into the patient’s body also protects against myeloproliferative neoplasia.

Myeloproliferative neoplasm is “a type of disease in which the bone marrow makes too many red blood cells, platelets, or certain white blood cells. Myeloproliferative neoplasms usually get worse over time as the number of extra cells build up in the blood and/or bone marrow. This may cause bleeding problems, anemia, infection, fatigue, or other signs and symptoms. Certain myeloproliferative neoplasms may become acute myeloid leukemia (AML). Myeloproliferative neoplasms include chronic myelogenous leukemia (CML), polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. Also called chronic myeloproliferative neoplasm.” via

As research continues, we learn more and more about the abilities of stem cells and their role as one of the most important healing systems in the human body.

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HEMATOPOIETIC STEM CELLS

Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders

Posted: 22 Jun 2014 11:22 AM PDT

“The protective microenvironment of the hematopoietic stem cell niche, which produces cells of the blood and the immune system, also protects against myeloproliferative neoplasia. Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment…”

 

 

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