DAVID GRANOVSKY

Archive for January, 2012|Monthly archive page

Heart patient’s stem cells harnessed for healing – CBC News

In VICTORIES & SUCCESS STORIES on January 27, 2012 at 1:26 pm
Not bad. They are only a half decade behind the times. – DG

Heart patient’s stem cells harnessed for healing

Some heart bypass patients are receiving cardiac stem cell transplants to try to repair damage.

This week, a 67-year-old James Culross from Toronto will be discharged from Toronto General Hospital after having 2.83 million stem cells injected into seven sites where his heart had been damaged by a heart attack in November.

When someone suffers a heart attack, part of the heart muscle dies and is replaced by a scar. In larger heart attacks, the patient can develop heart failure — a weakening of the heart that leaves the patient short of breath, said cardiac surgeon Dr. Terrence Yau of Toronto’s University Health Network.

Heart patient James Culross was the donor and recipient of his own stem cells. Heart patient James Culross was the donor and recipient of his own stem cells. (CBC)

Yau and his colleagues at Toronto General’s Peter Munk Cardiac Centre and Maisonneuve-Rosemont Hospital in Montreal are involved in a clinical trial testing the safety, effectiveness and feasibility of injecting stem cells into the hearts of people having bypass surgery.

“This kind of therapy can improve the function and blood flow of hearts that have been injured by heart attacks most commonly and potentially by other means as well,” said Yau.

About 50,000 Canadians are diagnosed with advanced heart failure each year. On average, men live only 18 months and women three years after diagnosis.

While angioplasty, bypass surgery and stents can prevent new heart attacks, they don’t reverse exisiting damage. A new heart is the only known treatment for that, but transplants are invasive and expensive, and there is a lack of available donor organs.

That’s where the stem cells could come in.

Stem cells taken from marrow

In Culross’s case, the stem cells were taken from the bone marrow in the hip and lower back in the operating suite. After four to six hours, the stem cells were isolated, the bypass grafts done and the stem cells injected back into the damaged areas of his heart.

“I thought it was great,” Culross said of the procedure. “It’s your stem cells, nobody else’s.”

Culross is now working on improving his strength and walking more in the hopes of returning to his auto body repair job.

Since 2010, eight patients have also had the experimental procedure in Montreal.

The Montreal and Toronto teams plan to combine their findings once each has results on 20 patients.

No one knows yet whether the stem cell treatment will improve survival or quality of life by healing the heart.

Investigators worldwide are testing whether giving stem cells after a heart attack works better than existing therapies.

Heart patient’s stem cells harnessed for healing – Health – CBC News.

Faulty French Fake Boob Boss Freed

In ALL ARTICLES on January 27, 2012 at 11:13 am
An undated police mugshot photo shows Jean-Claude Mas, the founder of the French Poly Implant Prothese (PIP) company, displayed on the ''red notice'' posted by Interpol on its website. REUTERS/InterpolFrench implant boss released, faces bodily harm charge
MARSEILLE, France (Reuters) – Jean-Claude Mas, the Frenchman who sparked a global health scare by selling substandard breast implants, was released from police custody on Friday and faces a charge of causing bodily harm, his lawyer said. | Full Article
China cadmium spill threatens drinking water for millions
January 27, 2012 04:45 AM ET
BEIJING (Reuters) – A cancer-causing cadmium discharge from a mining company has polluted a long stretch of two rivers in southern China, and officials warned some 3.7 million people of Liuzhou in the Guangxi region to avoid drinking water from the river, state media reported on Friday. | Full Article
Rivals see no need to match Roche’s big gene bet
January 27, 2012 09:08 AM ET
DAVOS, Switzerland (Reuters) – Roche Holding AG’s rivals Sanofi SA and Novartis AG see no need to match the Swiss drug maker in buying a gene-decoding business like Illumina Inc and reckon they can do partnerships instead. | Full Article
Bill Gates injects $750 million into troubled AIDS fund
January 26, 2012 03:31 PM ET
DAVOS, Switzerland (Reuters) – Microsoft chairman and philanthropist Bill Gates pledged a further $750 million to the troubled global AIDS fund on Thursday and urged governments to continue their support to save lives. | Full Article
James Murdoch to quit GSK board
January 27, 2012 07:56 AM ET
LONDON (Reuters) – News Corp executive James Murdoch, under pressure from a phone-hacking scandal at the News of the World tabloid, is to quit the board of drug maker GlaxoSmithKline to spend more time on his media roles. | Full Article

French implant boss released, faces bodily harm charge.

Men Replaced: Killing Spiders Not Enough

In VICTORIES & SUCCESS STORIES on January 24, 2012 at 4:20 am
Researchers to build artificial testicles for infertile men
San Francisco – Researchers in California are working to build an artificial testicle, a human “sperm-making biological machine,” that can produce human sperm and allow otherwise infertile men to make babies.
According to My Health News Daily, Dr. Paul Turek, director of the Turek Clinic, a men’s health medical practice in San Francisco, says that recent advances show that the idea of treating infertility in male animals by producing sperm using stem cells is feasible. While this has been done successfully in mice, it has not been done in humans.
Turek recently announced on his Turek on Men’s Health site that he has received a government grant to develop a human “sperm-making biological machine.” According to My Health News Daily, Turek and his colleague, Dr. Constance John, chief executive of MandalMed Inc., a biotech company in San Francisco, received a small research grant from the National Institute of Environmental Health Sciences.
Turek says the new “machine” will not be designed to resemble a testicle like non-sperm-producing prosthesis that are saline-filled implant for men who don’t have testicles. Rather, the sperm producing machine will come as a cylindrical bag a few inches in length and will look “like a transparent, over-sized Tootsie Roll.”
Turek on Men’s Health explains: “To be clear, this grant is not about creating a testicular implant for a man who is missing a real one. We did that a decade or so ago. This award is to develop a sperm making biological machine…We now have a couple of years to create human artificial sperm in a dish, or more formally, a ‘bioreactor,’ a fancy dish to be sure.” …

Read more: http://www.digitaljournal.com/article/318149#ixzz1kHKdE2hL

Reuters Health Report – dsgrano@gmail.com – Jan 23, 2012

In ALL ARTICLES on January 23, 2012 at 10:45 am
Korean research, a first step toward Dr. Smartphone?
“We have confirmed that (touch screens) are able to recognize DNA molecules with nearly 100 percent accuracy just as large, conventional medical equipment can and we believe equal results are possible for proteins,” Park told Reuters TV.“There are proteins known in the medical world like the ones used to diagnose liver cancer, and we would be able to see the liver condition of the patient…”
SEOUL (Reuters) – Tired of long waits at the hospital for medical tests? If Korean researchers have their way, your smartphone could one day eliminate that — and perhaps even tell you that you have cancer. | Full Article
U.S. consumers tell insurers to cover experimental drugs

January 23, 2012 09:42 AM ET

If stem cell treatments in the US are experimental, perhaps insurance will one day cover therm…but don’t hold your breath!

NEW YORK (Reuters) – When your health insurance provider denies an experimental treatment or a high-cost drug, how much are you willing to pay for the care you believe you need? | Full Article
Anxiety, other disorders more common in autism
January 23, 2012 02:13 AM ET
NEW YORK (Reuters Health) – Autism tends to go hand in hand with a variety of other mental and behavioral conditions in kids, suggests a new study that highlights the fuzzy nature of autism diagnoses themselves. | Full Article
Man dies of bird flu in southwest China: report
January 23, 2012 09:23 AM ET
BEIJING (Reuters) – A man in southwest China died of bird flu on Sunday after three days of intensive care treatment in hospital, the official Xinhua news agency quoted the Ministry of Health as saying. | Full Article
Fitting fitness inside the cubicle
January 23, 2012 06:29 AM ET
NEW YORK (Reuters) – Whether your office is in the business district or on the dining room table, sitting immobile for hours in front of a computer screen is at odds with the fit body. | Full Article

Reuters Health Report – dsgrano@gmail.com – Gmail.

WHAT IF GERTRUDE STEIN AND MR. ED HAD A STEM CELL BABY…

In VICTORIES & SUCCESS STORIES on January 23, 2012 at 4:01 am

Some articles are not only fascinating but they lend themselves so easily to have a little bit of fun with.  With apologies to both Gertrude Stein and Mr. Ed (and a richly deserved apology to the good Dr. Goodrich):

WHAT IF GERTRUDE STEIN AND MR. ED

LITERALLY HAD A STEM CELL BABY…

The following study researched the effectiveness of bone marrow stem cells taken from 2 different sites on horses – the hip bone (iliac crest) and the sternum.

In the end, there was very little difference between the results of stem cells taken from the two sites.  This information has extremely significant therapeutic relevance as doctors can now focus on other criteria for site selection; ease of extraction, quantity of  cells, proportion of cell types, etc.  Further, this study reinforces the idioms:

“A ROSE IS A ROSE IS A ROSE”

“A STEM CELL IS A STEM CELL IS A STEM CELL”

“A HORSE IS A HORSE, OF COURSE, OF COURSE”

“A HORSE STEM CELL IS A HORSE STEM CELL, OF COURSE, OF COURSE”

Apologies to Will Shakespeare for being odd man out at the dance.  Now to worry; you are gone but not forgotten.

“A stem cell by any other derivation site would smell just as sweet.”

(Four more equine stem cell articles below)

………………

Bone Marrow-Derived Stem Cell Sources Compared (AAEP 2011)

Stem cell source site has been debated among researchers in recent years as stem cells have been gaining popularity in equine medicine. A research group at Colorado State University recently compared the use of bone marrow-derived mesenchymal stem cells from two sites on the horse’s body to determine which might be most effective for treating specific soft tissue injuries. Laurie Goodrich, DVM, PhD, Dipl. ACVS, presented results at the 2011 American Association of Equine Practitioners Convention, held Nov. 18-22 in San Antonio, Texas.

According to Goodrich, stem cells are particularly useful for treating tissues such as joints and tendons-these tissues lack regenerative capability due to a deficiency in local stem cell response. Stem cells have been derived from adipose tissue (fat) and bone-marrow. However, for tendon healing, bone marrow-derived cells yield better matrix and collagen production, she noted.

The research team compared bone marrow-derived mesenchymal stem cells (BM-MSCs) from the two most common extraction sites in the horse: the sternum (breastbone) and the ilium (hip). For BM-MSC therapy to be effective, Goodrich said two aspects are crucial: using large numbers of cells (roughly 5-10 million cells/centimeter in tendon and 5-10 million cells/joint) and implanting the cells early during the critical period between the inflammatory and fibroblastic phases of healing.

Goodrich discussed previously noted advantages and disadvantages for each site:

For the sternum:

  • Advantages
    • The bone marrow aspirate flows better into the syringe;
    • The amount of aspirate is not influenced by age of the horse; and
    • Cells are easier to collect.
  • Disadvantages:
    • The site is close to vital structures (heart, lungs); and
    • The collector must crouch under the horse.

For the ilium:

  • Advantages
    • Practitioner doesn’t have to crouch while obtaining cells; and
    • There’s no risk of jabbing the heart or lungs.
  • Disadvantages
    • It’s more difficult to get adequate cell volume;
    • The sample size is age-dependent; and
    • Ilial samples often result in unsuccessful culture.

Explore the power of the human-horse connection as you travel the emotional journey that veterinarians at Rood and Riddle Equine Hospital and owners embark on when a beloved horse becomes ill in Equine ER

Researchers and clinicians had also noticed that the cells from sternal samples appeared different from those in ilial bone marrow samples.

Goodrich’s study sought to provide clinicians with better information to guide selection site and on whether the health of the MSCs varied between separate samples or (fractions) of bone marrow drawn from a site at one time. Goodrich and her co-authors examined two sequential 5 mL samples from both sternal and ilial bone marrow aspirates of seven horses (they “plated” cells from the sample/grew them in culture, referred to as a “passage”). They found that:

  • The first fractions of both samples yielded the highest cell counts;
  • The cells of the first fraction were no healthier than those of the second;
  • The health of the sternal and ilial samples was the same;
  • By the second and third culture passages, cell morphologies were similar between the two sites; and
  • Aspirates greater than 5-10 mL produced insignificant increases to the nucleated cell count.
  • Goodrich noted the following limitations to the study:
  • A relatively small number of horses was used;
  • There was some variability in age and gender of the horses; and
  • They didn’t calculate the cell-doubling times, although the measurement of cell numbers at each passage was more relevant.

Goodrich’s team concluded that bone marrow aspiration site should depend on clinician preference, since the cells of one site do not appear to be superior to the other.

via The Horse | Bone Marrow-Derived Stem Cell Sources Compared (AAEP 2011).

OTHER EQUINE STEM CELL ARTICLES:

Lions and puppys and horseys, oh my! « The Stem Cell Blog

repairstemcell.wordpress.com/…/lions-and-puppys-and-horseys-oh-m…

Mar 7, 2009 – http://repairstemcell.wordpress.com/2009/02/27/horse-racing-horse-racing-samantha-miss-has-stem-cell-treatment/

ANIMALS + STEM CELLS « The Stem Cell Blog

repairstemcell.wordpress.com/animals-stem-cells/

http://repairstemcell.wordpress.com/2009/02/27/equine-clinic-is-full-service-care-for-hoofed-friends-thecaliforniancom-the-salinas-californian/

GERON GIVES UP on EMBRYONIC STEM CELLS! « The Stem Cell …

repairstemcell.wordpress.com/…/geron-gives-up-on-embryonic-stem-…

Nov 14, 2011 – If Embryonic treatments were a horse race, Geron would be the strongest ….. repairstemcell.wordpress.com/2009/02/18/jewish-law-articles-the-

KCBS – Stem Cell Research on Horses Holds Promise for Human …

repairstemcell.wordpress.com/…/kcbs-stem-cell-research-on-horses-h…

May 20, 2009 – http://repairstemcell.wordpress.com/2009/02/27/equine-clinic-is-full-service-care-for-hoofed-friends-thecaliforniancom-the-salinas-californian/

DO SOMETHING TODAY THAT YOUR FUTURE SELF WILL THANK YOU FOR.

In QUOTE OF THE DAY on January 23, 2012 at 4:00 am

What should I do today?

.

.

.

.

It kind of says it all, doesn’t it!

CellNEWS: Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury

In VICTORIES & SUCCESS STORIES on January 22, 2012 at 9:20 am

“In this study, we found that our stem cell transplantation both prevents further axonal injury and promotes axonal regrowth, through a number of previously unknown molecular mechanisms.”

http://trialx.com/curetalk/wp-content/blogs.dir/7/files/2011/06/Tramautic_Brain_Injury.jpg

Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury  
Friday, 13 January 2012

For years, researchers seeking new therapies for traumatic brain injury have been tantalized by the results of animal experiments with stem cells. In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has remained a mystery.

Now, an important part of this puzzle has been pieced together by researchers at the University of Texas Medical Branch at Galveston. In experiments with both laboratory rats and an apparatus that enabled them to simulate the impact of trauma on human neurons, they identified key molecular mechanisms by which implanted human neural stem cells — stem cells that are in the process of developing into neurons but have not yet taken their final form — aid recovery from traumatic axonal injury.
A significant component of traumatic brain injury, traumatic axonal injury involves damage to axons and dendrites, the filaments that extend out from the bodies of the neurons. The damage continues after the initial trauma, since the axons and dendrites respond to injury by withdrawing back to the bodies of the neurons.
“Axons and dendrites are the basis of neuron-to-neuron communication, and when they are lost, neuron function is lost,” said UTMB professor Ping Wu, lead author of a paper on the research appearing in the Journal of Neurotrauma.

“In this study, we found that our stem cell transplantation both prevents further axonal injury and promotes axonal regrowth, through a number of previously unknown molecular mechanisms.”

 

Read more: CellNEWS: Scientists Learn How Stem Cell Implants Help Heal Traumatic Brain Injury.

HEARTS and KNEES – Patient, heal thyself | sciencebuz

In VICTORIES & SUCCESS STORIES on January 21, 2012 at 9:20 am

“The first study…uses stem cell therapy to repair heart tissue damaged by coronary heart disease. Of the 16 patients injected with autologous CSCs, 14 showed an increase in Left Ventricular Ejection Fraction (LVEF)…In seven of the patients, infarct (dead tissue) size decreased by 24 % at the end of 4 months, and a further 6 % at the end of a year. Both these results indicate CSCs had a positive impact on heart tissue regeneration.

The second study…focuses on using autologous stem cell therapy for repair of torn meniscal tissue…The “Cell Bandage” from Azellon will use patients own, expanded stem cells, harvested from the bone marrow…will grow into new menisci-type cells and heal the tear. The results of in vitro trials have so far been very promising. Phase I clinical trials are set to begin May 2012.”

http://www.designmom.com/wp-content/uploads/2011/02/5417124292_6a49ef3983.jpg

Two reports in the press this week focus on the use of autologous (patient’s own) stem cells for repair of damaged tissue.

The first study, led by Professor Roberto Bolli, of the University of Louisville, reports on early findings of a phase I clinical trial, which uses stem cell therapy to repair heart tissue damaged by coronary heart disease. Cardiac tissue, harvested from the patient during surgery, was used to  isolate autologous cardiac stem cells (CSCs). CSCs were grown in the laboratory till their numbers reached around 2 million cells. At this stage the cells were re-injected back at the site of tissue damage.

Of the 16 patients injected with autologous CSCs, 14 showed an increase in Left Ventricular Ejection Fraction (LVEF) – the amount of blood a left ventricle pumps through the aorta during each contraction of the heart, 4 months after infusion. In seven of the patients, infarct (dead tissue) size decreased by 24 % at the end of 4 months, and a further 6 % at the end of a year. Both these results indicate CSCs had a positive impact on heart tissue regeneration.

The second study, led by Professor Anthony Hollander, of Azellon Ltd, a University of Bristol spin-out company, focuses on using autologous stem cell therapy for repair of torn meniscal tissue. The menisci are found at the knee joints, and they act as shock absorbers for the knee. This tissue is often damaged as a result of sport-related injury, especially contact sports such as football or rugby.

Current treatment options include knee arthroscopy surgery, which involves removing part or whole of the damaged meniscal tissue. This reduces the shock-absorbing properties at the knee joint and leaves the patient vulnerable to early-onset osteoarthritis, eventually followed by total knee replacement.

The “Cell Bandage” from Azellon will use patients own, expanded stem cells, harvested from the bone marrow. These cells are seeded onto a special biocompatible membrane, which will be inserted at the site of damage using a simple surgical procedure.  Given the right conditions, the hope is that stem cells will grow into new menisci-type cells and heal the tear. The results of in vitro trials have so far been very promising. Phase I clinical trials are set to begin May 2012.

Patient, heal thyself | sciencebuz.

CELEB DOCTOR VICKI BELO GETS STEM CELLS

In CELEBRITIES & STEM CELLS on January 20, 2012 at 9:29 am

…if her face looks even more younger and radiates with more glow these days, there’s a more potent elixir for the 55-year-old celebrity doctor, in addition to the daily doses of Hayden that she is taking, to thank for, and it is called stem-cell treatment

Vicki Belo confesses

 

 

THE interview was supposed to last no more than 15 minutes, but Vicki Belo revealed such compelling anecdotes about her lover Hayden Kho and her colorful career that executive producer Giselle Ordinario and director Monti Parungao there and then decided to devote the entire 30-minutes of Cocktales talk show to the celebrity dermatologist.Did you know that Vicki, for instance, had tried to match Hayden with her daughter Cristalle, even setting up a date for the two?

 

But no matter how hard her mother pushed, Cristalle was not smitten by the good-looking doctor, preferring her Lebanese boyfriend instead. As it turned out, it was actually the mother, as we now know, who has the hots on her daughter’s date.

Lest we get ahead of the show, check out the Vicki Belo episode this Sunday, a Christmas Day special, at 9:30 p.m. on AksyonTV. Watch Vicki’s body language when she starts talking about Hayden, especially when asked about the May-December affair.

And if her face looks even more younger and radiates with more glow these days, there’s a more potent elixir for the 55-year-old celebrity doctor, in addition to the daily doses of Hayden that she is taking, to thank for, and it is called stem-cell treatment…

 

read more

CellNEWS: Bone Marrow-derived Cells Differentiate in the Brain through Mechanisms of Plasticity

In VICTORIES & SUCCESS STORIES on January 20, 2012 at 9:19 am

“This study shows a potential new contribution of bone marrow derived cells following transplantation into the brain, making these cells highly versatile, in their ability to both differentiate into and fuse with endogenous neurons

Bone Marrow-derived Cells Differentiate in the Brain through Mechanisms of Plasticity
Monday, 19 December 2011

Bone marrow-derived stem cells (BMDCs) have been recognized as a source for transplantation because they can contribute to different cell populations in a variety of organs under both normal and pathological conditions. Many BMDC studies have been aimed at repairing damaged brain tissue or helping to restore lost neural function, with much research focused on BMDC transplants to the cerebellum at the back of the brain. In a recent study, a research team from Spain has found that BMDCs, can contribute to a variety of neural cell types in other areas of the brain as well, including the olfactory bulb, because of a mechanism of “plasticity”.
Their results are published in the current issue of Cell Transplantation (20:8).
“To our knowledge, ours is the first work reporting the BMDC’s contribution to the olfactory neurons,” said study corresponding author Dr. Eduardo Weruaga of the University of Salamanca, Spain.
“We have shown for the first time how BMDCs contribute to the central nervous system in different ways in the same animal depending on the region and cell-specific factors.”
In this study, researchers grafted bone marrow cells into mutant mice suffering from the degeneration of specific neuronal populations at different ages, then compared them to similarly transplanted healthy controls. An increase in the number of BMDCs was found along the lifespan in both experimental groups. Six weeks after transplantation, however, more bone marrow-derived microglial cells were observed in the olfactory bulbs of the test animals where the degeneration of mitral cells was still in progress. The difference was not observed in the cerebellum where cell degeneration had been completed.
“Our findings demonstrate that the degree of neurodegenerative environment can foster the recruitment of neural elements derived from bone marrow,” explained Dr. Weruaga.
“But we also have provided the first evidence that BMDCs can contribute simultaneously to different encephalic areas through different mechanisms of plasticity – cell fusion for Purkinje cells – among the largest and most elaborately dendritic neurons in the human brain – and differentiation for olfactory bulb interneurons.”
Dr. Weruaga noted that they confirmed that BMDCs fuse with Purkinje cells but, unexpectedly, they found that the neurodegenerative environment had no effect on the behavior of the BMDCs.
“Interestingly, the contribution of BMDCs occurred through these two different plasticity mechanisms, which strongly suggests that plasticity mechanisms may be modulated by region and cell type-specific factors,” he said.
“This study shows a potential new contribution of bone marrow derived cells following transplantation into the brain, making these cells highly versatile, in their ability to both differentiate into and fuse with endogenous neurons” said Dr. Paul R. Sanberg , coeditor-in-chief of Cell Transplantation and distinguished professor of Neuroscience at the Center of Excellence for Aging and Brain Repair, University of South Florida.
Source: Cell Transplantation Center of Excellence for Aging and Brain Repair

Contact: David Eve

Reference:

Bone Marrow Contributes Simultaneously to Different Neural Types in the Central Nervous System Through Different Mechanisms of Plasticity
Recio, J. S.; Álvarez-Dolado, M.; Díaz, D.; Baltanás, F. C.; Piquer-Gil, M.; Alonso, J. R.; Werunga, E.
Cell Transplant. 20(8):1179-1192; 2011

CellNEWS: Bone Marrow-derived Cells Differentiate in the Brain through Mechanisms of Plasticity.

Follow

Get every new post delivered to your Inbox.

Join 2,994 other followers

%d bloggers like this: