DAVID GRANOVSKY

Man appears free of HIV after stem cell transplant – FOR 3 YEARS!

In STEM CELLS FROM THE PAST, VICTORIES & SUCCESS STORIES on December 10, 2010 at 7:43 am
Man appears free of HIV after stem cell transplant – FOR 5 YEARS! …and now there are TWO MORE HIV FREE PATIENTS!!!
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UPDATE TO STORY!!  Jul 26, 2012 3:06pm
Two More Patients HIV-Free After Bone Marrow Transplants

http://repairstemcell.wordpress.com/2012/09/12/two-more-patients-hiv-free-after-bone-marrow-transplants-abc-news/

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THE SIMPLE STORY

  1. 42 year old man has leukemia.
  2. 42 year old man also has HIV.
  3. Man needs bone marrow transplant for leukemia.
  4. Creative doctor uses bone marrow from “retrovirus resistant” donor (the donor can NOT get HIV due to a genetic mutation).
  5. Procedure costs about $150,000 (“retrovirus resistant” donors are very rare and very hard to find).
  6. 42 year old man’s body “TAKES ON” the retrovirus resistance from the donor’s bone marrow.
  7. 42 year old man’s symptoms go away and stay away for one year, two years, 3 years, 4 years  next month.
  8. 42 year old man is now a 46 year old man with no leukemia and no HIV to be found in his body.

SOME DETAILS

  • Doctors have not been able to detect the virus in his blood since about Jan of 2007.
  • In this case, there were 80 compatible blood donors living in Germany and on the 61st sample tested, they found one with the “retrovirus resistant” mutation from both parents.
  • There were no embryonic stem cells involved in this.  The stem cells in bone marrow are adult stem cells only.  Any time you see the words “treated” or “improved” or “recovered” associated with the words “stem cells”, assume it was from adult or repair stem cells until proven otherwise. http://repairstemcell.wordpress.com/stem-cells-for-newbies/

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STEM CELLS AND HIV – SOME PRE-HISTORY

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HISTORY OF THIS STORY (scroll down for full articles below)

  1. The original article that got almost no coverage is from Wall Street Journal – Nov 2008
  2. This article was then posted here in Feb 2009http://repairstemcell.wordpress.com/2009/02/20/stem-cells-hiv-part-2-a-doctor-a-mutation-and-a-potential-cure-for-aids-wsjcom/
  3. The abstract of the case was posted in the New England Journal of Medicine in Feb 2009 – See abstract below
  4. One of the most recent articles was in foxnews.com Dec 2010

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THE NOVEMBER 7, 2008 STORY

A Doctor, a Mutation and a Potential Cure for AIDS – A Bone Marrow Transplant to Treat a Leukemia Patient Also Gives Him Virus-Resistant Cells; Many Thanks, Sample 61

“A 42-year-old HIV patient with leukemia appears to have no detectable HIV in his blood and no symptoms after a stem cell transplant from a donor carrying a gene mutation that confers natural resistance to the virus that causes AIDS, according to a report published Wednesday in the New England Journal of Medicine.”

WHAT REALLY HAPPENED?

The startling case of an AIDS patient who underwent a bone marrow transplant to treat leukemia is stirring new hope that gene-therapy strategies on the far edges of AIDS research might someday cure the disease.

The patient, a 42-year-old American living in Berlin, is still recovering from his leukemia therapy, but he appears to have won his battle with AIDS. Doctors have not been able to detect the virus in his blood for more than 600 days, despite his having ceased all conventional AIDS medication. Normally when a patient stops taking AIDS drugs, the virus stampedes through the body within weeks, or days.

[Dr. Gero Hutter]
Sixten Koerper
Dr. Gero Hütter isn’t an AIDS specialist, but he ‘functionally cured’ a patient, who shows no sign of the disease.

“I was very surprised,” said the doctor, Gero Hütter.

The breakthrough appears to be that Dr. Hütter, a soft-spoken hematologist who isn’t an AIDS specialist, deliberately replaced the patient’s bone marrow cells with those from a donor who has a naturally occurring genetic mutation that renders his cells immune to almost all strains of HIV, the virus that causes AIDS.

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THE December 14, 2010 STORY

Doctors Claim HIV-Positive Man Cured by Stem Cell Transplant

Published December 14, 2010 – | FoxNews.com

There’s an estimated 33 million people worldwide living with HIV/AIDS, and now doctors believe one of them may have been cured of the virus after receiving a stem cell transplant in 2007, the medical journal Blood reported.

Timothy Ray Brown, an HIV-positive American living in Germany, had leukemia and was undergoing chemotherapy, when he received a transplant of stem cells from a donor carrying a rare, inherited gene mutation that seems to make carriers virtually immune to HIV infection.

The transplant appeared to wipe out both diseases, giving hope to doctors, but Dr. Anthony Fauci, director of the National Institutes of Allergy and Infectious Diseases, who has been studying HIV/AIDS for almost 30 years, said while this is an interesting proof of concept, it’s absurdly impractical.

“It’s hard enough to get a good compatible match for a transplant like this,” Fauci told FoxNews.com, “But you also have to find compatible donor that has this genetic defect, and this defect is only found in 1 percent of the Caucasian population and zero percent of the black population. This is very rare.”

Fauci said while this patient is “functionally cured” this is not something you can do with every HIV-infected individual.

“This is not prime time to me at all,” he said. “This is a very unusual situation that has little practical application for a simple reason. This donor not only had to be a good compatible match, but the donor had to have a genetic defect of cells that do not express the receptor that the HIV virus needs to enter the cell.”

Fauci also pointed to the fact that this transplant process is not only expensive, it’s incredibly painful and complicated, and requires the patient to start a whole new regimen of drugs.

“This patient is trading one poison for another. He may not have to be on antiretroviral drugs anymore, but he has to take immunosuppressant drugs now to prevent the rejection of his transplant cells. Again, what this is, is an interesting proof of concept, but it’s absolutely impractical.”

Dr. Thomas Quinn, director of Johns Hopkins Center for Global Health told FoxNews.com that he is very familiar with the “Berlin patient” case.

“This was a new report that looked much deeper into whether HIV could still be present or lurking in the body in some way, not cured, and since the transplant he remains viral free and his cells appear to be resistant to infection,” he said.

Quinn said he agrees with the researchers on this case that it would be qualified as the first HIV cure, opening the door to alternative means of curing HIV.

“He [Brown] has been without therapy for three years and appears to be free of the virus,” he said. “It gives hope to the millions of people infected with HIV that cure is a feasible option in the future.”

Even though Brown’s procedure proved to be successful, Quinn also warns that this was a rare case and a bone marrow transplant is not a cure-all for other HIV patients.

“It is a near fatal procedure that he had to have done because of the leukemia, but this procedure is very expensive and you have to be transplanted with a donor who is shown to be already resistant to HIV,” Quinn said. “You’re asking for a tall order to replicate this in the future.”

Brown’s case was published in a February 2009 issue of the New England Journal of Medicine

Read more: http://www.foxnews.com/health/2010/12/14/doctors-claim-hiv-positive-man-cured-stem-cell-transplant/#ixzz18Cug4Euz

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THE ABSTRACT FROM NEW ENGLAND JOURNAL OF MEDICINE

Volume 360:692-698  February 12, 2009  Number 7
NextNext

Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell

Transplantation

Gero Hütter, M.D., Daniel Nowak, M.D., Maximilian Mossner, B.S., Susanne Ganepola, M.D., Arne Müßig, M.D., Kristina Allers, Ph.D., Thomas Schneider, M.D., Ph.D., Jörg Hofmann, Ph.D., Claudia Kücherer, M.D., Olga Blau, M.D., Igor W. Blau, M.D., Wolf K. Hofmann, M.D., and Eckhard Thiel, M.D.

SUMMARY

Infection with the human immunodeficiency virus type 1 (HIV-1)requires the presence of a CD4 receptor and a chemokine receptor,principally chemokine receptor 5 (CCR5). Homozygosity for a32-bp deletion in the CCR5 allele provides resistance againstHIV-1 acquisition. We transplanted stem cells from a donor whowas homozygous for CCR5 delta32 in a patient with acute myeloidleukemia and HIV-1 infection. The patient remained without viralrebound 20 months after transplantation and discontinuationof antiretroviral therapy. This outcome demonstrates the criticalrole CCR5 plays in maintaining HIV-1 infection.
Source Information

From the Department of Hematology, Oncology, and Transfusion Medicine (G.H., D.N., M.M., S.G., A.M., O.B., I.W.B., W.K.H., E.T.) and the Department of Gastroenterology, Infectious Diseases, and Rheumatology (K.A., T.S.), Campus Benjamin Franklin; and the Institute of Medical Virology, Campus Mitte (J.H.) — all at Charité Universitätsmedizin Berlin; and the Robert Koch Institute (C.K.) — all in Berlin.

Drs. Hofmann and Thiel contributed equally to this article.

Address reprint requests to Dr. Hütter at Medical Department III Hematology, Oncology, and Transfusion Medicine, Charité Campus Benjamin Franklin, Hindenburgdamm 30 D-12203 Berlin, Germany, or at gero.huetter@charite.de// <!–[CDATA[-->
var u = "gero.huetter", d = "charite.de"; document.getElementById("em0").innerHTML = '' + u + '@' + d + ''
// ]]>.

Full Text of this Article

This article has been cited by other articles:

  • Arababadi, M. K., Hassanshahi, G., Azin, H., Salehabad, V. A., Araste, M., Pourali, R., Nekhei, Z. (2010). No Association Between CCR5-{Delta}32 Mutation and Multiple Sclerosis in Patients of Southeastern Iran. Lab Med 41: 31-33 [Abstract] [Full Text]
  • Fauci, A. S., Folkers, G. K. (2009). Investing To Meet The Scientific Challenges Of HIV/AIDS. Health Aff (Millwood) 28: 1629-1641 [Abstract] [Full Text]
  • Bonsignori, M., Moody, M. A., Parks, R. J., Holl, T. M., Kelsoe, G., Hicks, C. B., Vandergrift, N., Tomaras, G. D., Haynes, B. F. (2009). HIV-1 Envelope Induces Memory B Cell Responses That Correlate with Plasma Antibody Levels after Envelope gp120 Protein Vaccination or HIV-1 Infection. J. Immunol. 183: 2708-2717 [Abstract] [Full Text]
  • Levy, J. A. (2009). The Unexpected Pleiotropic Activities of RANTES. J. Immunol. 182: 3945-3946 [Full Text]
  • (2009). All you need to read in the other general journals. BMJ 338: b627-b627 [Full Text]
  • (2009). Stem-Cell Transplantation Enables Long-Term HIV Control. AIDS Clin Care 2009: 1-1 [Full Text]
  • Levy, J. A. (2009). Not an HIV Cure, but Encouraging New Directions. NEJM 360: 724-725 [Full Text]

From http://content.nejm.org/cgi/content/short/360/7/692

  1. Hi,

    It wasn’t picked up by the media originally because it was considered too dangerous and expensive to be a real cure. But it was a real cure for this one patient, who is doing very well right now and is still AIDS-free, according to Dr. Huetter and as of today 6/3/10. We see it as a major scientific milestone–on the road to a cure for lots of people but obviously not there yet. We gave him an award on the steps of San Francisco City Hall today-the first one he has every received!

    Cheers,

    Kate Krauss
    AIDS Policy Project

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