DAVID GRANOVSKY

Archive for April, 2010|Monthly archive page

US is #1 in Stem Cell Research! …sort of…

In BUSINESS OF STEM CELLS, CATCH UP! on April 29, 2010 at 7:39 pm

We are #1!

With the release of new lines of embryonic stem cells, the US may reclaim their title as #1!  But #1 in what regard? Consumption of stem cells?  Not quite…

Consumption of embryonic stem cells?  Well, yes…but…

We are really only the leader in “consumption of embryonic stem cells used for research”.  But there is a reason for this.  Many countries have tried to research embryonic stem cells for treatment, for a decade or more, with full governmental and fiduciary support and then…given up.  Embryonic stem cells bring with them transplant rejection issues and grow into tumors and cysts.

We are in fact about 8 years behind most of the developed world in adult stem cell research; the only stem cells that have over half a decade of proven safety and efficacy.  So hooray for us!

What else are we #1 in?

We are the…

  • #1 consumer of the stem cells that have shown the least potential for treatment (embryonic)!
  • #1 consumer of environmentally damaging and war causing oil!
  • #1 consumer of cocaine (shipped from Colombia through Mexico and the Caribbean), Colombian heroin, and Mexican heroin and marijuana!

Here’s an idea, snarky as it may be…
What do you say we load up an SUV with cocaine and heroin, have a slammin party, OD on drugs and die young!  We might as well cause embryonic stem cells won’t produce cures for diseases anytime soon!

Not a bad idea, at least we could go out with a bang…If only we could afford it.

Our country’s bank account is more than $-568,800,000,000 ranking us 188th in the world.  Not to worry, we still have a good chance of dying before needing stem cells.  The WHO ranks our health system at 37th, our life expectancy is 30th in the world, infant mortality is 34th in the world and this is all with our Health Expenditures as a % of GDP being almost the highest in the world (we are ranked #2).   Now that’s money well spent.

And we’ll all probably be shot soon anyway.  We are ranked 78th in intentional homicides (and in this category, #1 is good).

HOORAY FOR THE U.S.A.! What’s not to love? – dg

Power3 Medical’s Goldknopf to Give Plenary Address to the European Molecular Histopathology Symposium

In BUSINESS OF STEM CELLS on April 28, 2010 at 5:47 pm

Press Release Source: Power3 Medical Products, Inc. On Tuesday, April 27, 2010, 6:49 pm EDT

HOUSTON–(BUSINESS WIRE)–StemTroniX, Inc., a Texas corporation (“StemTroniX”), and Power3 Medical Products, Inc. (OTCBB:PWRM – News) announced today that a plenary address entitled “The Genesis of Prototype Biomarkers for Identification and Use of Stem Cells for Therapeutics of Alzheimer’s Disease” will be delivered by Ira L. Goldknopf, PhD, Power3’s President and Chief Scientific Officer, to the European Molecular Histopathology Symposium on The Impact of Personalized Medicine, April 29, 2010, in Chantilly, France, organized by Ventana Medical Systems, a member of the Roche Group.

The focus of the presentation is on the progress Power3 and StemTroniX have made towards enhanced effectiveness of Alzheimer’s disease therapy by combining StemTroniX’s patented and patent pending adult stem cell regenerative medicine technologies with Power3’s patent pending blood serum adult stem cell protein biomarkers and diagnostic technologies. StemTroniX’s technologies include a licensed patent and several patent disclosures for monitoring of stem cell therapy, technology to aid in the viability of adult stem cells, injection technology, and non-invasive imaging technology. These technologies complement Power3’s technologies for Alzheimer’s specific diagnosis, multiple forms of Alzheimer’s disease, response to Alzheimer’s drug therapy, predictive drug response, and discovery of more clinically relevant tissue, blood and adult stem cell biomarkers.

“Biomarkers for the support of autologous (a patient’s own) stem cell therapies of Alzheimer’s disease are needed to light the way to true recovery, i.e. to the restoration of the patient through repair and regeneration of the brain tissue ravaged by the disease. Nothing less is acceptable for true regenerative medicine,” said Goldknopf. “To achieve these ends, we believe it is necessary to set the bar high, so that we can find biomarkers related to the restoration of normality, not only with respect to symptoms, but also with respect to correcting the underlying and devastating pathophysiology of Alzheimer’s disease. We will demonstrate steps already taken towards this goal as well as illustrate essential requirements for the way forward.”

“In conjunction with the upcoming acquisition of StemTroniX by Power3, and recent patent filings, this presentation marks a significant step towards the joint goal of StemTroniX and Power3, to fulfill the promise of personalized medicine by providing desperately needed diagnosis and targeted therapy for Alzheimer’s disease,” said Helen R. Park, StemTroniX’s CEO.

Power3 Medical Products

Power3 Medical Products, Inc. is a leader in bio-medical research and the commercialization of biomarkers, tests, and mechanisms of disease. Power3′s patent-pending technologies are being used to develop screening and diagnostic tests for the early detection and prognosis of disease, identify protein biomarkers, and drug targets, to fulfill critical unmet needs in areas including neurodegenerative disease (NuroPro®) and breast cancer (BC-SeraPro™). Power3 operates a state-of-the-art CLIA certified laboratory in The Woodlands (Houston), Texas and continues to evolve and enhance its IP portfolio, employing sensitive and specific combinations of biomarkers blood-based tests for ALS, Alzheimer’s, and Parkinson’s diseases, breast cancer, and drug resistance.

For more information, please visit http://www.power3medical.com

StemTroniX

StemTroniX, Inc. is a medical biotechnology company that is committed to improving the lives of individuals by using autologous adult stem cell technology to repair tissue damage in patients. Autologous adult stem cell therapy is the process of using an individual’s own stem cells for the purpose of repairing and regenerating damaged tissue. StemTroniX also provides a patented system to augment this process in a non-invasive method for in-body monitoring of the stem cells at the site of injury as they are being introduced into the patients.

via Power3 Medical’s Goldknopf to Give Plenary Address to the European Molecular Histopathology Symposium – Yahoo! Finance.

The Science Behind “Super Stemmys – Doris and the Supercells”

In ALL ARTICLES on April 28, 2010 at 9:02 am

A brief epilogue regarding the scientific information portrayed in “Super Stemmys – Doris and the Supercells” …

Much of the book was based on my time spent at the first non-clinical trial stem cell treatment facility in the world in 2004.  What I saw practiced and researched there at that time and in the next few years was the use of stem cells that were autologous (patient derived) from the bone marrow and non-differentiated (non-specific).  The cells were then differentiated into cardiac stem cells and then introduced into the heart muscle via injection.  Symptom reduction and therapeutic benefit was reported in about 65-72% of patients.

This is similar to the “Injection of Autologous CD34-Positive (stem) Cells  for Neovascularization and Symptom Relief in Patients With Myocardial Ischemia” trial that was researched in the US in 2004 at [Scripps Clinic in La Jolla, California], [Caritas St. Elizabeth's Medical Center in Boston] and [Minneapolis Heart Institute in Minneapolis, Minnesota] http://clinicaltrial.gov/ct2/show/NCT00081913?term=stem+cell+heart&rank=58

The book is as accurate as possible given that:
*adult stem cell treatment therapy for chronic disease is a relatively new science
*new discoveries are made almost every day
*the book is written at a 6th grade level so some scientific detail had to be simplified
*the content of the book was reviewed by an oncologist, a biochemist, a GP, many stem cell doctors/scientists, a neuro-scientist and a many others

Background evidence:
“A Brief History of Stem Cell Treatment for Heart Disease” – http://repairstemcell.wordpress.com/2010/03/16/stem-cell-treatment-for-heart-disease/
“Do Stem Cell Treatments Work?” – http://repairstemcell.wordpress.com/2009/10/10/do-stem-cell-treatments-work/

Patient Case Study – James Eilert.  James was treated in 2006 and I include him because he is one of the best documented cases.  There were many others in 2004, 2005, 2006 but they don’t have as much data or press on them: http://repairstemcell.wordpress.com/2010/02/02/heart-muscle-health-aspects-vescell-adult-stem-cell-therapy/ http://repairstemcell.wordpress.com/2009/09/11/adult-stem-cells-fix-the-heart-part-1/

http://repairstemcell.wordpress.com/2009/09/11/adult-stem-cells-fix-the-heart-part-2/

http://repairstemcell.wordpress.com/2009/09/11/adult-stem-cells-fix-the-heart-part-3/

http://repairstemcell.wordpress.com/2009/09/11/adult-stem-cells-fix-the-heart-part-4/

If you need more information, I can put you in touch with James.

There are also ~318 other clinical trials dealing with adult stem cell treatment of heart disease – clinicaltrials.gov

There are a number of heart treatment centers currently treating patients – email me at dsgrano@gmail.com if you would like more information Read the rest of this entry »

Stem Cells From Menstrual Blood May Benefit Stroke Patients

In VICTORIES & SUCCESS STORIES on April 28, 2010 at 7:11 am

http://www.amc.edu/research/CNN/images/rat_stroke2a.jpg

Cerebral ischemia, or reduced blood flow to the brain, as occurs in stroke or trauma, is a significant clinical problem.

Menstrual Blood Cells Display Stem Cell–Like Phenotypic Markers and Exert Neuroprotection Following Transplantation in Experimental Stroke

Cesar V. Borlongan,1 Yuji Kaneko,1 Mina Maki,2 Seong-Jin Yu,1 Mohammed Ali,2 Julie G. Allickson,3 Cyndy D. Sanberg,4 Nicole Kuzmin-Nichols,4 and Paul R. Sanberg1,5

Cell therapy remains an experimental treatment for neurological disorders. A major obstacle in pursuing the clinical application of this therapy is fi nding the optimal cell type that will allow benefi t to a large patient population with minimal complications. A cell type that is a complete match of the transplant recipient appears as an optimal scenario.

Here, we report that menstrual blood may be an important source of autologous stem cells. Immunocytochemical assays of cultured menstrual blood reveal that they express embryonic-like stem cell phenotypic markers (Oct4, SSEA, Nanog), and when grown in appropriate conditioned media, express neuronal phenotypic markers (Nestin, MAP2). In order to test the therapeutic potential of these cells, we used the in vitro stroke model of oxygen glucose deprivation (OGD) and found that OGD-exposed primary rat neurons
that were co-cultured with menstrual blood-derived stem cells or exposed to the media collected from cultured menstrual blood exhibited signifi cantly reduced cell death. Trophic factors, such as VEGF, BDNF, and NT-3, were up-regulated in the media of OGD-exposed cultured menstrual blood-derived stem cells.

Transplantation of menstrual blood-derived stem cells, either intracerebrally or intravenously and without immunosuppression,
after experimentally induced ischemic stroke in adult rats also signifi cantly reduced behavioral and histological impairments compared to vehicle-infused rats. Menstrual blood-derived cells exemplify a source of “individually tailored” donor cells that completely match the transplant recipient, at least in women. The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke.

Via http://www.liebertonline.com/doi/abs/10.1089/scd.2009.0340 or scd.2009.0340 (application/pdf Object).

ADULT STEM CELLS Revealed: The secret of how worms re-grow amputated body parts… and how humans could one day do the same

In STEM CELLS IN THE NEWS on April 27, 2010 at 8:50 am

WORMS USE ADULT STEM CELLS TO REGROW PARTS

Revealed: The secret of how worms re-grow amputated body parts… and how humans could one day do the same

By Daily Mail Reporter

Scientists have discovered the gene that allows a worm to regenerate its own body parts after they are amputated, it was announced today.

The research into how Planarian worms can re-grow body parts – including a whole head and brain – could one day make it possible to regenerate old or damaged human organs and tissues, the University of Nottingham said.

The research, led by Dr Aziz Aboobaker, a Research Councils UK Fellow in the university’s School of Biology, shows a gene called ‘Smed-prep’ is essential for correctly regenerating a head and brain in Planarian worms.

Research into how Planarian worms can re-grow body parts could one day make it possible to regenerate old or damaged human organs and tissues

Research into how Planarian worms can re-grow body parts could one day make it possible to regenerate old or damaged human organs and tissues

The worms have the unusual ability to regenerate body parts, including a head and brain, following amputation.

They contain adult stem cells that are constantly dividing and can become all of the missing cell types.

They also have the right set of genes working to make this happen as it should so that when they re-grow body parts they end up in the right place and have the correct size, shape and orientation, the research showed.

The study is published today in the open access journal PLoS Genetics.

Dr Aboobaker said: ‘These amazing worms offer us the opportunity to observe tissue regeneration in a very simple animal that can regenerate itself to a remarkable extent and does so as a matter of course.

‘We want to be able to understand how adult stem cells can work collectively in any animal to form and replace damaged or missing organs and tissues.

‘Any fundamental advances in understanding from other animals can become relevant to humans surprisingly quickly.

‘If we know what is happening when tissues are regenerated under normal circumstances, we can begin to formulate how to replace damaged and diseased organs, tissues and cells in an organised and safe way following an injury caused by trauma or disease.

‘This would be desirable for treating Alzheimer’s disease, for example.

‘With this knowledge we can also assess the consequences of what happens when stem cells go wrong during the normal processes of renewal – for example in the blood cell system where rogue stem cells can result in Leukaemia.’

The researchers said Smed-prep is necessary for the correct differentiation and location of cells that make up a Planarian worm’s head, as well as for defining where the head should be located.

They found although the presence of Smed-prep is vital so the head and brain are in the right place, the worm stem cells can still be persuaded to form brain cells as a result of the action of other unrelated genes…

via Revealed: The secret of how worms re-grow amputated body parts… and how humans could one day do the same | Mail Online.

Virgin Founder Ready to Launch Stem Cell Bank

In BUSINESS OF STEM CELLS on April 26, 2010 at 7:33 pm

Now, even Sir Richard see’s the future! -David

http://www.puddleofred.com/blog/wp-content/uploads/2009/12/Virgin.Galactic.Richard.Branson.jpg

On Thursday Virgin founder Sir Richard Branson geared up to launch his stem-cells and biotech business. The new venture allows parents the ability to store the cells from their child’s umbilical cord.

Scientists believe the cells are useful to treat conditions such as Parkinson’s disease and cancer.
According to BBC reports, many parents of new born children have already used stem-cell storage. The parents are provided with collection kits at the time of birth of their child. The kits are then taken for processing and storage to companies who deal in the business.
Stem-cell storage saves human blood from the placenta or umbilical cord after birth. This blood is rich in hematopoietic stem cells, which are capable of adapting in the body and replacing damaged or diseased cells.
The controversial procedure is gaining popularity in the United States with many private firms intervening into the business. Many celebrities have also opted for cord blood registration.

Virgin Founder Ready to Launch Stem Cell Bank.

New Stem Cell Therapy For Dogs Launched In NZ | Voxy.co.nz

In VICTORIES & SUCCESS STORIES on April 26, 2010 at 7:29 pm

Tuesday, 27 April, 2010 – 10:22

A breakthrough stem cell therapy is being launched in New Zealand – offering a new lease on life for dogs suffering from degenerative joint disease.

New Zealand’s largest companion animal veterinary group, Pet Doctors, has announced a national license agreement to treat dogs with a stem cell technology called AdiCellTM.

Pet Doctors has partnered with Regeneus Pty Ltd, a Sydney-based pioneering biotech company, to distribute AdicellTM here. New Zealand will be only the third country in the world, following the US and Australia, to offer this type of therapy commercially…

via New Stem Cell Therapy For Dogs Launched In NZ | Voxy.co.nz.

Researchers find that single gene responsible for OCD-like behaviors in mice

In ALL ARTICLES on April 26, 2010 at 7:05 pm

http://repairstemcell.files.wordpress.com/2009/04/mouse-science-diabetes1.jpg?w=604

April 26, 2010

Researchers at the Ansary Stem Cell Institute and the Department of Psychiatry at Weill Cornell Medical College discovered that mice missing a single gene developed repetitive obsessive-compulsive-like behaviors. The genetically altered mice, which behaved much like people with a certain type of obsessive-compulsive disorder (OCD), could help scientists design new therapies for this debilitating condition.

The researchers made this serendipitous discovery while looking at the role of a gene, called Slitrk5, which they had earlier linked to blood stem cells and vascular cells. In the April 25 online edition of Nature Medicine they report how, in follow-up studies, mice in which the gene was disabled (“knocked-out”) demonstrated obsessive self-grooming and extreme anxiety. Further study showed that the frontal lobe-to-striatum circuitry of the brains of these mice were altered in the same ways that are implicated in OCD in humans.

This discovery links Slitrk5 to development of OCD-like behaviors, and offers scientists a new mouse model of the disorder, say the study’s senior co-investigators, Dr. Shahin Rafii and Dr. Francis S.Y. Lee. Dr. Rafii is director of the Ansary Stem Cell Institute and professor in genetic medicine Weill Cornell Medical College and and an HHMI investigator. Dr. Lee is associate professor of psychiatry and pharmacology at the Medical College.

“Overall, our data suggest that Slitrk5 may have a central role in the development of the core symptoms of OCD — self-injurious, repetitive behavior and increased anxiety,” Dr. Rafii says. “Very few psychiatric disorders have been linked to a single gene, and it will be important to find out if patients with the disorder have an alteration of Slitrk5.”

…..

via Researchers find that single gene responsible for OCD-like behaviors in mice.

Vatican to finance adult stem cell research

In STEM CELLS IN THE NEWS on April 26, 2010 at 1:31 pm

Cardinal Renato Martino gestures during a meeting at Rome’s National Institute of Health, Friday, April 23, 2010. The Vatican is pushing for research of adult stem cells as an alternative to the use of embryonic stem cells, which the Catholic Church opposes because it maintains that the destruction of the embryo amounts to the killing of human life. (AP Photo/Pier Paolo Cito)

By ALESSANDRA RIZZO | Posted: Friday, April 23, 2010 4:43 pm | buy this photo

The Vatican is pushing for research of adult stem cells as an alternative to the use of embryonic stem cells, which the Catholic Church opposes because it maintains that the destruction of the embryo amounts to the killing of human life.

On Friday, the Catholic Church threw its support and resources behind the study of intestinal adult stem cells by a group of experts led by the University of Maryland School of Medicine. The group wants to explore the potential use of those cells in the treatment of intestinal and possibly other diseases, and is seeking an initial euro2 million ($2.7 million) to get the project going, officials said.

“This research protects life,” Cardinal Renato Martino said during a meeting with Italian and American scientists and health officials to outline the project. “I want to stress that it doesn’t involve embryonic stem cells, where one helps oneself and then throws the embryo away and kills a human life.”

The church is opposed to embryonic stem cell research because it involves the destruction of embryos, but it supports the use of adult stem cells, which are found in the bodies of all humans…

Still, adult stem cells could be easier to use if they are taken from patients themselves, because the replacement tissue would have less chance of being rejected.

Martino, a powerful cardinal and retired head of the Pontifical Council for Justice and Peace, told The Associated Press after the meeting that he had “no doubt” that the Vatican would help finance the project through its Rome hospital, Bambin Gesu, and other funding. The exact amount and modalities will be worked out in future meetings with the University of Maryland and other scientists involved in the project.

http://mrhiggins.net/algebra2/wp-content/uploads/2008/04/vatican.jpg

In 2007, Pope Benedict XVI said the Catholic Church can encourage somatic stem cell research _ also known as adult stem cell research _ “because of the favorable results obtained through these alternative methods,” and more importantly because it respects “the life of the human being at every stage of his or her existence.”

During a meeting with President Barack Obama last year at the Vatican, Benedict underscored his beliefs about stem cells by giving the U.S. leader a copy of a Vatican document on bioethics that hardened the church’s opposition to using embryos for stem cell research, cloning and in-vitro fertilization.

Obama has lifted restrictions, imposed by his predecessor President George W. Bush, on federal funding of research using human embryonic stem cells.

The Vatican has drawn criticism for its opposition to embryonic stem cell research. But it insists there are scientifically viable alternatives and that the efforts of the scientific community should go in that direction.

Supporting this university project is part of those efforts.

“Ethically, the rules the Catholic Church promotes are really very simple: That all research be respectful of human life,” said Father Bob Gahl, an American professor of Moral Philosophy at the Pontifical University of the Holy Cross. “Nobody should be killed in the process of doing medical research. So this new project falls exactly within the Catholic Church’s ethical guidelines.”

Dr. George Daley, a stem cell expert at Children’s Hospital in Boston and past president of the International Society for Stem Cell Research, said both adult and embryonic stem cells may prove useful for treating different diseases.

“I applaud the Vatican for being interested in supporting biomedical research,” Daley said Friday, “but I can’t help but think there’s an agenda.”

He called intestinal stem cells “a very exciting area of basic research” but said therapeutic uses are only speculative at this point.

Researchers involved in the Vatican-backed project are convinced that intestinal stem cells _ a relatively new field _hold promise and want to assess their potential for therapeutic use.http://aftermathnews.files.wordpress.com/2009/07/pope_obama_jul_10_09_1.jpg?w=440&h=321

“We want to harvest them, we want to isolate them, we want to make them grow outside our body,” and transform them into cells of any kind, said Alessio Fasano, the scientist leading the project and the director of the University of Maryland’s Center for Celiac Research.

“If we reach that phase, if we are able to achieve that goal, then our next step is to eventually move to clinical application,” Fasano told the AP before Friday’s announcement.

Intestinal stem cells have certain features that make them appealing for this kind of research, Fasano said.

They are very active cells _ the intestine replenishes all its cells every few days _ and they are intrinsically flexible _ already programmed to generate all the various kinds of cells such as mucus cells or epithelial cells present in the highly complex organ. Furthermore, harvesting them can be done through a routine medical procedure, Fasano noted.

Fasano said his team hopes to decide about the feasibility of the project within the next two to three years. He said the network of experts, expected to be around 40 people, would work at their respective facilities, sharing information and the workload to speed up the process.

___

AP Medical Writer Maria Cheng in London and AP Science Writer Malcolm Ritter in New York contributed to this report.

Eds: CORRECTS to say meeting between pope and Obama took place at the Vatican in graf 10.

via Vatican to finance adult stem cell research.

Leftover Veins From Heart Surgery Yield Stem Cells | TopNews Arab Emirates

In VICTORIES & SUCCESS STORIES on April 26, 2010 at 1:16 pm

Scientists believe they have found a source of master cells for treating future heart problems, from human veins left over from lifesaving bypass surgery.

The journal Circulation reports a University of Bristol research team extracted stem cells from the veins and successfully used them to stimulate new blood vessel growth in mice…

Their latest discovery has been to use a waste product from thousands of heart operations carried out each year. Often, patients with heart disease have blocked or narrowed arteries that supply the heart muscle. Lack of blood leaves the muscle damaged, which can cause chest pain or even a heart attack….

via Leftover Veins From Heart Surgery Yield Stem Cells | TopNews Arab Emirates.

Follow

Get every new post delivered to your Inbox.

Join 819 other followers