DAVID GRANOVSKY

Archive for October, 2009|Monthly archive page

Scientists Create Sperm And Eggs From Stem Cells..No Men Or Women Needed | Infidels Paradise

In ALL ARTICLES on October 29, 2009 at 2:06 pm

 

 

 

Scientists Create Sperm And Eggs From Stem Cells..No Men Or Women Needed

October 28th, 2009 | by KurtTheInfidel

Human eggs and sperm have been grown in the laboratory in research which could change the face of parenthood.

It paves the way for a cure for infertility and could help those left sterile by cancer treatment to have children who are biologically their own.

But it raises a number of moral and ethical concerns. These include the possibility of children being born through entirely artificial means, and men and women being sidelined from the process of making babies.

Opponents argue that it is wrong to meddle with the building blocks of life and warn that the advances taking place to tackle infertility risk distorting and damaging relations between family members.

The U.S. government-funded research also offers the prospect of a ‘miracle pill’ which staves off the menopause, allowing women to wait longer to have a child.

It centres on stem cells, widely seen as a repair kit for the body.

via Scientists Create Sperm And Eggs From Stem Cells..No Men Or Women Needed | Infidels Paradise.

Adult Eyes Cells Can Be Transformed Into Pluripotent Stem Cells Without Introducing Foreign Genetic Material

In ALL ARTICLES on October 29, 2009 at 4:59 am

Adult Eyes Cells Can Be Transformed Into Pluripotent Stem Cells Without Introducing Foreign Genetic Material

Article Date: 23 Oct 2009 – 5:00 PDT

http://www.masternewmedia.org/images/eye-water_id620886_size1.jpg

Scientists have overcome a key barrier to the clinical use of stem cells with a technique which transforms regular body cells into artificial stem cells without the need for introducing foreign genetic materials, which could be potentially harmful. The research, published in Stem Cells, suggests that cells taken from a patient’s eye can be “reprogrammed” to replace or restore cells lost to degenerative diseases.

http://www.nccr-neuro.uzh.ch/projects/p1.jpg

The research, led by Professor Iqbal Ahmad and co-authors from the University of Nebraska Medical Center, is the first proof in principle that somatic, or body cells, can be reprogrammed into induced pluripotent stem cells (iPSCs) simply through the influence of the microenvironment in which the sampled cells are cultured. Until now genetic materials were introduced into somatic cells to re-programme them to become pluripotent, enabling them to generate cells of all three embryonic lineages.

“Our findings provide evidence for an emerging view that somatic cells may be reprogrammed safely and simply by defined chemicals and other factors, which may facilitate their clinical use,” said Ahmad. “The next step is to know how robust the reprogramming is and what existed within the microenvironment to cause it.”

The team sampled progenitor eye cells, which regenerate the eye’s cornea, from laboratory rats. By reprogramming them to resemble stem cells they acquired the properties necessary to replace or restore neurons, cardiomyocytes, and hepatocytes, cell types which are degenerated in Parkinson’s disease, heart disease, and liver disease.

This reprogramming technique may allow ‘autologous cell transplantation’, where the donor of the cells is also the recipient. This is preferable to using cells from another person which may cause the patient’s immune system to reject the transplanted cells.

Also, because this technique involves the use of iPSCs derived from adult eye cells and not embryonic stem cells (ES) it side steps many of the ethical dilemmas which have embroiled stem cell research.

“This research shows that it is possible to take cells from a patient’s eye without affecting vision and reprogram them for use in autologous cell therapy to replace or rescue degenerating cells,” concluded Ahmad, “this would allow us to circumvent ethical issues and the problems caused by the immune system rejecting foreign cells.”

via Adult Eyes Cells Can Be Transformed Into Pluripotent Stem Cells Without Introducing Foreign Genetic Material.

California Funds ADULT STEM CELLS – 10 to 4!

In VICTORIES & SUCCESS STORIES on October 29, 2009 at 3:40 am

California Awards Grants for Research Projects in NON-EMBRYONIC Stem Cells

By ANDREW POLLACK

Published: October 28, 2009

LOS ANGELES — In a tacit acknowledgment that the promise of human embryonic stem cells is still far in the future, California’s stem cell research program on Wednesday awarded grants intended to develop therapies using mainly other, less controversial cells.

“mainly other, less controversial cells”

Really? It’s like that, is it?  Ok, baby steps it is then…alright…take a deep breath…it’s ok…you can say it…don’t be afraid…say it with me…

A – D – U – L – T  stem cells…

good! Now all together…

ADULT STEM CELLS!

There, was that so hard?

http://www.rochester.edu/pr/Review/V69N1/images/feaStemCellImage.jpg
Adult Stem Cell

The $230 million in grants awarded Wednesday to California universities and companies represent a big step toward moving stem cells from basic research toward application in treating diseases like cancer and AIDS. Grant recipients are supposed to have a therapy ready for initial human testing in four years.

http://media.nowpublic.net/images//35/d/35d32e6d6f2873efcc8dc531569065ff.jpg
Grant Money ;)

But only 4 of the 14 projects involve embryonic stem cells. The others will use so-called adult stem cells or conventional drugs intended to kill cancer stem cells, which are thought to give rise to tumors.

http://www.urmc.rochester.edu/news/story/uploadedimages/cancer%20stem%20cellUCLA3.jpg
Cancer Stem Cell (from embryonic stem cells)

The grants thus represent a departure from the program’s original mission.

via California Awards Grants for Research Projects in Nonembryonic Stem Cells – NYTimes.com.

CATCH UP! – Stem Cell Therapy May Offer Hope For Acute Lung Injury

In CATCH UP! on October 29, 2009 at 3:28 am

The USA is so far behind the rest of the world it scares me.  The lungs are the greediest of all of the organs in the body for stem cells.  ALI, COPD, etc have been treated around the world with adult stem cells for a long time now.  There was even a clinical trial in Dresden on 86 human patients   -

“Acute Lung Injury After Allogeneic Transplantation – Diagnosis and Early Treatment”

Enrollment: 86
Study Start Date: December 2001
Primary Completion Date: August 2005 (Final data collection date for primary outcome measure)

…and the US is just barely putting a toe in the water with mouse studies? It’s time to CATCH UP!

-DG

http://stopsmokingnow.org.uk/wp-content/uploads/2009/02/lungs.gif

Lungs

Stem Cell Therapy May Offer Hope For Acute Lung Injury

ScienceDaily (Oct. 28, 2009) — Researchers at the University of Illinois at Chicago College of Medicine have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease.

http://news.stanford.edu/news/2005/august24/gifs/mice_smooth.jpg

Their results are reported online in the October issue of the journal Stem Cells.

Acute lung injury (ALI) is responsible for an estimated 74,500 deaths in the U.S. each year. ALI can be caused by any major inflammation or injury to the lungs and is a major cause of death in patients in hospital ICUs. There is no effective drug treatment…

Except for adult stem cell treatments outside the US which you can find here – TREATMENT INFO NOW

via Stem Cell Therapy May Offer Hope For Acute Lung Injury.

New ‘Schizophrenia Gene’ Prompts Researchers To Test Potential Drug Target

In SCIENCE & STEM CELLS on October 29, 2009 at 2:28 am

New ‘Schizophrenia Gene’ Prompts Researchers To Test Potential Drug Target

ScienceDaily (Oct. 27, 2009) — Johns Hopkins scientists report having used a commercially available drug to successfully “rescue” animal brain cells that they had intentionally damaged by manipulating a newly discovered gene that links susceptibility genes for schizophrenia and autism.

http://www.physio-pedia.com/images/a/a0/Schizophrenia_graphic_high_contrast1.jpg

Schizophrenia

The rescue, described as “surprisingly complete” by the researchers, was accomplished with rapamycin, a drug known to act on a protein called mTOR whose role involves the production of other proteins. The idea to test this drug’s effectiveness at rescuing impaired nerve cells occurred to the team as a result of having discovered a new gene that appears to act in concert with two previously identified schizophrenia susceptibility genes, one of which is involved in the activation of the protein mTOR. This piecing together of multiple genes adds support for the idea that susceptibility to schizophrenia and autism may have common genetic fingerprints, according to the researchers.

http://cdn.zmescience.com/wp-content/uploads/2011/05/autism-awareness.jpg

Autism

The newfound gene, dubbed KIAA1212, serves as a bridge linking two schizophrenia genes: DISC1 and AKT. Suspecting KIAA1212 as one of many potential binding partners interacting with DISC1, whose name is an acronym for “Disrupted-in-Schizophrenia,” the researchers genetically shut down the production of DISC1 proteins in newly born neurons in the hippocampus region of an adult mouse brain. The hippocampus contains a niche where native stem cells give rise to fully developed new neurons. The idea was to deliberately cause these cells to malfunction and then watch what happened.

http://huehueteotl.files.wordpress.com/2007/04/amygdala_hippocampus_lateral_large.jpg?w=305&h=278

Hippocampus

via New ‘Schizophrenia Gene’ Prompts Researchers To Test Potential Drug Target.

University of Edinburgh study paves way for stem cell library » The Journal

In VICTORIES & SUCCESS STORIES on October 29, 2009 at 2:15 am

University of Edinburgh study paves way for stem cell library

http://www.hepfoundation.org.nz/images/liver2.jpg

Research could revolutionise the development of drugs to treat diseases and pave way for the creation of a library of liver cells

by Chris Grainger -  Wednesday 28 October 2009, The Journal Issue 26

Scientists have, for the first time, produced liver cells from adult stem cells using technology called iPSC, or induced pluripotent stem cell.

Using either embryonic or induced pluripotent stem cells, the Gamm lab created aggregates of early retinal cells (green spheres). The blue spheres are early brain cells. Photo: Special arrangement - University of Wisconsin

Using induced pluripotent stem cells, aggregates of early retinal cells (green spheres) are created. The blue spheres are early brain cells. Photo: Special arrangement - University of Wisconsin

The liver cells were created by manipulating the skin cells to resemble embryonic stem cells, which have the ability to become different cells within the body.

The study, led by the University of Edinburgh’s Medical Research Council Centre for Regenerative Medicine, makes possible the creation of a liver cell library, which could revolutionise the development of drugs, making them more efficient and safe.

http://www.meritas.net/uploaded/school_graphics/Edinburgh_University.jpg

University of Edinburgh

via University of Edinburgh study paves way for stem cell library » The Journal.

HAPPY DIABETES AWARENESS MONTH!

In VICTORIES & SUCCESS STORIES on October 28, 2009 at 4:11 pm

To celebrate DIABETES AWARENESS MONTH I am posting this huge resource of the current state of diabetes treatment with stem cells.

diabetes-RED

  • FIRST USE OF CORD BLOOD TO ALTER COURSE OF TYPE 1 DIABETES, June 25, 2007 – (I’ll bet nobody heard of this one!)transfusion of stored, autologous (i.e. the person’s own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association’s 67th Annual Scientific Sessions. –http://parentsguidecordblood.org/content/media/m_pdf/ADA_T1D_PR-06-25-07.pdf(The ADA in 2007 knew stem cells can treat Diabetes type 1 in children!)
  • Why no diabetes clinical trial s in the US when mice were cured of diabetes type 1 in the 1990’s? -  Weissman, a professor of pathology and developmental biology at Stanford University, states: “Stem cells are rare, self-renewing, and can regenerate body tissues.” He repeatedly expressed frustration that while many of his discoveries seemed to hold remarkable potential for life-saving treatments, commercial or regulatory hurdles have prevented his scientific research from benefiting human beings. One example is, his mid-’90s research on type I diabetes, in which he demonstrated the ability to fully cure type I diabetes in mice using stem cells. Even though the experiments avoided political controversy by using adult/repair stem cells, which do not come from embryos, Weissman ran into a road block when pharmaceutical companies refused to sponsor clinical trials. The therapy went nowhere. “The pharmaceutical companies had put profit over principle, preferring to keep diabetes sufferers dependent on costly insulin than to cure them once and for all.” – http://repairstemcell.wordpress.com/2009/09/13/research-from-90s-cures-type-1-diabetes/

Gilligan’s Island, Coconut husk cars with no compass, Two Face from Batman Forever and the duplicitous approach to Treatment Results

In ALL ARTICLES, STEM CELLS IN THE NEWS on October 28, 2009 at 2:31 pm

In the latest episode of Gilligan’s Island, we have the stunning headline:

“Embryonic stem cell breakthrough –

treatment for age-related macular degeneration”

gillians-island-mobile-car coconut bamboo

gillians-island-mobile-car coconut bamboo ginger professor

Why Gilligan’s Island? Because on the show from the 70′s the brilliant Professor was able to make a car or a radio or a submarine out of coconuts, shells and bamboo.  Pretty nifty skill to have but the only problem was; there was no gas for the car, no batteries for the radio, etc.  All of these devices had to rely on Gilligan to power them and because he was… Gilligan … he always ended up “driving the same way that Woodstock flies” and the car invariably ended up sinking in the lagoon.

This latest triumphant headline of the “Embryonic stem cell breakthrough” is a Gilligan’s Island project.  The “breakthrough” looks and sounds good, the science that went into it’s making seems strong and over all, it seems ready to take the world by storm…until you look more closely.  Upon more rigorous inspection it becomes apparent that this breakthrough is really, like the Gilligan’s Island car, made of coconut husks, bamboo and shells.

Take for example that scientists haven’t figured out a way around the tumor causing qualities of embryonic stem cells (ESC).  Consider also that ESC transplants require immunosuppressive drugs to counter rejection issues (autologous ASC do not).  Also, and this is no minor point when you consider a “breakthrough” announcement; the article states that these results and treatments are not available today, but MAY possibly be available 7 years down the road.

“Breakthrough” indeed.  I think Gilligan needs to get his hands on a compass…

——————————————————-

We interrupt this episode of Gilligan’s Island with a word from our sponsor, “Two Face.”  “Two Face” is the evil nemesis in “Batman Forever” who is always of two minds on any given subject.  He chooses to bring about good or evil based upon the outcome of a coin flip (a philosophy called creatively enough, Flipism) and he apparently rules the media in regard to stem cells with a “fixed” variation of the Flipism decision theory.

2-face-batman-forever tommy lee jones

2-face-batman-forever tommy lee jones

I know, I’m on a bit of a tangent here.  Bare with me, I promise it will all get tied together.  So, before I lose you completely, let me spell it out in plain English.

For 6 years the media has used a coin toss to determine their coverage of and response to stem cell victories.  But the coin they used was fixed.

  • On one side was “adult stem cells” and when a story came out on ASC there was either no coverage or highly negative coverage.
  • On the other side was “embryonic stem cells” and when a story came out on ESC the coverage was either positive or in the often times scenario when there was very little positive to say, incredibly optimistic and forward looking.

ESC = good, ASC = bad…

regardless of what the actual story or science or results had to say.

Do you want proof?  OK.  You really don’t have to work hard to see the obvious duplicitous and blatant denial, deception or ignorance that is at work here.  If you want bragging rights we encourage you to be the first kid on your block to question this “historic embryonic breakthrough”.  How, you ask?  It’s easy and works every time on virtually every disease!  Just Google the name of the disease (any disease) and the words “stem cell”.

Do you know what you get when you Google “macular degeneration” and “stem cell?”

Mixed in with this “amazing embryonic breakthrough” (I still don’t understand how it can be a breakthrough if it is only going to “maybe become a reality in 7 years.”) you will find articles dating back to 2002…that speak to the therapeutic benefits of treating AMD with adult stem cells (ASC).

Now here’s the clever part.  How do they know it will take 7 years?  It’s easy.  WHEN did ASC treatments of macular degeneration first took place?  You got it!  7 years ago!  And today they are virtually common place.  So 7 years seems like a good guess for how long it will take ESC to develop treatments.  There aretwo big differences which are really quite large flies in their ointment though.  ASC never had to cure cancer or rejection issues before their treatments could be considered a success; ESC do.

Regardless, 7 years from now embryonic stem cells MAY BE able to treat macular degeneration.  Of course, the third fly in their ointment is that by then, ASC will have a 14 year history of treating AMD.

fly-in-the-ointment

the not so proverbial fly-in-the-ointment

So we must ask the question:

Why is it that ASC treat thousands successfully with 130+ diseases and all you see are words like, “unproven”, “snake oil”, “more research needed”?  Why is it that when there are monumental ASC treatment successes you see the credit going to “timing”, “physical therapy,” “dietary changes” or “a side effect of the treatment itself” (I still don’t understand that one!)?  Or when they really get their back against the wall, they pull out their trump card and accuse people who are pro- ASC of being either religious zealouts or Ludites (anti-progress).

Well, I’m no zealot and I’m no Ludite; I just focus on the results.

When ESC show the remotest possibility of treating something, the horns are sounded, the confetti comes out and the balloons and the doves are released.  But is it REALLY a reality?  Maybe, in 7 years.  But only IF they cure the rejection and tumor issues.  Well then check back with me in 7 years.  ASC will have cured every disease under the sun by then.  But the ESC practitioners can go ahead and launch new products or a new company based on a 7 year old treatment derived from ESC.

This all just goes to illustrate the blatant two faced double standard between the media treatment of proven safe and effective ASC and the mere possibility of ESC treatments that MIGHT happen 7 years out and only if they overcome some huge obstacles.

double standard...get it?

double standard...get it?

If the media is going to be so incredibly duplicitous to the point of fraudulent claims and outright deception, they should do us all a favor and at least get better at it.  These heavy handed and obvious attempts at obfuscation and misdirection are worse than watching a magician try to pull a drunk rabbit out of a hat while wearing a thick pair of wool mittens.

drunk-rabbit

The sick and suffering people around the world deserve better and the truth is…

We can all “see” right through this 2 faced farce.

Hwang Woo-suk Guilty of Fraud in Clone Research

In BUSINESS OF STEM CELLS on October 27, 2009 at 3:27 am

Disgraced Cloning Expert Convicted in South Korea

By CHOE SANG-HUN

http://aterrier.files.wordpress.com/2008/07/snuppy-3.jpg?w=296&h=257

Snuppy - First cloned dog

Published: October 26, 2009

SEOUL, South Korea — Hwang Woo-suk, a disgraced cloning expert from South Korea who had claimed major breakthroughs in stem-cell research, was convicted Monday of falsifying his papers and embezzling government research funds. A judge sentenced him to a suspended two-year prison term, saying Dr. Hwang had shown remorse and had not taken research money for personal use.

http://www.grg.org/images/HwangWooSukSnuppy.jpg

CLoned dog Snuppy and Dr Hwang

 

via Hwang Woo-suk Guilty of Fraud in Clone Research – NYTimes.com.

Bloomfield man fights cancer with his own stem cells

In VICTORIES & SUCCESS STORIES on October 27, 2009 at 3:24 am

Bloomfield man fights cancer with his own stem cells

Patti Singer • Staff writer • October 26, 2009

 

…pain shot through his back.  “It was just killing me,” said Wheeler, 63, of Bloomfield, Ontario County.

Dr. Gordon Phillips II, left, meets with Marty and Barbara Wheeler of Bloomfield recently at Strong Memorial Hospital. Marty is the first patient in the Rochester area to undergo a stem-cell transplant as an outpatient.

Dr. Gordon Phillips II, left, meets with Marty and Barbara Wheeler of Bloomfield recently at Strong Memorial Hospital. Marty is the first patient in the Rochester area to undergo a stem-cell transplant as an outpatient. (JAMIE GERMANO staff photographer)

 

A string of medical treatments — including a procedure to repair damaged vertebrae — brought no relief. A bone biopsy finally revealed multiple myeloma, a cancer of the plasma cells that can show up as back pain.

myeloma_smear

Multiple Myeloma

Wheeler became the first person in the Rochester region to undergo a stem-cell transplant as an outpatient at the Wilmot Cancer Center at the University of Rochester Medical Center.

 

Wheeler’s own cells were used in a procedure that is the same whether the person stays in the hospital or is an outpatient. Stem cells are collected from the person’s blood before high-dose chemotherapy. After the chemo has cleared the bloodstream, the stem cells are re-infused and go to the bone marrow, where they make new blood cells in 10 to 14 days.

 

Outpatient autologous transplants with myeloma patients have been done in other parts of the country for several years, and the best candidates are those who have no other disease, said Dr. Gordon L. Phillips II, director of the Samuel E. Durand Blood and Marrow Transplant Program at Wilmot.

 

Re-infusing a patient’s own cells lends itself to an outpatient procedure more than a transplant from a donor would, and the procedure enhances quality of life for those with a disease for which there is no cure.

http://www.jillstanek.com/archives/cancer.jpg

Cancer Cell

via Bloomfield man fights cancer with his own stem cells | democratandchronicle.com | Democrat and Chronicle.

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