DAVID GRANOVSKY

STEM CELLS ARE OUT OF THIS WORLD

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on July 21, 2014 at 4:38 pm

The potential of stem cells to regrow and/or prevent the deterioration of muscle and bone cells over time when subjected to zero gravity has garnered an enormous amount of interest from NASA and the entire space travel industry.   This has lead NASA to send stem cells into space to be researched in low or zero gravity on the space station.   The findings are extraordinary.  “The team discovered that 64 percent of the proteins found in the stem cells grown in simulated microgravity were not in control samples. In particular, the bioreactor cells contained several proteins involved in the breakdown of bone and in the regulation of calcium, neither type of which were found in stem cells grown in regular, Earth gravity.” 

We’ve know for some time that stem cells are smart and capable of:

  • differentiating into whatever cell types are needed without direction
  • growing every cell in a heart and organizing those cells perfectly into where they need to be
  • retro-differentiate into other cell types after finishing work on a particular organ or tissue type
  • traveling back through the umbilical cord from fetus in womb to mother with heart disease to aid the mother in the healing process
  • and many more incredible capabilities

But those actions took place in the patient’s body where the stem cells are able to read the needs of the body with the help of  numerous cues, messenger cells and the entire physiological road map of the patient to guide them.   Essentially, they have an awesome GPS system and just have to follow the directions they are given on roads the GPS “knows” very well.  Conversely, the astro-stem cells (stem cell-nauts?) are able to grow better in space than on earth and to grow with “space relevant capabilities.”  This is incredible.  Imagine going to space for the first time and knowing intrinsically what to do and further, knowing what to do to help your host body better survive and thrive in the conditions of space.  The astro-stem cells are taking cues from their external environment from factors they have never even been exposed to (unless you adhere to the ancient aliens theories) and modifying their proteins and genetic make up to accommodate for the difference in gravity.

What else can they do? If we assume the stem cells will react to the external cues as well as the internal cues, what other factors will they respond to?  We know they grow better in space and in a hyperbaric chamber; what type of response would they have to being underground, on the ocean or under it (long submarine voyages or sub-oceanic colonization), in the dark (increased optic nerve proliferation?), in radioactive areas (radiation resistance)?  Time will tell.  I would say the sky is the limit but apparently, it’s not.

Are we witnessing evolution?
evo·lu·tion  noun \ˌe-və-ˈlü-shən, ˌē-və-\ biology : a theory that the differences between modern plants and animals are because of changes that happened by a natural process over a very long time.  the process by which changes in plants and animals happen over time, a process of slow change and development

No.  Not evolution.  This is faster than the classic definition of evolution.  This is accelerated and positive mutation as a response to external and internal environmental factors.   This is…adaption, rapid adaption…”  Lending support to my analogy that stem cells are born Marines because “Marines are taught to adapt, improvise, overcome…” via

…and the line between science fiction and science reality grows ever thinner.
- David

Growing-stem-cells-in-space

Growing stem cells in space: Medicine’s next big thing

“When challenged by microgravity, living organisms’ genes can ‘turn on,’ transforming growth. Scientists at Zero Gravity Solutions work to direct cells toward healthier, hardier strains. It’s not genetic engineering, but accelerated hybridization.” via http://www.space.com/21885-stem-cells-in-space-can-solve-plant-and-animal-problems-video.html

Date:
March 31, 2014
Source:
Ivanhoe / Powered by NewsLook.com
Summary:
Currently, treatments for hemorrhagic stroke aim to control swelling but not regeneration of the damaged tissue. Now, researchers are using an out of this world idea to help stroke survivors. Video provided by Ivanhoe

http://www.sciencedaily.com/videos/58f619e8b7a37890f1857c84110e7e91.htm

RELATED/SOURCES:

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

- See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

- See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

 

AUTISM TRIAL AT DUKE UNIVERSITY

In STEM CELLS IN THE NEWS on July 18, 2014 at 1:00 pm

http://clinicaltrials.gov/ct2/show/record/NCT02176317
“Umbilical cord blood (UCB) has been shown to lessen the clinical and radiographic impact of hypoxic brain injury and stroke in animal models and in infants with hypoxic ischemic encephalopathy. UCB also engrafts and differentiates in the brain, facilitating neural cell repair in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation. Infusion of autologous UCB does not require immunosuppression and has been shown to be safe in young children with brain injuries such as cerebral palsy and stroke. In this study, the investigators hypothesize that infusion of a patient’s own umbilical cord blood cells (UCB) can offer neural protection/repair in the brain and reduction of inflammation associated with this disorder.”

DUKE STEM CELL AUTISM TRIAL

There’s a lot of skepticism surrounding this trial using cord blood stem cells to treat autism.  Apparently, the concerns are:

1.  Autism is a name given to a whole host of diseases yet to be named, ie. many different symptoms.
Stem cells are part of the natural healing system in the body.  They are smart and migrate to fix damaged tissue and cells.  Stem cells work within your body in conjunction with your physiology.  You can try to train and control them but they have a mind of their own.  For ex: When cardiac stem cells are injected into the heart, they often finish their work and then migrate down to the Pancreas and fix it.  IV implantation is very much in keeping with this idea and relies on the stem cells smart capabilities.  On a certain level, we don’t need to know what is broken.  They do.  A soldier is trained to respond to orders, then told what to do and they damn well do it.  Marines are taught to adapt, improvise, overcome and often sent into battle with limited intel.  When faced with an obstacle, they change their strategy and create a new one to succeed.  Both are very valuable.  Stem cells are born Marines.

2.  We don’t know what causes Autism so we can’t treat it.
The people saying we don’t “know” what causes Autism are the same people who “knew” cardiac cells don’t regenerate, central nervous system cells don’t regenerate, only Embryonic stem cells have value, Margarine is better than Butter, etc. Wrong, wrong, wrong, wrong. 

There are more things in heaven and earth, Horatio,
Than are dreamt of in your philosophy.
– Hamlet (1.5.167-8), Hamlet to Horatio

Our knowledge is incredibly limited.  As time goes on, we learn more and everything we held as inviolate becomes…violated.   Taking into consideration that everything we “know” will be proven wrong in a few decades and then wrong again in another few after that as we learn more…people should probably stop blocking treatments because of what they “know” or in this case, don’t “know.”

This just popped up and I had to add it. Regulation of developmental gene expression occurs in the reverse order to that expected   http://phys.org/news/2014-07-developmental-gene-reverse.html – “…modifications involving Polycomb proteins occur in a manner that contradicts existing models.” 

3.  Stem cells can’t make it into the brain where the damage is.
This is a test for safety of stem cells in Autistic children so efficacy is only a secondary consideration.  Let’s see if they tolerate a small amount of stem cells first before giving them a full dose, though I see no reason why they wouldn’t.   Duke U. is where a number of successful pediatric cord blood/Cerebral Palsy trials were held. http://repairstemcell.wordpress.com/2012/04/10/cerebral-palsy-and-stem-cells/  CP involves the brain.  Stem cells have a history of success with Ataxia, Traumatic Brain injury, etc. etc.

Conclusion:

  • Proof of concept with brain injury and stroke symptoms in animals and infants with hypoxic ischemic encephalopathy.
  • Proof of concept with facilitating neural cell repair in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation.
  • Autologous UCB means no immunosuppression required. 
  • Shown to be safe in young children with brain injuries such as cerebral palsy and stroke.
  • Stem cells are “smart” Marines.
  • Not knowing what causes a problem is no reason to not try to fix it.

That’s a lot of good reasons to forge ahead. 
Plus, tragically, it’s only getting worse out there.

Photo: Prevalence of ASDs with 8 Year olds

 

ADULT STEM CELL EVOLUTION AT A GLANCE

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on July 16, 2014 at 11:03 am

“Beginning in about 1990, the treatment of cardiovascular disease experienced major conceptual expansions through the application of new therapeutic paradigms targeted to angiogenesis and tissue healing. Initial strategies involved administering proteins involved in healing processes, then the genes that encoded them, and then, by the end of the decade, the use of stem cells to better achieve these objectives.” -‘Stem Cell Therapy in Cardiovascular Disease: Past Obstacles and Promising New Directions‘, genengnews.com

Stem Cell Therapy in Cardiovascular Disease: Past Obstacles and Promising New Directions

Adult Stem Cell Evolution At A Glance
Author: Sarah Hoffman

I know many people think that what we know about stem cells is all we have ever known. This is a misconception arising from the fact that people in the United States do not discuss the topic because it could be considered a political no-no-topic. In reality, many scientists from all over the earth research adult stem cells and are finding ways to use them that was never before imaginable. They are also perfecting ways in which we use them to treat patience with varying ailments. This article focuses on cardiovascular diseases.

Scientists began by trying varying methods of stem cell treatment, from utilizing many different types of cells at a time to using very specific cells. Through many studies and trial and error, scientists found that intravenous injection of stem cells to treat many cardiac ailments was effective, efficient, and affordable.

So it seems to me that a routine stem cell treatment may soon be available to cardiac patients.

Take a gander at the whole article and I know some more of your questions are sure to be answered!

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